Red X iconGreen tick iconYellow tick icon

Contact Details

Phone
+64 3 479 7399
Email
alison.heather@otago.ac.nz
Position
Professor
Department
Department of Physiology
Qualifications
BSc(Hons) PhD
Research summary
Atherosclerosis

Research

My research focuses on how the sex hormones, estrogen and testosterone, affect non-reproductive tissues in the body. My primary research investigates how these sex hormones promote calcification of atherosclerotic plaques. Atherosclerosis is the major cardiovascular disease and calcification of plaques leads to more ruptures causing heart attacks and strokes. The work performed in my laboratory is aimed at improving the understanding and safety of hormone replacement treatment use.

My research team also develops bioassays for the detection of designer androgens and estrogens that are used as doping agents in sports.

Publications

Clarkson, J., Yip, S. H., Porteous, R., Kauff, A., Heather, A. K., & Herbison, A. E. (2023). CRISPR-Cas9 knockdown of ESR1 in preoptic GABA-kisspeptin neurons suppresses the preovulatory surge and estrous cycles in female mice. eLIFE, 12, RP90959. doi: 10.7554/eLife.90959 Journal - Research Article

McQuillan, H. J., Clarkson, J., Kauff, A., Han, S. Y., Yip, S. H., Cheong, I., Porteous, R., Heather, A. K., & Herbison, A. E. (2022). Definition of the estrogen negative feedback pathway controlling the GnRH pulse generator in female mice. Nature Communications, 13, 7433. doi: 10.1038/s41467-022-35243-z Journal - Research Article

Sutherland, E., Lund, R., Ashley, Z., & Heather, A. K. (2022, August-September). Novel sensitive bioassays to assess efficacy of aromatase inhibitor therapy in postmenopausal estrogen receptor-positive breast cancer patients. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)

Ashley, Z., Ebenebe, O. V., Erickson, J. R., & Heather, A. K. (2022, August-September). A new scoring system to evaluate atherosclerotic lesions in female ApoE-/- mice. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)

Roberts-Craig, F., Ashley, Z., Worthington, L. P., O'Hara, S. P., Erickson, J. R., & Heather, A. K. (2022, August-September). Lack of CaMKII is protective against atherosclerosis progression in aging ApoE-/- mice. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)

Back to top