Contact Details
University Links
- Position
- Honorary Senior Lecturer
- Qualifications
- MSc PhD
- Research summary
- Pharmacometrics
- Memberships
- International Society of Pharmacometrics
Research
My research mainly involves the automated scale reduction of quantitative systems pharmacology (QSP) models for data-driven population modelling.
Publications
Sharif, S., Hasegawa, C., & Duffull, S. B. (2022). Exploring Inductive Linearization for simulation and estimation with an application to the Michaelis-Menten model. Journal of Pharmacokinetics & Pharmacodynamics, 49, 445-453. doi: 10.1007/s10928-022-09813-z
Derbalah, A., Al-Sallami, H., Hasegawa, C., Gulati, A., & Duffull, S. B. (2022). A framework for simplification of quantitative systems pharmacology models in clinical pharmacology. British Journal of Clinical Pharmacology, 88, 1430-1440. doi: 10.1111/bcp.14451
Ooi, Q. X., Hasegawa, C., Duffull, S. B., & Wright, D. F. B. (2020). Kinetic-pharmacodynamic model for drugs with non-linear elimination: Parameterisation matters. British Journal of Clinical Pharmacology, 86(2), 196-198. doi: 10.1111/bcp.14154
Hasegawa, C., & Duffull, S. B. (2019). Reusing smaller versions of large models: A case example of reuse of a simplified bone model. Clinical Pharmacology & Therapeutics, 106(6), 1184-1186. doi: 10.1002/cpt.1582
Hasegawa, C., & Duffull, S. B. (2018). Automated scale reduction of nonlinear QSP models with an illustrative application to a bone biology system. CPT: Pharmacometrics & Systems Pharmacology, 7, 562-572. doi: 10.1002/psp4.12324
Sharif, S., Hasegawa, C., & Duffull, S. B. (2022). Exploring Inductive Linearization for simulation and estimation with an application to the Michaelis-Menten model. Journal of Pharmacokinetics & Pharmacodynamics, 49, 445-453. doi: 10.1007/s10928-022-09813-z
Journal - Research Article
Hasegawa, C., & Duffull, S. B. (2018). Automated scale reduction of nonlinear QSP models with an illustrative application to a bone biology system. CPT: Pharmacometrics & Systems Pharmacology, 7, 562-572. doi: 10.1002/psp4.12324
Journal - Research Article
Hasegawa, C., & Duffull, S. B. (2018). Selection and qualification of simplified QSP models when using model order reduction techniques. AAPS Journal, 20, 2. doi: 10.1208/s12248-017-0170-9
Journal - Research Article
Hasegawa, C., & Duffull, S. B. (2017). Exploring inductive linearization for pharmacokinetic-pharmacodynamic systems of nonlinear ordinary differential equations. Journal of Pharmacokinetics & Pharmacodynamics, 45(1), 35-47. doi: 10.1007/s10928-017-9527-z
Journal - Research Article
Derbalah, A., Al-Sallami, H., Hasegawa, C., Gulati, A., & Duffull, S. B. (2022). A framework for simplification of quantitative systems pharmacology models in clinical pharmacology. British Journal of Clinical Pharmacology, 88, 1430-1440. doi: 10.1111/bcp.14451
Journal - Research Other
Ooi, Q. X., Hasegawa, C., Duffull, S. B., & Wright, D. F. B. (2020). Kinetic-pharmacodynamic model for drugs with non-linear elimination: Parameterisation matters. British Journal of Clinical Pharmacology, 86(2), 196-198. doi: 10.1111/bcp.14154
Journal - Research Other
Hasegawa, C., & Duffull, S. B. (2019). Reusing smaller versions of large models: A case example of reuse of a simplified bone model. Clinical Pharmacology & Therapeutics, 106(6), 1184-1186. doi: 10.1002/cpt.1582
Journal - Research Other