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Physiology profile

Dr Phil Heyward

PositionLecturer
DepartmentDepartment of Physiology
QualificationsBSc (Hons) PhD
Research summaryNeurophysiology and the sense of smell

Research

The sense of smell: Our ability to sense airborne chemicals is based on patterns of neuronal activity in the brain. We use electrophysiological recording from brain slices maintained in vitro to study how these patterns of activity are processed by individual neurons and circuits in the brain.

Neurological disorders: Bipolar disorder, depression and epilepsy seem like very different problems, but they each result from abnormal levels of brain neuron activity. To understand these diseases better and develop better treatments we need to know more about how the current treatments work. We therefore focus our studies on how current treatments act on neurons to control their activity as individuals, and as members of brain circuits.

Publications

Igelström, K. M., & Heyward, P. M. (2012). The antidepressant drug fluoxetine inhibits persistent sodium currents and seizure-like events. Epilepsy Research, 101(1-2), 174-181. doi: 10.1016/j.eplepsyres.2012.03.019

Igelström, K. M., & Heyward, P. M. (2012). Inhibition of hippocampal excitability by citalopram. Epilepsia, 53(11), 2034-2042. doi: 10.1111/j.1528-1167.2012.03660.x

Igelström, K. M., Shirley, C. H., & Heyward, P. M. (2011). Low-magnesium medium induces epileptiform activity in mouse olfactory bulb slices. Journal of Neurophysiology, 106(5), 2593-2605. doi: 10.1152/jn.00601.2011

Shirley, C. H., Coddington, E. J., & Heyward, P. M. (2010). All-or-none population bursts temporally constrain surround inhibition between mouse olfactory glomeruli. Brain Research Bulletin, 81(4-5), 406-415. doi: 10.1016/j.brainresbull.2009.10.022

Heyward, P. M. (2010). A brain slice bath for physiology and compound microscopy, with dual-sided perifusion. Journal of Microscopy, 240(3), 207-215. doi: 10.1111/j.1365-2818.2010.03382.x

Chapter in Book - Research

Heinbockel, T., & Heyward, P. M. (2008). Glutamate synapses in olfactory neural circuits. In B. F. Paley & T. E. Warfield (Eds.), Amino acid receptor research. (pp. 391-425). New York: Nova Science.

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Journal - Research Article

Igelström, K. M., & Heyward, P. M. (2012). The antidepressant drug fluoxetine inhibits persistent sodium currents and seizure-like events. Epilepsy Research, 101(1-2), 174-181. doi: 10.1016/j.eplepsyres.2012.03.019

Igelström, K. M., & Heyward, P. M. (2012). Inhibition of hippocampal excitability by citalopram. Epilepsia, 53(11), 2034-2042. doi: 10.1111/j.1528-1167.2012.03660.x

Igelström, K. M., Shirley, C. H., & Heyward, P. M. (2011). Low-magnesium medium induces epileptiform activity in mouse olfactory bulb slices. Journal of Neurophysiology, 106(5), 2593-2605. doi: 10.1152/jn.00601.2011

Shirley, C. H., Coddington, E. J., & Heyward, P. M. (2010). All-or-none population bursts temporally constrain surround inhibition between mouse olfactory glomeruli. Brain Research Bulletin, 81(4-5), 406-415. doi: 10.1016/j.brainresbull.2009.10.022

Heyward, P. M. (2010). A brain slice bath for physiology and compound microscopy, with dual-sided perifusion. Journal of Microscopy, 240(3), 207-215. doi: 10.1111/j.1365-2818.2010.03382.x

Butler-Munro, C., Coddington, E. J., Shirley, C. H., & Heyward, P. M. (2010). Lithium modulates cortical excitability in vitro. Brain Research, 1352, 50-60. doi: 10.1016/j.brainres.2010.07.021

Wachowiak, M., McGann, J. P., Heyward, P. M., Shao, Z., Puche, A. C., & Shipley, M. T. (2005). Inhibition of olfactory receptor neuron input to olfactory bulb glomeruli mediated by suppression of presynaptic calcium influx. Journal of Neurophysiology, 94, 2700-2712.

Heinbockel, T., Heyward, P., Conquet, F., & Ennis, M. (2004). Regulation of main olfactory bulb mitral cell excitability by metabotropic glutamate receptor mGluR1. Journal of Neurophysiology, 92, 3085-3096.

Puche, A. C., Heyward, P., & Shipley, M. T. (2004). Transmembrane dye labeling and immunohistochemical staining of electrophysiologically characterized single neurons. Journal of Neuroscience Methods, 137(2), 235-240.

Aungst, J. L., Heyward, P. M., Puche, A. C., Karnup, S. V., Hayar, A., Szabo, G., & Shipley, M. (2003). Centre-surround inhibition among olfactory bulb glomeruli. Nature, 426, 623-629.

Heyward, P. M., & Shipley, M. (2003). A device for automated control of pipette internal pressure for patch-clamp recording. Journal of Neuroscience Methods, 123, 109-115.

Heyward, P., Ennis, M., Keller, A., & Shipley, M. T. (2001). Membrane bistability in olfactory bulb mitral cells. Journal of Neuroscience, 21(14), 5311-5320.

Hayar, A., Heyward, P. M., Heinbockel, T., Shipley, M. T., & Ennis, M. (2001). Direct excitation of mitral cells via activation of α1-noradrenergic receptors in rat olfactory bulb slices. Journal of Neurophysiology, 86, 2173-2182.

More publications...