Monday, 29 July 2019
Jared Lopez Alamilla
Department of Physics
University of Otago
"Reconstructing free-energy landscapes for cyclic motor proteins using a Fourier-space based description of Brownian dynamics"
Motor proteins are biological macromolecules present in living cells that use chemical energy to perform specific tasks, including producing mechanical work. There are a vast array of motor proteins performing different mechano-chemical tasks of major relevance for the metabolism of cells, including intracellular transport, cell motility and growth, muscle contraction, transcription of gene information and synthesis/degradation of biomolecules for energy-storage. All these motors share certain properties that suggest we can study them by means of a general bio-physical framework. Due to the importance of their functions for life, motor proteins attract a great deal of research in biology, chemistry and physics. Diffusion on a free-energy landscape is a fundamental framework for describing molecular motors. In the landscape framework, energy conversion between different forms of energy, e.g., chemical and mechanical, is explicitly described using multidimensional nonseparable free-energy potential landscapes.
We developed a novel method to reconstruct the free-energy landscape associated with the dynamics of motor proteins. The method uses experimental data from single molecule experiments for this purpose. The method was shown to be robust using one-dimensional experimental data and also being capable to be upscale to handle state-of-the-art multidimensional experimental data. The method uses a fast and reliable Fourier-space based description of the Smoluchowski equation.
WHEN: Monday 29 July 2019
WHERE: Room 314, Science 3 Building
TIME: 3.00 pm–4.00 pm
All interested are welcome to attend
Light refreshments to follow in Common Room