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Physiology profile

Dr Tanya Cully

PositionLecturer
DepartmentDepartment of Physiology
QualificationsB Biomol Sci(Hons) PhD
Research summaryCalcium and ROS interactions in healthy and diseased skeletal muscle

Research

My research focus is to quantify the levels and movements of calcium and reactive oxygen species (ROS) within the triadic microdomain and bridge the knowledge gap in calcium and ROS crosstalk.

At rest, these two processes must interact to maintain muscle at the ready for peak performance. However, we currently do not understand how ROS and calcium interact to maintain the system for optimal muscle contraction.

My research aims to determine how calcium, ROS, and their interaction can alter muscle function in health and disease, via regulation of triadic microdomain homeostasis. To achieve this, my lab uses several techniques, including live-cell confocal microscopy of mechanically skinned and intact muscle fibres, western blotting, viral transductions and electroporation.

Publications

Loehr, J. A., Wang, S., Cully, T. R., Pal, R., Larina, I. V., Larina, K. V., & Rodney, G. G. (2018). NADPH oxidase mediates microtubule alterations and diaphragm dysfunction in dystrophic mice. eLIFE, 7, e31732.. doi: 10.7554/eLife.31732

Cully, T. R., Choi, R. H., Bjorksten, A. R., Stephenson, D. G., Murphy, R. M., & Launikonis, B. S. (2018). Junctional membrane Ca2+ dynamics in human muscle fibers are altered by malignant hyperthermia causative RyR mutation. PNAS, 115(32), 8215-8220. doi: 10.1073/pnas.1800490115

Cully, T. R. (2018). Milestones and frontiers in muscular physiology: Ca2+ handling in T-tubules. Iatreia, 31(1), S-20.

Launikonis, B. S., Cully, T. R., Csernoch, L., & Stephenson, D. G. (2018). NHE- and diffusion-dependent proton fluxes across the tubular system membranes of fast-twitch muscle fibers of the rat. Journal of General Physiology, 150(1), 95-110. doi: 10.1085/jgp.201711891

Bakker, A. J., Cully, T. R., Wingate, C. D., Barclay, C. J., & Launikonis, B. S. (2017). Doublet stimulation increases Ca2+ binding to troponin C to ensure rapid force development in skeletal muscle. Journal of General Physiology, 149(3), 323-334. doi: 10.1085/jgp.201611727

Journal - Research Article

Loehr, J. A., Wang, S., Cully, T. R., Pal, R., Larina, I. V., Larina, K. V., & Rodney, G. G. (2018). NADPH oxidase mediates microtubule alterations and diaphragm dysfunction in dystrophic mice. eLIFE, 7, e31732.. doi: 10.7554/eLife.31732

Launikonis, B. S., Cully, T. R., Csernoch, L., & Stephenson, D. G. (2018). NHE- and diffusion-dependent proton fluxes across the tubular system membranes of fast-twitch muscle fibers of the rat. Journal of General Physiology, 150(1), 95-110. doi: 10.1085/jgp.201711891

Cully, T. R. (2018). Milestones and frontiers in muscular physiology: Ca2+ handling in T-tubules. Iatreia, 31(1), S-20.

Cully, T. R., Choi, R. H., Bjorksten, A. R., Stephenson, D. G., Murphy, R. M., & Launikonis, B. S. (2018). Junctional membrane Ca2+ dynamics in human muscle fibers are altered by malignant hyperthermia causative RyR mutation. PNAS, 115(32), 8215-8220. doi: 10.1073/pnas.1800490115

Bakker, A. J., Cully, T. R., Wingate, C. D., Barclay, C. J., & Launikonis, B. S. (2017). Doublet stimulation increases Ca2+ binding to troponin C to ensure rapid force development in skeletal muscle. Journal of General Physiology, 149(3), 323-334. doi: 10.1085/jgp.201611727

Cully, T. R., Murphy, R. M., Roberts, L., Raastad, T., Fassett, R. G., Coombes, J. S., … Launikonis, B. S. (2017). Human skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise. Nature Communications, 8, 14266. doi: 10.1038/ncomms14266

Cully, T. R., Edwards, J. N., Murphy, R. M., & Launikonis, B. S. (2016). A quantitative description of tubular system Ca2+ handling in fast- and slow-twitch muscle fibres. Journal of Physiology, 594(11), 2795-2810. doi: 10.1113/JP271658

Li, R., Steyn, F. J., Stout, M. B., Lee, K., Cully, T. R., Calderón, J. C., & Ngo, S. T. (2016). Development of a high-throughput method for real-time assessment of cellular metabolism in intact long skeletal muscle fibre bundles. Journal of Physiology, 594(24), 7197-7213. doi: 10.1113/JP272988

Cully, T. R., & Launikonis, B. S. (2016). Leaky ryanodine receptors delay the activation of store overload-induced ca2+ release, a mechanism underlying malignant hyperthermia-like events in dystrophic muscle. American Journal of Physiology: Cell Physiology, 310(8), C673-C680. doi: 10.1152/ajpcell.00366.2015

Cully, T. R., Edwards, J. N., & Launikonis, B. S. (2014). Activation and propagation of Ca2+ release from inside the sarcoplasmic reticulum network of mammalian skeletal muscle. Journal of Physiology, 592(17), 3727-3746. doi: 10.1113/jphysiol.2014.274274

Friedrich, O., Yi, B., Edwards, J. N., Reischl, B., Wirth-Hücking, A., Buttgereit, A., … Cully, T. R., … Völkers, M. (2014). IL-1α reversibly inhibits skeletal muscle ryanodine receptor a novel mechanism for critical illness myopathy? American Journal of Respiratory Cell & Molecular Biology, 50(6), 1096-1106. doi: 10.1165/rcmb.2013-0059OC

Thundyil, J., Manzanero, S., Pavlovski, D., Cully, T. R., Lok, K.-Z., Widiapradja, A., … Arumugam, T. V. (2013). Evidence That the EphA2 Receptor Exacerbates Ischemic Brain Injury. PLoS ONE, 8(1), e53528. doi: 10.1371/journal.pone.0053528

Cully, T. R., Edwards, J. N., Friedrich, O., Stephenson, D. G., Murphy, R. M., & Launikonis, B. S. (2012). Changes in plasma membrane Ca-ATPase and stromal interacting molecule 1 expression levels for Ca2+ signaling in dystrophic mdx mouse muscle. American Journal of Physiology: Cell Physiology, 303(5), C567-C576. doi: 10.1152/ajpcell.00144.2012

Edwards, J. N., Cully, T. R., Shannon, T. R., Stephenson, D. G., & Launikonis, B. S. (2012). Longitudinal and transversal propagation of excitation along the tubular system of rat fast-twitch muscle fibres studied by high speed confocal microscopy. Journal of Physiology, 590(3), 475-492. doi: 10.1113/jphysiol.2011.221796

Edwards, J. N., Friedrich, O., Cully, T. R., von Wegner, F., Murphy, R. M., & Launikonis, B. S. (2010). Upregulation of store-operated Ca2+ entry in dystrophic mdx mouse muscle. American Journal of Physiology: Cell Physiology, 299(1), C42-C50. doi: 10.1152/ajpcell.00524.2009

Edwards, J. N., Murphy, R. M., Cully, T. R., von Wegner, F., Friedrich, O., & Launikonis, B. S. (2010). Ultra-rapid activation and deactivation of store-operated Ca2+ entry in skeletal muscle. Cell Calcium, 47(5), 458-467. doi: 10.1016/j.ceca.2010.04.001

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