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Contact Details

Phone
+64 3 479 7279
Email
sumit.dadhwal@otago.ac.nz
Position
Research Fellow
Research summary
Polymer chemistry, drug delivery and animal health formulations.

Research

My primary research interests are the development and evaluation of novel drug delivery platforms. I am particularly interested in developing targeted and disease-specific formulations to deliver bioactive molecules.

In my post-doctoral training, I worked as a formulation scientist for Elanco Animal Health (previously Bayer) and developed intramammary formulations for dairy cows.

I have extensive experience in small organic molecule synthesis, block co-polymer synthesis, engineering formulations for biopharmaceuticals, project management and pre-clinical studies.

As team leader (current role) of the Animal Health Formulations and Product Innovations group at the School of Pharmacy, I apply my synthesis, formulation, and drug delivery expertise to develop sustained-release veterinary formulations.

Publications

Lee, A., Dadhwal, S., & Gamble, A. (2022). Liposomes with cyclodextrin channels and polyethyleneimine (PEI) improves cytoplasmic vaccine delivery and induces anti-cancer immune activity in mice. Journal of Liposome Research, 32(1), 22-31. doi: 10.1080/08982104.2020.1831016

Dadhwal, S., Lee, A., Goswami, S. K., Hook, S., & Gamble, A. B. (2021). Synthesis and formulation of self-immolative PEG-aryl azide block copolymers and click-to-release reactivity with trans-cyclooctene. Journal of Polymer Science, 59, 646-658. doi: 10.1002/pol.20210020

Fairhall, J. M., Murayasu, M., Dadhwal, S., Hook, S., & Gamble, A. B. (2020). Tuning activation and self-immolative properties of the bioorthogonal alkene-azide click-and-release strategy. Organic & Biomolecular Chemistry, 18, 4754-4762. doi: 10.1039/d0ob00936a

Dadhwal, S., Fairhall, J. M., Hook, S., & Gamble, A. B. (2020). Tetrafluoroaryl azide as an N-terminal capping group for click-to-dissolve diphenylalanine hydrogels. RSC Advances, 10(16), 9234-9244. doi: 10.1039/d0ra01013h

Dadhwal, S., Fairhall, J. M., Goswami, S. K., Hook, S., & Gamble, A. B. (2019). Alkene-azide 1,3-dipolar cycloaddition as a trigger for ultrashort peptide hydrogel dissolution. Chemistry: An Asian Journal, 14, 1143-1150. doi: 10.1002/asia.201801184

Lee, A., Dadhwal, S., & Gamble, A. (2022). Liposomes with cyclodextrin channels and polyethyleneimine (PEI) improves cytoplasmic vaccine delivery and induces anti-cancer immune activity in mice. Journal of Liposome Research, 32(1), 22-31. doi: 10.1080/08982104.2020.1831016

Journal - Research Article

Dadhwal, S., Lee, A., Goswami, S. K., Hook, S., & Gamble, A. B. (2021). Synthesis and formulation of self-immolative PEG-aryl azide block copolymers and click-to-release reactivity with trans-cyclooctene. Journal of Polymer Science, 59, 646-658. doi: 10.1002/pol.20210020

Journal - Research Article

Dadhwal, S., Fairhall, J. M., Hook, S., & Gamble, A. B. (2020). Tetrafluoroaryl azide as an N-terminal capping group for click-to-dissolve diphenylalanine hydrogels. RSC Advances, 10(16), 9234-9244. doi: 10.1039/d0ra01013h

Journal - Research Article

Fairhall, J. M., Murayasu, M., Dadhwal, S., Hook, S., & Gamble, A. B. (2020). Tuning activation and self-immolative properties of the bioorthogonal alkene-azide click-and-release strategy. Organic & Biomolecular Chemistry, 18, 4754-4762. doi: 10.1039/d0ob00936a

Journal - Research Article

Dadhwal, S., Fairhall, J. M., Goswami, S. K., Hook, S., & Gamble, A. B. (2019). Alkene-azide 1,3-dipolar cycloaddition as a trigger for ultrashort peptide hydrogel dissolution. Chemistry: An Asian Journal, 14, 1143-1150. doi: 10.1002/asia.201801184

Journal - Research Article

Abel, S. D. A., Dadhwal, S., Gamble, A. B., & Baird, S. K. (2018). Honey reduces the metastatic characteristics of prostate cancer cell lines by promoting a loss of adhesion. PeerJ, 6, e5115. doi: 10.7717/peerj.5115

Journal - Research Article

Shil, A. K., Kumar, S., Reddy, C. B., Dadhwal, S., Thakur, V., & Das, P. (2015). Supported palladium nanoparticle-catalyzed carboxylation of aryl halides, alkenylsilanes, and organoboronic acids employing oxalic acid as the C1 source. Organic Letters, 17(21), 5352-5355. doi: 10.1021/acs.orglett.5b02701

Journal - Research Article

Dar, B. A., Dadhwal, S., Singh, G., Garg, P., Sharma, P., & Singh, S. (2013). Vapour phase conversion of glycerol to acrolein over supported copper. Arabian Journal for Science & Engineering, 38, 37-40. doi: 10.1007/s13369-012-0395-y

Journal - Research Article

Shard, A., Sharma, N., Bharti, R., Dadhwal, S., Kumar, R., & Sinha, A. K. (2012). Tandem Heck/decarboxylation/Heck strategy: Protecting-group-free synthesis of symmetric and unsymmetric hydrolated stilbenoids. Angewandte Chemie International Edition, 51(49), 12250-12253. doi: 10.1002/anie.201206346

Journal - Research Article

Singh, P. P., Gudup, S., Ambala, S., Singh, U., Dadhwal, S., Singh, B., … Vishwakarma, R. A. (2011). Iron oxide mediated direct C—H arylation/alkylation at α-position of cyclic aliphatic ethers. Chemical Communications, 47(20), 5852-5854. doi: 10.1039/c1cc11094b

Journal - Research Article

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