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Physiology profile

Associate Professor Kirk Hamilton

PositionAssociate Professor
DepartmentDepartment of Physiology
QualificationsMA (Texas) PhD (Utah State)
Research summaryIon channels and transport

Research

My main research interest is the molecular regulation, physiology and function of ion channels of epithelial tissues. My research is focused on the molecular regulation and trafficking of K+ channels, in particular, the human intermediate-conductance Ca2+-activated K+ channel, KCa3.1 and the one transmembrane domain K+ channels β-subunits KCNE1 and KCNE3. We are using biotin-ligase acceptor peptide (BLAP) technology to tagged K+ channels in order to examine their cellular and membrane fate. We hope to further understand the role of KCa3.1 in cell biology.

A new research avenue has emerged from collaboration with members of the Auckland Bioengineering Institute in which we are developing mathematical modeling approaches to understand the function of the nephron. The goal of this research is to develop a framework for the comprehensive model description of biophysically detailed multi-scale physiological model of multi-nephron complex.

Publications

Bertuccio, C. A., Wang, T. T., Hamilton, K. L., Rodriguez-Gil, D. J., Condliffe, S. B., & Devor, D. C. (2018). Plasma membrane insertion of KCa2.3 (SK3) is dependent upon the SNARE proteins, syntaxin-4 and SNAP23. PLoS ONE, 13(5). doi: 10.1371/journal.pone.0196717

Olivan-Viguera, A., Garcia-Otin, A. L., Lozano-Gerona, J., Abarca-Lachen, E., Garcia-Malinis, A. J., Hamilton, K. L., … Köhler, R. (2018). Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes. PLoS ONE, 13(1), e0190307. doi: 10.1371/journal.pone.0190307

Delpire, E., Hamilton, K. L., Hawke, T. J., Isenberg, J. S., Lotersztajn, S., Yuan, J. X.-J., & Adams, J. C. (2018). AJP-Cell Physiology begins landmark reviews in cell physiology: An editorial from the senior editors of AJP-Cell Physiology. American Journal of Physiology: Cell Physiology, 314(1), C1. doi: 10.1152/ajpcell.00256.2017

Lee, B. S.-L., Devor, D. C., & Hamilton, K. L. (2017). Modulation of retrograde trafficking of KCa3.1 in a polarized epithelium. Frontiers in Physiology, 8, 489. doi: 10.3389/fphys.2017.00489

Farquhar, R. E., Rodrigues, E., & Hamilton, K. L. (2017). The role of the cytoskeleton and Myosin-Vc in the targeting of KCa3.1 to the basolateral membrane of polarized epithelial cells. Frontiers in Physiology, 7, 639. doi: 10.3389/fphys.2016.00639

Edited Book - Research

Hamilton, K. L., & Devor, D. C. (Eds.). (2016). Ion channels and transporters of epithelia in health and disease. New York: Springer, 1019p. doi: 10.1007/978-1-4939-3366-2

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Chapter in Book - Research

Nickerson, D. P., Hamilton, K. L., & Hunter, P. J. (2016). Mathematical modeling of epithelial ion transport. In K. L. Hamilton & D. C. Devor (Eds.), Ion channels and transporters of epithelia in health and disease. (pp. 265-278). New York: Springer. doi: 10.1007/978-1-4939-3366-2_6

Devor, D. C., Bertuccio, C. A., & Hamilton, K. L. (2016). KCa3.1 in epithelia. In K. L. Hamilton & D. C. Devor (Eds.), Ion channels and transporters of epithelia in health and disease. (pp. 659-705). New York: Springer. doi: 10.1007/978-1-4939-3366-2_20

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Journal - Research Article

Bertuccio, C. A., Wang, T. T., Hamilton, K. L., Rodriguez-Gil, D. J., Condliffe, S. B., & Devor, D. C. (2018). Plasma membrane insertion of KCa2.3 (SK3) is dependent upon the SNARE proteins, syntaxin-4 and SNAP23. PLoS ONE, 13(5). doi: 10.1371/journal.pone.0196717

Olivan-Viguera, A., Garcia-Otin, A. L., Lozano-Gerona, J., Abarca-Lachen, E., Garcia-Malinis, A. J., Hamilton, K. L., … Köhler, R. (2018). Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes. PLoS ONE, 13(1), e0190307. doi: 10.1371/journal.pone.0190307

Farquhar, R. E., Rodrigues, E., & Hamilton, K. L. (2017). The role of the cytoskeleton and Myosin-Vc in the targeting of KCa3.1 to the basolateral membrane of polarized epithelial cells. Frontiers in Physiology, 7, 639. doi: 10.3389/fphys.2016.00639

Lee, B. S.-L., Devor, D. C., & Hamilton, K. L. (2017). Modulation of retrograde trafficking of KCa3.1 in a polarized epithelium. Frontiers in Physiology, 8, 489. doi: 10.3389/fphys.2017.00489

Hamilton, K. L., & Moore, A. B. (2016). 50 years of renal physiology from one man and the perfused tubule: Maurice B. Burg. American Journal of Physiology: Renal Physiology, 311(2), F291-F304. doi: 10.1152/ajprenal.00198.2016

Pilmore, E., & Hamilton, K. L. (2015). The role of microRNAs in the regulation of K+ channels in epithelial tissue. Frontiers in Physiology, 6, 352. doi: 10.3389/fphys.2015.00352

Sun, H., Niisato, N., Nishio, K., Hamilton, K. L., & Marunaka, Y. (2014). Distinct action of flavonoids, myricetin and quercetin, on epithelial Cl- secretion: Useful tools as regulators of Cl- secretion. BioMed Research International, 2014, 902735. doi: 10.1155/2014/902735

Bertuccio, C. A., Lee, S.-L., Wu, G., Butterworth, M. B., Hamilton, K. L., & Devor, D. C. (2014). Anterograde trafficking of KCa3.1 in polarized epithelia is Rab1- and Rab8-dependent and recycling endosome-independent. PLoS ONE, 9(3), e92013. doi: 10.1371/journal.pone.0092013

Hamilton, K. L. (2014). Even an old technique is suitable in the molecular world of science: The everted sac preparation - turns 60 years old. American Journal of Physiology: Cell Physiology, 306(8), C715-C720. doi: 10.1152/ajpcell.00041.2014

Hamilton, K. L., & Butt, A. G. (2013). Glucose transport into everted sacs of the small intestine of mice. Advances in Physiology Education, 37(4), 415-426. doi: 10.1152/advan.00017.2013

Hamilton, K. L., & Devor, D. C. (2012). Basolateral membrane K+ channels in renal epithelial cells. American Journal of Physiology: Renal Physiology, 302(9), F1069-F1081. doi: 10.1152/ajprenal.00646.2011

Hamilton, K. L., & Pao, A. C. (2012). βPix is a new player in renal physiology. Frontiers in Physiology, 3, 268. doi: 10.3389/fphys.2012.00268

Balut, C. M., Hamilton, K. L., & Devor, D. C. (2012). Trafficking of intermediate (KCa3.1) and small (KCa2.x) conductance, Ca2+-activated K+ channels: A novel target for medicinal chemistry efforts? ChemMedChem, 7(10), 1741-1755. doi: 10.1002/cmdc.201200226

Hamilton, K. L. (2012). BLAP-tags, TUBEs and DUB-Chips: Combined novel technologies will advance molecular epithelial physiology. Frontiers in Physiology, 3, 137. doi: 10.3389/fphys.2012.00137

Nickerson, D. P., Terkildsen, J. R., Hamilton, K. L., & Hunter, P. J. (2011). A tool for multi-scale modelling of the renal nephron. Interface Focus, 1, 417-425. doi: 10.1098/rsfs.2010.0032

Millership, J. E., Devor, D. C., Hamilton, K. L., Balut, C. M., Bruce, J. I. E., & Fearon, I. M. (2011). Calcium-activated K+ channels increase cell proliferation independent of K+ conductance. American Journal of Physiology: Cell Physiology, 300(4), C792-C802. doi: 10.1152/ajpcell.00274.2010

Chao, P.-C., & Hamilton, K. L. (2009). Genistein stimulates electrogenic Cl- secretion via phosphodiesterase modulation in the mouse jejunum. American Journal of Physiology: Cell Physiology, 297(3), C688-C698. doi: 10.1152/ajpcell.00152.2009

Jones, H. M., Bailey, M. A., Baty, C. J., MacGregor, G. G., Syme, C. A., Hamilton, K. L., & Devor, D. C. (2007). An NH2-terminal multi-basic RKR motif is required for the ATP-dependent regulation of hlK1. Channels, 1(2), 80-91.

Hamilton, K. L., & Kiessling, M. (2006). DCEBIO stimulates Cl- secretion in the mouse jejunum. American Journal of Physiology: Cell Physiology, 290, C152-C164. doi: 10.1152/ajpcell.00187.2005

Jones, H. M., Hamilton, K. L., & Devor, D. C. (2005). Role of an S4-S5 linker lysine in the trafficking of the Ca2+ -activated K+ channels IK1 and SK3. Journal of Biological Chemistry, 280(44), 37257-37265.

Syme, C. A., Hamilton, K. L., Jones, H. M., Gerlach, A. C., Giltinan, L., Papworth, G. D., … Devor, D. C. (2003). Trafficking of the Ca2+ -activated K+ channel, hIK1, is dependent upon a C-terminal leucine zipper. Journal of Biological Chemistry, 278(10), 8476-8486.

Hamilton, K. L., Butt, A. G., Cheng, S., & Carter, D. J. (2002). Methoxsalen stimulates electrogenic Cl- secretion in the mouse jejunum. Experimental Physiology, 87(4), 437-445.

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Journal - Research Other

Delpire, E., Hamilton, K. L., Hawke, T. J., Isenberg, J. S., Lotersztajn, S., Yuan, J. X.-J., & Adams, J. C. (2018). AJP-Cell Physiology begins landmark reviews in cell physiology: An editorial from the senior editors of AJP-Cell Physiology. American Journal of Physiology: Cell Physiology, 314(1), C1. doi: 10.1152/ajpcell.00256.2017

Hamilton, K. L. (2016). New life in overactive bladder: Focus on "Novel regulatory mechanism in human urinary bladder: Central role of transient receptor potential melastatin 4 channels in detrusor smooth muscle function". American Journal of Physiology: Cell Physiology, 310(7), C597-C599. doi: 10.1152/ajpcell.00039.2016

Hamilton, K. L. (2014). Cleavage: What’s up with prostasin and ENaC these days? American Journal of Physiology: Renal Physiology, 307(11), F1196-F1197. doi: 10.1152/ajprenal.00522.2014

Hamilton, K. L. (2013). Cyclosporine A and lovastatin: The Good and the bad, but who will be the winner? American Journal of Physiology: Renal Physiology, 305(5), F643-F644. doi: 10.1152/ajprenal.00321.2013

Hamilton, K. L. (2013). Robert K. Crane: Na+-glucose cotransporter to cure? Frontiers in Physiology, 4, 53. doi: 10.3389/fphys.2013.00053

Hamilton, K. L. (2011). Ussing's ″little chamber″: 60 years+ old and counting. Frontiers in Physiology, 2, 6. doi: 10.3389/fphys.2011.00006

Hamilton, K. L. (2010). BLAP-tagged channel technology: A new direction trafficking toward epithelial physiology. Frontiers in Physiology, 1, 162. doi: 10.3389/fphys.2010.00162

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