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Bioorthogonal chemical reactions for activation of prodrugs and diagnostics

Presented by Dr Allan Gamble

School of Pharmacy, University of Otago

Our group is interested in designing ‘click-and-release’ type strategies for controlled drug delivery applications and diagnostics. We have identified a new and general bioorthogonal activation strategy based on the 1,3-dipolar cycloaddition of an azide-substituted self-immolative linker (SIL) and trans-cyclooctene (TCO).

The development of this chemistry and the in vitro and in vivo applications using a tumour prodrug strategy will be presented. The ‘click-and-release’ approach could be extended to other areas of medicinal chemistry and chemical biology.

Date Monday, 3 May 2021
Time 12:00pm - 1:00pm
Audience All University
Event Category Health Sciences
Event Type Seminar
DepartmentMicrobiology and Immunology
LocationMIcrobiology Building, 720 Cumberland Street, 2nd Floor - Room 208, Dunedin
Contact NameJennifer van Eunen
Contact Phone03 479 7734

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