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Department of Pharmacology and Toxicology staff profiles

Professor Michelle Glass

PositionHead of Department
DepartmentDepartment of Pharmacology and Toxicology
QualificationsPhD BSc
Research summaryCannabinoids, neurodegenerative diseases, Huntington’s disease, G-protein coupled receptors

Research

Professor Michelle Glass is the Head of the Department of Pharmacology and Toxicology. The molecular pharmacologist had most recently been working at the University of Auckland for 18 years where she was Head of the Department of Pharmacology and in 2017 appointed Professor of Pharmacology.

She has now returned to the department where her working career began 23 years ago. Professor Glass’ first role after graduating with a PhD from the Department of Pharmacology at the University of Auckland in 1995 was as an Assistant Lecturer in the Department of Pharmacology at the University of Otago.

Her initial stint at Otago was brief as she took up a fellowship in the United States the following year. She worked as a postdoctoral Fellow in the Laboratory of Cellular and Molecular Regulation at the National Institute of Mental Health in Bethesda, Maryland for 18 months before moving on to work as a Visiting Fellow in the Laboratory of Cell Biology at the National Institute of Deafness and Other Communications Disorders in Rockville, Maryland. She returned to New Zealand in 2000 and took up a role as a Lecturer within the Department of Pharmacology at the University of Auckland.

Professor Glass’ research focuses on the expression, function and molecular pharmacology of the cannabinoid receptors and their potential role in treatment of neurodegenerative diseases. Her recent research interests have extended to identifying the mechanism by which synthetic cannabinoids are resulting in high levels of toxicity in the community and advising on the development of clinical trials for medicinal cannabis products.

Currently, Professor Glass is a member of the Medical Cannabis Research Collaborative (NZ), which aims to ensure robust clinical research of medical cannabis products in New Zealand is undertaken. It will also set informal standards for the development and testing of medical cannabis products, as well as increasing understanding and the base of evidence for or against the use of medical cannabis products in specific clinical conditions. Her contributions to the field have been acknowledged by an early career award from the International Cannabinoid Research Society in 2009 and by election to President of this society.

She acknowledges it is an interesting time with change potentially in the wind with so many countries legalising cannabis.

“I think it’s important that the science keeps up with the public debate.”

Read more in Otago Bulletin:
Synthetic cannabis under spotlight for new Pharmacology head

Publications

Daldegan-Bueno, D., Maia, L. O., Glass, M., Jutras-Aswad, D., & Fischer, B. (2021). Co-exposure of cocaine and cannabinoids and its association with select biological, behavioural and health outcomes: A systematic scoping review of multi-disciplinary studies. European Neuropsychopharmacology, 51, 106-131. doi: 10.1016/j.euroneuro.2021.06.002

Yang, L., Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2021). Exploring group size for statistical analysis of real-time signalling experiments. British Journal of Pharmacology. Advance online publication. doi: 10.1111/bph.15572

Manning, J. J., Green, H. M., Glass, M., & Finlay, D. B. (2021). Pharmacological selection of cannabinoid receptor effectors: Signalling, allosteric modulation and bias. Neuropharmacology. Advance online publication. doi: 10.1016/j.neuropharm.2021.108611

Nguyen, T., Gamage, T. F., Decker, A. M., Finlay, D. B., Langston, T. L., Barrus, D., Glass, M., … Zhang, Y. (2021). Rational design of cannabinoid type-1 receptor allosteric modulators: Org27569 and PSNCBAM-1 hybrids. Bioorganic & Medicinal Chemistry. Advance online publication. doi: 10.1016/j.bmc.2021.116215

Patel, M., Finlay, D. B., & Glass, M. (2021). Biased agonism at the cannabinoid receptors: Evidence from synthetic cannabinoid receptor agonists. Cellular Signaling, 78, 109865. doi: 10.1016/j.cellsig.2020.109865

Ashton, J. C., Dowie, M. J., & Glass, M. (2017). The endocannabinoid system and human brain functions: Insight from memory, motor, and mood pathologies. In E. Murillo-Rodríguez (Ed.), The endocannabinoid system. (pp. 115-186). London, UK: Academic Press. doi: 10.1016/B978-0-12-809666-6.00005-8

Chapter in Book - Research

Cawston, E. E., Hunter, M. R., & Glass, M. (2017). Allosteric modulation of the cannabinoid CB1 receptor. In V. R. Preedy (Ed.), Handbook of cannabis and related pathologies: Biology, pharmacology, diagnosis, and treatment. (pp. 573-583). London, UK: Academic Press. doi: 10.1016/B978-0-12-800756-3.00070-3

Chapter in Book - Research

Hunter, M. R., Finlay, D. B., & Glass, M. (2017). Signal transduction and regulation of the cannabinoid CB1 receptor. In V. R. Preedy (Ed.), Handbook of cannabis and related pathologies: Biology, pharmacology, diagnosis, and treatment. (pp. 563-572). London, UK: Academic Press. doi: 10.1016/B978-0-12-800756-3.00069-7

Chapter in Book - Research

Hunter, M. R., Finlay, D. B., Macdonald, C. E., Cawston, E. E., Grimsey, N. L., & Glass, M. (2017). Real-time measurement of cannabinoid receptor-mediated cAMP signaling. In P. H. Reggio (Ed.), Methods in enzymology: Cannabinoids and their receptors (Vol. 593). (pp. 43-59). Cambridge, MA: Academic Press. doi: 10.1016/bs.mie.2017.05.001

Chapter in Book - Research

Kho, D. T., Glass, M., & Graham, E. S. (2017). Is the cannabinoid CB2 receptor a major regulator of the neuroinflammatory axis of the neurovascular unit in humans? In D. Kendall & S. P. H. Alexander (Eds.), Advances in Pharmacology [Vol. 80: Cannabinoid pharmacology]. (pp. 207-221). Cambridge, MA: Academic Press. doi: 10.1016/bs.apha.2017.03.005

Chapter in Book - Research

Priestley, R., Glass, M., & Kendall, D. (2017). Functional selectivity at cannabinoid receptors. In D. Kendall & S. P. H. Alexander (Eds.), Advances in Pharmacology [Vol. 80: Cannabinoid pharmacology]. (pp. 207-221). Cambridge, MA: Academic Press. doi: 10.1016/bs.apha.2017.03.005

Chapter in Book - Research

Goodfellow, C. E., & Glass, M. (2009). Anandamide receptor signal transduction. In G. Litwack (Ed.), Vitamins and hormones. (pp. 79-110). London, UK: Academic Press. doi: 10.1016/S0083-6729(09)81004-2

Chapter in Book - Research

Ashton, J. C., & Glass, M. (2008). Multiple roles for cannabinoids in neuroprotection during oxidative stress injury. In O. M. Roux (Ed.), Brain hypoxia-ischemia research progress. (pp. 229-244). New York: Nova.

Chapter in Book - Research

Manning, J. J., Green, H. M., Glass, M., & Finlay, D. B. (2021). Pharmacological selection of cannabinoid receptor effectors: Signalling, allosteric modulation and bias. Neuropharmacology. Advance online publication. doi: 10.1016/j.neuropharm.2021.108611

Journal - Research Article

Nguyen, T., Gamage, T. F., Decker, A. M., Finlay, D. B., Langston, T. L., Barrus, D., Glass, M., … Zhang, Y. (2021). Rational design of cannabinoid type-1 receptor allosteric modulators: Org27569 and PSNCBAM-1 hybrids. Bioorganic & Medicinal Chemistry. Advance online publication. doi: 10.1016/j.bmc.2021.116215

Journal - Research Article

Patel, M., Finlay, D. B., & Glass, M. (2021). Biased agonism at the cannabinoid receptors: Evidence from synthetic cannabinoid receptor agonists. Cellular Signaling, 78, 109865. doi: 10.1016/j.cellsig.2020.109865

Journal - Research Article

Yang, L., Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2021). Exploring group size for statistical analysis of real-time signalling experiments. British Journal of Pharmacology. Advance online publication. doi: 10.1111/bph.15572

Journal - Research Article

Ametovski, A., Macdonald, C., Manning, J. J., Syed Haneef, S. A., Santiago, M., Martin, L., … Glass, M., & Banister, S. D. (2020). Exploring stereochemical and conformational requirements at cannabinoid receptors for synthetic cannabinoids relating to SDB-006, 5F-SDB-006, CUMYL-PICA, and 5F-CUMYL-PICA. ACS Chemical Neuroscience. Advance online publication. doi: 10.1021/acschemneuro.0c00591

Journal - Research Article

Finlay, D. B., Sircombe, K. J., Nimick, M., Jones, C., & Glass, M. (2020). Terpenoids from cannabis do not mediate an entourage effect by acting at cannabinoid receptors. Frontiers in Pharmacology, 11, 359. doi: 10.3389/fphar.2020.00359

Journal - Research Article

Gamage, T. F., Barrus, D. A., Kevin, R. C., Finlay, D. B., Lefever, T. W., Patel, P. R., … Glass, M., … Thomas, B. F. (2020). In vitro and in vivo pharmacological evaluation of the synthetic cannabinoid receptor agonist EG-018. Pharmacology Biochemistry & Behavior, 193, 172918. doi: 10.1016/j.pbb.2020.172918

Journal - Research Article

Mielnik, C. A., Sugamori, K. S., Finlay, D. B., Thorpe, H. H. A., Schapira, M., Sivananthan, N., … Glass, M., … Ross, R. A. (2020). A novel allosteric modulator of the cannabinoid CB1 receptor ameliorates hyperdopaminergia endophenotypes in rodent models. Neuropsychopharmacology. Advance online publication. doi: 10.1038/s41386-020-00876-5

Journal - Research Article

Narayan, P., Reid, S., Scotter, E. L., McGregor, A. L., Mehrabi, N. F., Singh-Bains, M. K., Glass, M., … Dragunow, M. (2020). Inconsistencies in histone acetylation patterns among different HD model systems and HD post-mortem brains. Neurobiology of Disease, 146, 105092. doi: 10.1016/j.nbd.2020.105092

Journal - Research Article

Ong, R. S., Kappatos, D. C., Russell, S. G. G., Poulsen, H. A., Banister, S. D., Gerona, R. R., Glass, M., … McCarthy, M.-J. (2020). Simultaneous analysis of 29 synthetic cannabinoids and metabolites, amphetamines and cannabinoids in human whole blood by liquid chromatography-tandem mass spectrometry: A New Zealand perspective of use in 2018. Drug Testing & Analysis, 12, 195-214. doi: 10.1002/dta.2697

Journal - Research Article

Patel, M., Manning, J. J., Finlay, D. B., Javitch, J. A., Banister, S. D., Grimsey, N. L., & Glass, M. (2020). Signalling profiles of a structurally diverse panel of synthetic cannabinoid receptor agonists. Biochemical Pharmacology, 175, 113871. doi: 10.1016/j.bcp.2020.113871

Journal - Research Article

Robson, H., Braund, R., Glass, M., Ashton, J., & Tatley, M. (2020). Synthetic cannabis: Adverse events reported to the New Zealand Pharmacovigilance Centre. Clinical Toxicology. Advance online publication. doi: 10.1080/15563650.2020.1828592

Journal - Research Article

Singh, S., Liddle, I., Macdonald, C., Tyndall, J. D. A., Glass, M., & Vernall, A. (2020). Development of chromenopyrazole-based selective cannabinoid 2 receptor agonists. Australian Journal of Chemistry. Advance online publication. doi: 10.1071/CH20263

Journal - Research Article

Van den Berg, M., John, M., Black, M., Semprini, A., Oldfield, K., Glass, M., & Braithwaite, I. (2020). Cannabis-based medicinal products in arthritis, a painful conundrum. New Zealand Medical Journal, 133(1515), 35-45. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2020). Evaluation of the profiles of CB1 cannabinoid receptor signalling bias using joint kinetic modelling. British Journal of Pharmacology, 177, 3449-3463. doi: 10.1111/bph.15066

Journal - Research Article

Banister, S. D., Adams, A., Kevin, R. C., Macdonald, C., Glass, M., Boyd, R., … Gerona, R. R. (2019). Synthesis and pharmacology of new psychoactive substance 5F‐CUMYL‐P7AICA, a scaffold-hopping analog of synthetic cannabinoid receptor agonists 5F‐CUMYL‐PICA and 5F‐CUMYL‐PINACA. Drug Testing & Analysis, 11(2), 279-291. doi: 10.1002/dta.2491

Journal - Research Article

Finlay, D. B., Manning, J. J., Ibsen, M. S., Macdonald, C. E., Patel, M., Javitch, J. A., … Glass, M. (2019). Do toxic synthetic cannabinoid receptor agonists have signature in vitro activity profiles? A case study of AMB-FUBINACA. ACS Chemical Neuroscience, 10, 4350-4360. doi: 10.1021/acschemneuro.9b00429

Journal - Research Article

Ibsen, M. S., Finlay, D. B., Patel, M., Javtich, J. A., Glass, M., & Grimsey, N. L. (2019). Cannabinoid CB1 and CB2 receptor-mediated arrestin translocation: Species, subtype, and agonist-dependence. Frontiers in Pharmacology, 10, 350. doi: 10.3389/fphar.2019.00350

Journal - Research Article

Kevin, R. C., Anderson, L., McGregor, I. S., Boyd, R., Manning, J. J., Glass, M., … Banister, S. D. (2019). CUMYL-4CN-BINACA is an efficacious and potent pro-convulsant synthetic cannabinoid receptor agonist. Frontiers in Pharmacology, 10, 595. doi: 10.3389/fphar.2019.00595

Journal - Research Article

Saroz, Y., Kho, D. T., Glass, M., Graham, E. S., & Grimsey, N. L. (2019). Cannabinoid receptor 2 (CB2) signals via G-alpha-s and induces IL-6 and IL-10 cytokine secretion in human primary leukocytes. ACS Pharmacology & Translational Science, 2(6), 414-428. doi: 10.1021/acsptsci.9b00049

Journal - Research Article

Singh, S., Oyagawa, C. R. M., Macdonald, C., Grimsey, N. L., Glass, M., & Vernall, A. J. (2019). Chromenopyrazole-based high affinity, selective fluorescent ligands for cannabinoid type 2 receptor. ACS Medicinal Chemistry Letters, 10, 209-214. doi: 10.1021/acsmedchemlett.8b00597

Journal - Research Article

Wiley, J. L., Lefever, T. W., Glass, M., & Thomas, B. F. (2019). Do you feel it now? Route of administration and Δ9-tetrahydrocannabinol-like discriminative stimulus effects of synthetic cannabinoids in mice. NeuroToxicology, 73, 161-167. doi: 10.1016/j.neuro.2019.04.002

Journal - Research Article

Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2019). An intact model for quantifying functional selectivity. Scientific Reports, 9, 2557. doi: 10.1038/s41598-019-39000-z

Journal - Research Article

Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2019). Model-free and kinetic modelling approaches for characterising non-equilibrium pharmacological pathway activity: Internalisation of cannabinoid CB1 receptors. British Journal of Pharmacology, 176, 2593-2607. doi: 10.1111/bph.14684

Journal - Research Article

Cooper, A. G., MacDonald, C., Glass, M., Hook, S., Tyndall, J. D. A., & Vernall, A. J. (2018). Alkyl indole-based cannabinoid type 2 receptor tools: Exploration of linker and fluorophore attachment. European Journal of Medicinal Chemistry, 145, 770-789. doi: 10.1016/j.ejmech.2017.11.076

Journal - Research Article

Cooper, A. G., Oyagawa, C. R. M., Manning, J. J., Singh, S., Hook, S., Grimsey, N. L., Glass, M., Tyndall, J. D. A., & Vernall, A. J. (2018). Development of selective, fluorescent cannabinoid type 2 receptor ligands based on a 1,8-naphthyridin-2-(1H)-one-3-carboxamide scaffold. MedChemComm, 9(12), 2055-2067. doi: 10.1039/c8md00448j

Journal - Research Article

Hosie, S., Malone, D. T., Liu, S., Glass, M., Adlard, P. A., Hannan, A. J., & Hill-Yardin, E. L. (2018). Altered amygdala excitation and CB1 receptor modulation of aggressive behavior in the neuroligin-3 R451C mouse model of autism. Frontiers in Cellular Neuroscience, 12, 234. doi: 10.3389/fncel.2018.00234

Journal - Research Article

Oyagawa, C. R. M., de la Harpe, S. M., Saroz, Y., Glass, M., Vernall, A. J., & Grimsey, N. L. (2018). Cannabinoid Receptor 2 signalling bias elicited by 2,4,6-trisubstituted 1,3,5-triazines. Frontiers in Pharmacology, 9, 1202. doi: 10.3389/fphar.2018.01202

Journal - Research Article

Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2018). An evaluation of the operational model when applied to quantify functional selectivity. British Journal of Pharmacology, 175, 1654-1668. doi: 10.1111/bph.14171

Journal - Research Article

Finlay, D. B., Cawston, E. E., Grimsey, N. L., Hunter, M. R., Korde, A., Vemuri, V. K., … Glass, M. (2017). Gαs signalling of the CB1 receptor and the influence of receptor number. British Journal of Pharmacology, 174(15), 2545-2562. doi: 10.1111/bph.13866

Journal - Research Article

Soethoudt, M., Grether, U., Fingerle, J., Grim, T. W., Fezza, F., de Petrocellis, L., … Finlay, D., … Glass, M., & van der Stelt, M. (2017). Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity. Nature Communications, 8, 13958. doi: 10.1038/ncomms13958

Journal - Research Article

Banister, S. D., Longworth, M., Kevin, R., Sachdev, S., Santiago, M., Stuart, J., … Glass, M., … Kassiou, M. (2016). Pharmacology of valinate and tert-leucinate synthetic cannabinoids 5F-AMBICA, 5F-AMB, 5F-ADB, AMB-FUBINACA, MDMB-FUBINACA, MDMB-CHMICA, and their analogues. ACS Chemical Neuroscience, 7(9), 1241-1254. doi: 10.1021/acschemneuro.6b00137

Journal - Research Article

Finlay, D. B., Joseph, W. R., Grimsey, N. L., & Glass, M. (2016). GPR18 undergoes a high degree of constitutive trafficking but is unresponsive to N-arachidonoyl glycine. PeerJ, 2016(4), e1835. doi: 10.7717/peerj.1835

Journal - Research Article

Hunter, M. R., Grimsey, N. L., & Glass, M. (2016). Sulfation of the FLAG epitope is affected by co-expression of G protein-coupled receptors in a mammalian cell model. Scientific Reports, 6, 27316. doi: 10.1038/srep27316

Journal - Research Article

Longworth, M., Banister, S. D., Mack, J. B. C., Glass, M., Connor, M., & Kassiou, M. (2016). The 2-alkyl-2H-indazole regioisomers of synthetic cannabinoids AB-CHMINACA, AB-FUBINACA, AB-PINACA, and 5F-AB-PINACA are possible manufacturing impurities with cannabimimetic activities. Forensic Toxicology, 34(2), 286-303. doi: 10.1007/s11419-016-0316-y

Journal - Research Article

Redmond, W. J., Cawston, E. E., Grimsey, N. L., Stuart, J., Edington, A. R., Glass, M., & Connor, M. (2016). Identification of N‐arachidonoyl dopamine as a highly biased ligand at cannabinoid CB1 receptors. British Journal of Pharmacology, 173(1), 115-127. doi: 10.1111/bph.13341

Journal - Research Article

Banister, S. D., Moir, M., Stuart, J., Kevin, R. C., Wood, K. E., Longworth, M., … Glass, M., … Kassiou, M. (2015). Pharmacology of indole and indazole synthetic cannabinoid designer drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA. ACS Chemical Neuroscience, 6(9), 1546-1559. doi: 10.1021/acschemneuro.5b00112

Journal - Research Article

Banister, S. D., Stuart, J., Conroy, T., Longworth, M., Manohar, M., Beinat, C., … Glass, M., … Kassiou, M. (2015). Structure–activity relationships of synthetic cannabinoid designer drug RCS-4 and its regioisomers and C4 homologues. Forensic Toxicology, 33(2), 355-366. doi: 10.1007/s11419-015-0282-9

Journal - Research Article

Banister, S. D., Stuart, J., Kevin, R. C., Edington, A., Longworth, M., Wilkinson, S. M., … Glass, M., … Kassiou, M. (2015). Effects of bioisosteric fluorine in synthetic cannabinoid designer drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135. ACS Chemical Neuroscience, 6(8), 1445-1458. doi: 10.1021/acschemneuro.5b00107

Journal - Research Article

Cawston, E. E., Connor, M., Di Marzo, V., Silvestri, R., & Glass, M. (2015). Distinct temporal fingerprint for cyclic adenosine monophosphate (cAMP) signaling of indole-2-carboxamides as allosteric modulators of the cannabinoid receptors. Journal of Medicinal Chemistry, 58(15), 5979-5988. doi: 10.1021/acs.jmedchem.5b00579

Journal - Research Article

Khajehali, E., Malone, D. T., Glass, M., Sexton, P. M., & Christopoulos, A. (2015). Biased agonism and biased allosteric modulation at the CB1 cannabinoid receptor. Molecular Pharmacology, 88(2), 368-379. doi: 10.1124/mol.115.099192

Journal - Research Article

Dowie, M. J., Grimsey, N. L., Hoffman, T., Faull, R. L. M., & Glass, M. (2014). Cannabinoid receptor CB2 is expressed on vascular cells, but not astroglial cells in the post-mortem human Huntington's disease brain. Journal of Chemical Neuroanatomy, 59-60, 62-71. doi: 10.1016/j.jchemneu.2014.06.004

Journal - Research Article

MacDonald, C., Finlay, D. B., Jabed, A., Glass, M., & Graham, E. S. (2014). Development of positive control tissue for in situ hybridisation using Alvetex scaffolds. Journal of Neuroscience Methods, 238, 70-77. doi: 10.1016/j.jneumeth.2014.09.006

Journal - Research Article

Yee, A. G., Lee, S.-M., Hunter, M. R., Glass, M., Freestone, P. S., & Lipski, J. (2014). Effects of the Parkinsonian toxin MPP+ on electrophysiological properties of nigral dopaminergic neurons. NeuroToxicology, 45, 1-11. doi: 10.1016/j.neuro.2014.08.009

Journal - Research Article

Young, D., Fong, D. M., Lawlor, P. A., Wu, A., Mouravlev, A., McRae, M., Glass, M., … During, M. J. (2014). Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy. Gene Therapy, 21(12), 1029-1040. doi: 10.1038/gt.2014.82

Journal - Research Article

Banister, S. D., Wilkinson, S. M., Longworth, M., Stuart, J., Apetz, N., English, K., … Glass, M., … Kassiou, M. (2013). The synthesis and pharmacological evaluation of adamantane-derived indoles: Cannabimimetic drugs of abuse. ACS Chemical Neuroscience, 4(7), 1081-1092. doi: 10.1021/cn400035r

Journal - Research Article

Cawston, E. E., Redmond, W. J., Breen, C. M., Grimsey, N. L., Connor, M., & Glass, M. (2013). Real-time characterization of cannabinoid receptor 1 (CB1) allosteric modulators reveals novel mechanism of action. British Journal of Pharmacology, 170(4), 893-907. doi: 10.1111/bph.12329

Journal - Research Article

Graham, E. S., Woo, K. K., Aalderink, M., Fry, S., Greenwood, J. M., Glass, M., & Dragunow, M. (2013). M1 muscarinic receptor activation mediates cell death in M1-HEK293 cells. PLoS ONE, 8(9), e72011. doi: 10.1371/journal.pone.0072011

Journal - Research Article

Grimsey, N. L., Moodley, K. S., Glass, M., & Graham, E. S. (2012). Sensitive and accurate quantification of human leukocyte migration using high-content discovery-1 imaging system and ATPlite assay. Journal of Biomolecular Screening, 17(3), 386-393. doi: 10.1177/1087057111428985

Journal - Research Article

Horváth, B., Magid, L., Mukhopadhyay, P., Bátkai, S., Rajesh, M., Park, O., … Glass, M., … Pacher, P. (2012). A new cannabinoid CB2 receptor agonist HU-910 attenuates oxidative stress, inflammation and cell death associated with hepatic ischaemia/reperfusion injury. British Journal of Pharmacology, 165(8), 2462-2478. doi: 10.1111/j.1476-5381.2011.01381.x

Journal - Research Article

Goodfellow, C. E., Graham, S. E., Dragunow, M., & Glass, M. (2011). Characterization of NTera2/D1 cells as a model system for the investigation of cannabinoid function in human neurons and astrocytes. Journal of Neuroscience Research, 89(10), 1685-1697. doi: 10.1002/jnr.22692

Journal - Research Article

Grimsey, N. L., Goodfellow, C. E., Dragunow, M., & Glass, M. (2011). Cannabinoid receptor 2 undergoes Rab5-mediated internalization and recycles via a Rab11-dependent pathway. Biochimica et Biophysica Acta: Molecular Cell Reserch, 1813(8), 1554-1560. doi: 10.1016/j.bbamcr.2011.05.010

Journal - Research Article

Moodley, K., Angel, C. E., & Glass, M. (2011). Real-time profiling of NK cell killing of human astrocytes using xCELLigence technology. Journal of Neuroscience Methods, 200(2), 173-180. doi: 10.1016/j.jneumeth.2011.07.005

Journal - Research Article

Dowie, M. J., Howard, M. L., Nicholson, L. F. B., Faull, R. L. M., Hannan, A. J., & Glass, M. (2010). Behavioural and molecular consequences of chronic cannabinoid treatment in Huntington's disease transgenic mice. Neuroscience, 170(1), 324-336. doi: 10.1016/j.neuroscience.2010.06.056

Journal - Research Article

Dowie, M. J., Scotter, E. L., Molinari, E., & Glass, M. (2010). The therapeutic potential of G-protein coupled receptors in Huntington's disease. Pharmacology & Therapeutics, 128(2), 305-323. doi: 10.1016/j.pharmthera.2010.07.008

Journal - Research Article

Graham, E. S., Angel, C. E., Schwarcz, L. E., Dunbar, P. R., & Glass, M. (2010). Detailed characterisation of CB2 receptor protein expression in peripheral blood immune cells from healthy human volunteers using flow cytometry. International Journal of Immunopathology & Pharmacology, 23(1), 25-34. doi: 10.1177/039463201002300103

Journal - Research Article

Grimsey, N. L., Graham, E. S., Dragunow, M., & Glass, M. (2010). Cannabinoid Receptor 1 trafficking and the role of the intracellular pool: Implications for therapeutics. Biochemical Pharmacology, 80(7), 1050-1062. doi: 10.1016/j.bcp.2010.06.007

Journal - Research Article

Scotter, E. L., Abood, M. E., & Glass, M. (2010). The endocannabinoid system as a target for the treatment of neurodegenerative disease. British Journal of Pharmacology, 160(3), 480-498. doi: 10.1111/j.1476-5381.2010.00735.x

Journal - Research Article

Scotter, E. L., Goodfellow, C. E., Graham, E. S., Dragunow, M., & Glass, M. (2010). Neuroprotective potential of CB1 receptor agonists in an in vitro model of Huntington's disease. British Journal of Pharmacology, 160(3), 747-761. doi: 10.1111/j.1476-5381.2010.00773.x

Journal - Research Article

Allen, K. L., Waldvogel, H. J., Glass, M., & Faull, R. L. M. (2009). Cannabinoid (CB1), GABAA and GABAB receptor subunit changes in the globus pallidus in Huntington's disease. Journal of Chemical Neuroanatomy, 37(4), 266-281. doi: 10.1016/j.jchemneu.2009.02.001

Journal - Research Article

Dowie, M. J., Bradshaw, H. B., Howard, M. L., Nicholson, L. F. B., Faull, R. L. M., Hannan, A. J., & Glass, M. (2009). Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington's disease. Neuroscience, 163(1), 456-465. doi: 10.1016/j.neuroscience.2009.06.014

Journal - Research Article

Graham, E. S., Ashton, J. C., & Glass, M. (2009). Cannabinoid receptors: A brief history and 'What's hot'. Frontiers in Bioscience, 14, 944-957. doi: 10.2741/3288

Journal - Research Article

Chamley, L. W., Bhalla, A., Stone, P. R., Liddell, H., O’Carroll, S., Kearn, C., & Glass, M. (2008). Nuclear localisation of the endocannabinoid metabolizing enzyme fatty acid amide hydrolase (FAAH) in invasive trophoblasts and an association with recurrent miscarriage. Placenta, 29(11), 970-975. doi: 10.1016/j.placenta.2008.08.003

Journal - Research Article

Grimsey, N. L., Goodfellow, C. E., Scotter, E. L., Dowie, M. J., Glass, M., & Graham, E. S. (2008). Specific detection of CB1 receptors: Cannabinoid CB1 receptor antibodies are not all created equal! Journal of Neuroscience Methods, 171(1), 78-86. doi: 10.1016/j.jneumeth.2008.02.014

Journal - Research Article

Mitchell, M. D., Sato, T. A., Wang, A., Keelan, J. A., Ponnampalam, A. P., & Glass, M. (2008). Cannabinoids stimulate prostaglandin production by human gestational tissues through a tissue- and CB1-receptor-specific mechanism. American Journal of Physiology: Endocrinology & Metabolism, 294(2), E352-E356. doi: 10.1152/ajpendo.00495.2007

Journal - Research Article

Scotter, E. L., Narayan, P. J., Glass, M., & Dragunow, M. (2008). High throughput quantification of mutant huntingtin aggregates. Journal of Neuroscience Methods, 171(1), 174-179. doi: 10.1016/j.jneumeth.2008.02.007

Journal - Research Article

Ashton, J. C., & Glass, M. (2007). The cannabinoid CB2 receptor as a target for inflammation-dependent neurodegeneration. Current Neuropharmacology, 5(2), 73-80.

Journal - Research Article

Ashton, J. C., Rahman, R. M. A., Nair, S. M., Sutherland, B. A., Glass, M., & Appleton, I. (2007). Cerebral hypoxia-ischemia and middle cerebral artery occlusion induce expression of the cannabinoid CB2 receptor in the brain. Neuroscience Letters, 412, 114-117.

Journal - Research Article

McPartland, J. M., Glass, M., & Pertwee, R. B. (2007). Meta-analysis of cannabinoid ligand binding affinity and receptor distribution: Interspecies differences. British Journal of Pharmacology, 152(5), 583-593. doi: 10.1038/sj.bjp.0707399

Journal - Research Article

McPartland, J. M., Glass, M., Matias, I., Norris, R. W., & Kilpatrick, C. W. (2007). A shifted repertoire of endocannabinoid genes in the zebrafish (Danio rerio). Molecular Genetics & Genomics, 277(5), 555-570. doi: 10.1007/s00438-007-0207-3

Journal - Research Article

Curtis, M. A., Faull, R. L. M., & Glass, M. (2006). A novel population of progenitor cells expressing cannabinoid receptors in the subependymal layer of the adult normal and Huntington's disease human brain. Journal of Chemical Neuroanatomy, 31(3), 210-215. doi: 10.1016/j.jchemneu.2006.01.005

Journal - Research Article

Graham, E. S., Ball, N., Scotter, E. L., Narayan, P., Dragunow, M., & Glass, M. (2006). Induction of Krox-24 by endogenous cannabinoid type 1 receptors in Neuro2a cells is mediated by the MEK-ERK MAPK pathway and is suppressed by the phosphatidylinositol 3-kinase pathway. Journal of Biological Chemistry, 281(39), 29085-29095. doi: 10.1074/jbc.M602516200

Journal - Research Article

McPartland, J. M., Agraval, J., Gleeson, D., Heasman, K., & Glass, M. (2006). Cannabinoid receptors in invertebrates. Journal of Evolutionary Biology, 19(2), 366-373. doi: 10.1111/j.1420-9101.2005.01028.x

Journal - Research Article

McPartland, J. M., Matias, I., Di Marzo, V., & Glass, M. (2006). Evolutionary origins of the endocannabinoid system. Gene, 370(1-2), 64-74. doi: 10.1016/j.gene.2005.11.004

Journal - Research Article

Saidak, Z., Blake-Palmer, K., Hay, D. L., Northup, J. K., & Glass, M. (2006). Differential activation of G-proteins by μ-opioid receptor agonists. British Journal of Pharmacology, 147(6), 671-680. doi: 10.1038/sj.bjp.0706661

Journal - Research Article

Kearn, C. S., Blake-Palmer, K., Daniel, E., Mackie, K., & Glass, M. (2005). Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors enhances heterodimer formation: A mechanism for receptor cross-talk? Molecular Pharmacology, 67(5), 1697-1704. doi: 10.1124/mol.104.006882

Journal - Research Article

Glass, M., van Dellen, A., Blakemore, C., Hannan, A. J., & Faull, R. L. M. (2004). Delayed onset of Huntington's disease in mice in an enriched environment correlates with delayed loss of cannabinoid CB1 receptors. Neuroscience, 123(1), 207-212. doi: 10.1016/S0306-4522(03)00595-5

Journal - Research Article

Helliwell, R. J. A., Chamley, L. W., Blake-Palmer, K., Mitchell, M. D., Wu, J., Kearn, C. S., & Glass, M. (2004). Characterization of the endocannabinoid system in early human pregnancy. Journal of Clinical Endocrinology & Metabolism, 89(10), 5168-5174. doi: 10.1210/jc.2004-0388

Journal - Research Article

Park, B., McPartland, J. M., & Glass, M. (2004). Cannabis, cannabinoids and reproduction. Prostaglandins, Leukotrienes & Essential Fatty Acids, 70(2), 189-197. doi: 10.1016/j.plefa.2003.04.007

Journal - Research Article

McPartland, J. M., & Glass, M. (2003). Functional mapping of cannabinoid receptor homologs in mammals, other vertebrates, and invertebrates. Gene, 312(1-2), 297-303. doi: 10.1016/S0378-1119(03)00638-3

Journal - Research Article

Park, B., Gibbons, H. M., Mitchell, M. D., & Glass, M. (2003). Identification of the CB1 cannabinoid receptor and fatty acid amide hydrolase (FAAH) in the human placenta. Placenta, 24(10), 990-995. doi: 10.1016/S0143-4004(03)00165-6

Journal - Research Article

McAllister, S. D., & Glass, M. (2002). CB1 and CB2 receptor-mediated signalling: A focus on endocannabinoids. Prostaglandins, Leukotrienes & Essential Fatty Acids, 66(2-3), 161-171. doi: 10.1054/plef.2001.0344

Journal - Research Article

Glass, M. (2001). The role of cannabinoids in neurodegenerative diseases. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 25(4), 743-765. doi: 10.1016/S0278-5846(01)00162-2

Journal - Research Article

McPartland, J., Di Marzo, V., De Petrocellis, L., Mercer, A. R., & Glass, M. (2001). Cannabinoid receptors absent in insects. Journal of Comparative Neurology, 436, 423-429.

Journal - Research Article

McPartland, J., Di Marzo, V., De Petrocellis, L., Mercer, A., & Glass, M. (2001). Cannabinoid receptors are absent in insects. Journal of Comparative Neurology, 436(4), 423-429. doi: 10.1002/cne.1078

Journal - Research Article

Buckley, N. E., McCoy, K. L., Mezey, É., Bonner, T., Zimmer, A., Felder, C. C., & Glass, M. (2000). Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB2 receptor. European Journal of Pharmacology, 396(2-3), 141-149. doi: 10.1016/S0014-2999(00)00211-9

Journal - Research Article

Glass, M., Dragunow, M., & Faull, R. L. M. (2000). The pattern of neurodegeneration in Huntington's disease: A comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease. Neuroscience, 97(3), 505-519. doi: 10.1016/S0306-4522(00)00008-7

Journal - Research Article

Glass, M., & Northup, J. K. (1999). Agonist selective regulation of G proteins by cannabinoid CB1 and CB2 receptors. Molecular Pharmacology, 56(6), 1362-1369. doi: 10.1124/mol.56.6.1362

Journal - Research Article

Felder, C. C., & Glass, M. (1998). Cannabinoid receptors and their endogenous agonists. Annual Review of Pharmacology & Toxicology, 38, 179-200.

Journal - Research Article

Felder, C. C., Joyce, K. E., Briley, E. M., Glass, M., Mackie, K. P., Fahey, K. J., … Brownstein, M. (1998). LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation. Journal of Pharmacology & Drug Metabolism, 284(1), 291-297.

Journal - Research Article

Glass, M., & Felder, C. C. (1997). Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: Evidence for a Gs linkage to the CB1 receptor. Journal of Neuroscience, 17(14), 5327-5333. doi: 10.1523/JNEUROSCI.17-14-05327.1997

Journal - Research Article

Glass, M., Dragunow, M., & Faull, R. L. M. (1997). Cannabinoid receptors in the human brain: A detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain. Neuroscience, 77(2), 299-318. doi: 10.1016/S0306-4522(96)00428-9

Journal - Research Article

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