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Physiology profile

Dr Regis Lamberts

PositionSenior Lecturer
DepartmentDepartment of Physiology
QualificationsBSc MSc PhD
Research summaryCardiovascular physiology

Research

How the heart maintains its function under conditions of stress has been the major focus of my research career.

My research aims to determine the changes in autonomic regulation of heart function (brain-heart axis) in diabetes, and how the fat surrounding the heart affects cardiac function. My lab generates biomedical data at the cellular and organ level, and obtains functional human myocardial and clinical data through HeartOtago.

This translational knowledge creates the platform that is vital for the development of more specific therapeutics for the increasing cohort of individuals with obesity and diabetes to improve their health.

Publications

Bussey, C. T., Thaung, H. P. A., Hughes, G., Bahn, A., & Lamberts, R. R. (2018). Cardiac β-adrenergic responsiveness of obese Zucker rats: The role of AMPK. Experimental Physiology. Advance online publication. doi: 10.1113/ep087054

Daniels, L. J., Wallace, R. S., Nicholson, O. M., Wilson, G. A., McDonald, F. J., Jones, P. P., Baldi, J. C., Lamberts, R. R., & Erickson, J. R. (2018). Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats. Cardiovascular Diabetology, 17, 89. doi: 10.1186/s12933-018-0732-x

Pearson, J. T., Collie, N., Lamberts, R. R., Inagaki, T., Yoshimoto, M., Umetani, K., … Wilkins, G., Jones, P. P., … Schwenke, D. O. (2018). Ghrelin preserves ischemia-induced vasodilation of male rat coronary vessels following beta-adrenergic receptor blockade. Endocrinology, 159(4), 1763-1773. doi: 10.1210/en.2017-03070

Bussey, C. T., & Lamberts, R. R. (2017). Effect of type 2 diabetes, surgical incision, and volatile anesthesia on hemodynamics in the rat. Physiological Reports, 5(14), e13352. doi: 10.14814/phy2.13352

Cook, R. F., Bussey, C. T., Mellor, K. M., Cragg, P. A., & Lamberts, R. R. (2017). β1-Adrenoceptor, but not β2-adrenoceptor, subtype regulates heart rate in type 2 diabetes rats in vivo. Experimental Physiology, 102(8), 911-923. doi: 10.1113/ep086293

Journal - Research Article

Pearson, J. T., Collie, N., Lamberts, R. R., Inagaki, T., Yoshimoto, M., Umetani, K., … Wilkins, G., Jones, P. P., … Schwenke, D. O. (2018). Ghrelin preserves ischemia-induced vasodilation of male rat coronary vessels following beta-adrenergic receptor blockade. Endocrinology, 159(4), 1763-1773. doi: 10.1210/en.2017-03070

Daniels, L. J., Wallace, R. S., Nicholson, O. M., Wilson, G. A., McDonald, F. J., Jones, P. P., Baldi, J. C., Lamberts, R. R., & Erickson, J. R. (2018). Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats. Cardiovascular Diabetology, 17, 89. doi: 10.1186/s12933-018-0732-x

Bussey, C. T., Thaung, H. P. A., Hughes, G., Bahn, A., & Lamberts, R. R. (2018). Cardiac β-adrenergic responsiveness of obese Zucker rats: The role of AMPK. Experimental Physiology. Advance online publication. doi: 10.1113/ep087054

Wilson, G. A., Wilkins, G. T., Cotter, J. D., Lamberts, R. R., Lal, S., & Baldi, J. C. (2017). Impaired ventricular filling limits cardiac reserve during submaximal exercise in people with type 2 diabetes. Cardiovascular Diabetology, 16, 160. doi: 10.1186/s12933-017-0644-1

Cook, R. F., Bussey, C. T., Mellor, K. M., Cragg, P. A., & Lamberts, R. R. (2017). β1-Adrenoceptor, but not β2-adrenoceptor, subtype regulates heart rate in type 2 diabetes rats in vivo. Experimental Physiology, 102(8), 911-923. doi: 10.1113/ep086293

Satthenapalli, V. R., Lamberts, R. R., & Katare, R. G. (2017). Challenges in regenerating the diabetic heart: A comprehensive review. Stem Cells, 35(9), 2009-2026. doi: 10.1002/stem.2661

Bussey, C. T., & Lamberts, R. R. (2017). Effect of type 2 diabetes, surgical incision, and volatile anesthesia on hemodynamics in the rat. Physiological Reports, 5(14), e13352. doi: 10.14814/phy2.13352

Wilson, G. A., Wilson, L. C., Lamberts, R. R., Majeed, K., Lal, S., Wilkins, G. T., & Baldi, J. C. (2017). β-adrenergic responsiveness in the type 2 diabetic heart: Effects on cardiac reserve. Medicine & Science in Sports & Exercise, 49(5), 907-914. doi: 10.1249/mss.0000000000001184

Rawal, S., Munasinghe, E. P., Nagesh, P. T., Lew, J. K. S., Jones, G. T., Williams, M. J. A., Davis, P., Bunton, R. W., Galvin, I. F., Manning, P., Lamberts, R. R., & Katare, R. (2017). Downregulation of miR-15a/b accelerates fibrotic remodelling in the Type-2 diabetic human and mouse heart. Clinical Science, 131(9), 847-863. doi: 10.1042/cs20160916

Munasinghe, P. E., Riu, F., Dixit, P., Edamatsu, M., Saxena, P., Hamer, N. S. J., Galvin, I. F., Bunton, R. W., Lequeux, S., Jones, G., Lamberts, R. R., … Katare, R. (2016). Type-2 diabetes increases autophagy in the human heart through promotion of Beclin-1 mediated pathway. International Journal of Cardiology, 202, 13-20. doi: 10.1016/j.ijcard.2015.08.111

Baldi, J. C., Wilson, G. A., Wilson, L. C., Wilkins, G. T., & Lamberts, R. R. (2016). The type 2 diabetic heart: Its role in exercise intolerance and the challenge to find effective exercise interventions. Sports Medicine, 46, 1605-1617. doi: 10.1007/s40279-016-0542-9

Thaung, H. P. A., Baldi, J. C., Wang, H.-Y., Hughes, G., Cook, R. F., Bussey, C. T., Sheard, P. W., Bahn, A., Jones, P. P., Schwenke, D. O., & Lamberts, R. R. (2015). Increased efferent cardiac sympathetic nerve activity and defective intrinsic heart rate regulation in type 2 diabetes. Diabetes, 64(8), 2944-2956. doi: 10.2337/db14-0955

Green, S., Egaña, M., Baldi, J. C., Lamberts, R., & Regensteiner, J. G. (2015). Cardiovascular control during exercise in type 2 diabetes mellitus. Journal of Diabetes Research, 2015, 654204. doi: 10.1155/2015/654204

Daniels, L., Bell, J. R., Delbridge, L. M. D., McDonald, F. J., Lamberts, R. R., & Erickson, J. R. (2015). The role of CaMKII in diabetic heart dysfunction. Heart Failure Reviews, 20(5), 589-600. doi: 10.1007/s10741-015-9498-3

Jahn, N., Lamberts, R. R., Busch, C. J., Voelker, M. T., Koel-Simmelink, M. J. A., Teunissen, C. E., … Weimann, J. (2015). Inhaled carbon monoxide protects time-dependently from loss of hypoxic pulmonary vasoconstriction in endotoxemic mice. Respiratory Research, 16, 119. doi: 10.1186/s12931-015-0274-7

Thaung, H. P. A., Yao, Y., Bussey, C. T., Hughes, G., Jones, P. P., Bahn, A., Sammut, I. A., & Lamberts, R. R. (2015). Chronic bilateral renal denervation reduces cardiac hypertrophic remodelling but not β-adrenergic responsiveness in hypertensive type 1 diabetic rats. Experimental Physiology, 100(6), 628-639. doi: 10.1113/EP085021

Bussey, C. T., Hughes, G., Saxena, P., Galvin, I. F., Bunton, R. W., Noye, M. K., Coffey, S., Williams, M. J. A., Baldi, J. C., Jones, P. P., & Lamberts, R. R. (2015). Chamber-specific changes in calcium-handling proteins in the type 2 diabetic human heart with preserved ejection fraction. International Journal of Cardiology, 193, 53-55. doi: 10.1016/j.ijcard.2015.05.053

Bussey, C. T., de Leeuw, A. E., Cook, R. F., Ashley, Z., Schofield, J., & Lamberts, R. R. (2014). Dual implantation of a radio-telemeter and vascular access port allows repeated hemodynamic and pharmacological measures in conscious lean and obese rats. Laboratory Animals, 48(3), 250-260. doi: 10.1177/0023677214530687

Bussey, C. T., de Leeuw, A. E., & Lamberts, R. R. (2014). Increased haemodynamic adrenergic load with isoflurane anaesthesia in type 2 diabetic and obese rats in vivo. Cardiovascular Diabetology, 13, 161. doi: 10.1186/s12933-014-0161-4

Lamberts, R. R., Lingam, S. J., Wang, H.-Y., Bollen, I. A. E., Hughes, G., Galvin, I. F., Bunton, R. W., Bahn, A., Katare, R., Baldi, J. C., Williams, M. J. A., Saxena, P., Coffey, S., & Jones, P. P. (2014). Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction. Cardiovascular Diabetology, 13, 72. doi: 10.1186/1475-2840-13-72

Smeding, L., Plötz, F. B., Lamberts, R. R., van der Laarse, W. J., Kneyber, M. C. J., & Groeneveld, A. B. J. (2012). Mechanical ventilation with high tidal volumes attenuates myocardial dysfunction by decreasing cardiac edema in a rat model of LPS-induced peritonitis. Respiratory Research, 13, 23. doi: 10.1186/1465-9921-13-23

Smeding, L., van der Laarse, W. J., van Veelen, T. A., Lamberts, R. R., Niessen, H. W. M., Kneyber, M. C. J., … Plötz, F. B. (2012). Early myocardial dysfunction is not caused by mitochondrial abnormalities in a rat model of peritonitis. Journal of Surgical Research, 176(1), 178-184. doi: 10.1016/j.jss.2011.05.055

Bouwman, R. A., Vreden, M. J. A., Hamdani, N., Wassenaar, L. E. J., Smeding, L., Loer, S., … Lamberts, R. R. (2010). Effect of bupivacaine on sevoflurane-induced preconditioning in isolated rat hearts. European Journal of Pharmacology, 647(1-3), 132-138. doi: 10.1016/j.ejphar.2010.08.014

de Mooji, Y. M., Bartelings, M. M., Twisk, J. W. R., Lamberts, R. R., Gittenberger-de Groot, A. C., van Vugt, J. M. G., & Bekker, M. N. (2010). Altered jugular vein and ductus venosus flow velocities in fetuses with increased nuchal translucency and distended jugular lymphatic sacs. American Journal of Obstetrics & Gynecology, 202(6), e566.1-e566.8. doi: 10.1016/j.ajog.2010.01.054

Handoko, M. L., Lamberts, R. R., Redout, E. M., de Man, F. S., Boer, C., Simonides, W. S., … Vonk-Noordegraaf, A. (2009). Right ventricular pacing improves right heart function in experimental pulmonary arterial hypertension: A study in the isolated heart. American Journal of Physiology: Heart & Circulatory Physiology, 297(5), H1752-H1759. doi: 10.1152/ajpheart.00555.2009

Hamdani, N., de Waard, M., Messer, A. E., Boontje, N. M., Kooij, V., van Dijk, S., … Lamberts, R., … van der Velden, J. (2009). Myofilament dysfunction in cardiac disease from mice to men. Journal of Muscle Research & Cell Motility, 29(6-8), 189-201. doi: 10.1007/s10974-008-9160-y

Lamberts, R. R., Onderwater, G., Hamdani, N., Vreden, M. J. A., Steenhuisen, J., Eringa, E. C., … Bouwman, R. A. (2009). Reactive oxygen species—induced stimulation of 5'AMP-activated protein kinase mediates sevoflurane-induced cardioprotection. Circulation, 120(Suppl. 1), S10-S15. doi: 10.1161/CIRCULATIONAHA.108.828426

Lamberts, R. R., Caldenhoven, E., Lansink, M., Witte, G., Vaessen, R. J., St Cyr, J. A., & Stienen, G. J. M. (2007). Preservation of diastolic function in monocrotaline-induced right ventricular hypertrophy in rats. American Journal of Physiology: Heart & Circulatory Physiology, 293(4), H1869-H1876. doi: 10.1152/ajpheart.00294.2007

Lamberts, R. R., Hamdani, N., Soekhoe, T. W., Boontje, N. M., Zaremba, R., Walker, L. A., … Stienen, G. J. M. (2007). Frequency-dependent myofilament Ca2+ desensitization in failing rat myocardium. Journal of Physiology, 582(2), 695-709. doi: 10.1113/jphysiol.2007.134486

Bouwman, R. A., Musters, R. J. P., van Beek-Harmsen, B. J., de Lange, J. J., Lamberts, R. R., Loer, S., & Boer, C. (2007). Sevoflurane-induced cardioprotection depends on PKC-α activation via production of reactive oxygen species. British Journal of Anaesthesia, 99(5), 639-645. doi: 10.1093/bja/aem202

Lamberts, R. R., Vaessen, R. J., Westerhof, N., & Stienen, G. J. M. (2007). Right ventricular hypertrophy causes impairment of left ventricular diastolic function in the rat. Basic Research in Cardiology, 102(1), 19-27. doi: 10.1007/s00395-006-0620-5

van der Velden, J., Narolska, N. A., Lamberts, R. R., Boontje, N. M., Borbély, A., Zaremba, R., … Stienen, G. J. M. (2006). Functional effects of protein kinase C-mediated myofilament phosphorylation in human myocardium. Cardiovascular Research, 69, 876-887. doi: 10.1016/j.cardiores.2005.11.021

Westerhof, N., Boer, C., Lamberts, R. R., & Sipkema, P. (2006). Cross-talk between cardiac muscle and coronary vasculature. Physiological Reviews, 86(4), 1268-1308. doi: 10.1152/physrev.00029.2005

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Journal - Research Other

Aitken-Buck, H. M., & Lamberts, R. R. (2017). To the heart of activation heat. Journal of Physiology, 595(14), 4577-4578. doi: 10.1113/jp274582

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