Dr Clare Strachan
|Position||Associate Professor, Faculty of Pharmacy, University of Helsinki|
|Qualifications||MPS(NZ) BPharm PhD(Otago)|
|Research summary||The physicochemical characterisation and optimisation of solid drugs and dosage forms|
Clare Strachan’s main research interests revolve around the physicochemical characterisation and optimisation of solid drugs and dosage forms, with two main focuses:
1. Formulation of poorly water soluble drugs using solid state modification
This work focuses the amorphous and other solid state forms for improved drug dissolution, with a view to understanding their physicochemical behaviour during the product lifecycle (preformulation, formulation, manufacturing, storage, and drug release).
2. Advanced spectroscopic analysis and imaging
This work focuses on new insights into solid drugs and dosage form behaviour using a range of spectroscopic and imaging methods. The main spectroscopic techniques used are infrared, near-infrared, Raman, and terahertz pulsed spectroscopies. Imaging includes Raman mapping and coherent Raman (CARS) imaging which allows label-free imaging of solid drugs and dosage forms during the product lifecycle, including in situ analysis during drug release. Analysis of the data generated is supported by various chemometrics approaches, both qualitative and quantitative, and computational chemistry methods including ab initio calculations. Analysis is supported by complimentary physical characterisation methods including X-ray powder diffraction, microscopy and thermal methods.