Research interests
- Pharmacogenetics
- Pharmacogenomics
Publications
Hitchman, L. M., Faatoese, A., Merriman, T. R., Miller, A. L., Liau, Y., Graham, O. E. E., Kee, P. S., Pearson, J. F., … Cameron, V. A., Kennedy, M. A., & Maggo, S. D. S. (2022). Allelic diversity of the pharmacogene CYP2D6 in New Zealand Māori and Pacific peoples. Frontiers in Genetics, 13, 1016416. doi: 10.3389/fgene.2022.1016416
Hitchman, L. M., Faatoese, A., Merriman, T. R., Miller, A. L., Liau, Y., Graham, O. E. E., Kee, P. S., Pearson, J. F., … Cameron, V. A., Kennedy, M. A., & Maggo, S. D. S. (2022, August-September). Allelic diversity of the pharmacogene CYP2D6 in New Zealand Māori and Pacific peoples. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Liau, Y., Maggo, S., Lehnert, K., Doogue, M. P., Scull, A., Miller, A. L., Pearson, J. F., & Kennedy, M. A. (2022, August-September). Genomic analysis of angiotensin converting enzyme inhibitor-induced angioedema. Verbal presentation at the Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists (ASCEPT) NZ Annual Scientific Meeting, Queenstown, New Zealand.
Kee, P. S., Maggo, S., Kennedy, M. A., Barclay, M. L., Miller, A., Lehnert, K., … Faull, R. L. M., … Chin, P. K. L. (2022, August-September). Omeprazole treatment failure in gastro-oesophageal reflux disease and genetic variation at the CYP2C locus. Verbal presentation at the Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists (ASCEPT) NZ Annual Scientific Meeting, Queenstown, New Zealand.
Maggo, S., Kee, J., Hitchman, L., Chin, P., Doogue, M., Miller, A., … Kennedy, M. (2021). Assessing the pharmacogenomic landscape of adverse drug reactions in Aotearoa [Invited]. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go
Hitchman, L. M., Faatoese, A., Merriman, T. R., Miller, A. L., Liau, Y., Graham, O. E. E., Kee, P. S., Pearson, J. F., … Cameron, V. A., Kennedy, M. A., & Maggo, S. D. S. (2022). Allelic diversity of the pharmacogene CYP2D6 in New Zealand Māori and Pacific peoples. Frontiers in Genetics, 13, 1016416. doi: 10.3389/fgene.2022.1016416
Journal - Research Article
Ip, H. F., van der Laan, C. M., Krapohl, E. M. L., Brikell, I., Sánchez-Mora, C., Nolte, I. M., … Miller, A., … Boden, J., Pearson, J., Horwood, L. J., Kennedy, M., Poulton, R., … Boomsma, D. I. (2021). Genetic association study of childhood aggression across raters, instruments, and age. Translational Psychiatry, 11, 413. doi: 10.1038/s41398-021-01480-x
Journal - Research Article
Seddon, A. R., Liau, Y., Pace, P. E., Miller, A. L., Das, A. B., Kennedy, M. A., Hampton, M. B., & Stevens, A. J. (2021). Genome-wide impact of hydrogen peroxide on maintenance DNA methylation in replicating cells. Epigenetics & Chromatin, 14(1), 17. doi: 10.1186/s13072-021-00388-6
Journal - Research Article
Sinha, P., Cree, S. L., Miller, A. L., Pearson, J. F., & Kennedy, M. A. (2021). Transcriptional analysis of sodium valproate in a serotonergic cell line reveals gene regulation through both HDAC inhibition-dependent and independent mechanisms. Pharmacogenomics Journal, 21, 359-375. doi: 10.1038/s41397-021-00215-x
Journal - Research Article
Ward, Z., Schmeier, S., Saddic, L., Sigurdsson, M. I., Cameron, V. A., Pearson, J., Miller, A., Morley-Bunker, A., … Pilbrow, A. P. (2021). Novel and annotated long noncoding RNAs associated with ischemia in the human heart. International Journal of Molecular Sciences, 22, 11324. doi: 10.3390/ijms222111324
Journal - Research Article
Graham, O. E. E., Pitcher, T. L., Liau, Y., Miller, A. L., Dalrymple-Alford, J. C., Anderson, T. J., & Kennedy, M. A. (2020). Nanopore sequencing of the glucocerebrosidase (GBA) gene in a New Zealand Parkinson's disease cohort. Parkinsonism & Related Disorders, 70, 36-41. doi: 10.1016/j.parkreldis.2019.11.022
Journal - Research Article
Searchfield, G. D., Poppe, T. N. E. R., Durai, M., Jensen, M., Kennedy, M. A., Maggo, S., Miller, A. L., … Russell, B. R., … Wise, K. (2020). A proof-of-principle study of the short-term effects of 3,4-methylenedioxymethamphetamine (MDMA) on tinnitus and neural connectivity. International Journal of Neuroscience, 130(7), 671-682. doi: 10.1080/00207454.2019.1702544
Journal - Research Article
Taylor, W. S., Pearson, J., Miller, A., Schmeier, S., Frizelle, F. A., & Purcell, R. V. (2020). MinION sequencing of colorectal cancer tumour microbiomes: A comparison with amplicon-based and RNA-sequencing. PLoS ONE, 15(5), e0233170. doi: 10.1371/journal.pone.0233170
Journal - Research Article
Liau, Y., Cree, S. L., Maggo, S., Miller, A. L., Pearson, J. F., Gladding, P. A., & Kennedy, M. A. (2019). A multiplex pharmacogenetics assay using the MinION nanopore sequencing device. Pharmacogenetics & Genomics, 29(9), 207-215. doi: 10.1097/fpc.0000000000000385
Journal - Research Article
Liau, Y., Maggo, S., Miller, A. L., Pearson, J. F., Kennedy, M. A., & Cree, S. L. (2019). Nanopore sequencing of the pharmacogene CYP2D6 allows simultaneous haplotyping and detection of duplications. Pharmacogenomics, 20(14), 1033-1047. doi: 10.2217/pgs-2019-0080
Journal - Research Article
Maggo, S. D. S., Sycamore, K. L. V., Miller, A. L., & Kennedy, M. A. (2019). The three ps: Psychiatry, pharmacy, and pharmacogenomics, a brief report from New Zealand. Frontiers in Psychiatry, 10, 690. doi: 10.3389/fpsyt.2019.00690
Journal - Research Article
Prickett, T. C. R., Spittlehouse, J. K., Miller, A. L., Liau, Y., Kennedy, M. A., Cameron, V. A., Pearson, J. F., Boden, J. M., Troughton, R. W., & Espiner, E. A. (2019). Contrasting signals of cardiovascular health among natriuretic peptides in subjects without heart disease. Scientific Reports, 9, 12108. doi: 10.1038/s41598-019-48553-y
Journal - Research Article
de Jong, L. C., Cree, S., Lattimore, V., Wiggins, G. A. R., Spurdle, A. B., kConFab Investigators, Miller, A., Kennedy, M. A., & Walker, L. C. (2017). Nanopore sequencing of full-length BRCA1 mRNA transcripts reveals co-occurrence of known exon skipping events. Breast Cancer Research, 19, 127. doi: 10.1186/s13058-017-0919-1
Journal - Research Article
Shchepetkina, A. A., Hock, B. D., Miller, A., Kennedy, M. A., & Gieseg, S. P. (2017). Effect of 7,8-dihydroneopterin mediated CD36 down regulation and oxidant scavenging on oxidised low-density lipoprotein induced cell death in human macrophages. International Journal of Biochemistry & Cell Biology, 87, 27-33. doi: 10.1016/j.biocel.2017.03.017
Journal - Research Article
Cree, S. L., Fredericks, R., Miller, A., Pearce, F. G., Filichev, V., Fee, C., & Kennedy, M. A. (2016). DNA G-quadruplexes show strong interaction with DNA methyltransferases in vitro. FEBS Letters, 590(17), 2870-2883. doi: 10.1002/1873-3468.12331
Journal - Research Article
Jodczyk, S., Pearson, J. F., Aitchison, A., Miller, A. L., Hampton, M. B., & Kennedy, M. A. (2015). Telomere length measurement on the Roche LightCycler 480 platform. Genetic Testing & Molecular Biomarkers, 19(2), 63-68. doi: 10.1089/gtmb.2014.0208
Journal - Research Article
Stevens, A. J., Stuffrein-Roberts, S., Cree, S. L., Gibb, A., Miller, A. L., Doudney, K., Aitchison, A., Eccles, M. R., Joyce, P. R., … Kennedy, M. A. (2014). G-quadruplex structures and CpG methylation cause drop-out of the maternal allele in polymerase chain reaction amplification of the imprinted MEST gene promoter. PLoS ONE, 9(12), e113955. doi: 10.1371/journal.pone.0113955
Journal - Research Article
Chua, E. W., Foulds, J., Miller, A. L., & Kennedy, M. A. (2013). Novel CYP2D6 and CYP2C19 variants identified in a patient with adverse reactions towards venlafaxine monotherapy and dual therapy with nortriptyline and fluoxetine. Pharmacogenetics & Genomics, 23(9), 494-497. doi: 10.1097/FPC.0b013e328363688d
Journal - Research Article
Fergusson, D. M., Boden, J. M., Horwood, L. J., Miller, A., & Kennedy, M. A. (2012). Moderating role of the MAOA genotype in antisocial behaviour. British Journal of Psychiatry, 200(2), 116-123. doi: 10.1192/bjp.bp.111.093328
Journal - Research Article
Fergusson, D. M., Boden, J. M., Horwood, L. J., Miller, A. L., & Kennedy, M. A. (2011). MAOA, abuse exposure and antisocial behaviour: 30-year longitudinal study. British Journal of Psychiatry, 198, 457-463. doi: 10.1192/bjp.bp.110.086991
Journal - Research Article
Fergusson, D. M., Horwood, L. J., Miller, A. L., & Kennedy, M. A. (2011). Life stress, 5-HTTLPR and mental disorder: Findings from a 30-year longitudinal study. British Journal of Psychiatry, 198, 129-135. doi: 10.1192/bjp.bp.110.085993
Journal - Research Article
Doudney, K., Harley, J. A., Pearson, J. F., Miller, A., Aitchison, A., Kennedy, M. A., Porter, R. J., Elmslie, J. L., & Joyce, P. R. (2009). Upstream genetic variant near INSIG2, influences response to carnitine supplementation in bipolar patients with valproate-induced weight gain. Acta Neuropsychiatrica, 21(3), 133-140. doi: 10.1111/j.1601-5215.2009.00379.x
Journal - Research Article
Joyce, P. R., McHugh, P. C., Light, K. J., Rowe, S., Miller, A. L., & Kennedy, M. A. (2009). Relationships between angry-impulsive personality traits and genetic polymorphisms of the dopamine transporter. Biological Psychiatry, 66(8), 717-721. doi: 10.1016/j.biopsych.2009.03.005
Journal - Research Article
Porter, R. J., Mulder, R. T., Joyce, P. R., Miller, A. L., & Kennedy, M. (2008). Tryptophan hydroxylase gene (TPH1) and peripheral tryptophan levels in depression. Journal of Affective Disorders, 109(1-2), 209-212. doi: 10.1016/j.jad.2007.11.010
Journal - Research Article
Light, K. J., Joyce, P. R., Luty, S. E., Mulder, R. T., Carter, J. D., Frampton, C. M. A., Miller, A. L., & Kennedy, M. A. (2007). An association study of DRD2 and COMT polymorphisms with novelty seeking and harm avoidance scores, in two independent samples of depressed patients. Behavioral & Brain Functions, 3(3). Retrieved from http://www.behavioralandbrainfunctions.com/content/3/1/3
Journal - Research Article
Roberts, R. L., Gearry, R. B., Hollis-Moffatt, J. E., Miller, A. L., Reid, J., Abkevich, V., … Merriman, T. R., Barclay, M. L., & Kennedy, M. A. (2007). IL23R R381Q and ATG16L1 T300A are strongly associated with Crohn's disease in a study of New Zealand Caucasians with inflammatory bowel disease. American Journal of Gastroenterology, 102, 2754-2761.
Journal - Research Article
Joyce, P. R., McHugh, P. C., McKenzie, J. M., Sullivan, P. F., Mulder, R. T., Luty, S. E., Carter, J. D., Frampton, C. M. A., … Miller, A. L., & Kennedy, M. A. (2006). A dopamine transporter polymorphism is a risk factor for borderline personality disorder in depressed patients. Psychological Medicine, 36, 807-813. doi: 10.1017/s0033291706007288
Journal - Research Article
Joyce, P. R., McKenzie, J. M., Mulder, R. T., Luty, S. E., Sullivan, P. F., Miller, A. L., & Kennedy, M. A. (2006). Genetic, developmental and personality correlates of self-mutilation in depressed patients. Australian & New Zealand Journal of Psychiatry, 40, 225-229.
Journal - Research Article
Light, K. J., Joyce, P. R., Luty, S. E., Mulder, R. T., Frampton, C. M. A., Joyce, L. R. M., Miller, A. L., & Kennedy, M. A. (2006). Preliminary evidence for an association between a dopamine D3 receptor gene variant and obsessive-compulsive personality disorder in patients with major depression. American Journal of Medical Genetics Part B, 141B(4), 409-413. doi: 10.1002/ajmg.b.30308
Journal - Research Article
Joyce, P. R., Porter, R. J., Mulder, R. T., Luty, S. E., McKenzie, J. M., Miller, A. L., & Kennedy, M. A. (2005). Reversed diurnal variation in depression: Associations with a differential antidepressant response, tryptophan: Large neutral amino acid ratio and serotonin transporter polymorphisms. Psychological Medicine, 35, 511-517.
Journal - Research Article
Taylor, D. R., Epton, M. J., Kennedy, M. A., Smith, A. D., Iles, S., Miller, A. L., Littlejohn, M. D., Cowan, J. O., Hewitt, T., Swanney, M. P., Brassett, K. P., & Herbison, G. P. (2005). Bronchodilator response in relation to β2-adrenoceptor haplotype in patients with asthma. American Journal of Respiratory & Critical Care Medicine, 172(6), 700-703.
Journal - Research Article
Rogers, G., Joyce, P., Mulder, R., Sellman, D., Miller, A., Allington, M., Olds, R., Wells, E., & Kennedy, M. (2004). Association of a duplicated repeat polymorphism in the 5′-untranslated region of the DRD4 gene with novelty seeking. American Journal of Medical Genetics Part B, 126B, 95-98.
Journal - Research Article
Joyce, P. R., Mulder, R. T., Luty, S. E., McKenzie, J. M., Miller, A., Rogers, G. R., & Kennedy, M. A. (2003). Age-dependent antidepressant pharmacogenomics: Polymorphisms of the serotonin transporter and G protein β3 subunit as predictors of response to fluoxetine and nortriptyline. International Journal of Neuropsychopharmacology, 6, 339-346.
Journal - Research Article
Joyce, P. R., Rogers, G. R., Miller, A., Mulder, R. T., Luty, S. E., & Kennedy, M. A. (2003). Polymorphisms of DRD4 and DRD3 and risk of avoidant and obsessive personality traits and disorders. Psychiatry Research, 119, 1-10.
Journal - Research Article
Littlejohn, M. D., Taylor, D. R., Miller, A. L., & Kennedy, M. A. (2002). Determination of β2-adrenergic receptor (ADRB2) haplotypes by a multiplexed polymerase chain reaction assay. Human Mutation, 20(6), 479. doi: 10.1002/humu.9091
Journal - Research Article
Wood, J. G., Joyce, P. R., Miller, A., Mulder, R. T., & Kennedy, M. A. (2002). A polymorphism in the dopamine β-hydroxylase gene is associated with "paranoid ideation" in patients with major depression. Biological Psychiatry, 51, 365-369.
Journal - Research Article
Kennedy, M. A., Rowland, S., Miller, A., Morris, C. M., Neville, L., Dodd, A., … Love, D. R. (1996). Structure and location of the murine adrenoleukodystrophy gene. Genomics, 32(3), 395-400.
Journal - Research Article
Bulik, C. M., Thornton, L. M., Parker, R., Kennedy, H., Baker, J. H., MacDermod, C., … Cleland, L., Miller, A. L., … Jordan, J., Kennedy, M. A., & Martin, N. G. (2021). The Eating Disorders Genetics Initiative (EDGI): Study protocol. BMC Psychiatry, 21(1), 234. doi: 10.1186/s12888-021-03212-3
Journal - Research Other
Clemens, B. J., Arakawa, H., Baker, C., Coghlan, S., Kucheryavyy, A., Lampman, R., … Miller, A., … Yanai, S. (2021). Management of anadromous lampreys: Common threats, different approaches. Journal of Great Lakes Research, 47, s129-s146. doi: 10.1016/j.jglr.2020.09.005
Journal - Research Other
Maggo, S., Kennedy, M. A., Barczyk, Z. A., Miller, A. L., Rucklidge, J. J., Mulder, R. T., & Foulds, J. A. (2019). Common CYP2D6, CYP2C9, and CYP2C19 gene variants, health anxiety, and neuroticism are not associated with self-reported antidepressant side effects [Brief report]. Frontiers in Genetics, 10, 1199. doi: 10.3389/fgene.2019.01199
Journal - Research Other
Bridgman, P. G., Finsterer, J., Lacey, C., Kimber, B., Parkin, P. J., Miller, A. L., & Kennedy, M. A. (2016). CTG-repeat expansions in the DMPK gene do not cause takotsubo syndrome [Short communication]. International Journal of Cardiology, 203, 107-108. doi: 10.1016/j.ijcard.2015.10.112
Journal - Research Other
Chua, E.-W., Miller, A. L., & Kennedy, M. A. (2015). Choice of PCR microtube can impact on the success of long-range PCRs. Analytical Biochemistry, 477, 115-117. doi: 10.1016/j.ab.2015.02.023
Journal - Research Other
Pearson, J. F., Fergusson, D. M., Horwood, L. J., Miller, A. L., Sullivan, P. F., Youfang, L. E., & Kennedy, M. A. (2013). Increased risk of major depression by childhood abuse is not modified by CNR1 genotype. American Journal of Medical Genetics Part B, 162(2), 224-226. doi: 10.1002/ajmg.b.32124
Journal - Research Other
Light, K. J., Miller, A. L., Doughty, C. J., Joyce, P. R., Olds, R. J., & Kennedy, M. A. (2007). FAT and bipolar affective disorder [Letter to the editor]. Molecular Psychiatry, 12, 899-900.
Journal - Research Other
Maggo, S., Kee, J., Hitchman, L., Chin, P., Doogue, M., Miller, A., … Kennedy, M. (2021). Assessing the pharmacogenomic landscape of adverse drug reactions in Aotearoa [Invited]. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go
Conference Contribution - Published proceedings: Abstract
Maggo, S., Kennedy, M., Barczyk, Z., Miller, A., Rucklidge, J., Mulder, R., & Foulds, J. (2019). Pharmacogenetic variants and psychological factors do not explain self-reported antidepressant side effects. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and the Population Approach Group of Australia & New Zealand (PAGANZ) Joint Scientific Meeting: Shared Horizons: Optimizing Drug Response to Improve Patient Outcomes. (pp. 66). Retrieved from https://www.asceptasm.com
Conference Contribution - Published proceedings: Abstract
Cree, S., Maggo, S., Slow, S., Ton, K., de Jong, L., Anderson, T., Pearson, J., Miller, A., Walker, L., Murdoch, D., & Kennedy, M. (2017). Long read nanopore sequencing in the laboratory. Proceedings of the MapNet Conference. Retrieved from http://scienceevents.co.nz/mapnet/
Conference Contribution - Published proceedings: Abstract
Kennedy, M. A., Maggo, S. D. S., Foulds, J., Luty, S., Chua, E. W., Cree, S., Ton, K., Liau, Y., Miller, A. L., Chin, P., … Doogue, M. (2017). DNA banking and genetic analysis of adverse drug reactions in the New Zealand healthcare setting. Proceedings of the American Society of Human Genetics (ASHG) Annual Meeting. 2123. Retrieved from http://www.ashg.org/2017meeting/
Conference Contribution - Published proceedings: Abstract
Macmil, S. L., Fredericks, R., Miller, A., Fee, C., Filichev, V. V., & Kennedy, M. A. (2013). Structure based function: Investigating the role of G-quadruplex structures in de novo DNA methylation. Proceedings of the 4th International Meeting on G-quadruplex Nucleic Acids: From Structure to Chemistry and Biology. 79. Retrieved from http://www.g4meeting2013.com/
Conference Contribution - Published proceedings: Abstract
Stevens, A. J., Stuffrein-Roberts, S., Macmil, S., Gibb, A., Doudney, K., Miller, A. L., Bagshaw, A., Aitchison, A., Eccles, M. R., Joyce, P. R., … Kennedy, M. A. (2013). Allelic-dropout during PCR of the imprinted MEST promoter caused by interaction between G-quadruplex structures and DNA methylation. Proceedings of the 4th International Meeting on G-quadruplex Nucleic Acids: From Structure to Chemistry and Biology. 83. Retrieved from http://www.g4meeting2013.com/
Conference Contribution - Published proceedings: Abstract