Presented by Dr Allan Gamble
School of Pharmacy, University of Otago
Our group is interested in designing ‘click-and-release’ type strategies for controlled drug delivery applications and diagnostics. We have identified a new and general bioorthogonal activation strategy based on the 1,3-dipolar cycloaddition of an azide-substituted self-immolative linker (SIL) and trans-cyclooctene (TCO).
The development of this chemistry and the in vitro and in vivo applications using a tumour prodrug strategy will be presented. The ‘click-and-release’ approach could be extended to other areas of medicinal chemistry and chemical biology.
|Date||Monday, 3 May 2021|
|Time||12:00pm - 1:00pm|
|Event Category||Health Sciences|
|Department||Microbiology and Immunology|
|Location||MIcrobiology Building, 720 Cumberland Street, 2nd Floor - Room 208, Dunedin|
|Contact Name||Jennifer van Eunen|
|Contact Phone||03 479 7734|