Accessibility Skip to Global Navigation Skip to Local Navigation Skip to Content Skip to Search Skip to Site Map Menu

Bioorthogonal chemical reactions for activation of prodrugs and diagnostics

Presented by Dr Allan Gamble

School of Pharmacy, University of Otago

Our group is interested in designing ‘click-and-release’ type strategies for controlled drug delivery applications and diagnostics. We have identified a new and general bioorthogonal activation strategy based on the 1,3-dipolar cycloaddition of an azide-substituted self-immolative linker (SIL) and trans-cyclooctene (TCO).

The development of this chemistry and the in vitro and in vivo applications using a tumour prodrug strategy will be presented. The ‘click-and-release’ approach could be extended to other areas of medicinal chemistry and chemical biology.

Date Monday, 3 May 2021
Time 12:00pm - 1:00pm
Audience All University
Event Category Health Sciences
Event Type Seminar
CampusDunedin
DepartmentMicrobiology and Immunology
LocationMIcrobiology Building, 720 Cumberland Street, 2nd Floor - Room 208, Dunedin
CostFree
Contact NameJennifer van Eunen
Contact Phone03 479 7734
Contact Emailjennifer.vaneunen@otago.ac.nz

Save this event