Contact Details
- Phone
- +64 3 479 7399
- alison.heather@otago.ac.nz
University Links
- Position
- Professor
- Department
- Department of Physiology
- Qualifications
- BSc(Hons) PhD
- Research summary
- Atherosclerosis
Research
My research focuses on how the sex hormones, estrogen and testosterone, affect non-reproductive tissues in the body. My primary research investigates how these sex hormones promote calcification of atherosclerotic plaques. Atherosclerosis is the major cardiovascular disease and calcification of plaques leads to more ruptures causing heart attacks and strokes. The work performed in my laboratory is aimed at improving the understanding and safety of hormone replacement treatment use.
My research team also develops bioassays for the detection of designer androgens and estrogens that are used as doping agents in sports.
Publications
Clarkson, J., Yip, S. H., Porteous, R., Kauff, A., Heather, A. K., & Herbison, A. E. (2023). CRISPR-Cas9 knockdown of ESR1 in preoptic GABA-kisspeptin neurons suppresses the preovulatory surge and estrous cycles in female mice. eLIFE, 12, RP90959. doi: 10.7554/eLife.90959 Journal - Research Article
McQuillan, H. J., Clarkson, J., Kauff, A., Han, S. Y., Yip, S. H., Cheong, I., Porteous, R., Heather, A. K., & Herbison, A. E. (2022). Definition of the estrogen negative feedback pathway controlling the GnRH pulse generator in female mice. Nature Communications, 13, 7433. doi: 10.1038/s41467-022-35243-z Journal - Research Article
Sutherland, E., Lund, R., Ashley, Z., & Heather, A. K. (2022, August-September). Novel sensitive bioassays to assess efficacy of aromatase inhibitor therapy in postmenopausal estrogen receptor-positive breast cancer patients. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Ashley, Z., Ebenebe, O. V., Erickson, J. R., & Heather, A. K. (2022, August-September). A new scoring system to evaluate atherosclerotic lesions in female ApoE-/- mice. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Roberts-Craig, F., Ashley, Z., Worthington, L. P., O'Hara, S. P., Erickson, J. R., & Heather, A. K. (2022, August-September). Lack of CaMKII is protective against atherosclerosis progression in aging ApoE-/- mice. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
2023
Journal - Research Article
Clarkson, J., Yip, S. H., Porteous, R., Kauff, A., Heather, A. K., & Herbison, A. E. (2023). CRISPR-Cas9 knockdown of ESR1 in preoptic GABA-kisspeptin neurons suppresses the preovulatory surge and estrous cycles in female mice. eLIFE, 12, RP90959. doi: 10.7554/eLife.90959
2022
Journal - Research Article
McQuillan, H. J., Clarkson, J., Kauff, A., Han, S. Y., Yip, S. H., Cheong, I., Porteous, R., Heather, A. K., & Herbison, A. E. (2022). Definition of the estrogen negative feedback pathway controlling the GnRH pulse generator in female mice. Nature Communications, 13, 7433. doi: 10.1038/s41467-022-35243-z
Heather, A. K. (2022). Transwoman elite athletes: Their extra percentage relative to female physiology. International Journal of Environmental Research & Public Health, 19, 9103. doi: 10.3390/ijerph19159103
Handelsman, D., Cooper, E. R., & Heather, A. K. (2022). Bioactivity of 11 keto and hydroxy androgens in yeast and mammalian host cells. Journal of Steroid Biochemistry & Molecular Biology, 218, 106049. doi: 10.1016/j.jsbmb.2021.106049
Journal - Research Other
Roberts-Craig, F. T., Worthington, L. P., O'Hara, S. P., Erickson, J. R., Heather, A. K., & Ashley, Z. (2022). CaMKII splice variants in vascular smooth muscle cells: The next step or redundancy? International Journal of Molecular Sciences, 23, 7916. doi: 10.3390/ijms23147916
Conference Contribution - Poster Presentation (not in published proceedings)
Sutherland, E., Lund, R., Ashley, Z., & Heather, A. K. (2022, August-September). Novel sensitive bioassays to assess efficacy of aromatase inhibitor therapy in postmenopausal estrogen receptor-positive breast cancer patients. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Ashley, Z., Ebenebe, O. V., Erickson, J. R., & Heather, A. K. (2022, August-September). A new scoring system to evaluate atherosclerotic lesions in female ApoE-/- mice. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Roberts-Craig, F., Ashley, Z., Worthington, L. P., O'Hara, S. P., Erickson, J. R., & Heather, A. K. (2022, August-September). Lack of CaMKII is protective against atherosclerosis progression in aging ApoE-/- mice. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2021
Journal - Research Article
Cooper, E. R., Hughes, G., Kauff, A., Sutherland, E., Ashley, Z., & Heather, A. K. (2021). A cell-free bioassay for the detection of androgens. Drug Testing & Analysis, 13, 903-915. doi: 10.1002/dta.3024
Heather, A. K., Thorpe, H., Ogilvie, M., Sims, S. T., Beable, S., Milsom, S., … Hamilton, B. (2021). Biological and socio-cultural factors have the potential to influence the health and performance of elite female athletes: A cross sectional survey of 219 elite female athletes in Aotearoa New Zealand. Frontiers in Sports & Active Living, 3, 601420. doi: 10.3389/fspor.2021.601420
Gillon, A., Ho, E. N. M., Chan, G. H. M., Kauff, A., Hughes, G., Lund, R. A., Ashley, Z., … Heather, A. K. (2021). Unravelling androgens in sport: Altrenogest shows strong activation of the androgen receptor in a mammalian cell bioassay. Drug Testing & Analysis, 13, 523-528. doi: 10.1002/dta.2941
Journal - Research Other
Lund, R. A., Cooper, E. R., Wang, H., Ashley, Z., Cawley, A. T., & Heather, A. K. (2021). Non-targeted detection of designer androgens: Underestimated role of in vitro bioassays. Drug Testing & Analysis, 13, 894-902. doi: 10.1002/dta.3049
Conference Contribution - Published proceedings: Abstract
Worthington, L. P. I., Erickson, J. R., & Heather, A. K. (2021). Calcium calmodulin dependent protein kinase II δ in the pathogenesis of atherosclerosis. New Zealand Medical Journal, 134(1537), (pp. 112). Retrieved from https://www.nzma.org.nz/journal
2020
Journal - Research Article
Ebenebe, O. V., Ashley, Z., Erickson, J. R., & Heather, A. K. (2020). A timing effect of 17-β estradiol on atherosclerotic lesion development in female ApoE−/− mice. International Journal of Molecular Sciences, 21(13), 4710. doi: 10.3390/ijms21134710
Waller, C. C., Weththasinghe, S. A., McClure, L., Cawley, A. T., Suann, C., Suann, E., Sutherland, E., Cooper, E., Heather, A., & McLeod, M. D. (2020). In vivo metabolism of the designer anabolic steroid hemapolin in the thoroughbred horse. Drug Testing & Analysis, 12, 752-762. doi: 10.1002/dta.2769
McGrath, K. C., Li, X., Twigg, S. M., & Heather, A. K. (2020). Apolipoprotein-AI mimetic peptides D-4F and L-5F decrease hepatic inflammation and increase insulin sensitivity in C57BL/6 mice. PLoS ONE, 15(1), e0226931. doi: 10.1371/journal.pone.0226931
Conference Contribution - Published proceedings: Abstract
Ashley, Z., Ebenebe, O., Worthington, L. P. I., Erickson, J., & Heather, A. K. (2020). Understanding the subtleties of development of atherosclerosis and the effect of sex hormones. New Zealand Medical Journal, 133(1518), (pp. 97-98). Retrieved from https://www.nzma.org.nz/journal
2019
Journal - Research Article
Knox, T., Anderson, L. C., & Heather, A. (2019). Transwomen in elite sport: Scientific and ethical considerations. Journal of Medical Ethics, 45, 395-403. doi: 10.1136/medethics-2018-105208
Journal - Research Other
Anderson, L., Knox, T., & Heather, A. (2019). Trans-athletes in elite sport: Inclusion and fairness. Emerging Topics in Life Sciences, 3(6), 759-762. doi: 10.1042/ETLS20180071
Conference Contribution - Published proceedings: Abstract
Knox, T., Anderson, L., & Heather, A. (2019). Transwomen in elite sport: The ethics. Proceedings of the Sports Medicine New Zealand Annual Conference. (pp. 36). Dunedin, New Zealand: Sports Medicine New Zealand. [Abstract]
Heather, A. K. (2019). Androgen excess in the elite female sports division. Proceedings of the Sports Medicine New Zealand Annual Conference. (pp. 35). Dunedin, New Zealand: Sports Medicine New Zealand. [Abstract]
Knox, T., Anderson, L., & Heather, A. (2019). Fairness and inclusion: Is it time to replace the gender binary in elite sport? Proceedings of the International Sociology of Sport Association (ISSA) World Congress of Sociology of Sport. (pp. 57). Retrieved from https://www.otago.ac.nz/issa-2019
Conference Contribution - Poster Presentation (not in published proceedings)
O'Hara, S. P., Worthington, L. P., Ashley, Z., & Heather, A. K. (2019, September). The role of CaMKII in vascular smooth muscle cell migration and atherosclerotic plaque development. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Lund, R. A., & Heather, A. K. (2019, September). An androgen sensitive bioassay optimized clinical purposes. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2018
Journal - Research Article
Cooper, E. R., McGrath, K. C. Y., Li, X., & Heather, A. K. (2018). Androgen bioassay for the detection of nonlabeled androgenic compounds in nutritional supplements. International Journal of Sport Nutrition & Exercise Metabolism, 28(1), 10-18. doi: 10.1123/ijsnem.2017-0018
Journal - Research Other
Sims, S. T., & Heather, A. K. (2018). Myths and methodologies: Reducing scientific design ambiguity in studies comparing sexes and/or menstrual cycle phases. Experimental Physiology, 103(10), 1309-1317. doi: 10.1113/ep086797
Ebenebe, O. V., Heather, A., & Erickson, J. R. (2018). CaMKII in vascular signalling: “Friend or foe”? Heart, Lung & Circulation, 27(5), 560-567. doi: 10.1016/j.hlc.2017.12.003
Conference Contribution - Published proceedings: Abstract
Knox, T., Anderson, L., & Heather, A. (2018). Fairness and inclusion: Is it time to replace the gender binary in elite sport? Proceedings of the Australasian Association of Bioethics and Health Law (AABHL) Conference. Retrieved from http://aabhlconference.com
Conference Contribution - Poster Presentation (not in published proceedings)
Worthington, L. P. I., Erickson, J. R., Jones, G. T., & Heather, A. K. (2018, August). CaMKII inhibition as a novel target to control the early progression of atherosclerosis. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Lund, R. A., & Heather, A. K. (2018, August). Validation of an androgen bioassay for measurement breast cancer patient serum. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Denny, A. P., & Heather, A. K. (2018, August). High-density lipoprotein cholesterol: Towards reversing the pathology of facioscapulohumeral muscular dystrophy. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Lund, R. A., & Heather, A. K. (2018, August). Optimisation of an androgen bioassay for measurement of clinically relevant samples: Breast cancer as a clinical focus. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Other Research Output
Anderson, L., Heather, A. & Knox, T. Transgender women's participation in sport. Bioethics Centre, University of Otago, Dunedin, New Zealand. [Department Seminar].
2017
Journal - Research Article
McRobb, L. S., McGrath, K. C. Y., Tsatralis, T., Liong, E. C., Tan, J. T. M., Hughes, G., … Heather, A. K. (2017). Estrogen receptor control of atherosclerotic calcification and smooth muscle cell osteogenic differentiation. Arteriosclerosis, Thrombosis, & Vascular Biology, 37(6), 1127-1137. doi: 10.1161/atvbaha.117.309054
Cooper, E. R., McGrath, K. C. Y., Li, X., Akram, O., Kasz, R., Kazlauskas, R., … Heather, A. K. (2017). The use of tandem yeast and mammalian cell in vitro androgen bioassays to detect androgens in internet-sourced sport supplements. Drug Testing & Analysis, 9(4), 545-552. doi: 10.1002/dta.2000
Journal - Research Other
Denny, A. P., & Heather, A. K. (2017). Are antioxidants a potential therapy for FSHD? A review of the literature. Oxidative Medicine & Cellular Longevity, 7020295. doi: 10.1155/2017/7020295
Conference Contribution - Published proceedings: Abstract
Denny, A., & Heather, A. (2017). Is high density-lipoprotein-based therapy an option for the treatment of muscle damage in facioscapulohumeral muscular dystrophy? Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 17-18). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html
Ebenebe, O., Heather, A., & Erickson, J. (2017). The role of CaMKII in atherosclerotic plaque calcification in the ApoE-null mouse. Heart, Lung & Circulation, 26(Suppl. 2), (pp. S65). doi: 10.1016/j.hlc.2017.06.051
Conference Contribution - Poster Presentation (not in published proceedings)
Worthington, L. P. I., Erickson, J. R., Jones, G. T., & Heather, A. K. (2017, September). CaMKII inhibition reduces foam cell lesion development in the brachiocephalic artery of apolipoprotein E-/- knockout mice. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Jagau, K., Worthington, L., & Heather, A. (2017, September). Changes in expression of CaMKII isoforms in ApoE-/- mouse aorta. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Ebenebe, O. V., Heather, A. K., & Erickson, J. R. (2017, September). The role of CaMKII in atherosclerotic plaque calcification in the ApoE-null mouse. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Denny, A. P., & Heather, A. K. (2017, September). Is high-density lipoprotein-based therapy an option for the treatment of muscle damage in facioscapulohumeral muscular dystrophy? Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2016
Journal - Research Article
Geronimo, F. R. B., Barter, P. J., Rye, K. A., Heather, A. K., Shearston, K. D., & Rodgers, K. J. (2016). Plaque stabilizing effects of apolipoprotein A-IV. Atherosclerosis, 251, 39-46. doi: 10.1016/j.atherosclerosis.2016.04.019
Cawley, A. T., Blakey, K., Waller, C. C., McLeod, M. D., Boyd, S., Heather, A., … Willis, A. C. (2016). Detection and metabolic investigations of a novel designer steroid: 3-chloro-17α-methyl-5α-androstan-17β-ol. Drug Testing & Analysis, 8(7), 621-632. doi: 10.1002/dta.1832
Conference Contribution - Published proceedings: Abstract
Heather, A., Ebenebe, O. V., & McRobb, L. S. (2016). Estradiol promotes atherosclerotic lesion calcification in aged, female mice. Endocrine Reviews, 37(2, Suppl.), FRI-657. Retrieved from http://press.endocrine.org/series/endo-meetings
Conference Contribution - Poster Presentation (not in published proceedings)
Ebenebe, O. V., Heather, A. K., & Erickson, J. R. (2016, August-September). 17β-Estradiol induced calcification and altered CaMKII expression in a mouse model of atherosclerosis. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Denny, A., Erickson, J. R., Jones, P. P., & Heather, A. K. (2016, August-September). RyR2 leak and CaMKII post-translational modifications in the heart: Can this explain the altered Ca2+ handling in FSHD? Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Worthington, L. P., Erickson, J. R., & Heather, A. K. (2016, August-September). CaMKII mediates vascular smooth muscle cell activation central to the development of atherosclerosis. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Ebenebe, O. V., Heather, A. K., & Erickson, J. R. (2016, August). 17β-Estradiol induced calcification and alters CaMKII expression in a mouse model of atherosclerosis. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
Denny, A., Jones, P. P., Erickson, J. R., & Heather, A. K. (2016, August). Oxidised CaMKII: A novel mechanism in the pathophysiology of FSHD. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Heather, A. K. (2016, August-September). Ischemic heart disease in women. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Worthington, L. P., Erickson, J. R., & Heather, A. K. (2016, August). CaMKII activation in endothelial dysfunction. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
2015
Journal - Research Article
McGrath, K. C. Y., Li, X.-H., McRobb, L. S., & Heather, A. K. (2015). Inhibitory effect of a French maritime pine bark extract-based nutritional supplement on TNF-α-induced inflammation and oxidative stress in human coronary artery endothelial cells. Evidence-Based Complementary & Alternative Medicine, 2015, 260530. doi: 10.1155/2015/260530
Conference Contribution - Verbal presentation and other Conference outputs
Ebenebe, O. V., Heather, A. K., & Erickson, J. R. (2015, August-September). The role of CaMKII activation in atheroma formation in the ApoE-null mouse. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Heather, A. (2015, December). Designer steroids in sport. Verbal presentation at the Doping and the Culture of Sport Symposium, Dunedin, New Zealand.
2014
Journal - Research Article
McGrath, K. C., Li, X. H., Whitworth, P. T., Kasz, R., Tan, J. T., McLennan, S. V., … Heather, A. K. (2014). High density lipoproteins improve insulin sensitivity in high-fat diet-fed mice by suppressing hepatic inflammation. Journal of Lipid Research, 55(3), 421-430. doi: 10.1194/jlr.M043281
Brown, B. E., Kim, C. H. J., Torpy, F. R., Bursill, C. A., McRobb, L. S., Heather, A. K., … van Reyk, D. M. (2014). Supplementation with carnosine decreases plasma triglycerides and modulates atherosclerotic plaque composition in diabetic apo E-/- mice. Atherosclerosis, 232(2), 403-409. doi: 10.1016/j.atherosclerosis.2013.11.068
Conference Contribution - Published proceedings: Abstract
Cooper, E. R., Li, X., McGrath, K., & Heather, A. (2014). Steroidal extracts from nutritional sports supplements sold in Australia test positive for androgenic activity. Endocrine Reviews, 35(3, Suppl.), SUN-0413. Retrieved from http://press.endocrine.org/series/endo-meetings
McGrath, K. C. Y., Li, X., & Heather, A. K. (2014). Apolipoporotein A-I mimetic peptides improved insulin sensitivity in high fat diet fed mice. Obesity Research & Clinical Practice, 8(Suppl. 1), (pp. 64-65). doi: 10.1016/j.orcp.2014.10.119
Heather, A. K. (2014). Sex hormones, metabolic agents and inflammatory diseases. Proceedings of the Medical Sciences Congress (MedSci). (pp. 14). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts
Conference Contribution - Verbal presentation and other Conference outputs
Heather, A. (2014, August). Anti-diabetic effects of apolipoprotein mimetic peptides. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Other Research Output
Heather, A. (2014, May). Sex matters to the heart. University of Otago, Dunedin, New Zealand. [Inaugural Professorial Lecture].
2013
Journal - Research Article
Li, X.-H., McGrath, K. C. Y., Tran, V. H., Li, Y.-M., Duke, C. C., Roufogalis, B. D., & Heather, A. K. (2013). Attenuation of proinflammatory responses by S-[6]-gingerol via inhibition of ROS/NF-Kappa B/COX2 activation in HuH7 cells. Evidence-Based Complementary & Alternative Medicine, 2013, 146142. doi: 10.1155/2013/146142
Cooper, E. R., McGrath, K. C. Y., & Heather, A. K. (2013). In vitro androgen bioassays as a detection method for designer androgens. Sensors, 13(2), 2148-2163. doi: 10.3390/s130202148
Lim, H. Y., Chiam, C. H., Yeo, K. P., Bisoendial, R., Hii, C. S., McGrath, K. C. Y., … Heather, A., … Angeli, V. (2013). Lymphatic vessels are essential for the removal of cholesterol from peripheral tissues by SR-BI-Mediated transport of HDL. Cell Metabolism, 17(5), 671-684. doi: 10.1016/j.cmet.2013.04.002
Li, X.-H., McGrath, K. C. Y., Tran, V. H., Li, Y.-M., Mandadi, S., Duke, C. C., Heather, A. K., & Roufogalis, B. D. (2013). Identification of a calcium signalling pathway of S-[6]-gingerol in HuH-7 cells. Evidence-Based Complementary & Alternative Medicine, 2013, 951758. doi: 10.1155/2013/951758
2012
Chapter in Book - Research
Heather, A., & McGrath, K. (2012). Cardiovascular disease and inflammation. In M. Garg & L. Wood (Eds.), Nutrition and physical activity in inflammatory diseases. (pp. 243-259). Cabi.
Journal - Research Article
Li, X.-H., McGrath, K. C.-Y., Nammi, S., Heather, A. K., & Roufogalis, B. D. (2012). Attenuation of liver pro-inflammatory responses by Zingiber officinale via inhibition of NF-kappa B activation in high-fat diet-fed rats. Basic & Clinical Pharmacology & Toxicology, 110(3), 238-244. doi: 10.1111/j.1742-7843.2011.00791.x
Journal - Research Other
McGrath, K. C. Y., & Heather, A. K. (2012). Endoplasmic reticulum stress in inflammatory disease. Endocrinology, 153(7), 2949-2952. doi: 10.1210/en.2012-1478
2011
Journal - Research Article
Moheimani, F., Tan, J. T. M., Brown, B. E., Heather, A. K., van Reyk, D. M., & Davies, M. J. (2011). Effect of exposure of human monocyte-derived macrophages to high, versus normal, glucose on subsequent lipid accumulation from glycated and acetylated low-density lipoproteins. Experimental Diabetes Research, 2011, 851280. doi: 10.1155/2011/851280
Di Bartolo, B. A., Nicholls, S. J., Bao, S., Rye, K.-A., Heather, A. K., Barter, P. J., & Bursill, C. (2011). The apolipoprotein A-I mimetic peptide ETC-642 exhibits anti-inflammatory properties that are comparable to high density lipoproteins. Atherosclerosis, 217(2), 395-400. doi: 10.1016/j.atherosclerosis.2011.04.001
Akram, O. N., Bursill, C., Desai, R., Heather, A. K., Kaslzuskas, R., Handelsman, D. J., & Lambert, G. (2011). Evaluation of androgenic activity of nutraceutical-derived steroids using mammalian and yeast in vitro androgen bioassays. Analytical Chemistry, 83(6), 2065-2074. doi: 10.1021/ac102845y
2010
Journal - Research Article
Bursill, C. A., Castro, M. L., Beattie, D. T., Nakhla, S., van der Vorst, E., Heather, A. K., … Rye, K.-A. (2010). High-density lipoproteins suppress chemokines and chemokine receptors in vitro and in vivo. Arteriosclerosis, Thrombosis, & Vascular Biology, 30(9), 1773-1778. doi: 10.1161/ATVBAHA.110.211342
Sieveking, D. P., Lim, P., Chow, R. W. Y., Dunn, L. L., Bao, S., McGrath, K. C. Y., Heather, A. K., … Ng, M. K. C. (2010). A sex-specific role for androgens in angiogenesis. Journal of Experimental Medicine, 207(2), 345-352. doi: 10.1084/jem.20091924
Patel, S., Di Bartolo, B. A., Nakhla, S., Heather, A. K., Mitchell, T. W., Jessup, W., … Rye, K.-A. (2010). Anti-inflammatory effects of apolipoprotein A-I in the rabbit. Atherosclerosis, 212(2), 392-397. doi: 10.1016/j.atherosclerosis.2010.05.035
Lane, A. E., Tan, J. T. M., Hawkins, C. L., Heather, A. K., & Davies, M. J. (2010). The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages. Biochemical Journal, 430(1), 161-169. doi: 10.1042/BJ20100082
Fryirs, M. A., Barter, P. J., Appavoo, M., Tuch, B. E., Tabet, F., Heather, A. K., & Rye, K.-A. (2010). Effects of high-density lipoproteins on pancreatic β-cell insulin secretion. Arteriosclerosis, Thrombosis, & Vascular Biology, 30(8), 1642-1648. doi: 10.1161/ATVBAHA.110.207373
2009
Journal - Research Article
McGrath, K. C. Y., Li, X. H., Puranik, R., Liong, E. C., Tan, J. T. M., Dy, V. M., … Heather, A. K. (2009). Role of 3β-hydroxysteroid-Δ24 reductase in mediating antiinflammatory effects of high-density lipoproteins in endothelial cells. Arteriosclerosis, Thrombosis, & Vascular Biology, 29(6), 877-882. doi: 10.1161/ATVBAHA.109.184663
McRobb, L., Handelsman, D. J., & Heather, A. K. (2009). Androgen-induced progression of arterial calcification in apolipoprotein E-null mice is uncoupled from plaque growth and lipid levels. Endocrinology, 150(2), 841-848. doi: 10.1210/en.2008-0760
2008
Journal - Research Article
McRobb, L., Handelsman, D. J., Kazlauskas, R., Wilkinson, S., McLeod, M. D., & Heather, A. K. (2008). Structure—activity relationships of synthetic progestins in a yeast-based in vitro androgen bioassay. Journal of Steroid Biochemistry & Molecular Biology, 110(1-2), 39-47. doi: 10.1016/j.jsbmb.2007.10.008
McGrath, K.-C. Y., McRobb, L. S., & Heather, A. K. (2008). Androgen therapy and atherosclerotic cardiovascular disease. Vascular Health & Risk Management, 4(1), 11-21. doi: 10.2147/vhrm.2008.04.01.11
Lind, J. M., Chiu, C., Ingles, J., Yeates, L., Humphries, S. E., Heather, A. K., & Semsarian, C. (2008). Sex hormone receptor gene variation associated with phenotype in male hypertrophic cardiomyopathy patients. Journal of Molecular & Cellular Cardiology, 45(2), 217-222. doi: 10.1016/j.yjmcc.2008.05.016
Handelsman, D. J., & Heather, A. (2008). Androgen abuse in sports. Asian Journal of Andrology, 10(3), 403-415. doi: 10.1111/j.1745-7262.2008.00406.x