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Pharmacy staff profile

Dr Chihiro Hasegawa

PositionHonorary Senior Lecturer
QualificationsMSc PhD
Research summaryPharmacometrics
MembershipsInternational Society of Pharmacometrics

Research

My research mainly involves the automated scale reduction of quantitative systems pharmacology (QSP) models for data-driven population modelling.

Publications

Derbalah, A., Al-Sallami, H., Hasegawa, C., Gulati, A., & Duffull, S. B. (2020). A framework for simplification of quantitative systems pharmacology models in clinical pharmacology. British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.14451

Ooi, Q. X., Hasegawa, C., Duffull, S. B., & Wright, D. F. B. (2020). Kinetic-pharmacodynamic model for drugs with non-linear elimination: Parameterisation matters. British Journal of Clinical Pharmacology, 86(2), 196-198. doi: 10.1111/bcp.14154

Hasegawa, C., & Duffull, S. B. (2019). Reusing smaller versions of large models: A case example of reuse of a simplified bone model. Clinical Pharmacology & Therapeutics, 106(6), 1184-1186. doi: 10.1002/cpt.1582

Hasegawa, C., & Duffull, S. B. (2018). Automated scale reduction of nonlinear QSP models with an illustrative application to a bone biology system. CPT: Pharmacometrics & Systems Pharmacology, 7, 562-572. doi: 10.1002/psp4.12324

Hasegawa, C., & Duffull, S. B. (2018). Selection and qualification of simplified QSP models when using model order reduction techniques. AAPS Journal, 20, 2. doi: 10.1208/s12248-017-0170-9

Hasegawa, C., & Duffull, S. B. (2018). Automated scale reduction of nonlinear QSP models with an illustrative application to a bone biology system. CPT: Pharmacometrics & Systems Pharmacology, 7, 562-572. doi: 10.1002/psp4.12324

Journal - Research Article

Hasegawa, C., & Duffull, S. B. (2018). Selection and qualification of simplified QSP models when using model order reduction techniques. AAPS Journal, 20, 2. doi: 10.1208/s12248-017-0170-9

Journal - Research Article

Hasegawa, C., & Duffull, S. B. (2017). Exploring inductive linearization for pharmacokinetic-pharmacodynamic systems of nonlinear ordinary differential equations. Journal of Pharmacokinetics & Pharmacodynamics, 45(1), 35-47. doi: 10.1007/s10928-017-9527-z

Journal - Research Article

Derbalah, A., Al-Sallami, H., Hasegawa, C., Gulati, A., & Duffull, S. B. (2020). A framework for simplification of quantitative systems pharmacology models in clinical pharmacology. British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.14451

Journal - Research Other

Ooi, Q. X., Hasegawa, C., Duffull, S. B., & Wright, D. F. B. (2020). Kinetic-pharmacodynamic model for drugs with non-linear elimination: Parameterisation matters. British Journal of Clinical Pharmacology, 86(2), 196-198. doi: 10.1111/bcp.14154

Journal - Research Other

Hasegawa, C., & Duffull, S. B. (2019). Reusing smaller versions of large models: A case example of reuse of a simplified bone model. Clinical Pharmacology & Therapeutics, 106(6), 1184-1186. doi: 10.1002/cpt.1582

Journal - Research Other

More publications...