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Physiology profile

Dr Andrew Bahn

PositionSenior Lecturer
DepartmentDepartment of Physiology
QualificationsPhD
Research summaryOrganic anion transport especially urate and tryptophan metabolite transport

Research

The aim of research is to identify how high (diabetes, prostate cancer and gout) or low (neurodegenerative diseases) urate plasma levels contribute to the above diseases.

Publications

Ashley, Z., Futi, T., Van Hout, I., Coffey, S., Schwenke, D. O., Bahn, A., & Lamberts, R. R. (2022). Cardiac fibrosis in right atrial tissue is not different in male Pasifika and Pākehā cardiac surgery patients in Aotearoa. Pacific Journal of Medical Sciences, 22(2), 11-30.

Reily-Bell, M., Bahn, A., & Katare, R. (2021). Reactive oxygen species-mediated diabetic heart disease: Mechanisms and therapies. Antioxidants & Redox Signaling. Advance online publication. doi: 10.1089/ars.2021.0098

Purvis, N., Kumari, S., Chandrasekera, D., Bellae Papannarao, J., Gandhi, S., van Hout, I., Coffey, S., Bunton, R., Sugunesegran, R., Parry, D., Davis, P., Williams, M. J. A., Bahn, A., & Katare, R. (2021). Diabetes induces dysregulation of microRNAs associated with survival, proliferation and self-renewal in cardiac progenitor cells. Diabetologia, 64, 1422-1435. doi: 10.1007/s00125-021-05405-7

Cook, R. F., Bussey, C. T., Fomison-Nurse, I. C., Hughes, G., Bahn, A., Cragg, P. A., & Lamberts, R. R. (2019). β2-adrenoceptors indirectly support impaired β1-adrenoceptor responsiveness in the isolated type 2 diabetic rat heart. Experimental Physiology, 104, 808-818. doi: 10.1113/EP087437

Bussey, C. T., Thaung, H. P. A., Hughes, G., Bahn, A., & Lamberts, R. R. (2018). Cardiac β-adrenergic responsiveness of obese Zucker rats: The role of AMPK. Experimental Physiology, 103(8), 1067-1075. doi: 10.1113/ep087054

Bahn, A. (2017). Water, electrolytes, and acid-base balance. In J. Mann & A. S. Truswell (Eds.), Essentials of human nutrition. (5th ed.) (pp. 113-130). Oxford University Press.

Chapter in Book - Research

Ashley, Z., Futi, T., Van Hout, I., Coffey, S., Schwenke, D. O., Bahn, A., & Lamberts, R. R. (2022). Cardiac fibrosis in right atrial tissue is not different in male Pasifika and Pākehā cardiac surgery patients in Aotearoa. Pacific Journal of Medical Sciences, 22(2), 11-30.

Journal - Research Article

Purvis, N., Kumari, S., Chandrasekera, D., Bellae Papannarao, J., Gandhi, S., van Hout, I., Coffey, S., Bunton, R., Sugunesegran, R., Parry, D., Davis, P., Williams, M. J. A., Bahn, A., & Katare, R. (2021). Diabetes induces dysregulation of microRNAs associated with survival, proliferation and self-renewal in cardiac progenitor cells. Diabetologia, 64, 1422-1435. doi: 10.1007/s00125-021-05405-7

Journal - Research Article

Reily-Bell, M., Bahn, A., & Katare, R. (2021). Reactive oxygen species-mediated diabetic heart disease: Mechanisms and therapies. Antioxidants & Redox Signaling. Advance online publication. doi: 10.1089/ars.2021.0098

Journal - Research Article

Cook, R. F., Bussey, C. T., Fomison-Nurse, I. C., Hughes, G., Bahn, A., Cragg, P. A., & Lamberts, R. R. (2019). β2-adrenoceptors indirectly support impaired β1-adrenoceptor responsiveness in the isolated type 2 diabetic rat heart. Experimental Physiology, 104, 808-818. doi: 10.1113/EP087437

Journal - Research Article

Bussey, C. T., Thaung, H. P. A., Hughes, G., Bahn, A., & Lamberts, R. R. (2018). Cardiac β-adrenergic responsiveness of obese Zucker rats: The role of AMPK. Experimental Physiology, 103(8), 1067-1075. doi: 10.1113/ep087054

Journal - Research Article

Sangkop, F., Singh, G., Rodrigues, E., Gold, E., & Bahn, A. (2016). Uric acid: A modulator of prostate cells and activin sensitivity. Molecular & Cellular Biochemistry, 414(1-2), 187-199. doi: 10.1007/s11010-016-2671-8

Journal - Research Article

Purvis, N., Bahn, A., & Katare, R. (2015). The role of microRNAs in cardiac stem cells. Stem Cells International, 2015(2015), 194894. doi: 10.1155/2015/194894

Journal - Research Article

Thaung, H. P. A., Baldi, J. C., Wang, H.-Y., Hughes, G., Cook, R. F., Bussey, C. T., Sheard, P. W., Bahn, A., Jones, P. P., Schwenke, D. O., & Lamberts, R. R. (2015). Increased efferent cardiac sympathetic nerve activity and defective intrinsic heart rate regulation in type 2 diabetes. Diabetes, 64(8), 2944-2956. doi: 10.2337/db14-0955

Journal - Research Article

Thaung, H. P. A., Yao, Y., Bussey, C. T., Hughes, G., Jones, P. P., Bahn, A., Sammut, I. A., & Lamberts, R. R. (2015). Chronic bilateral renal denervation reduces cardiac hypertrophic remodelling but not β-adrenergic responsiveness in hypertensive type 1 diabetic rats. Experimental Physiology, 100(6), 628-639. doi: 10.1113/EP085021

Journal - Research Article

Knake, C., Stamp, L., & Bahn, A. (2014). Molecular mechanism of an adverse drug-drug interaction of allopurinol and furosemide in gout treatment. Biochemical & Biophysical Research Communications, 452, 157-162. doi: 10.1016/j.bbrc.2014.08.068

Journal - Research Article

Lamberts, R. R., Lingam, S. J., Wang, H.-Y., Bollen, I. A. E., Hughes, G., Galvin, I. F., Bunton, R. W., Bahn, A., Katare, R., Baldi, J. C., Williams, M. J. A., Saxena, P., Coffey, S., & Jones, P. P. (2014). Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction. Cardiovascular Diabetology, 13, 72. doi: 10.1186/1475-2840-13-72

Journal - Research Article

Dinour, D., Bahn, A., Ganon, L., Ron, R., Geifman-Holtzman, O., Knecht, A., … Holtzman, E. J. (2011). URAT1 mutations cause renal hypouricemia type 1 in Iraqi Jews. Nephrology Dialysis Transplantation, 26(7), 2175-2181. doi: 10.1093/ndt/gfq722

Journal - Research Article

Rödiger, M., Zhang, X., Ugele, B., Gersdorff, N., Wright, S. H., Burckhardt, G., & Bahn, A. (2010). Organic anion transporter 3 (OAT3) and renal transport of the metal chelator 2,3-dimercapto-1-propanesulfonic acid (DMPS). Canadian Journal of Physiology & Pharmacology, 88(2), 141-146. doi: 10.1139/Y09-123

Journal - Research Article

Bakhiya, N., Arlt, V. M., Bahn, A., Burckhardt, G., Phillips, D. H., & Glatt, H. (2009). Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy. Toxicology, 264(1-2), 74-79. doi: 10.1016/j.tox.2009.07.014

Journal - Research Article

Bahn, A., Hagos, Y., Reuter, S., Balen, D., Brzica, H., Krick, W., … Burckhardt, G. (2008). Identification of a new urate and high affinity nicotinate transporter: hOAT10 (SCL22A13). Journal of Biological Chemistry, 283(24), 16332-16341. doi: 10.1074/jbc.M800737200

Journal - Research Article

Ugele, B., Bahn, A., & Rex-Haffner, M. (2008). Functional differences in steroid sulfate uptake of organic anion transporter 4 (OAT4) and organic anion transporting polypeptide 2B1 (OATP2B1) in human placenta. Journal of Steroid Biochemistry & Molecular Biology, 111(1-2), 1-6. doi: 10.1016/j.jsbmb.2008.04.001

Journal - Research Article

Hagos, Y., Bahn, A., Vormfelde, S. V., Brockmöller, J., & Burckhardt, G. (2007). Torasemide transport by organic anion transporters contributes to hyperuricemia. Journal of the American Society of Nephrology, 18(12), 3101-3109. doi: 10.1681/ASN.2007010106

Journal - Research Article

Hagos, Y., Stein, D., Ugele, B., Burckhardt, G., & Bahn, A. (2007). Human renal organic anion transporter 4 operates as an asymmetric urate transporter. Journal of the American Society of Nephrology, 18(2), 430-439. doi: 10.1681/ASN.2006040415

Journal - Research Article

Ljubojević, M., Balen, D., Breljak, D., Kušan, M., Anzai, N., Bahn, A., … Sabolić, I. (2007). Renal expression of organic anion transporter OAT2 in rats and mice is regulated by sex hormones. American Journal of Physiology: Renal Physiology, 292(1), F361-F372. doi: 10.1152/ajprenal.00207.2006

Journal - Research Article

Sabolić, I., Asif, A. R., Budach, W. E., Wanke, C., Bahn, A., & Burckhardt, G. (2007). Gender differences in kidney function. Pflügers Archiv: European Journal of Physiology, 455(3), 397-429. doi: 10.1007/s00424-007-0308-1

Journal - Research Article

Bakhiya, N., Stephani, M., Bahn, A., Ugele, B., Seidel, A., Burckhardt, G., & Glatt, H. (2006). Uptake of chemically reactive, DNA-damaging sulfuric acid esters into renal cells by human organic anion transporters. Journal of the American Society of Nephrology, 17(5), 1414-1421. doi: 10.1681/ASN.2005080801

Journal - Research Article

Ljubojević, M., Balen, D., Breljak, D., Kusan, M., Anzai, N., Bahn, A., … Sabolic, I. (2007). Corrigendum to "Renal expression of organic anion transporter OAT2 in rats and mice is regulated by sex hormones" [Am. J. Physiol. Renal Physiol. 292(1): F361-F372]. American Journal of Physiology: Renal Physiology, 292(4), F1302. doi: 10.1152/ajprenal.zh2-4716-corr.2007

Journal - Research Other

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