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Otago Pharmacometrics Group Profile

Dr Hesham Al-Sallami

PositionSenior Lecturer
QualificationsBPharm MClinPharm PhD
Research summaryPharmacometrics and clinical pharmacy
TeachingClinical pharmacy, Therapeutics
Memberships
  • Registered Pharmacist, RegPharmNZ
  • Member of the Population Approach Group in Australia and New Zealand
  • Member of the Australasian Society for Clinical and Experimental Pharmacologists
  • Member of the Pharmaceutical Society of New Zealand
  • Secretary of the Otago branch of the Pharmaceutical Society of New Zealand committee
  • Member of the New Zealand Hospital Pharmacists’ Association
ClinicalClinical pharmacy practice

Research

  • Dose-individualisation
  • Quantitative clinical pharmacology
  • Paediatric pharmacology
  • Influence of body composition on the dose-response of medicines

Dr Al-Sallami on PubMed

Publications

Al-Sallami, H., & Loke, S.-K. (2018). Learning a complex dose–response relationship with the computer simulation CoaguSim. Currents in Pharmacy Teaching & Learning. Advance online publication. doi: 10.1016/j.cptl.2018.07.009

Mooranian, A., Negrulj, R., Takechi, R., Mamo, J., Al-Sallami, H., & Al-Salami, H. (2018). The biological effects of the hypolipidaemic drug probucol microcapsules fed daily for 4 weeks, to an insulin-resistant mouse model: Potential hypoglycaemic and anti-inflammatory effects. Drug Delivery & Translational Research, 8(3), 543-551. doi: 10.1007/s13346-017-0473-5

Sinha, J., Al-Sallami, H. S., & Duffull, S. B. (2018). Choosing the allometric exponent in covariate model building. Clinical Pharmacokinetics. Advance online publication. doi: 10.1007/s40262-018-0667-0

Dowd, L. A., Wheeler, B. J., Al-Sallami, H. S., Broadbent, R. S., Edmonds, L. K., & Medlicott, N. J. (2018). Paracetamol treatment for patent ductus arteriosus: Practice and attitudes in Australia and New Zealand. Journal of Maternal-Fetal & Neonatal Medicine. Advance online publication. doi: 10.1080/14767058.2018.1456520

Muller, M., Wheeler, B. J., Blackwell, M., Colas, M., Reith, D. M., Medlicott, N. J., & Al-Sallami, H. S. (2018). The influence of patient variables on insulin total daily dose in paediatric inpatients with new onset type 1 diabetes mellitus. Journal of Diabetes & Metabolic Disorders. Advance online publication. doi: 10.1007/s40200-018-0355-5

Journal - Research Article

Al-Sallami, H., & Loke, S.-K. (2018). Learning a complex dose–response relationship with the computer simulation CoaguSim. Currents in Pharmacy Teaching & Learning. Advance online publication. doi: 10.1016/j.cptl.2018.07.009

Muller, M., Wheeler, B. J., Blackwell, M., Colas, M., Reith, D. M., Medlicott, N. J., & Al-Sallami, H. S. (2018). The influence of patient variables on insulin total daily dose in paediatric inpatients with new onset type 1 diabetes mellitus. Journal of Diabetes & Metabolic Disorders. Advance online publication. doi: 10.1007/s40200-018-0355-5

Dowd, L. A., Wheeler, B. J., Al-Sallami, H. S., Broadbent, R. S., Edmonds, L. K., & Medlicott, N. J. (2018). Paracetamol treatment for patent ductus arteriosus: Practice and attitudes in Australia and New Zealand. Journal of Maternal-Fetal & Neonatal Medicine. Advance online publication. doi: 10.1080/14767058.2018.1456520

Sinha, J., Al-Sallami, H. S., & Duffull, S. B. (2018). Choosing the allometric exponent in covariate model building. Clinical Pharmacokinetics. Advance online publication. doi: 10.1007/s40262-018-0667-0

Mooranian, A., Negrulj, R., Takechi, R., Mamo, J., Al-Sallami, H., & Al-Salami, H. (2018). The biological effects of the hypolipidaemic drug probucol microcapsules fed daily for 4 weeks, to an insulin-resistant mouse model: Potential hypoglycaemic and anti-inflammatory effects. Drug Delivery & Translational Research, 8(3), 543-551. doi: 10.1007/s13346-017-0473-5

Gogoi-Tiwari, J., Williams, V., Waryah, C. B., Costantino, P., Al-Salami, H., Mathavan, S., … Al-Sallami, H., & Mukkur, T. (2017). Mammary gland pathology subsequent to acute infection with strong versus weak biofilm forming Staphylococcus aureus bovine mastitis isolates: A pilot study using non-invasive mouse mastitis model. PLoS ONE, 12(1), e0170668. doi: 10.1371/journal.pone.0170668

Selvakumar, D., Al-Sallami, H. S., de Bock, M., Ambler, G. R., Benitez-Aguirre, P., Wiltshire, E., … Willis, J., Wheeler, B. J., on behalf of the Paediatric Society of New Zealand Diabetes Clinical Network. (2017). Insulin regimens for newly diagnosed children with type 1 diabetes mellitus in Australia and New Zealand: A survey of current practice. Journal of Paediatrics & Child Health, 53(12), 1208-1214. doi: 10.1111/jpc.13631

Al-Sallami, H., Newall, F., Monagle, P., Ignjatovic, V., Cranswick, N., & Duffull, S. (2016). Development of a population pharmacokinetic-pharmacodynamic model of a single bolus dose of unfractionated heparin in paediatric patients. British Journal of Clinical Pharmacology, 82(1), 178-184. doi: 10.1111/bcp.12930

Tordoff, J. M., Ailabouni, N. J., Browne, D. P., Al-Sallami, H. S., & Gray, A. R. (2016). Improvements in the prescribing of antipsychotics in dementia and psychogeriatric units in New Zealand. International Journal of Clinical Pharmacy, 38(4), 941-949. doi: 10.1007/s11096-016-0318-1

Negrulj, R., Mooranian, A., Chen-Tan, N., Al-Sallami, H. S., Mikov, M., Golocorbin-Kon, S., … Al-Salami, H. (2016). Swelling, mechanical strength, and release properties of probucol microcapsules with and without a bile acid, and their potential oral delivery in diabetes. Artificial Cells, Nanomedicine, & Biotechnology, 44(5), 1290-1297. doi: 10.3109/21691401.2015.1024845

Al-Sallami, H. S., & Medlicott, N. J. (2015). Investigation of an anti-activated factor X (anti-Xa) assay for the quantification of enoxaparin in human plasma. Journal of Pharmacy & Pharmacology, 67(2), 209-214. doi: 10.1111/jphp.12333

Mooranian, A., Negrulj, R., Al-Sallami, H. S., Fang, Z., Mikov, M., Golocorbin-Kon, S., … Al-Salami, H. (2015). Probucol release from novel multicompartmental microcapsules for the oral targeted delivery in type 2 diabetes. AAPS PharmSciTech, 16(1), 45-52. doi: 10.1208/s12249-014-0205-9

Mooranian, A., Negrulj, R., Al-Sallami, H. S., Fang, Z., Mikov, M., Golocorbin-Kon, S., … Al-Salami, H. (2015). Release and swelling studies of an innovative antidiabetic-bile acid microencapsulated formulation, as a novel targeted therapy for diabetes treatment. Journal of Microencapsulation, 32(2), 151-156. doi: 10.3109/02652048.2014.958204

Al-Sallami, H. S., Goulding, A., Grant, A., Taylor, R., Holford, N., & Duffull, S. B. (2015). Prediction of fat-free mass in children. Clinical Pharmacokinetics, 54(11), 1169-1178. doi: 10.1007/s40262-015-0277-z

Mooranian, A., Negrulj, R., Chen-Tan, N., Al-Sallami, H. S., Fang, Z., Mukkur, T., Mikov, M., … Al-Salami, H. (2014). Novel artificial cell microencapsulation of a complex gliclazide-deoxycholic bile acid formulation: A characterization study. Drug Design, Development & Therapy, 8, 1003-1012. doi: 10.2147/dddt.s65396

Mooranian, A., Negrulj, R., Chen-Tan, N., Al-Sallami, H. S., Fang, Z., Mukkur, T. K., Mikov, M., … Al-Salami, H. (2014). Microencapsulation as a novel delivery method for the potential antidiabetic drug, Probucol. Drug Design, Development & Therapy, 8, 1221-1230. doi: 10.2147/dddt.s67349

Loke, S.-K., Al-Sallami, H. S., Wright, D. F. B., McDonald, J., Jadhav, S., & Duffull, S. B. (2012). Challenges in integrating a complex systems computer simulation in class: An educational design research. Australasian Journal of Educational Technology, 28(4), 671-683. doi: 10.14742/ajet.834

Wright, D. F. B., Pavan Kumar, V. V., Al-Sallami, H. S., & Duffull, S. B. (2011). The influence of dosing time, variable compliance and circadian low-density lipoprotein production on the effect of simvastatin: Simulations from a pharmacokinetic—pharmacodynamic model. Basic & Clinical Pharmacology & Toxicology, 109(6), 494-498. doi: 10.1111/j.1742-7843.2011.00757.x

Al-Sallami, H. S., Barras, M. A., Green, B., & Duffull, S. B. (2010). Routine plasma anti-Xa monitoring is required for low-molecular-weight heparins. Clinical Pharmacokinetics, 49(9), 567-571. doi: 10.2165/11532960-000000000-00000

Wright, D. F. B., Al-Sallami, H. S., Jackson, P. M., & Reith, D. M. (2010). Falsely elevated vancomycin plasma concentrations sampled from central venous implantable catheters (portacaths). British Journal of Clinical Pharmacology, 70(5), 769-772. doi: 10.1111/j.1365-2125.2010.03749.x

Al-Sallami, H. S., Kumar, V. V. P., Landersdorfer, C. B., Bulitta, J. B., & Duffull, S. B. (2009). The time course of drug effects. Pharmaceutical Statistics, 8, 176-185. doi: 10.1002/pst.393

Al-Sallami, H., Ferguson, R., Wilkins, G., Gray, A., & Medlicott, N. J. (2008). Bleeding events in patients receiving enoxaparin for the management of non-ST-elevation acute coronary syndrome (NSTEACS) at Dunedin Public Hospital, New Zealand. New Zealand Medical Journal, 121(1285). Retrieved from http://journal.nzma.org.nz/journal/121-1285/3342/content.pdf

Al-Sallami, H., Ball, P. A., & Davey, A. (2001). Metered-dose inhaler with spacer versus nebuliser for acute exacerbation of asthma - a literature review. Australian Journal of Hospital Pharmacy, 31(3), 189-192.

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Journal - Research Other

Reith, D. M., & Al-Sallami, H. S. (2018). Comment on van Rongen et al., "Higher midazolam clearance in obese adolescents compared with morbidly obese adults". Clinical Pharmacokinetics. Advance online publication. doi: 10.1007/s40262-018-0691-0

Sinha, J., Duffull, S. B., & Al-Sallami, H. S. (2018). A review of the methods and associated mathematical models used in the measurement of fat-free mass. Clinical Pharmacokinetics. Advance online publication. doi: 10.1007/s40262-017-0622-5

Al-Sallami, H. S., Cheah, S. L., Han, S. Y., Liew, J., Lim, J., Ng, M. A., Solanki, H., Soo, R. J., Tan, V., & Duffull, S. B. (2014). Between-subject variability: Should high be the new normal? European Journal of Clinical Pharmacology, 70(11), 1403-1404. doi: 10.1007/s00228-014-1740-8

Wright, D. F. B., Al-Sallami, H. S., & Duffull, S. B. (2013). Is the dose of dabigatran really more predictable than warfarin? British Journal of Clinical Pharmacology, 76(6), 997-998. doi: 10.1111/bcp.12144

Duffull, S. B., Wright, D. F. B., Al-Sallami, H. S., Zufferey, P. J., & Faed, J. M. (2012). Dabigatran: Rational dose individualisation and monitoring guidance is needed. New Zealand Medical Journal, 125(1357). Retrieved from http://www.nzma.org.nz/journal

Al-Sallami, H., Jordan, S., Ferguson, R., Medlicott, N. J., Schollum, J., & Duffull, S. B. (2010). Current enoxaparin dosing guidelines have dubious credibility [Viewpoint]. New Zealand Medical Journal, 123(1313). Retrieved from http://journal.nzma.org.nz/journal/123-1313/4076/content.pdf

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