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Lab personnel

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Research interests

Our research group principally uses electrophysiology and immunohistochemistry to determine how the brain controls birth, lactation, and cardiovascular function. Our main focus is on how oxytocin and vasopressin contribute to preterm labour, high blood pressure and heart problems..

Keywords

Oxytocin, vasopressin, hypothalamus, dehydration, hypertension.

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Projects

  • Hypothalamic regulation of reproductive and cardiovascular function

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Current funding

  • 2014–2019: Health Research Council of New Zealand: Healthy pregnancies, healthy babies

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Previous funding

  • 2013–2016: Health Research Council of New Zealand: Central regulation of natural birth process
  • 2010–2014: Royal Society of New Zealand Marsden Fund: Hormonal regulation of bodyweight in reproduction
  • 2010–2013: Health Research Council of New Zealand: Kisspeptin-oxytocin regulation of pregnancy: implications for preterm delivery
  • 2008: New Zealand Lottery Grants Board: Neural-hormonal communication in the brain
  • 2006–2008: New Zealand Lottery Grants Board: Mechanisms of plasticity in vasopressin cell activity during dehydration
  • 2003–2006: Wellcome Trust: Cellular mechanisms underlying neuronal excitability during morphine withdrawal
  • 2000–2003: Wellcome Trust Fellowship: Investigation of dendritic regulation of activity by endogenous kappa-opioid peptides in the neurohypophysial system

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Collaborators

  • Charles Bourque, McGill University, Canada
  • David Grattan, University of Otago, New Zealand
  • Gareth Leng, University of Edinburgh, UK
  • Mike Ludwig, University of Edinburgh, UK
  • Javier Stern, Medical College of Georgia, USA

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Teaching

  • HUBS 191
  • PHSL 231
  • PHSL 251
  • PHSL 342
  • PHSL 472
  • PHSL 474

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Selected publications

Roy, R. K., Althammer, F., Seymour, A. J., Du, W., Biancardi, V. C., Hamm, J. P., … Brown, C. H., & Stern, J. E. (2021). Inverse neurovascular coupling contributes to positive feedback excitation of vasopressin neurons during a systemic homeostatic challenge. Cell Reports, 37(5), 109925. doi: 10.1016/j.celrep.2021.109925

Sethi, S., Augustine, R. A., Bouwer, G. T., Perkinson, M. R., Cheong, I., Bussey, C. T., Schwenke, D. O., Brown, C. H., & Lamberts, R. R. (2021). Increased neuronal activation in sympathoregulatory regions of the brain and spinal cord in type 2 diabetic rats. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.13016

Perkinson, M., Augustine, R. A., Bouwer, G. T., Brown, E. F., Cheong, I., Seymour, A. J., Fronius, M., & Brown, C. H. (2021). Plasticity in intrinsic excitability of hypothalamic magnocellular neurosecretory neurons in late-pregnant and lactating rats. International Journal of Molecular Sciences, 22(13), 7140. doi: 10.3390/ijms22137140

Perkinson, M. R., Kim, J. S., Iremonger, K. J., & Brown, C. H. (2021). Visualising oxytocin neurone activity in vivo: The key to unlocking central regulation of parturition and lactation [Invited review]. Journal of Neuroendocrinology, e13012. Advance online publication. doi: 10.1111/jne.13012

Li, T., Jia, S.-W., Hou, D., Liu, X., Li, D., Liu, Y., … Brown, C. H., & Wang, Y.-F. (2021). Intranasal oxytocin restoration of maternal behavior and oxytocin neuronal activity in the supraoptic nucleus in rat dams with pre-labor cesarean delivery. Neuroscience. Advance online publication. doi: 10.1016/j.neuroscience.2021.06.020

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