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Physiology profile

Dr Xinhuai Liu

PositionSenior Research Fellow
DepartmentDepartment of Physiology
QualificationsMD PhD
Research summaryNeural regulation of fertility

Research

Dr Liu is a Senior Research Fellow in Professor Allan Herbison's lab.

Research interests include:

  • Neural regulation of fertility; in particular, understanding how the GnRH neurons control pituitary gonadotropin secretion.
  • Mechanisms through which gonadal steroids influence brain function.

Publications

Liu, X., Lee, K., & Herbison, A. E. (2008). Kisspeptin excites gonadotropin-releasing hormone neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels. Endocrinology, 149(9), 4605-4614.

Liu, X., Porteous, R., d'Anglemont de Tassigny, X., Colledge, W. H., Millar, R., Petersen, S. L., & Herbison, A. E. (2011). Frequency-dependent recruitment of fast amino acid and slow neuropeptide neurotransmitter release controls gonadotropin-releasing hormone neuron excitability. Journal of Neuroscience, 31(7), 2421-2430. doi: 10.1523/JNEUROSCI.5759-10.2011

Liu, X., & Herbison, A. E. (2008). Small-conductance calcium-activated potassium channels control excitability and firing dynamics in Gonadotropin-Releasing Hormone (GnRH) neurons. Endocrinology, 149(7), 3598-3604.

Liu, X., & Herbison, A. E. (2011). Estrous cycle- and sex-dependent changes in pre- and postsynaptic GABAB control of GnRH neuron excitability. Endocrinology, 152(12), 4856-4864. doi: 10.1210/en.2011-1369

Campbell, R. E., Ducret, E., Porteous, R., Liu, X., Herde, M. K., Wellerhaus, K., … Herbison, A. E. (2011). Gap junctions between neuronal inputs but not gonadotropin-releasing hormone neurons control estrous cycles in the mouse. Endocrinology, 152(6), 2290-2301. doi: 10.1210/en.2010-1311

Journal - Research Article

Liu, X., Porteous, R., d'Anglemont de Tassigny, X., Colledge, W. H., Millar, R., Petersen, S. L., & Herbison, A. E. (2011). Frequency-dependent recruitment of fast amino acid and slow neuropeptide neurotransmitter release controls gonadotropin-releasing hormone neuron excitability. Journal of Neuroscience, 31(7), 2421-2430. doi: 10.1523/JNEUROSCI.5759-10.2011

Campbell, R. E., Ducret, E., Porteous, R., Liu, X., Herde, M. K., Wellerhaus, K., … Herbison, A. E. (2011). Gap junctions between neuronal inputs but not gonadotropin-releasing hormone neurons control estrous cycles in the mouse. Endocrinology, 152(6), 2290-2301. doi: 10.1210/en.2010-1311

Liu, X., & Herbison, A. E. (2011). Estrous cycle- and sex-dependent changes in pre- and postsynaptic GABAB control of GnRH neuron excitability. Endocrinology, 152(12), 4856-4864. doi: 10.1210/en.2011-1369

Clarkson, J., Han, S.-K., Liu, X., Lee, K., & Herbison, A. E. (2010). Neurobiological mechanisms underlying kisspeptin activation of gonadotropin-releasing hormone (GnRH) neurons at puberty. Molecular & Cellular Endocrinology, 324, 45-50. doi: 10.1016/j.mce.2010.01.026

Iremonger, K. J., Constantin, S., Liu, X., & Herbison, A. E. (2010). Glutamate regulation of GnRH neuron excitability. Brain Research, 1364, 35-43. doi: 10.1016/j.brainres.2010.08.071

Quennell, J. H., Mulligan, A. C., Tups, A., Liu, X., Phipps, S. J., Kemp, C. J., Herbison, A. E., Grattan, D. R., & Anderson, G. M. (2009). Leptin indirectly regulates gonadotropin-releasing hormone neuronal function. Endocrinology, 150(6), 2805-2812. doi: 10.1210/en.2008-1693

Liu, X., Popescu, I. R., Denisova, J. V., Neve, R. L., Corriveau, R. A., & Belousov, A. B. (2008). Regulation of cholinergic phenotype in developing neurons. Journal of Neurophysiology, 99, 2443-2455. doi: 10.1152/jn.00762.2007

Liu, X., & Herbison, A. E. (2008). Small-conductance calcium-activated potassium channels control excitability and firing dynamics in Gonadotropin-Releasing Hormone (GnRH) neurons. Endocrinology, 149(7), 3598-3604.

Liu, X., Lee, K., & Herbison, A. E. (2008). Kisspeptin excites gonadotropin-releasing hormone neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels. Endocrinology, 149(9), 4605-4614.

Qu, L., Liu, X., Wu, C., & Leung, L. S. (2007). Hyperthermia decreases GABAergic synaptic transmission in hippocampal neurons of immature rats. Neurobiology of Disease, 27, 320-327.

Grattan, D. R., Jasoni, C. L., Liu, X., Anderson, G. M., & Herbison, A. E. (2007). Prolactin regulation of gonadotropin-releasing hormone neurons to suppress luteinizing hormone secretion in mice. Endocrinology, 148(9), 4344-4351.

More publications...