Dr Shane Ohline
Position | Research Fellow |
---|---|
Department | Department of Physiology |
Research summary | The role of ryanodine receptors in Alzheimer's disease |
Research
The ryanodine receptor has been shown to be faulty in both Alzheimer’s (AD) and heart disease.
We study the receptor in neurons by determining how it is organised and trafficked in a mouse model of AD. Additionally, we will study the effects of already approved heart medications on the brain of this model mouse using patch clamp electrophysiology.
We aim to understand the function, and dysfunction, of this receptor in the brain and to find some way to restore its normal function in AD.
Publications
Ohline, S. M., Liu, X., Ibrahim, M. F., Mockett, B. G., Empson, R. M., Abraham, W. C., Iremonger, K. J., & Jones, P. P. (2022). Altered membrane properties but unchanged intrinsic excitability and spontaneous postsynaptic currents in an aged APPswe/PS1dE9 model of Alzheimer’s disease. Frontiers in Cellular Neuroscience, 16, 958876. doi: 10.3389/fncel.2022.958876
Ohline, S. M., Chan, C., Schoderboeck, L., Wicky, H. E., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2022). Effect of soluble amyloid precursor protein-alpha on adult hippocampal neurogenesis in a mouse model of Alzheimer's disease. Molecular Brain, 15, 5. doi: 10.1186/s13041-021-00889-1
Singh, A., Jones, O. D., Mockett, B. G., Ohline, S. M., & Abraham, W. C. (2019). Tumor necrosis factor-α-mediated metaplastic inhibition of LTP is constitutively engaged in an Alzheimer's disease model. Journal of Neuroscience, 39(46), 9083-9097. doi: 10.1523/jneurosci.1492-19.2019
Morrissey, J. A., Mockett, B. G., Singh, A., Kweon, D., Ohline, S. M., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2019). A C-terminal peptide from secreted amyloid precursor protein-α enhances long-term potentiation in rats and a transgenic mouse model of Alzheimer's disease. Neuropharmacology, 157, 107670. doi: 10.1016/j.neuropharm.2019.107670
Ohline, S. M., & Abraham, W. C. (2019). Environmental enrichment effects on synaptic and cellular physiology of hippocampal neurons [Invited]. Neuropharmacology, 145(A), 3-12. doi: 10.1016/j.neuropharm.2018.04.007
Ohline, S. M., Chan, C., Schoderboeck, L., Wicky, H. E., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2022). Effect of soluble amyloid precursor protein-alpha on adult hippocampal neurogenesis in a mouse model of Alzheimer's disease. Molecular Brain, 15, 5. doi: 10.1186/s13041-021-00889-1
Journal - Research Article
Ohline, S. M., Liu, X., Ibrahim, M. F., Mockett, B. G., Empson, R. M., Abraham, W. C., Iremonger, K. J., & Jones, P. P. (2022). Altered membrane properties but unchanged intrinsic excitability and spontaneous postsynaptic currents in an aged APPswe/PS1dE9 model of Alzheimer’s disease. Frontiers in Cellular Neuroscience, 16, 958876. doi: 10.3389/fncel.2022.958876
Journal - Research Article
Morrissey, J. A., Mockett, B. G., Singh, A., Kweon, D., Ohline, S. M., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2019). A C-terminal peptide from secreted amyloid precursor protein-α enhances long-term potentiation in rats and a transgenic mouse model of Alzheimer's disease. Neuropharmacology, 157, 107670. doi: 10.1016/j.neuropharm.2019.107670
Journal - Research Article
Singh, A., Jones, O. D., Mockett, B. G., Ohline, S. M., & Abraham, W. C. (2019). Tumor necrosis factor-α-mediated metaplastic inhibition of LTP is constitutively engaged in an Alzheimer's disease model. Journal of Neuroscience, 39(46), 9083-9097. doi: 10.1523/jneurosci.1492-19.2019
Journal - Research Article
Ohline, S. M., Wake, K. L., Hawkridge, M.-V., Dinnunhan, M. F., Hegemann, R. U., Wilson, A., Schoderboeck, L., Logan, B. J., … Hughes, S. M., & Abraham, W. C. (2018). Adult-born dentate granule cell excitability depends on the interaction of neuron age, ontogenetic age and experience. Brain Structure & Function, 223(7), 3213-3228. doi: 10.1007/s00429-018-1685-2
Journal - Research Article
Tan, V. T. Y., Mockett, B. G., Ohline, S. M., Parfitt, K. D., Wicky, H. E., Peppercorn, K., Schoderboeck, L., Yahaya, M. F. b., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2018). Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha prevents development of memory and plasticity deficits in a mouse model of Alzheimer's disease. Molecular Brain, 11, 7. doi: 10.1186/s13041-018-0348-9
Journal - Research Article
Xiong, M., Jones, O. D., Peppercorn, K., Ohline, S. M., Tate, W. P., & Abraham, W. C. (2017). Secreted amyloid precursor protein-alpha can restore novel object location memory and hippocampal LTP in aged rats. Neurobiology of Learning & Memory, 138, 291-299. doi: 10.1016/j.nlm.2016.08.002
Journal - Research Article
Taylor, C. J., Ohline, S. M., Moss, T., Ulrich, K., & Abraham, W. C. (2016). The persistence of long-term potentiation in the ventral hippocampus to medial prefrontal cortex projection in awake rats. European Journal of Neuroscience, 43(6), 811-822. doi: 10.1111/ejn.13167
Journal - Research Article
Ohline, S. M., Reid, M. R., Husheer, S. L. G., Currie, K. I., & Hunter, K. A. (2007). Spectrophotometric determination of pH in seawater off Taiaroa Head, Otago, New Zealand: Full-spectrum modelling and prediction of pCO2 levels. Marine Chemistry, 107, 143-155.
Journal - Research Article
Ohline, S. M., Campbell, M. L., Turnbull, M. T., & Kohler, S. J. (2001). Differential scanning calorimetric study of bilayer membrane phase transitions: A biophysical chemistry experiment. Journal of Chemical Education, 78(9), 1251.
Journal - Research Article
Ohline, S. M., Lee, S., Williams, S., & Chang, C. (2001). Quantification of methylene blue aggregation on a fused silica surface and resolution of individual absorbance spectra. Chemical Physics Letters, 346, 9-15.
Journal - Research Article
Hamm, P., Ohline, S., Zurek, M., & Röschinger, T. (1999). Vibrational cooling after photo isomerisation: First application of a novel intramolecular thermometer. Laser Chemistry, 19, 45-49.
Journal - Research Article
Joireman, P. W., Ohline, S. M., & Felker, P. M. (1998). Structural characterization of aromatic-aromatic complexes by rotational coherence spectroscopy. Journal of Physical Chemistry A, 102, 4481-4494. doi: 10.1021/jp9808678
Journal - Research Article
Hamm, P., Ohline, S. M., & Zinth, W. (1997). Vibrational cooling after ultrafast photoisomerization of azobenzene measured by femtosecond infrared spectroscopy. Journal of Chemical Physics, 106(2), 519-529. doi: 10.1063/1.473392
Journal - Research Article
Ohline, S. M., Romascan, J., & Felker, P. M. (1995). Rotational coherence spectroscopy of aromatic-(Ar)n clusters: Geometries of anthracene-(Ar)n, 9,10-dichloroanthracene-Ar, and Tetracen-Ar. Journal of Physical Chemistry, 99, 7311-7319. doi: 10.1021/j100019a014
Journal - Research Article
Maxton, P. M., Schaeffer, M. W., Ohline, S. M., Kim, W., Venturo, V. A., & Felker, P. M. (1994). The raman and vibronic activity of intermolecular vibrations in aromatic-containing complexes and clusters. Journal of Chemical Physics, 101, 8391-8408. doi: 10.1063/1.468102
Journal - Research Article
Ohline, S. M., Romascan, J., & Felker, P. M. (1994). Rotational coherence spectroscopy and excited-state dynamics of tolane and its van der Waals complexes with argon and nitrogen. Laser Chemistry, 14, 45-59. doi: 10.1155/1994/60684
Journal - Research Article
Joireman, P. W., Ohline, S. M., Connell, L. L., & Felker, P. M. (1993). Picosecond methods applied to a structural study of N-H—X hydrogen bonds: Geometries of carbazole-water and carbazole-ammonia by rotational coherence spectroscopy. Journal of Physical Chemistry, 97, 12504-12508. doi: 10.1021/j100150a010
Journal - Research Article
Ohline, S. M., Romascan, J., & Felker, P. M. (1993). Time-resolved ionization depletion: A new picosecond method for molecular beam studies. Chemical Physics Letters, 207(4-6), 563-568. doi: 10.1016/0009-2614(93)89048-M
Journal - Research Article
Connell, L. L., Ohline, S. M., Joireman, P. W., Corcoran, T. C., & Felker, P. M. (1992). Rotational coherence spectroscopy and structure of phenol dimer. Journal of Chemical Physics, 96, 2585-2593. doi: 10.1063/1.462009
Journal - Research Article
Joireman, P. W., Connell, L. L., Ohline, S. M., & Felker, P. M. (1992). Characterization of asymmetry transients in rotational coherence spectroscopy. Journal of Chemical Physics, 96, 4118-4130. doi: 10.1063/1.461867
Journal - Research Article
Ohline, S. M., Connell, L. L., Joireman, P. W., Venturo, V. A., & Felker, P. M. (1992). The geometry of carbazole-(Ar)2 from rotational coherence spectroscopy. Chemical Physics Letters, 193(5), 335-341. doi: 10.1016/0009-2614(92)85640-V
Journal - Research Article
Ohline, S. M., Joireman, P. W., Connell, L. L., & Felker, P. M. (1992). Structural characterization of clusters of perylene with argon and neon by rotational coherence spectroscopy. Chemical Physics Letters, 191(3-4), 362-370. doi: 10.1016/0009-2614(92)85315-2
Journal - Research Article
Connell, L. L., Ohline, S. M., Joireman, P. W., Corcoran, T. C., & Felker, P. M. (1991). Rotational coherence spectroscopy of 1-naphthol-(water)2 clusters: Structural evidence for a cyclic hydrogen-bonded trimer. Journal of Chemical Physics, 94, 4668-4671. doi: 10.1063/1.460597
Journal - Research Article
Joireman, P. W., Connell, L. L., Ohline, S. M., & Felker, P. M. (1991). Rotational coherence spectroscopy and structure of the perylene-benzene van der Waals complex. Chemical Physics Letters, 182(5), 385-392. doi: 10.1016/0009-2614(91)90095-Q
Journal - Research Article
Joireman, P. W., Connell, L. L., Ohline, S. M., & Felker, P. M. (1991). Structure of fluorene-benzene aromatic dimer from rotational coherence spectroscopy. Journal of Physical Chemistry, 95, 4935-4939. doi: 10.1021/j100166a006
Journal - Research Article
Ohline, S. M., & Abraham, W. C. (2019). Environmental enrichment effects on synaptic and cellular physiology of hippocampal neurons [Invited]. Neuropharmacology, 145(A), 3-12. doi: 10.1016/j.neuropharm.2018.04.007
Journal - Research Other