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Lab personnel

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Research interests

I am interested in defining how the gonadotrophin releasing hormone (GnRH) neurons, well established as the ultimate downstream regulators of the central control of reproductive function, are regulated by the multitude of external and internal cues necessary for successful fertility. I am investigating the synaptic regulation of GnRH neurons, with particular emphasis on the innervation to their lengthy dendrites, through a variety of morphological imaging and transgenic mouse model approaches. In addition to understanding the regulation of normal fertility, I am also interested in addressing the central neuroendocrine abnormalities of polycystic ovarian syndrome (PCOS), the leading cause of infertility in women.

Keywords

GnRH neurons, dendrites, synchronization, PCOS

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Research topics

  • Exploring the neuroendocrine mechanism of polycystic ovary syndrome (PCOS)
  • Investigating the spatial distribution of synaptic inputs to GnRH dendrites
  • Mechanisms of pulse generation in the GnRH neuronal network

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Current funding

  • 2015–2018 Health Research Council (HRC) Grant, Probing novel pathways mediating PCOS. Principal Investigator (NZ$910,000).
  • 2015–2018 Royal Society Marsden Fund, Functional dissection of a novel GABAergic pathway in the brain circuitry controlling fertility. Principal Investigator (NZ$943,000).
  • 2012–2017 Health Research Council (HRC) Programme Grant, Neural control of fertility. Joint Principal Investigator (0.10FTE) (NZ$4,935,490). Director: Professor Allan Herbison.

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Previous funding

  • 2015 University of Otago Research Grant, Putting the pieces together: Getting the bigger picture on fertility regulation – Part II. Principal Investigator (NZ$30,000).
  • 2014 University of Otago Research Grant, Putting the pieces together: Getting the bigger picture on fertility regulation. Principal Investigator (NZ$42,085).
  • 2011–2014 Health Research Council (HRC) Grant, Investigating the Neuroendocrine Abnormalities of Polycystic Ovarian Syndrome. Principal Investigator (0.2FTE; NZ$650,735).
  • 2010–2013 Royal Society Marsden Fund, Primary cilia and the central regulation of fertility. Principal Investigator (0.25FTE; NZ$575,000).

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Previous lab personnel

  • Katrin Geist
  • Galina Gaidamaka

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Selected publications

Sati, A., Prescott, M., Holland, S., Jasoni, C. L., Desroziers, E., & Campbell, R. E. (2021). Morphological evidence indicate a role for microglia in shaping the polycystic ovary syndrome (PCOS)-like brain. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.12999

Sati, A., Prescott, M., Jasoni, C. L., Desroziers, E., & Campbell, R. E. (2021). The role of microglia in the polycystic ovary syndrome (PCOS)-like brain. Journal of the Endocrine Society, 5(Suppl. 1), (pp. A556). doi: 10.1210/jendso/bvab048.1133

Nair, B. B., Khant Aung, Z., Porteous, R., Prescott, M., Glendining, K. A., Jenkins, D. E., Augustine, R. A., … Yip, S. H., Bouwer, G. T., Brown, C. H., Jasoni, C. L., Campbell, R. E., Bunn, S. J., Anderson, G. M., Grattan, D. R., Herbison, A. E., & Iremonger, K. J. (2021). Impact of chronic variable stress on neuroendocrine hypothalamus and pituitary in male and female C57BL/6J mice. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.12972

Jamieson, B. B., Bouwer, G. T., Campbell, R. E., & Piet, R. (2021). Estrous cycle plasticity in the central clock output to kisspeptin neurons: Implications for the preovulatory surge. Endocrinology. Advance online publication. doi: 10.1210/endocr/bqab071

Sucquart, I. E., Nagarkar, R., Edwards, M. C., Paris, V. R., Aflatounian, A., Bertoldo, M. J., Campbell, R. E., … Walters, K. A. (2021). Neurokinin 3 receptor antagonism ameliorates key metabolic features in a hyperandrogenic PCOS mouse model. Endocrinology. Advance online publication. doi: 10.1210/endocr/bqab020

Elenis, E., Desroziers, E., Persson, S., Sundström Poromaa, I., & Campbell, R. E. (2021). Early initiation of anti-androgen treatment is associated with increased probability of spontaneous conception leading to childbirth in women with polycystic ovary syndrome: A population-based multiregistry cohort study in Sweden. Human Reproduction. Advance online publication. doi: 10.1093/humrep/deaa357

Marshall, C. J., Prescott, M., & Campbell, R. E. (2020). Investigating the NPY/AgRP/GABA to GnRH neuron circuit in prenatally androgenized PCOS-like mice. Journal of the Endocrine Society. Advance online publication. doi: 10.1210/jendso/bvaa129

Coutinho, E. A., Prescott, M., Hessler, S., Marshall, C. J., Herbison, A. E., & Campbell, R. E. (2020). Activation of a classic hunger circuit slows luteinizing hormone pulsatility. Neuroendocrinology, 110(7-8), 671-687. doi: 10.1159/000504225

Stener-Victorin, E., Padmanabhan, V., Walters, K. A., Campbell, R. E., Benrick, A., Giacobini, P., … Abbott, D. H. (2020). Animal models to understand the etiology and pathophysiology of polycystic ovary syndrome. Endocrine Reviews, 41, 538-576. doi: 10.1210/endrev/bnaa010

McCartney, C. R., & Campbell, R. E. (2020). Abnormal GnRH pulsatility in polycystic ovary syndrome: Recent insights. Current Opinion in Endocrine & Metabolic Research, 12, 78-84. doi: 10.1016/j.coemr.2020.04.005

Rim, Y., Jamieson, B., Bouwer, G., Thomas, S., Campbell, R. E., & Piet, R. (2019, September). Investigating suprachiasmatic neuromedin S neuronal projections to kisspeptin neurons in the RP3V. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Ruddenklau, A., Prescott, M., & Campbell, R. E. (2019, September). Role of central progesterone signalling in PCOS pathology. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Jamieson, B. B., Campbell, R. E., & Piet, R. (2019, September). Projections of suprachiasmatic nucleus vasopressin neurons regulate preoptic kisspeptin neuron electrical activity. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Sati, A., Prescott, M., Desroziers, E., Jasoni, C. L., & Campbell, R. E. (2019, September). The impact of prenatal androgen excess on microglia in the female mouse brain. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Watanabe, Y., Prescott, M., Fisher, L. C., Campbell, R. E., Anderson, G. M., & Jasoni, C. L. (2019). Investigating changes in androgen and progesterone receptor expression in the aetiology of PNA-induced polycystic ovary syndrome. Proceedings of the Queenstown Molecular Biology (QMB) Meetings. [Abstract]

Desroziers, E., Prescott, M., & Campbell, R. E. (2019, August-September). Prenatal androgen excess impairs sexual behavior in adult female mice: Perspective on sexual dysfunction in PCOS. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Marshall, C. J., Coutinho, E., & Campbell, R. E. (2019, August-September). Examining alterations to arcuate nucleus NPY neurons and their neural projections in a mouse model of polycystic ovary syndrome. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Coyle, C., Jamieson, B., Prescott, M., & Campbell, R. E. (2019, August-September). Androgen receptor expression across the estrous cycle in the hypothalamus and new methods for its targeted deletion. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Jamieson, B. B., Bouwer, G. T., Campbell, R. E., & Piet, R. (2019, August-September). Suprachiasmatic vaasopressin neurons alter the activity of preoptic kisspeptin neurons in female mice. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Desroziers, E., Hessler, S., Prescott, M., Coyle, C., Herbison, A. E., & Campbell, R. E. (2019, August-September). Chemogenetic activation of arcuate GABA neurons lead to reproductive dysfunction in female: Implication for polycystic ovary syndrome. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Campbell, R. E. (2019, August-September). Shedding light on the role of the brain in polycystic ovary syndrome. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Jamieson, B. B., Campbell, R. E., & Piet, R. (2019). Projections of suprachiasmatic nucleus vasopressin neurons regulate preoptic kisspeptin neuron electrical activity. Proceedings of the Society for Neuroscience Annual Meeting. 673.09/N39. SfN. Retrieved from https://www.sfn.org

Gordon, C., Campbell, R., & Ranta, A. (2019). Impact of the national public 'FAST' campaigns. New Zealand Medical Journal, 132(1507), 48-56. Retrieved from https://www.nzma.org.nz/journal

Holland, S., Prescott, M., Pankhurst, M., & Campbell, R. E. (2019). The influence of maternal androgen excess on the male reproductive axis. Scientific Reports, 9, 18908. doi: 10.1038/s41598-019-55436-9

Coyle, C., & Campbell, R. E. (2019). Pathological pulses in PCOS. Molecular & Cellular Endocrinology, 498, 110561. doi: 10.1016/j.mce.2019.110561

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