Professor Alex McLellan

Research

CAR T cells (Chimeric Antigen Receptor-modified T cells) against solid tumours. Cancer stem cell antigens, tumour-associated antigens, and tumour microenvironment metabolites. Cytokine and chemokine receptor strategies to improve T cell function against solid tumours.

Research projects

• Chimeric Antigen Receptor T cells (CAR-T cells) and NK cells targeting solid tumours
• Dual CAR constructs against B cell malignancies and solid tumours using bi-directional promoters
• Sleeping Beauty and Retroviral vector constructs utilising drug and auto-inducible-promoters
• Targeting the tumour microenvironment
• Fighting the cytokine storm
• Improved anti-cancer T cell migration using targeted cytokines