Dr Dorothy Saville
|Position||Senior Lecturer in Pharmaceutical Science|
|Qualifications||BPharm(Hons) MSc PhD|
|Research summary||Solid state pharmaceutics; formulation and drug delivery; pharmacokinetics and drug metabolism|
Physical pharmacy; pharmacokinetics
I have good knowledge of the grapefruit–medicines interaction and also an interest in clinical pharmacokinetics, particularly of drugs acting in CNS.
In order to improve oral bioavailability of drugs with poor aqueous solubility, an amorphous form or a metastable polymorph may be used. These forms, however, have a risk of either crystallising (amorphous) or changing to a more stable polymorph with loss of oral bioavailability. Research focuses on factors influencing the stability of the amorphous form or the metastable polymorphic form. Current projects in this area include:
- The stability of amorphous drug upon milling
- The formulation of amorphous suspensions
In addition, the effect of storage conditions on release from enteric coated tablets is under study.
- Review of papers for publication International Journal of Pharmaceutics (1998–present)
Surwase, S. A., Itkonen, L., Aaltonen, J., Saville, D., Rades, T., Peltonen, L., & Strachan, C. J. (2015). Polymer incorporation method affects the physical stability of amorphous indomethacin in aqueous suspension. European Journal of Pharmaceutics & Biopharmaceutics, 96, 32-43. doi: 10.1016/j.ejpb.2015.06.005
Surwase, S. A., Boetker, J. P., Saville, D., Boyd, B. J., Gordon, K. C., Peltonen, L., & Strachan, C. J. (2013). Indomethacin: New polymorphs of an old drug. Molecular Pharmaceutics, 10(12), 4472-4480. doi: 10.1021/mp400299a
Chieng, N., Aaltonen, J., Saville, D., & Rades, T. (2009). Physical characterization and stability of amorphous indomethacin and ranitidine hydrochloride binary systems prepared by mechanical activation. European Journal of Pharmaceutics & Biopharmaceutics, 71(1), 47-54. doi: 10.1016/j.ejpb.2008.06.022
Chieng, N., Rehder, S., Saville, D., Rades, T., & Aaltonen, J. (2009). Quantitative solid-state analysis of three solid forms of ranitidine hydrochloride in ternary mixtures using Raman spectroscopy and X-ray powder diffraction. Journal of Pharmaceutical & Biomedical Analysis, 49(1), 18-25. doi: 10.1016/j.jpba.2008.09.054
Zhang, F., Aaltonen, J., Tian, F., Saville, D. J., & Rades, T. (2009). Influence of particle size and preparation methods on the physical and chemical stability of amorphous simvastatin. European Journal of Pharmaceutics & Biopharmaceutics, 71(1), 64-70. doi: 10.1016/j.ejpb.2008.07.010