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Department of Pharmacology and Toxicology staff profiles

Professor Debbie Hay

PositionProfessor
DepartmentDepartment of Pharmacology and Toxicology

Research

After 18 years at the University of Auckland, Debbie moved to the University of Otago in 2020. Research in the Hay laboratory focuses on G protein-coupled receptors (GPCRs). These proteins are the cellular targets of natural hormones and are some of the most important drug targets. Her research aims to contribute to the development of medicines to treat migraine, among other conditions. Debbie is passionate about raising the profile of migraine in New Zealand and improving the lives of patients who have this condition.

Work in the lab spans a range of areas with local and international collaborators in academia and industry, including: pharmacology, medicinal chemistry, peptide chemistry, structural biology, molecular biology, immunohistochemistry and culture of cell lines and primary cells. A particular focus of the lab is class B GPCRs and their interactions with accessory proteins known as “receptor activity-modifying proteins”.

Debbie is a well-cited researcher (Web of Science, Highly Cited), who was elected Fellow of the British Pharmacological Society in 2018 (FBPhS). Other honours include the Gavin and Ann Kellaway Medical Research Fellowship for senior medical researchers (2018), an RSNZ James Cook Research Fellowship (2017), the prestigious 2015 Tregear Award (Australian Peptide Association), the 2013 Novartis Prize (British Pharmacological Society) and the 2013 Custom Science NZSBMB award.

She is an Editorial Board member of the British Journal of Pharmacology since 2015 (Editor Performance Award 2016), and Corresponding Member of the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR), chairing its subcommittee on nomenclature of CGRP peptide family receptors. This committee provides influential educational resources for pharmacologists and non-pharmacologists, the pharmaceutical industry and academia.

Debbie is an active mentor of young researchers, is a British Pharmacological Society Women in Pharmacology mentor (2012-present), and has given many invited talks on mentoring, such as 'Mentors: what are they and how do I find one', 'Keep calm and write a paper', 'Keep calm and write a grant application', for early career researchers.

Publications

Tasma, Z., Siow, A., Harris, P. W. R., Brimble, M. A., Hay, D. L., & Walker, C. S. (2021). Characterisation of agonist signalling profiles and agonist-dependent antagonism at PACAP-responsive receptors: Implications for drug discovery. British Journal of Pharmacology. Advance online publication. doi: 10.1111/bph.15700

Alexander, S. P. H., Christopoulos, A., Davenport, A. P., Kelly, E., Mathie, A., Peters, J. A., … Hay, D. L., … Ye, R. D. (2021). The concise guide to Pharmacology 2021/22: G protein-coupled receptors. British Journal of Pharmacology, 178(Suppl. 1), S27-S156. doi: 10.1111/bph.15538

Garelja, M. L., Bower, R. L., Brimble, M. A., Chand, S., Harris, P. W. R., Jamaluddin, M. A., … Hay, D. L. (2021). Pharmacological characterisation of mouse calcitonin and calcitonin receptor-like receptors reveals differences compared to human receptors. British Journal of Pharmacology. Advance online publication. doi: 10.1111/bph.15628

Rees, T. A., Hendrikse, E. R., Hay, D. L., & Walker, C. S. (2021). Beyond CGRP: The calcitonin peptide family as targets for migraine and pain. British Journal of Pharmacology. Advance online publication. doi: 10.1111/bph.15605

Blumenfeld, A., Durham, P. L., Feoktistov, A., Hay, D. L., Russo, A. F., & Turner, I. (2021). Hypervigilance, allostatic load, and migraine prevention: Antibodies to CGRP or receptor. Neurology & Therapy. Advance online publication. doi: 10.1007/s40120-021-00250-7

Hay, D. L., & Dickerson, I. M. (Eds.). (2010). The calcitonin gene-related peptide family: Form, function and future perspectives. Dordrecht, The Netherlands: Springer, 236p. doi: 10.1007/978-90-481-2909-6

Edited Book - Research

Chuang, C.-L., & Hay, D. L. (2020). Amylin. In S. Offermanns & W. Rosenthal (Eds.), Encyclopaedia of molecular pharmacology. Cham, Switzerland: Springer. doi: 10.1007/978-3-030-21573-6_10021-1

Chapter in Book - Research

Pioszak, A. A., & Hay, D. L. (2020). RAMPs as allosteric modulators of the calcitonin and calcitonin-like class B G protein-coupled receptors. In C. J. Langmead (Ed.), From structure to clinical development: Allosteric modulation of G protein-coupled receptors. (pp. 115-141). Cambridge, MA: Academic Press. doi: 10.1016/bs.apha.2020.01.001

Chapter in Book - Research

Hay, D. L. (2019). CGRP receptor biology: Is there more than one receptor? In S. Brain & P. Geppetti (Eds.), Calcitonin gene-related peptide (CGRP) mechanisms: Focus on migraine. (pp. 13-22). Cham, Switzerland: Springer. doi: 10.1007/164_2018_131

Chapter in Book - Research

Gingell, J. J., Walker, C. S., & Hay, D. L. (2017). Class B GPCR: Receptors and RAMPs. In K. Herrick-Davis, G. Milligan & G. Di Giovanni (Eds.), G-protein-coupled receptor dimers. (pp. 289-305). Cham, Switzerland: Humana Press. doi: 10.1007/978-3-319-60174-8_11

Chapter in Book - Research

Hay, D. L., Conner, A. C., & Poyner, D. R. (2013). Calcitonin gene-related peptide and adrenomedullin receptors. In M. D. Lane & W. J. Lennarz (Eds.), Encyclopedia of biological chemistry. (2nd ed.) (pp. 265-269). London, UK: Academic Press. doi: 10.1016/B978-0-12-378630-2.00363-7

Chapter in Book - Research

Barwell, J., Wootten, D., Simms, J., Hay, D. L., & Poyner, D. R. (2012). RAMPs and CGRP receptors. In W. S. Spielman & N. Parameswaran (Eds.), RAMPs. (pp. 13-24). Austin, TX: Landes Bioscience. doi: 10.1007/978-1-4614-2364-5_2

Chapter in Book - Research

Sexton, P. M., Poyner, D. R., Simms, J., Christopoulos, A., & Hay, D. L. (2012). RAMPs as drug targets. In W. S. Spielman & N. Parameswaran (Eds.), RAMPs. (pp. 61-74). Austin, TX: Landes Bioscience. doi: 10.1007/978-1-4614-2364-5_6

Chapter in Book - Research

Barwell, J., Simms, J., Conner, A., Hay, D., Wheatley, M., & Poyner, D. (2010). Ligand binding and activation of the CGRP receptor. In D. L. Hay & I. M. Dickerson (Eds.), The calcitonin gene-related peptide family: Form, function and future perspectives. (pp. 23-40). Dordrecht, The Netherlands: Springer. doi: 10.1007/978-90-481-2909-6_2

Chapter in Book - Research

Hay, D. L. (2010). Conclusions and future perspectives. In D. L. Hay & I. M. Dickerson (Eds.), The calcitonin gene-related peptide family: Form, function and future perspectives. (pp. 235-236). Dordrecht, The Netherlands: Springer. doi: 10.1007/978-90-481-2909-6_14

Chapter in Book - Research

Wootten, D. L., Simms, J., Hay, D. L., Christopoulos, A., & Sexton, P. M. (2010). Receptor activity modifying proteins and their potential as drug targets. In C. A. Lunn (Ed.), Membrane proteins as drug targets. (pp. 53-79). London, UK: Academic Press. doi: 10.1016/S1877-1173(10)91003-X

Chapter in Book - Research

Hay, D. (2008). Amylin receptor. In S. J. Enna & D. B. Byland (Eds.), xPharm: The comprehensive pharmacology reference. (Online ed.) Elsevier. doi: 10.1016/B978-008055232-3.60178-3

Chapter in Book - Research

Hay, D. (2008). Calcitonin gene-related peptide receptor. In S. J. Enna & D. B. Byland (Eds.), xPharm: The comprehensive pharmacology reference. (Online ed.) Elsevier. doi: 10.1016/B978-008055232-3.60177-1

Chapter in Book - Research

Hay, D. (2008). Calcitonin receptor. In S. J. Enna & D. B. Byland (Eds.), xPharm: The comprehensive pharmacology reference. (Online ed.) Elsevier. doi: 10.1016/B978-008055232-3.60176-X

Chapter in Book - Research

Hay, D. (2008). Calcitonin-type receptor. In S. J. Enna & D. B. Byland (Eds.), xPharm: The comprehensive pharmacology reference. (Online ed.) Elsevier. doi: 10.1016/B978-008055232-3.60175-8

Chapter in Book - Research

Alexander, S. P. H., Christopoulos, A., Davenport, A. P., Kelly, E., Mathie, A., Peters, J. A., … Hay, D. L., … Ye, R. D. (2021). The concise guide to Pharmacology 2021/22: G protein-coupled receptors. British Journal of Pharmacology, 178(Suppl. 1), S27-S156. doi: 10.1111/bph.15538

Journal - Research Article

Ashina, M., Terwindt, G. M., Al-Karagholi, M. A.-M., de Boer, I., Lee, M. J., Hay, D. L., … Goadsby, P. J. (2021). Migraine: Disease characterisation, biomarkers, and precision medicine. Lancet. Advance online publication. doi: 10.1016/s0140-6736(20)32162-0

Journal - Research Article

Garelja, M. L., Bower, R. L., Brimble, M. A., Chand, S., Harris, P. W. R., Jamaluddin, M. A., … Hay, D. L. (2021). Pharmacological characterisation of mouse calcitonin and calcitonin receptor-like receptors reveals differences compared to human receptors. British Journal of Pharmacology. Advance online publication. doi: 10.1111/bph.15628

Journal - Research Article

Ghanizada, H., Al-Karagholi, M. A.-M., Arngrim, N., Mørch-Rasmussen, M., Walker, C. S., Hay, D. L., & Ashina, M. (2021). Effect of adrenomedullin on migraine-like attacks in patients with migraine: A randomized crossover study. Neurology. Advance online publication. doi: 10.1212/wnl.0000000000011930

Journal - Research Article

Ghanizada, H., Al-Karagholi, M. A.-M., Walker, C. S., Arngrim, N., Rees, T., Petersen, J., … Hay, D. L., & Ashina, M. (2021). Amylin analog pramlintide induces migraine-like attacks in patients. Annals of Neurology. Advance online publication. doi: 10.1002/ana.26072

Journal - Research Article

Josephs, T. M., Belousoff, M. J., Liang, Y.-L., Piper, S. J., Cao, J., Garama, D. J., … Hay, D. L., … Sexton, P. M. (2021). Structure and dynamics of the CGRP receptor in apo and peptide-bound forms. Science. Advance online publication. doi: 10.1126/science.abf7258

Journal - Research Article

Rees, T. A., Hendrikse, E. R., Hay, D. L., & Walker, C. S. (2021). Beyond CGRP: The calcitonin peptide family as targets for migraine and pain. British Journal of Pharmacology. Advance online publication. doi: 10.1111/bph.15605

Journal - Research Article

Tasma, Z., Siow, A., Harris, P. W. R., Brimble, M. A., Hay, D. L., & Walker, C. S. (2021). Characterisation of agonist signalling profiles and agonist-dependent antagonism at PACAP-responsive receptors: Implications for drug discovery. British Journal of Pharmacology. Advance online publication. doi: 10.1111/bph.15700

Journal - Research Article

Garelja, M. L., Au, M., Brimble, M. A., Gingell, J. J., Hendrikse, E. R., Lovell, A., … Hay, D. L. (2020). Molecular mechanisms of class B GPCR activation: Insights from adrenomedullin receptors. ACS Pharmacology & Translational Science, 3(2), 246-262. doi: 10.1021/acsptsci.9b00083

Journal - Research Article

Gingell, J. J., Rees, T. A., Hendrikse, E. R., Siow, A., Rennison, D., Scotter, J., … Hay, D. L. (2020). Distinct patterns of internalization of different calcitonin gene-related peptide receptors. ACS Pharmacology & Translational Science, 3(2), 296-304. doi: 10.1021/acsptsci.9b00089

Journal - Research Article

Hendrikse, E. R., Liew, L. P., Bower, R. L., Bonnet, M., Jamaluddin, M. A., Prodan, N., … Hay, D. L. (2020). Identification of small-molecule positive modulators of calcitonin-like receptor-based receptors. ACS Pharmacology & Translational Science, 3(2), 305-320. doi: 10.1021/acsptsci.9b00108

Journal - Research Article

Liang, Y.-L., Belousoff, M. J., Fletcher, M. M., Zhang, X., Khoshouei, M., Deganutti, G., … Hay, D. L., … Sexton, P. M. (2020). Structure and dynamics of adrenomedullin receptors AM1 and AM2 reveal key mechanisms in the control of receptor phenotype by receptor activity-modifying proteins. ACS Pharmacology & Translational Science, 3(2), 263-284. doi: 10.1021/acsptsci.9b00080

Journal - Research Article

Lu, B. L., Loomes, K. M., Hay, D. L., Harris, P. W. R., & Brimble, M. A. (2020). Synthesis of isotopically labelled αCGRP8-37 and its lipidated analogue. Journal of Labelled Compounds & Radiopharmaceuticals, 63, 325-332. doi: 10.1002/jlcr.3838

Journal - Research Article

Noh, D., Bower, R. L., Hay, D. L., Zhyvoloup, A., & Raleigh, D. P. (2020). Analysis of amylin consensus sequences suggests that human amylin is not optimized to minimize amyloid formation and provides clues to factors that modulate amyloidogenicity. ACS Chemical Biology, 15(6), 1408-1416. doi: 10.1021/acschembio.9b01050

Journal - Research Article

Pan, K. S., Siow, A., Hay, D. L., & Walker, C. S. (2020). Antagonism of CGRP signaling by rimegepant at two receptors. Frontiers in Pharmacology, 11, 1240. doi: 10.3389/fphar.2020.01240

Journal - Research Article

Sowers, L. P., Wang, M., Rea, B. J., Taugher, R. J., Kuburas, A., Kim, Y., … Hay, D. L., & Russo, A. F. (2020). Stimulation of posterior thalamic nuclei induces photophobic behavior in mice. Headache, 60, 1961-1981. doi: 10.1111/head.13917

Journal - Research Article

Tasma, Z., Wills, P., Hay, D. L., & Walker, C. S. (2020). Agonist bias and agonist-dependent antagonism at corticotrophin releasing factor receptors. Pharmacology Research & Perspectives, 8(3), e00595. doi: 10.1002/prp2.595

Journal - Research Article

Alexander, S. P. H., Christopoulos, A., Davenport, A. P., Kelly, E., Mathie, A., Peters, J. A., … and CGTP Collaborators, including Hay, D. (2019). The concise guide to pharmacology 2019/2020. British Journal of Pharmacology, 176(Suppl. 1), S1-S493. doi: 10.1111/bph.14746

Journal - Research Article

Musa, H., Hendrikse, E. R., Brimble, M. A., Garelja, M. L., Watkins, H. A., Harris, P. W. R., & Hay, D. L. (2019). Pharmacological characterization and investigation of N-terminal loop amino acids of adrenomedullin 2 that are important for receptor activation. Biochemistry, 58(32), 3468-3474. doi: 10.1021/acs.biochem.9b00571

Journal - Research Article

Yule, L. R., Garelja, M. L., Hendrikse, E. R., Gingell, J. J., Poyner, D. R., Harris, P. W. H., Brimble, M. A., & Hay, D. L. (2019). A potent fluorescent calcitonin gene-related peptide analogue enables visualization of receptor internalization. Peptide Science, 111(6), e2416. doi: 10.1002/pep2.24126

Journal - Research Article

Akter, R., Bower, R. L., Abedini, A., Schmidt, A. M., Hay, D. L., & Raleigh, D. P. (2018). Amyloidogenicity, cytotoxicity and receptor activity of bovine amylin: Implications for xenobiotic transplantation and the design of non-toxic amylin variants. ACS Chemical Biology, 13, 2747-2757. doi: 10.1021/acschembio.8b00690

Journal - Research Article

Booe, J. M., Warner, M. L., Roehrkasse, A. M., Hay, D. L., & Pioszak, A. A. (2018). Probing the mechanism of receptor activity-modifying protein modulation of GPCR ligand selectivity through rational design of potent adrenomedullin and calcitonin gene-related peptide antagonists. Molecular Pharmacology, 93(4), 355-367. doi: 10.1124/mol.117.110916

Journal - Research Article

Dal Maso, E., Zhu, Y., Pham, V., Reynolds, C. A., Deganutti, G., Hick, C. A., … Hay, D. L., … Wootten, D. (2018). Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy. Biochemical Pharmacology, 150, 214-244. doi: 10.1016/j.bcp.2018.02.005

Journal - Research Article

Garelja, M. L., Walker, C. A., Siow, A., Yang, S. H., Harris, P. W. R., Brimble, M. A., … Hay, D. L. (2018). Receptor activity modifying proteins have limited effects on the class B G protein-coupled receptor calcitonin receptor-like receptor stalk. Biochemistry, 57(8), 1410-1422. doi: 10.1021/acs.biochem.7b01180

Journal - Research Article

Liang, Y.-L., Khoshouei, M., Deganutti, G., Glukhova, A., Koole, C., Peat, T. S., … Hay, D. L., … Sexton, P. M. (2018). Cryo-EM structure of the active, Gs protein complexed, human CGRP receptor. Nature, 561(7724), 492-497. doi: 10.1038/s41586-018-0535-y

Journal - Research Article

Simms, J., Uddin, R., Sakmar, T. P., Gingell, J. J., Garelja, M. L., Hay, D. L., … Poyner, D. R. (2018). Photoaffinity cross-linking and unnatural amino acid mutagenesis reveal insights into calcitonin gene-related peptide binding to the CalcitoninRreceptor-Like Receptor/Receptor Activity-Modifying Protein 1 (CLR/RAMP1) complex. Biochemistry, 57(32), 4915-4922. doi: 10.1021/acs.biochem.8b00502

Journal - Research Article

Walker, C. S., Raddant, A. C., Woolley, M. J., Russo, A. F., & Hay, D. L. (2018). CGRP receptor antagonist activity of olcegepant depends on the signalling pathway measured. Cephalagia, 38(3), 437-451. doi: 10.1177/0333102417691762

Journal - Research Article

Williams, E. T., Harris, P. W. R., Jamaluddin, M. A., Loomes, K. M., Hay, D. L., & Brimble, M. A. (2018). Solid-phase thiol–ene lipidation of peptides for the synthesis of a potent CGRP receptor antagonist. Angewandte Chemie International Edition, 57(36), 11640-11643. doi: 10.1002/anie.201805208

Journal - Research Article

Alexander, S. P. H., Kelly, E., Marrion, N. V., Peters, J. A., Faccenda, E., Harding, S. D., … and CGTP Collaborators, including Hay, D. L. (2017). The concise guide to pharmacology 2017/18. British Journal of Pharmacology, 174(Suppl. 1), S1-S446. doi: 10.1111/bph.13987

Journal - Research Article

Lee, S.-M., Booe, J. M., Gingell, J. J., Sjoelund, V., Hay, D. L., & Pioszak, A. A. (2017). N-glycosylation of asparagine 130 in the extracellular domain of the human calcitonin receptor significantly increases peptide hormone affinity. Biochemistry, 56(26), 3380-3393. doi: 10.1021/acs.biochem.7b00256

Journal - Research Article

Woolley, M. J., Reynolds, C. A., Simms, J., Walker, C. S., Mobarec, J. C., Garelja, M. L., … Hay, D. L. (2017). Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs. Biochemical Pharmacology, 142, 96-110. doi: 10.1016/j.bcp.2017.07.005

Journal - Research Article

Bower, R. L., & Hay, D. L. (2016). Amylin structure-function relationships and receptor pharmacology: Implications for amylin mimetic drug development. British Journal of Pharmacology, 173(12), 1883-1898. doi: 10.1111/bph.13496

Journal - Research Article

Bower, R. L., Eftekhari, S., Waldvogel, H. J., Faull, R. L. M., Tajti, J., Edvinsson, L., Hay, D. L., & Walker, C. S. (2016). Mapping the calcitonin receptor in human brain stem. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 310(9), R788-R793. doi: 10.1152/ajpregu.00539.2015

Journal - Research Article

Gingell, J. J., Simms, J., Barwell, J., Poyner, D. R., Watkins, H. A., Pioszak, A. A., … Hay, D. L. (2016). An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology. Cell Discovery, 2, 16012. doi: 10.1038/celldisc.2016.12

Journal - Research Article

Lee, S.-M., Hay, D. L., & Pioszak, A. A. (2016). Calcitonin and amylin receptor peptide interaction mechanisms: Insights into peptide-binding modes and allosteric modulation of the calcitonin receptor by receptor activity-modifying proteins. Journal of Biological Chemistry, 291(16), 8686-8700. doi: 10.1074/jbc.A115.713628

Journal - Research Article

Watkins, H. A., Chakravarthy, M., Abhayawardana, R. S., Gingell, J. J., Garelja, M. L., Pardamwar, M., … Hay, D. L. (2016). Receptor activity-modifying proteins 2 and 3 generate adrenomedullin receptor subtypes with distinct molecular properties. Journal of Biological Chemistry, 291(22), 11657-11675. doi: 10.1074/jbc.M115.688218

Journal - Research Article

Yule, L. R., Bower, R. L., Kaur, H., Kowalczyk, R., Hay, D. L., & Brimble, M. A. (2016). Synthesis and amylin receptor activity of glycomimetics of pramlintide using click chemistry. Organic & Biomolecular Chemistry, 14(23), 5238-5245. doi: 10.1039/c6ob00850j

Journal - Research Article

Alexander, S. P. H., Kelly, E., Marrion, N., Peters, J. A., Benson, H. E., Faccenda, E., … and CGTP Collaborators, including Hay, D. L. (2015). The concise guide to Pharmacology 2015/16: Overview. British Journal of Pharmacology, 172(24), 5729-6202. doi: 10.1111/bph.12931

Journal - Research Article

Booe, J. M., Walker, C. S., Barwell, J., Kuteyi, G., Simms, J., Jamaluddin, M. A., … Hay, D. L. (2015). Structural basis for receptor activity-modifying protein-dependent selective peptide recognition by a G protein-coupled receptor. Molecular Cell, 58(6), 1040-1052. doi: 10.1016/j.molcel.2015.04.018

Journal - Research Article

Kim, J. S., Brownjohn, P. W., Dyer, B. S., Beltramo, M., Walker, C. S., Hay, D. L., … Tyndall, J. D. A., & Anderson, G. M. (2015). Anxiogenic and stressor effects of the hypothalamic neuropeptide RFRP-3 are overcome by the NPFFR antagonist GJ14. Endocrinology, 156(11), 4152-4162. doi: 10.1210/en.2015-1532

Journal - Research Article

Walker, C. S., Eftekhari, S., Bower, R. L., Wilderman, A., Insel, P. A., Edvinsson, L., … Hay, D. L. (2015). A second trigeminal CGRP receptor: Function and expression of the AMY1 receptor. Annals of Clinical & Translational Neurology, 2(6), 595-608. doi: 10.1002/acn3.197

Journal - Research Article

Whiting, L., Stewart, K. W., Hay, D. L., Harris, P. W., Choong, Y. S., Phillips, A. R. J., … Cooper, G. J. S. (2015). Glicentin-related pancreatic polypeptide inhibits glucose-stimulated insulin secretion from the isolated pancreas of adult male rats. Physiological Reports, 3(12), e12638. doi: 10.14814/phy2.12638

Journal - Research Article

Gingell, J. J., Burns, E. R., & Hay, D. L. (2014). Activity of pramlintide, rat and human amylin but not Aβ1-42 at human amylin receptors. Endocrinology, 155(1), 21-26. doi: 10.1210/en.2013-1658

Journal - Research Article

Hay, D. L., Harris, P. W. R., Kowalczyk, R., Brimble, M. A., Rathbone, D. L., Barwell, J., … Poyner, D. R. (2014). Structure-activity relationships of the N-terminus of calcitonin gene-related peptide: Key roles of alanine-5 and threonine-6 in receptor activation. British Journal of Pharmacology, 171(2), 415-426. doi: 10.1111/bph.12464

Journal - Research Article

Kowalczyk, R., Brimble, M. A., Tomabechi, Y., Fairbanks, A. J., Fletcher, M., & Hay, D. L. (2014). Convergent chemoenzymatic synthesis of a library of glycosylated analogues of pramlintide: Structure-activity relationships for amylin receptor agonism. Organic & Biomolecular Chemistry, 12(41), 8142-8151. doi: 10.1039/c4ob01208a

Journal - Research Article

Walker, C. S., Hay, D. L., Fitzpatrick, S. M., Cooper, G. J. S., & Loomes, K. M. (2014). α-Calcitonin gene related peptide (α-CGRP) mediated lipid mobilization in 3T3-L1 adipocytes. Peptides, 58, 14-19. doi: 10.1016/j.peptides.2014.05.011

Journal - Research Article

Walker, C. S., Sundrum, T., & Hay, D. L. (2014). PACAP receptor pharmacology and agonist bias: Analysis in primary neurons and glia from the trigeminal ganglia and transfected cells. British Journal of Pharmacology, 171(6), 1521-1533. doi: 10.1111/bph.12541

Journal - Research Article

Watkins, H. A., Walker, C. S., Ly, K. N., Bailey, R. J., Barwell, J., Poyner, D. R., & Hay, D. L. (2014). Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: Implications for adrenomedullin and calcitonin gene-related peptide pharmacology. British Journal of Pharmacology, 171(3), 772-788. doi: 10.1111/bph.12508

Journal - Research Article

Cognard, E., Dargaville, C. G., Hay, D. L., & Shepherd, P. R. (2013). Identification of a pathway by which glucose regulates β-catenin signalling via the cAMP/protein kinase A pathway in β-cell models. Biochemical Journal, 449(3), 803-811. doi: 10.1042/BJ20121454

Journal - Research Article

Harris, P. W. R., Kowalczyk, R., Hay, D. L., & Brimble, M. A. (2013). A single pseudoproline and microwave solid phase peptide synthesis facilitates an efficient synthesis of human amylin 1-37. International Journal of Peptide Research & Therapeutics, 19(2), 147-155. doi: 10.1007/s10989-012-9325-9

Journal - Research Article

Kuwasako, K., Hay, D. L., Nagata, S., Murakami, M., Kitamura, K., & Kato, J. (2013). Functions of third extracellular loop and helix 8 of family B GPCRs complexed with RAMPs and characteristics of their receptor trafficking. Current Protein & Peptide Science, 14(5), 416-428. doi: 10.2174/13892037113149990058

Journal - Research Article

Qi, T., Dong, M., Wootten, D., Miller, L. J., & Hay, D. L. (2013). Receptor activity-modifying protein-dependent impairment of calcitonin receptor splice variant Δ(1-47)hCT(a) function. British Journal of Pharmacology, 168(3), 644-657. doi: 10.1111/j.1476-5381.2012.02197.x

Journal - Research Article

Vohra, S., Taddese, B., Conner, A. C., Poyner, D. R., Hay, D. L., Barwell, J., … Reynolds, C. A. (2013). Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies. Journal of the Royal Society Interface, 10(79), 20120846. doi: 10.1098/rsif.2012.0846

Journal - Research Article

Watkins, H. A., Au, M., Bobby, R., Archbold, J. K., Abdul-Manan, N., Moore, J. M., … Hay, D. L. (2013). Identification of key residues involved in adrenomedullin binding to the AM1 receptor. British Journal of Pharmacology, 169(1), 143-155. doi: 10.1111/bph.12118

Journal - Research Article

Woolley, M. J., Watkins, H. A., Taddese, B., Karakullukcu, Z. G., Barwell, J., Smith, K. J., Hay, D. L., … Conner, A. C. (2013). The role of ECL2 in CGRP receptor activation: A combined modelling and experimental approach. Journal of the Royal Society Interface, 10(88), 20130589. doi: 10.1098/rsif.2013.0589

Journal - Research Article

Bailey, R. J., Walker, C. S., Ferner, A. H., Loomes, K. M., Prijic, G., Halim, A., … Hay, D. L. (2012). Pharmacological characterization of rat amylin receptors: Implications for the identification of amylin receptor subtypes. British Journal of Pharmacology, 166(1), 151-167. doi: 10.1111/j.1476-5381.2011.01717.x

Journal - Research Article

Halim, A., & Hay, D. L. (2012). The role of glutamic acid 73 in adrenomedullin interactions with rodent AM2 receptors. Peptides, 36(1), 137-141. doi: 10.1016/j.peptides.2012.04.011

Journal - Research Article

Kuwasako, K., Hay, D. L., Nagata, S., Hikosaka, T., Kitamura, K., & Kato, J. (2012). The third extracellular loop of the human calcitonin receptor-like receptor is crucial for the activation of adrenomedullin signalling. British Journal of Pharmacology, 166(1), 137-150. doi: 10.1111/j.1476-5381.2011.01803.x

Journal - Research Article

Qi, T., Ly, K., Poyner, D. R., Christopoulos, G., Sexton, P. M., & Hay, D. L. (2011). Structure-function analysis of amino acid 74 of human RAMP1 and RAMP3 and its role in peptide interactions with adrenomedullin and calcitonin gene-related peptide receptors. Peptides, 32(5), 1060-1067. doi: 10.1016/j.peptides.2011.03.004

Journal - Research Article

Bailey, R. J., Bradley, J. W. I., Poyner, D. R., Rathbone, D. L., & Hay, D. L. (2010). Functional characterization of two human receptor activity-modifying protein 3 variants. Peptides, 31(4), 579-584. doi: 10.1016/j.peptides.2009.12.016

Journal - Research Article

Gingell, J. J., Qi, T., Bailey, R. J., & Hay, D. L. (2010). A key role for tryptophan 84 in receptor activity-modifying protein 1 in the amylin 1 receptor. Peptides, 31(7), 1400-1404. doi: 10.1016/j.peptides.2010.03.027

Journal - Research Article

Moore, E. L., Gingell, J. J., Kane, S. A., Hay, D. L., & Salvatore, C. A. (2010). Mapping the CGRP receptor ligand binding domain: Tryptophan-84 of RAMP1 is critical for agonist and antagonist binding. Biochemical & Biophysical Research Communications, 394(1), 141-145. doi: 10.1016/j.bbrc.2010.02.131

Journal - Research Article

Qi, T., Simms, J., Bailey, R. J., Wheatley, M., Rathbone, D. L., Hay, D. L., & Poyner, D. R. (2010). Structure—function analysis of RAMP1 - RAMP3 chimeras. Biochemistry, 49(3), 522-531. doi: 10.1021/bi9019093

Journal - Research Article

Walker, C. S., Li, X., Whiting, L., Glyn-Jones, S., Zhang, S., Hickey, A. J., … Hay, D. L., … Loomes, K. M. (2010). Mice lacking the neuropeptide α-calcitonin gene-related peptide are protected against diet-induced obesity. Endocrinology, 151(9), 4257-4269. doi: 10.1210/en.2010-0284

Journal - Research Article

Robinson, S. D., Aitken, J. F., Bailey, R. J., Poyner, D. R., & Hay, D. L. (2009). Novel peptide antagonists of adrenomedullin and calcitonin gene-related peptide receptors: Identification, pharmacological characterization, and interactions with position 74 in receptor activity-modifying protein 1/3. Journal of Pharmacology & Experimental Therapeutics, 331(2), 513-521. doi: 10.1124/jpet.109.156448

Journal - Research Article

Simms, J., Hay, D. L., Bailey, R. J., Konycheva, G., Bailey, G., Wheatley, M., & Poyner, D. R. (2009). Structure—function analysis of RAMP1 by alanine mutagenesis. Biochemistry, 48(1), 198-205. doi: 10.1021/bi801869n

Journal - Research Article

Danaher, R. N., Loomes, K. M., Leonard, B. L., Whiting, L., Hay, D. L., Xu, L. Y., … Cooper, G. J. S. (2008). Evidence that α-calcitonin gene-related peptide is a neurohormone that controls systemic lipid availability and utilization. Endocrinology, 149(1), 154-160. doi: 10.1210/en.2007-0583

Journal - Research Article

Qi, T., Christopoulos, G., Bailey, R. J., Christopoulos, A., Sexton, P. M., & Hay, D. L. (2008). Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function. Molecular Pharmacology, 74(4), 1059-1071. doi: 10.1124/mol.108.047142

Journal - Research Article

Bailey, R. J., & Hay, D. L. (2007). Agonist-dependent consequences of proline to alanine substitution in the transmembrane helices of the calcitonin receptor. British Journal of Pharmacology, 151(5), 678-687. doi: 10.1038/sj.bjp.0707246

Journal - Research Article

Bailey, R. J., & Hay, D. L. (2006). Pharmacology of the human CGRP1 receptor in Cos 7 cells. Peptides, 27(6), 1367-1375. doi: 10.1016/j.peptides.2005.11.014

Journal - Research Article

Hay, D. L., Christopoulos, G., Christopoulos, A., & Sexton, P. M. (2006). Determinants of 1-piperidinecarboxamide, N-[2-[[5-amino-/-[[4-(4-pyridinyl) -/-piperazinyl]carbonyl]pentyl]amino]-1-[(3,5-dibromo-4-hydroxyphenyl)methyl] -2-oxoethyl]-4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl) (BIBN4096BS) affinity for calcitonin gene-related peptide and amylin receptors: The role of receptor activity modifying protein 1. Molecular Pharmacology, 70(6), 1984-1991. doi: 10.1124/mol.106.027953

Journal - Research Article

Hay, D. L., Poyner, D. R., & Sexton, P. M. (2006). GPCR modulation by RAMPs. Pharmacology & Therapeutics, 109(1-2), 173-197. doi: 10.1016/j.pharmthera.2005.06.015

Journal - Research Article

Saidak, Z., Blake-Palmer, K., Hay, D. L., Northup, J. K., & Glass, M. (2006). Differential activation of G-proteins by μ-opioid receptor agonists. British Journal of Pharmacology, 147(6), 671-680. doi: 10.1038/sj.bjp.0706661

Journal - Research Article

Simms, J., Hay, D. L., Wheatley, M., & Poyner, D. R. (2006). Characterization of the structure of RAMP1 by mutagenesis and molecular modeling. Biophysical Journal, 91(2), 662-669. doi: 10.1529/biophysj.106.084582

Journal - Research Article

Conner, A. C., Hay, D. L., Simms, J., Howitt, S. G., Schindler, M., Smith, D. M., … Poyner, D. R. (2005). A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: Implications for family B G-protein-coupled receptors. Molecular Pharmacology, 67(1), 20-31. doi: 10.1124/mol.67.1.20

Journal - Research Article

Hay, D. L., & Poyner, D. (2005). The preclinical pharmacology of BIBN4096BS, a CGRP antagonist. Cardiovascular Drug Reviews, 23(1), 31-42. doi: 10.1111/j.1527-3466.2005.tb00155.x

Journal - Research Article

Hay, D. L., Christopoulos, G., Christopoulos, A., Poyner, D. R., & Sexton, P. M. (2005). Pharmacological discrimination of calcitonin receptor: Receptor activity-modifying protein complexes. Molecular Pharmacology, 67(5), 1655-1665. doi: 10.1124/mol.104.008615

Journal - Research Article

Conner, A. C., Simms, J., Hay, D. L., Mahmoud, K., Howitt, S. G., Wheatley, M., & Poyner, D. R. (2004). Heterodimers and family-B GPCRs: RAMPs, CGRP and adrenomedullin. Biochemical Society Transactions, 32(5), 843-846. doi: 10.1042/BST0320843

Journal - Research Article

Hay, D. L., Conner, A. C., Howitt, S. G., Smith, D. M., & Poyner, D. R. (2004). The pharmacology of adrenomedullin receptors and their relationship to CGRP receptors. Journal of Molecular Neuroscience, 22(1-2), 105-113. doi: 10.1385/JMN:22:1-2:105

Journal - Research Article

Hagner, S., Haberberger, R., Hay, D. L., Facer, P., Reiners, K., Voigt, K., & McGregor, G. P. (2003). Immunohistochemical detection of the calcitonin receptor-like receptor protein in the microvasculature of rat endothelium. European Journal of Pharmacology, 481(2-3), 147-151. doi: 10.1016/j.ejphar.2003.09.030

Journal - Research Article

Hay, D. L., Howitt, S. G., Conner, A. C., Schindler, M., Smith, D. M., & Poyner, D. R. (2003). CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors: A comparison of effects of adrenomedullin22-52, CGRP8-37 and BIBN4096BS. British Journal of Pharmacology, 140(3), 477-486. doi: 10.1038/sj.bjp.0705472

Journal - Research Article

Choksi, T., Hay, D. L., Legon, S., Poyner, D. R., Hagner, S., Bloom, S. R., & Smith, D. M. (2002). Comparison of the expression of calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) with CGRP and adrenomedullin binding in cell lines. British Journal of Pharmacology, 136(5), 784-792. doi: 10.1038/sj.bjp.0704761

Journal - Research Article

Hay, D. L., Howitt, S. G., Conner, A. C., Doods, H., Schindler, M., & Poyner, D. R. (2002). A comparison of the actions of BIBN4096BS and CGRP8-37 on CGRP and adrenomedullin receptors expressed on SK-N-MC, L6, Col 29 and Rat 2 cells. British Journal of Pharmacology, 137(1), 80-86. doi: 10.1038/sj.bjp.0704844

Journal - Research Article

Kim, M. S., Small, C. J., Russell, S. H., Morgan, D. G. A., Abbott, C. R., AlAhmed, S. H., Hay, D. L., … Bloom, S. R. (2002). Effects of melanocortin receptor ligands on thyrotropin-releasing hormone release: Evidence for the differential roles of melanocortin 3 and 4 receptors. Journal of Neuroendocrinology, 14(4), 276-282. doi: 10.1046/j.1365-2826.2002.00769.x

Journal - Research Article

Dakin, C. L., Gunn, I., Small, C. J., Edwards, C. M. B., Hay, D. L., Smith, D. M., … Bloom, S. R. (2001). Oxyntomodulin inhibits food intake in the rat. Endocrinology, 142(10), 4244-4250. doi: 10.1210/endo.142.10.8430

Journal - Research Article

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