Three-dimensional scaffolds for tissue engineering applications
Tissue engineering applications ordinarily involve the use of three-dimensional (3D) scaffolds to serve as suitable microenvironments for the combination of cells or growth factors to regenerate damaged tissue or organs. The biomaterials used to make these 3D scaffolds are biocompatible and biodegradable, and can be tuned chemically, mechanically, and physically in order to achieve optimal cell growth and function. Cells, biomaterials, and bioactive molecules can be positioned with accurate spatial control in a layer-by-layer fashion using 3D bioprinting technology.
Research in our group is interested in developing new bioink design strategies for the delivery of bone-marrow derived mesenchymal stem cells (BMSCs), among other cell types, using a variety of 3D printing techniques in order to make more in vivo-like 3D constructs for regenerative medicine and tissue engineering purposes. Our work focuses on the use of 3D melt-electrowriting (MEW) technology, an advanced additive manufacturing technique, using the only instrument of its kind in New Zealand, the GeSiM 3.1 Bioscaffolder, to create micron level mesh scaffolds for cell seeding (a). A different additive manufacturing technique, core/shell or co-axial 3D bioprinting technology was used to create regenerative, vascularized constructs to serve as personalised “living dressings” for the treatment of non-healing wounds (b). Other current projects focus on bioactive delivery, i.e. antimicrobials, drugs, etc. using hydrogel depots and nano- or micro-bioink formulations for healthcare applications.
|Date||Tuesday, 15 June 2021|
|Time||12:00pm - 1:00pm|
|Event Category||Health Sciences|
|Location||Biochemistry Seminar Room G.13 (BIG13), Dunedin.|
|Contact Name||Department of Biochemistry|