Effective cancer treatment begins with timely diagnosis and continues through to curative therapy and, finally, restorative treatment for survivors. In recent decades more effective curative treatments have meant an increase in survivorship for patients with cancer; however, there are still subgroups of patients who do not respond to current therapies and can experience significant toxicities associated with these treatments. Furthermore, with increased survivorship there is an increased focus on repairing the damage left by curative treatments and improving patient quality of life.
Extracellular vesicles (EVs) are membrane bound packages that act as intercellular messengers in the tissue microenvironment. They can work in a paracrine or endocrine fashion and carry a range of molecular cargo, including small non-coding RNA (sncRNA).
Research in our group is focussed on how we can use these EVs and their sncRNA cargo to improve diagnosis and treatment of cancer. Our current projects include using circulating sncRNA as predictive biomarkers for treatment response in colorectal cancer (CRC), the function of EVs and sncRNAs in CRC pathology and treatment, and the use of adipose-derived stem cell EVs as a therapeutic modality in autologous fat grafting for breast reconstruction post-breast cancer treatment.
|Date||Tuesday, 1 June 2021|
|Time||12:00pm - 1:00pm|
|Event Category||Health Sciences|
|Location||Biochemistry Seminar Room G.13 (BIG13), Dunedin|
|Contact Name||Department of Biochemistry|