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Physiology profile

Dr Shane Ohline

PositionPostdoctoral Fellow
DepartmentDepartment of Physiology
Research summaryThe role of ryanodine receptors in Alzheimer's disease

Research

The ryanodine receptor has been shown to be faulty in both Alzheimer’s (AD) and heart disease.

We study the receptor in neurons by determining how it is organised and trafficked in a mouse model of AD. Additionally, we will study the effects of already approved heart medications on the brain of this model mouse using patch clamp electrophysiology.

We aim to understand the function, and dysfunction, of this receptor in the brain and to find some way to restore its normal function in AD.

Publications

Ohline, S. M., Chan, C., Schoderboeck, L., Wicky, H. E., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2022). Effect of soluble amyloid precursor protein-alpha on adult hippocampal neurogenesis in a mouse model of Alzheimer's disease. Molecular Brain, 15, 5. doi: 10.1186/s13041-021-00889-1

Singh, A., Jones, O. D., Mockett, B. G., Ohline, S. M., & Abraham, W. C. (2019). Tumor necrosis factor-α-mediated metaplastic inhibition of LTP is constitutively engaged in an Alzheimer's disease model. Journal of Neuroscience, 39(46), 9083-9097. doi: 10.1523/jneurosci.1492-19.2019

Morrissey, J. A., Mockett, B. G., Singh, A., Kweon, D., Ohline, S. M., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2019). A C-terminal peptide from secreted amyloid precursor protein-α enhances long-term potentiation in rats and a transgenic mouse model of Alzheimer's disease. Neuropharmacology, 157, 107670. doi: 10.1016/j.neuropharm.2019.107670

Ohline, S. M., & Abraham, W. C. (2019). Environmental enrichment effects on synaptic and cellular physiology of hippocampal neurons [Invited]. Neuropharmacology, 145(A), 3-12. doi: 10.1016/j.neuropharm.2018.04.007

Ohline, S. M., Wake, K. L., Hawkridge, M.-V., Dinnunhan, M. F., Hegemann, R. U., Wilson, A., Schoderboeck, L., Logan, B. J., … Hughes, S. M., & Abraham, W. C. (2018). Adult-born dentate granule cell excitability depends on the interaction of neuron age, ontogenetic age and experience. Brain Structure & Function, 223(7), 3213-3228. doi: 10.1007/s00429-018-1685-2

Ohline, S. M., Chan, C., Schoderboeck, L., Wicky, H. E., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2022). Effect of soluble amyloid precursor protein-alpha on adult hippocampal neurogenesis in a mouse model of Alzheimer's disease. Molecular Brain, 15, 5. doi: 10.1186/s13041-021-00889-1

Journal - Research Article

Morrissey, J. A., Mockett, B. G., Singh, A., Kweon, D., Ohline, S. M., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2019). A C-terminal peptide from secreted amyloid precursor protein-α enhances long-term potentiation in rats and a transgenic mouse model of Alzheimer's disease. Neuropharmacology, 157, 107670. doi: 10.1016/j.neuropharm.2019.107670

Journal - Research Article

Singh, A., Jones, O. D., Mockett, B. G., Ohline, S. M., & Abraham, W. C. (2019). Tumor necrosis factor-α-mediated metaplastic inhibition of LTP is constitutively engaged in an Alzheimer's disease model. Journal of Neuroscience, 39(46), 9083-9097. doi: 10.1523/jneurosci.1492-19.2019

Journal - Research Article

Ohline, S. M., Wake, K. L., Hawkridge, M.-V., Dinnunhan, M. F., Hegemann, R. U., Wilson, A., Schoderboeck, L., Logan, B. J., … Hughes, S. M., & Abraham, W. C. (2018). Adult-born dentate granule cell excitability depends on the interaction of neuron age, ontogenetic age and experience. Brain Structure & Function, 223(7), 3213-3228. doi: 10.1007/s00429-018-1685-2

Journal - Research Article

Tan, V. T. Y., Mockett, B. G., Ohline, S. M., Parfitt, K. D., Wicky, H. E., Peppercorn, K., Schoderboeck, L., Yahaya, M. F. b., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2018). Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha prevents development of memory and plasticity deficits in a mouse model of Alzheimer's disease. Molecular Brain, 11, 7. doi: 10.1186/s13041-018-0348-9

Journal - Research Article

Xiong, M., Jones, O. D., Peppercorn, K., Ohline, S. M., Tate, W. P., & Abraham, W. C. (2017). Secreted amyloid precursor protein-alpha can restore novel object location memory and hippocampal LTP in aged rats. Neurobiology of Learning & Memory, 138, 291-299. doi: 10.1016/j.nlm.2016.08.002

Journal - Research Article

Taylor, C. J., Ohline, S. M., Moss, T., Ulrich, K., & Abraham, W. C. (2016). The persistence of long-term potentiation in the ventral hippocampus to medial prefrontal cortex projection in awake rats. European Journal of Neuroscience, 43(6), 811-822. doi: 10.1111/ejn.13167

Journal - Research Article

Ohline, S. M., Reid, M. R., Husheer, S. L. G., Currie, K. I., & Hunter, K. A. (2007). Spectrophotometric determination of pH in seawater off Taiaroa Head, Otago, New Zealand: Full-spectrum modelling and prediction of pCO2 levels. Marine Chemistry, 107, 143-155.

Journal - Research Article

Ohline, S. M., Campbell, M. L., Turnbull, M. T., & Kohler, S. J. (2001). Differential scanning calorimetric study of bilayer membrane phase transitions: A biophysical chemistry experiment. Journal of Chemical Education, 78(9), 1251.

Journal - Research Article

Ohline, S. M., Lee, S., Williams, S., & Chang, C. (2001). Quantification of methylene blue aggregation on a fused silica surface and resolution of individual absorbance spectra. Chemical Physics Letters, 346, 9-15.

Journal - Research Article

Ohline, S. M., & Abraham, W. C. (2019). Environmental enrichment effects on synaptic and cellular physiology of hippocampal neurons [Invited]. Neuropharmacology, 145(A), 3-12. doi: 10.1016/j.neuropharm.2018.04.007

Journal - Research Other

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