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Department of Medicine Seminar Series

Model-based Dosing in Patients with Gout: The Curious Case of Allopurinol 

Dr Daniel F.B. Wright
BScPharm(Dal) MA(Brist) MSc PhD(Otago)

The dosing of allopurinol would appear to be anything but “curious”. A standard dose of 300mg daily was commonly prescribed in the past and is still used in comparative clinical trials for newer urate-lowering agents. Dose reduction in patients with renal impairment is not unexpected for a drug with a renally-cleared active metabolite (oxypurinol). The recent finding that maintenance dose requirements may vary by 6-9 fold is not particularly unusual either. What is curious however is that dose reduction in patients with renal impairment results in a dramatic reduction in treatment success, even though the plasma concentrations of oxypurinol are normalised within a presumed ‘therapeutic range’ across different levels of renal function. This talk will present a model-based analysis designed to determine the factors that influence allopurinol dose requirements and to predict the doses required to achieve the serum urate target of ≤ 0.36 mmol/L.


Date Friday, 22 November 2019
Time 1:00pm - 2:00pm
Audience Public
Event Category Health Sciences
Event Type Departmental Seminar
DepartmentMedicine (Dunedin)
Location9th floor Seminar Room
Dunedin Public Hospital
Contact NameAmanda Buchanan

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