Professor Stephen Duffull
|Qualifications||MPharm PhD(Otago) DipPharm(CIT) FNZCP MPS RegPharmNZ|
|Research summary||Clinical pharmacy; pharmacometrics|
Expertise in pharmacometrics. Pharmacometrics involves the quantitative design, analysis and inference from pharmacological studies. In particular this involves optimal design and population analysis techniques for pharmacokinetic and pharmacodynamic data.
Currently my research involves the development of pharmacological models, modelling of data and the design of clinical studies. These foci essentially revolve around the therapeutic areas of coagulation, malaria and clinical toxicology.
Sinha, J., Al-Sallami, H. S., & Duffull, S. B. (2018). Choosing the allometric exponent in covariate model building. Clinical Pharmacokinetics. Advance online publication. doi: 10.1007/s40262-018-0667-0
Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2018). An evaluation of the operational model when applied to quantify functional selectivity. British Journal of Pharmacology. Advance online publication. doi: 10.1111/bph.14171
Sinha, J., Duffull, S. B., & Al-Sallami, H. S. (2018). A review of the methods and associated mathematical models used in the measurement of fat-free mass. Clinical Pharmacokinetics. Advance online publication. doi: 10.1007/s40262-017-0622-5
Ooi, Q. X., Wright, D. F. B., Tait, R. C., Isbister, G. K., & Duffull, S. B. (2017). A joint model for vitamin K-dependent clotting factors and anticoagulation proteins. Clinical Pharmacokinetics, 56(12), 1555-1556. doi: 10.1007/s40262-017-0541-5
Saffian, S. M., Duffull, S. B., & Wright, D. F. B. (2017). Warfarin dosing algorithms underpredict dose requirements in patients requiring ≥ 7mg daily: A systematic review and meta-analysis. Clinical Pharmacology & Therapeutics, 102(2), 297-304. doi: 10.1002/cpt.649