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Pharmacy staff profile

Professor Stephen Duffull

PositionProfessor
QualificationsDipPharm(CIT) MPharm PhD(Otago) FNZCP FISOP MPS RegPharmNZ
Research summaryClinical pharmacy; pharmacometrics
Teaching

Clinical pharmacy to undergraduate and postgraduate students; including undergraduate papers on Principles of Pharmacy Practice and Quality Use of Medicines, pharmacokinetics and clinical decision making

ClinicalExpertise in pharmacometrics

Research

Expertise in pharmacometrics. Pharmacometrics involves the quantitative design, analysis and inference from pharmacological studies. In particular this involves optimal design and population analysis techniques for pharmacokinetic and pharmacodynamic data.

Currently my research involves the development of pharmacological models, modelling of data and the design of clinical studies. These foci essentially revolve around the therapeutic areas of coagulation, malaria and clinical toxicology.

I also have an education arm to my research with an interest in therapeutic decision-making.

Professor Duffull on Google Scholar

Professor Duffull on PubMed

Current PhD students

Biography

Stephen Duffull registered as a pharmacist in 1986. He has practiced in hospital and community pharmacy and worked and trained in the Department of Clinical Pharmacology at Christchurch Hospital for 10 years. During this time he completed his Masters and PhD degrees. His PhD involved the design and analysis of clinical pharmacokinetic studies.

Dr Duffull took up a postdoctoral position at the University of Manchester working with Dr Leon Aarons in the area of pharmacometrics. He was then appointed to as a Lecturer at the University of Queensland Dept of Pharmacy. In 2006 he was then offered a position as a Professor of clinical pharmacy at the University of Otago where he has worked since.

Publications

Sanhajariya, S., Duffull, S. B., & Isbister, G. K. (2021). Investigating myotoxicity following Australian red-bellied black snake (Pseudechis porphyriacus) envenomation. PLoS ONE, 16(9), e0256653. doi: 10.1371/journal.pone.0256653

Abdul Aziz, Y. H., Heydon, S. J., Duffull, S. B., & Marra, C. A. (2021). Are professional pharmacy services being offered for free in pharmacies? A feasibility study exploring the use of a time motion study in New Zealand. Pharmacy Practice, 19(3), 2422. doi: 10.18549/PharmPract.2021.3.2422

Li, J., Chiew, A. L., Isbister, G. K., & Duffull, S. B. (2021). Population pharmacokinetics of immediate-release and modified-release paracetamol and its major metabolites in a supratherapeutic dosing study. Clinical Toxicology. Advance online publication. doi: 10.1080/15563650.2021.1928163

Yang, L., Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2021). Exploring group size for statistical analysis of real-time signalling experiments. British Journal of Pharmacology. Advance online publication. doi: 10.1111/bph.15572

Pradhan, S., Duffull, S. B., Wilson, L. C., Kuan, I. H. S., Walker, R. J., Putt, T. L., Schollum, J. B. W., & Wright, D. F. B. (2021). Does the intact nephron hypothesis provide a reasonable model for metformin dosing in chronic kidney disease? British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.14919

Heydon, S., & Duffull, S. (2013). Pharmacy at Otago: The first 50 years: The school, the profession and the people. Dunedin, New Zealand: National School of Pharmacy, University of Otago, 80p.

Authored Book - Research

Kimko, H. C., & Duffull, S. B. (Eds.). (2003). Simulation for designing clinical trials: A pharmacokinetic-pharmacodynamic modeling perspective. New York, NY: Marcel Dekker, 416p.

Edited Book - Research

Vajjah, P., Isbister, G. K., & Duffull, S. B. (2012). Introduction to pharmacokinetics in clinical toxicology. In B. Reisfeld & A. N. Mayeno (Eds.), Computational toxicology: Volume I: Methods in molecular biology (Vol. 929). (pp. 289-312). Humana Press. doi: 10.1007/978-1-62703-050-2_12

Chapter in Book - Research

Foo, L.-K., & Duffull, S. B. (2011). Optimal design of pharmacokinetic-pharmacodynamic studies. In P. L. Bonate & D. R. Howard (Eds.), Pharmacokinetics in drug development: Advances and applications (Vol. 3). (pp. 175-193). New York: Springer. doi: 10.1007/978-1-4419-7937-7_8

Chapter in Book - Research

Kimko, H. C., & Duffull, S. B. (2003). Introduction to simulation for design of clinical trials. In H. C. Kimko & S. B. Duffull (Eds.), Simulation for designing clinical trials: A pharmacokinetic-pharmacodynamic modeling perspective. (pp. 1-16). New York, NY: Marcel Dekker.

Chapter in Book - Research

Monteleone, J. P. R., & Duffull, S. B. (2003). Choice of best design. In H. C. Kimko & S. B. Duffull (Eds.), Simulation for designing clinical trials: A pharmacokinetic-pharmacodynamic modeling perspective. (pp. 173-200). New York, NY: Marcel Dekker.

Chapter in Book - Research

Nestorov, I. A., Graham, G., Aarons, L., & Duffull, S. B. (2003). Model-based integration for clinical trial simulation and design: A phase II case study for naratriptan. In H. C. Kimko & S. B. Duffull (Eds.), Simulation for designing clinical trials: A pharmacokinetic-pharmacodynamic modeling perspective. (pp. 313-325). New York, NY: Marcel Dekker.

Chapter in Book - Research

Abdul Aziz, Y. H., Heydon, S. J., Duffull, S. B., & Marra, C. A. (2021). Are professional pharmacy services being offered for free in pharmacies? A feasibility study exploring the use of a time motion study in New Zealand. Pharmacy Practice, 19(3), 2422. doi: 10.18549/PharmPract.2021.3.2422

Journal - Research Article

Abdul Aziz, Y. H., Heydon, S. J., Duffull, S. B., & Marra, C. A. (2021). What free services do pharmacists offer? Investigating the provision of unfunded pharmacy services provided in community pharmacies. Research in Social & Administrative Pharmacy, 17, 588-594. doi: 10.1016/j.sapharm.2020.05.007

Journal - Research Article

Anakin, M. G., Duffull, S. B., & Wright, D. F. B. (2021). Therapeutic decision-making in primary care pharmacy practice. Research in Social & Administrative Pharmacy, 17, 326-331. doi: 10.1016/j.sapharm.2020.04.005

Journal - Research Article

Derbalah, A., Al-Sallami, H. S., & Duffull, S. B. (2021). Reduction of quantitative systems pharmacology models using artificial neural networks. Journal of Pharmacokinetics & Pharmacodynamics. Advance online publication. doi: 10.1007/s10928-021-09742-3

Journal - Research Article

Li, J., Chiew, A. L., Isbister, G. K., & Duffull, S. B. (2021). Population pharmacokinetics of immediate-release and modified-release paracetamol and its major metabolites in a supratherapeutic dosing study. Clinical Toxicology. Advance online publication. doi: 10.1080/15563650.2021.1928163

Journal - Research Article

Pradhan, S., Duffull, S. B., Wilson, L. C., Kuan, I. H. S., Walker, R. J., Putt, T. L., Schollum, J. B. W., & Wright, D. F. B. (2021). Does the intact nephron hypothesis provide a reasonable model for metformin dosing in chronic kidney disease? British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.14919

Journal - Research Article

Sanhajariya, S., Duffull, S. B., & Isbister, G. K. (2021). Investigating myotoxicity following Australian red-bellied black snake (Pseudechis porphyriacus) envenomation. PLoS ONE, 16(9), e0256653. doi: 10.1371/journal.pone.0256653

Journal - Research Article

Sanhajariya, S., Duffull, S. B., & Isbister, G. K. (2021). Population pharmacokinetics of Pseudechis porphyriacus (red-bellied black snake) venom in snakebite patients. Clinical Toxicology. Advance online publication. doi: 10.1080/15563650.2021.1896731

Journal - Research Article

Yang, L., Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2021). Exploring group size for statistical analysis of real-time signalling experiments. British Journal of Pharmacology. Advance online publication. doi: 10.1111/bph.15572

Journal - Research Article

Bahnasawy, S., Al-Sallami, H., & Duffull, S. (2020). A minimal model to describe short-term haemodynamic changes of the cardiovascular system. British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.14541

Journal - Research Article

Derbalah, A., Duffull, S., Moynihan, K., & Al-Sallami, H. (2020). The influence of haemostatic system maturation on the dose-response relationship of unfractionated heparin. Clinical Pharmacokinetics. Advance online publication. doi: 10.1007/s40262-020-00949-0

Journal - Research Article

Donnellan, S., Wright, D. F. B., Roberts, J. A., Duffull, S. B., Schollum, J. B. W., Putt, T. L., … Walker, R. J. (2020). The pharmacokinetics of meropenem and piperacillin-tazobactam during sustained low efficiency haemodiafiltration (SLED-HDF). European Journal of Clinical Pharmacology, 76, 239-247. doi: 10.1007/s00228-019-02792-0

Journal - Research Article

Duffull, S., Peterson, A., Chai, B., Cho, F., Opoku, J., Sissing, T., Smith, D., Tongskul, T., & Wilby, K. (2020). Exploring a scalable real-time simulation for interprofessional education in pharmacy and medicine. MedEdPublish. Advance online publication. doi: 10.15694/mep.2020.000240.1

Journal - Research Article

Gwee, A., Autmizguine, J., Curtis, N., & Duffull, S. B. (2020). Twice-and thrice-daily cephalexin dosing for Staphylococcus aureus infections in children. Pediatric Infectious Disease Journal, 39, 519-522. doi: 10.1097/INF.0000000000002646

Journal - Research Article

Gwee, A., Duffull, S., Zhu, X., Tong, S. Y. C., Cranswick, N., McWhinney, B., … Steer, A. C. (2020). Population pharmacokinetics of ivermectin for the treatment of scabies in Indigenous Australian children. PLoS Neglected Tropical Diseases, 14(12), e0008886. doi: 10.1371/journal.pntd.0008886

Journal - Research Article

Li, J., Karlsson, M. O., Sanhajariya, S., Isbister, G. K., & Duffull, S. B. (2020). A general model for cell death and biomarker release from injured tissues. Journal of Pharmacokinetics & Pharmacodynamics. Advance online publication. doi: 10.1007/s10928-020-09720-1

Journal - Research Article

Pradhan, S., Wright, D. F. B., & Duffull, S. B. (2020). Evaluation of designs for renal drug studies based on the EMA and FDA guidelines for drugs that are predominantly secreted. British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.14536

Journal - Research Article

Sanhajariya, S., Isbister, G. K., & Duffull, S. B. (2020). The influence of the different disposition characteristics of snake toxins on the pharmacokinetics of snake venom. Toxins, 12(3), 188. doi: 10.3390/toxins12030188

Journal - Research Article

Sinha, J., Al-Sallami, H. S., & Duffull, S. B. (2020). An extension of Janmahasatian’s Fat-Free Mass model for universal application across populations of different ethnicities. Clinical Pharmacokinetics, 59, 1161-1170. doi: 10.1007/s40262-020-00883-1

Journal - Research Article

Sinha, J., Duffull, S. B., Green, B., & Al-Sallami, H. S. (2020). Evaluating the relationship between lean liver volume and fat-free mass. Clinical Pharmacokinetics, 59, 475-483. doi: 10.1007/s40262-019-00824-7

Journal - Research Article

Stamp, L. K., Chapman, P., Frampton, C., Duffull, S. B., Drake, J., Zhang, Y., & Neogi, T. (2020). Lack of effect of tart cherry concentrate dose on serum urate in people with gout. Rheumatology, 59, 2374-2380. doi: 10.1093/rheumatology/kez606

Journal - Research Article

Wright, D. F. B., Duffull, S. B., Wilby, K. J., Peterson, A. K., & Anakin, M. G. (2020). Measuring the development of therapeutic-decision-making skills by practicing pharmacists undertaking a university-based postgraduate clinical qualification at distance. Pharmacy, 8(2), 83. doi: 10.3390/pharmacy8020083

Journal - Research Article

Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2020). Evaluation of the profiles of CB1 cannabinoid receptor signalling bias using joint kinetic modelling. British Journal of Pharmacology, 177, 3449-3463. doi: 10.1111/bph.15066

Journal - Research Article

Kuan, I. H. S., Savage, R. L., Duffull, S. B., Walker, R. J., & Wright, D. F. B. (2019). The association between metformin therapy and lactic acidosis. Drug Safety, 42, 1449-1469. doi: 10.1007/s40264-019-00854-x

Journal - Research Article

Liu, Z., Diana, A., Slater, C., Preston, T., Gibson, R. S., Houghton, L., & Duffull, S. B. (2019). Development of a nonlinear hierarchical model to describe the disposition of deuterium in mother-infant pairs to assess exclusive breastfeeding practice. Journal of Pharmacokinetics & Pharmacodynamics, 46, 1-13. doi: 10.1007/s10928-018-9613-x

Journal - Research Article

Liu, Z., Diana, A., Slater, C., Preston, T., Gibson, R. S., Houghton, L., & Duffull, S. B. (2019). Development of a parsimonious design for optimal classification of exclusive breastfeeding. Clinical & Translational Science, 8, 596-605. doi: 10.1002/psp4.12428

Journal - Research Article

Pan, S., & Duffull, S. B. (2019). Automated proper lumping for simplification of linear physiologically based pharmacokinetic systems. Journal of Pharmacokinetics & Pharmacodynamics, 46, 361-370. doi: 10.1007/s10928-019-09644-5

Journal - Research Article

Pradhan, S., Duffull, S. B., Walker, R. J., & Wright, D. F. B. (2019). The intact nephron hypothesis as a model for renal drug handling. European Journal of Clinical Pharmacology, 75(2), 147-156. doi: 10.1007/s00228-018-2572-8

Journal - Research Article

Sinha, J., Al-Sallami, H. S., & Duffull, S. B. (2019). Choosing the allometric exponent in covariate model building. Clinical Pharmacokinetics, 28(1), 89-100. doi: 10.1007/s40262-018-0667-0

Journal - Research Article

Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2019). An intact model for quantifying functional selectivity. Scientific Reports, 9, 2557. doi: 10.1038/s41598-019-39000-z

Journal - Research Article

Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2019). Model-free and kinetic modelling approaches for characterising non-equilibrium pharmacological pathway activity: Internalisation of cannabinoid CB1 receptors. British Journal of Pharmacology, 176, 2593-2607. doi: 10.1111/bph.14684

Journal - Research Article

Duffull, S. B., Wright, D. F. B., Marra, C. A., & Anakin, M. G. (2018). A philosophical framework for pharmacy in the 21st century guided by ethical principles. Research in Social & Administrative Pharmacy, 14(3), 309-316. doi: 10.1016/j.sapharm.2017.04.049

Journal - Research Article

Hasegawa, C., & Duffull, S. B. (2018). Automated scale reduction of nonlinear QSP models with an illustrative application to a bone biology system. CPT: Pharmacometrics & Systems Pharmacology, 7, 562-572. doi: 10.1002/psp4.12324

Journal - Research Article

Hasegawa, C., & Duffull, S. B. (2018). Selection and qualification of simplified QSP models when using model order reduction techniques. AAPS Journal, 20, 2. doi: 10.1208/s12248-017-0170-9

Journal - Research Article

Ng, D. P. J., Duffull, S. B., Faed, J. M., Isbister, G. K., & Gulati, A. (2018). An evaluation of a factor Xa-based clotting time test for enoxaparin: A proof-of-concept study. Clinical & Applied Thrombosis/Hemostasis, 24(4), 669-676. doi: 10.1177/1076029617711802

Journal - Research Article

Ooi, Q. X., Wright, D. F. B., Isbister, G. K., & Duffull, S. B. (2018). A factor VII-based method for the prediction of anticoagulant response to warfarin. Scientific Reports, 8, 12041. doi: 10.1038/s41598-018-30516-4

Journal - Research Article

Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2018). An evaluation of the operational model when applied to quantify functional selectivity. British Journal of Pharmacology, 175, 1654-1668. doi: 10.1111/bph.14171

Journal - Research Article

Zufferey, P. J., Ollier, E., Delavenne, X., Laporte, S., Mismetti, P., & Duffull, S. B. (2018). Incidence and risk factors of major bleeding following major orthopaedic surgery with fondaparinux thromboprophylaxis: A time-to-event analysis. British Journal of Clinical Pharmacology, 84(10), 2242-2251. doi: 10.1111/bcp.13663

Journal - Research Article

Duffull, S. B., & Hooker, A. C. (2017). Assessing robustness of designs for random effects parameters for nonlinear mixed-effects models. Journal of Pharmacokinetics & Pharmacodynamics, 44(6), 611-616. doi: 10.1007/s10928-017-9552-y

Journal - Research Article

Foo, L. K., & Duffull, S. (2017). Designs to balance cost and success rate for an early phase clinical study. Journal of Biopharmaceutical Statistics, 27(1), 148-158. doi: 10.1080/10543406.2016.1148703

Journal - Research Article

Hasegawa, C., & Duffull, S. B. (2017). Exploring inductive linearization for pharmacokinetic-pharmacodynamic systems of nonlinear ordinary differential equations. Journal of Pharmacokinetics & Pharmacodynamics, 45(1), 35-47. doi: 10.1007/s10928-017-9527-z

Journal - Research Article

Kuan, I. H. S., Duffull, S. B., Putt, T. L., Schollum, J. B. W., Walker, R. J., & Wright, D. F. B. (2017). A population pharmacokinetic model for 51Cr EDTA to estimate renal function. Clinical Pharmacokinetics, 56(6), 671-678. doi: 10.1007/s40262-016-0489-x

Journal - Research Article

Ooi, Q. X., Wright, D. F. B., Tait, R. C., Isbister, G. K., & Duffull, S. B. (2017). A joint model for vitamin K-dependent clotting factors and anticoagulation proteins. Clinical Pharmacokinetics, 56(12), 1555-1556. doi: 10.1007/s40262-017-0541-5

Journal - Research Article

Saffian, S. M., Duffull, S. B., & Wright, D. F. B. (2017). Warfarin dosing algorithms underpredict dose requirements in patients requiring ≥ 7mg daily: A systematic review and meta-analysis. Clinical Pharmacology & Therapeutics, 102(2), 297-304. doi: 10.1002/cpt.649

Journal - Research Article

Siripuram, V. K., Wright, D. F. B., Barclay, M. L., & Duffull, S. B. (2017). Deterministic identifiability of population pharmacokinetic and pharmacokinetic-pharmacodynamic models. Journal of Pharmacokinetics & Pharmacodynamics, 44(5), 415-423. doi: 10.1007/s10928-017-9530-4

Journal - Research Article

Al-Sallami, H., Newall, F., Monagle, P., Ignjatovic, V., Cranswick, N., & Duffull, S. (2016). Development of a population pharmacokinetic-pharmacodynamic model of a single bolus dose of unfractionated heparin in paediatric patients. British Journal of Clinical Pharmacology, 82(1), 178-184. doi: 10.1111/bcp.12930

Journal - Research Article

Assawasuwannakit, P., Braund, R., & Duffull, S. B. (2016). A framework for quantifying the influence of adherence and dose individualization. Clinical Pharmacology & Therapeutics, 99(4), 452-459. doi: 10.1002/cpt.268

Journal - Research Article

Brussee, J. M., Yeo, T. W., Lampah, D. A., Anstey, N. M., & Duffull, S. B. (2016). A pharmacokinetic-pharmacodynamic model for the effect of L-arginine on endothelial function in patients with moderately severe falciparum malaria. Antimicrobial Agents & Chemotherapy, 60(1), 198-205. doi: 10.1128/aac.01479-15

Journal - Research Article

Chiew, A. L., Isbister, G. K., Duffull, S. B., & Buckley, N. A. (2016). Evidence for the changing regimens of acetylcysteine. British Journal of Clinical Pharmacology, 81(3), 471-481. doi: 10.1111/bcp.12789

Journal - Research Article

Foo, L.-K., Duffull, S. B., Calver, L., Schneider, J., & Isbister, G. K. (2016). Population pharmacokinetics of intramuscular droperidol in acutely agitated patients. British Journal of Clinical Pharmacology, 82(6), 1550-1556. doi: 10.1111/bcp.13093

Journal - Research Article

Saffian, S. M., Duffull, S. B., Roberts, R. L., Tait, R. C., Black, L., Lund, K. A., … Wright, D. F. B. (2016). Influence of genotype on warfarin maintenance dose predictions produced using a Bayesian dose individualization tool. Therapeutic Drug Monitoring, 38(6), 677-683. doi: 10.1097/ftd.0000000000000347

Journal - Research Article

Shivva, V., Cox, P. J., Clarke, K., Veech, R. L., Tucker, I. G., & Duffull, S. B. (2016). The population pharmacokinetics of D-β-hydroxybutyrate following administration of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate. AAPS Journal, 18(3), 678-688. doi: 10.1208/s12248-016-9879-0

Journal - Research Article

Shivva, V., Tucker, I. G., & Duffull, S. B. (2016). An in silico knockout model for gastrointestinal absorption using a systems pharmacology approach: Development and application for ketones. PLoS ONE, 11(9), e0163795. doi: 10.1371/journal.pone.0163795

Journal - Research Article

Wright, D. F. B., Duffull, S. B., Merriman, T. R., Dalbeth, N., Barclay, M. L., & Stamp, L. K. (2016). Predicting allopurinol response in patients with gout. British Journal of Clinical Pharmacology, 81(2), 277-289. doi: 10.1111/bcp.12799

Journal - Research Article

Al-Sallami, H. S., Goulding, A., Grant, A., Taylor, R., Holford, N., & Duffull, S. B. (2015). Prediction of fat-free mass in children. Clinical Pharmacokinetics, 54(11), 1169-1178. doi: 10.1007/s40262-015-0277-z

Journal - Research Article

Assawasuwannakit, P., Braund, R., & Duffull, S. B. (2015). A model-based meta-analysis of the influence of factors that impact adherence to medications. Journal of Clinical Pharmacy & Therapeutics, 40(1), 24-31. doi: 10.1111/jcpt.12219

Journal - Research Article

Assawasuwannakit, P., Braund, R., & Duffull, S. B. (2015). Quantification of the forgiveness of drugs to imperfect adherence. CPT: Pharmacometrics & Systems Pharmacology, 4(3), 204-211. doi: 10.1002/psp4.4

Journal - Research Article

Cooper, J. M., Duffull, S. B., Saiao, A. S., & Isbister, G. K. (2015). The pharmacokinetics of sertraline in overdose and the effect of activated charcoal. British Journal of Clinical Pharmacology, 79(2), 307-315. doi: 10.1111/bcp.12500

Journal - Research Article

Duffull, S. B., & Wright, D. F. B. (2015). What do we learn from repeated population analyses? British Journal of Clinical Pharmacology, 79(1), 40-47. doi: 10.1111/bcp.12233

Journal - Research Article

Gulati, A., Faed, J. M., Isbister, G. K., & Duffull, S. B. (2015). Application of adaptive DP-optimality to design a pilot study for a clotting time test for enoxaparin. Pharmaceutical Research, 32(10), 3391-3402. doi: 10.1007/s11095-015-1715-1

Journal - Research Article

Lagishetty, C. V., & Duffull, S. B. (2015). Evaluation of approaches to deal with low-frequency nuisance covariates in population pharmacokinetic analyses. AAPS Journal, 17(6), 1388-1394. doi: 10.1208/s12248-015-9793-x

Journal - Research Article

Nyberg, J., Bazzoli, C., Ogungbenro, K., Aliev, A., Leonov, S., Duffull, S., … Mentré, F. (2015). Methods and software tools for design evaluation for population pharmacokinetics-pharmacodynamics studies. British Journal of Clinical Pharmacology, 79(1), 6-17. doi: 10.1111/bcp.12352

Journal - Research Article

Pan, S., Korell, J., Stamp, L. K., & Duffull, S. B. (2015). Simplification of a pharmacokinetic model for red blood cell methotrexate disposition. European Journal of Clinical Pharmacology, 71(12), 1509-1516. doi: 10.1007/s00228-015-1951-7

Journal - Research Article

Saffian, S. M., Wright, D. F. B., Roberts, R. L., & Duffull, S. B. (2015). Methods for predicting warfarin dose requirements. Therapeutic Drug Monitoring, 37(4), 531-538. doi: 10.1097/ftd.0000000000000177

Journal - Research Article

Salahudeen, M. S., Duffull, S. B., & Nishtala, P. S. (2015). Anticholinergic burden quantified by anticholinergic risk scales and adverse outcomes in older people: A systematic review. BMC Geriatrics, 15, 31. doi: 10.1186/s12877-015-0029-9

Journal - Research Article

Salahudeen, M. S., Nishtala, P. S., & Duffull, S. B. (2015). The influence of patient characteristics on anticholinergic events in older people. Dementia & Geriatric Cognitive Disorders Extra, 5(3), 530-541. doi: 10.1159/000441718

Journal - Research Article

Duffull, S. B., & Hegarty, G. (2014). An inductive approximation to the solution of systems of nonlinear ordinary differential equations in pharmacokinetics-pharmacodynamics. Journal of Theoretical & Computational Science, 1(4), 1000119. doi: 10.4172/jtco.1000119

Journal - Research Article

Gulati, A., Isbister, G. K., & Duffull, S. B. (2014). Scale reduction of a systems coagulation model with an application to modeling pharmacokinetic-pharmacodynamic data. CPT: Pharmacometrics & Systems Pharmacology, 3, e90. doi: 10.1038/psp.2013.67

Journal - Research Article

Hatah, E., Braund, R., Tordoff, J., & Duffull, S. B. (2014). A systematic review and meta-analysis of pharmacist-led fee-for-services medication review. British Journal of Clinical Pharmacology, 77(1), 102-115. doi: 10.1111/bcp.12140

Journal - Research Article

Hatah, E., Tordoff, J., Duffull, S. B., & Braund, R. (2014). Pharmacists' performance of clinical interventions during adherence support medication reviews. Research in Social & Administrative Pharmacy, 10(1), 185-194. doi: 10.1016/j.sapharm.2013.04.008

Journal - Research Article

Hatah, E., Tordoff, J., Duffull, S. B., Cameron, C., & Braund, R. (2014). Retrospective examination of selected outcomes of Medicines Use Review (MUR) services in New Zealand. International Journal of Clinical Pharmacy, 36(3), 503-512. doi: 10.1007/s11096-014-9913-1

Journal - Research Article

Korell, J., Duffull, S. B., Dalrymple, J. M., Drake, J., Zhang, M., Barclay, M. L., & Stamp, L. K. (2014). Comparison of intracellular methotrexate kinetics in red blood cells with the kinetics in other cell types. British Journal of Clinical Pharmacology, 77(3), 493-497. doi: 10.1111/bcp.12209

Journal - Research Article

Pan, S., Stamp, L. K., Duffull, S. B., Barclay, M. L., Dalrymple, J. M., Drake, J., Zhang, M., & Korell, J. (2014). Assessment of the relationship between methotrexate polyglutamates in red blood cells and clinical response in patients commencing methotrexate for rheumatoid arthritis. Clinical Pharmacokinetics, 53(12), 1161-1170. doi: 10.1007/s40262-014-0179-5

Journal - Research Article

Putt, T. L., Duffull, S. B., Schollum, J. B. W., & Walker, R. J. (2014). GFR may not accurately predict aspects of proximal tubule drug handling. European Journal of Clinical Pharmacology, 70(10), 1221-1226. doi: 10.1007/s00228-014-1733-7

Journal - Research Article

Salahudeen, M. S., Duffull, S. B., & Nishtala, P. S. (2014). Impact of anticholinergic discontinuation on cognitive outcomes in older people: A systematic review. Drugs & Aging, 31(3), 185-192. doi: 10.1007/s40266-014-0158-4

Journal - Research Article

Shivva, V., Korell, J., Tucker, I. G., & Duffull, S. B. (2014). Parameterisation affects identifiability of population models. Journal of Pharmacokinetics & Pharmacodynamics, 41, 81-86. doi: 10.1007/s10928-013-9347-8

Journal - Research Article

Duffull, S. B., & Isbister, G. K. (2013). Predicting the requirement for N-acetylcysteine in paracetamol poisoning from reported dose. Clinical Toxicology, 51(8), 772-776. doi: 10.3109/15563650.2013.830733

Journal - Research Article

Gulati, A., Isbister, G. K., & Duffull, S. B. (2013). Effect of Australian elapid venoms on blood coagulation: Australian Snakebite Project (ASP-17). Toxicon, 61, 94-104. doi: 10.1016/j.toxicon.2012.11.001

Journal - Research Article

Hatah, E., Braund, R., Duffull, S. B., & Tordoff, J. (2013). General practitioners' views of pharmacists' current and potential contributions to medication review and prescribing in New Zealand. Journal of Primary Health Care, 5(3), 223-233.

Journal - Research Article

Jamsen, K. M., Duffull, S. B., Tarning, J., Price, R. N., & Simpson, J. (2013). A robust design for identification of the Parasite Clearance Estimator. Malaria Journal, 12, 410. doi: 10.1186/1475-2875-12-410

Journal - Research Article

Korell, J., & Duffull, S. B. (2013). A semi-mechanistic red blood cell survival model provides some insight into red blood cell destruction mechanisms. Journal of Pharmacokinetics & Pharmacodynamics, 40(4), 469-478. doi: 10.1007/s10928-013-9322-4

Journal - Research Article

Korell, J., Stamp, L. K., Barclay, M. L., Dalrymple, J. M., Drake, J., Zhang, M., & Duffull, S. B. (2013). A population pharmacokinetic model for low-dose methotrexate and its polyglutamated metabolites in red blood cells. Clinical Pharmacokinetics, 52(6), 475-485. doi: 10.1007/s40262-013-0052-y

Journal - Research Article

Shaw, J. P., Print, S. A., & Duffull, S. B. (2013). Development of a postgraduate educational program for pharmacist prescribers in New Zealand. Journal of Pharmacy Practice & Research, 43(2), 122-127.

Journal - Research Article

Shivva, V., Korell, J., Tucker, I. G., & Duffull, S. B. (2013). An approach for identifiability of population pharmacokinetic–pharmacodynamic models. CPT: Pharmacometrics & Systems Pharmacology, 2(6), e49. doi: 10.1038/psp.2013.25

Journal - Research Article

Wright, D. F. B., & Duffull, S. B. (2013). A bayesian dose-individualization method for warfarin. Clinical Pharmacokinetics, 52(1), 59-68. doi: 10.1007/s40262-012-0017-6

Journal - Research Article

Wright, D. F. B., Stamp, L. K., Merriman, T. R., Barclay, M. L., Duffull, S. B., & Holford, N. H. G. (2013). The population pharmacokinetics of allopurinol and oxypurinol in patients with gout. European Journal of Clinical Pharmacology, 69(7), 1411-1421. doi: 10.1007/s00228-013-1478-8

Journal - Research Article

Yeo, T. W., Lampah, D. A., Rooslamiati, I., Gitawati, R., Tjitra, E., Kenangalem, E., … Duffull, S. B., & Anstey, N. A. (2013). A randomized pilot study of L-arginine infusion in severe falciparum malaria: Preliminary safety, efficacy and pharmacokinetics. PLoS ONE, 8(7), e69587. doi: 10.1371/journal.pone.0069587

Journal - Research Article

Alskär, O., Korell, J., & Duffull, S. B. (2012). A pharmacokinetic model for the glycation of albumin. Journal of Pharmacokinetics & Pharmacodynamics, 39(3), 273-282. doi: 10.1007/s10928-012-9249-1

Journal - Research Article

Duffull, S. B., Graham, G., Mengersen, K., & Eccleston, J. (2012). Evaluation of the pre-posterior distribution of optimized sampling times for the design of pharmacokinetic studies. Journal of Biopharmaceutical Statistics, 22(1), 16-29. doi: 10.1080/10543406.2010.500065

Journal - Research Article

Foo, L. K., & Duffull, S. (2012). Adaptive optimal design for bridging studies with an application to population pharmacokinetic studies. Pharmaceutical Research, 29(6), 1530-1543. doi: 10.1007/s11095-011-0659-3

Journal - Research Article

Foo, L. K., McGree, J., & Duffull, S. (2012). A general method to determine sampling windows for nonlinear mixed effects models with an application to population pharmacokinetic studies. Pharmaceutical Statistics, 11(4), 325-333. doi: 10.1002/pst.1509

Journal - Research Article

Foo, L. K., McGree, J., Eccleston, J., & Duffull, S. (2012). Comparison of robust criteria for D-optimal designs. Journal of Biopharmaceutical Statistics, 22(6), 1193-1205. doi: 10.1080/10543406.2011.580484

Journal - Research Article

Gulati, A., Faed, J. M., Isbister, G. K., & Duffull, S. B. (2012). Development and evaluation of a prototype of a novel clotting time test to monitor enoxaparin. Pharmaceutical Research, 29(1), 225-235. doi: 10.1007/s11095-011-0537-z

Journal - Research Article

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