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Lab personnel

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Research interests

  • Neurophysiology of midbrain dopamine systems and pathways which modulate dopamine neuron activity
  • Effects of abnormal dopamine activity such as occurs in Parkinson's disease on activity in the motor control pathways

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Current funding

  • Health Research Council
  • Marsden Fund
  • Boehringer Ingelheim Pharma GmbH
  • New Zealand Neurological Foundation

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Collaborators

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Selected publications

Reynolds, J. N. J., Hyland, B. I., & Wickens, J. (2001). A cellular mechanism of reward-related learning. Nature, 413, 67-70.

Hyland, B. I., Reynolds, J. N. J., Hay, J., Perk, C. G., & Miller, R. (2002). Firing modes of midbrain dopamine cells in the freely moving rat. Neuroscience, 114(2), 475-492.

Pan, W.-X., Schmidt, R., Wickens, J. R., & Hyland, B. I. (2005). Dopamine cells respond to predicted events during classical conditioning: Evidence for eligibility traces in the reward-learning network. Journal of Neuroscience, 25(26), 6235-6242.

Dejean, C., Arbuthnott, G., Wickens, J. R., Le Moine, C., Boraud, T., & Hyland, B. I. (2011). Power fluctuations in beta and gamma frequencies in rat globus pallidus: Association with specific phases of slow oscillations and differential modulation by dopamine D1 and D2 receptors. Journal of Neuroscience, 31(16), 6098-6107. doi: 10.1523/JNEUROSCI.3311-09.2011

Li, Y., Dalphin, N., & Hyland, B. I. (2013). Association with reward negatively modulates short latency phasic conditioned responses of dorsal raphe nucleus neurons in freely moving rats. Journal of Neuroscience, 33(11), 5065-5078. doi: 10.1523/jneurosci.5679-12.2013

Li, Y., Lindemann, C., Goddard, M. J., & Hyland, B. I. (2016). Complex multiplexing of reward-cue- and licking-movement-related activity in single midline thalamus neurons. Journal of Neuroscience, 36(12), 3567-3578. doi: 10.1523/jneurosci.1107-15.2016

Pan, W.-X., Schmidt, R., Wickens, J. R., & Hyland, B. I. (2008). Tripartite mechanism of extinction suggested by dopamine neuron activity and temporal difference model. Journal of Neuroscience, 28(39), 9619-9631. doi: 10.1523/JNEUROSCI.0255-08.2008

Pan, W.-X., & Hyland, B. I. (2005). Pedunculopontine tegmental nucleus controls conditioned responses of midbrain dopamine neurons in behaving rats. Journal of Neuroscience, 25(19), 4725-4732.

Dejean, C., Hyland, B., & Arbuthnott, G. (2009). Cortical effects of subthalamic stimulation correlate with behavioral recovery from dopamine antagonist induced akinesia. Cerebral Cortex, 19(5), 1055-1063. doi: 10.1093/cercor/bhn149

Wickens, J., Reynolds, J. N. J., & Hyland, B. I. (2003). Neural mechanisms of reward-related motor learning. Current Opinion in Neurobiology, 13, 685-690.

Seeger-Armbruster, S., Bosch-Bouju, C., Little, S. T. C., Smither, R. A., Hughes, S. M., Hyland, B. I., & Parr-Brownlie, L. C. (2015). Patterned, but not tonic, optogenetic stimulation in motor thalamus improves reaching in acute drug-induced Parkinsonian rats. Journal of Neuroscience, 35(3), 1211-1216. doi: 10.1523/jneurosci.3277-14.2015

Parr-Brownlie, L. C., & Hyland, B. I. (2005). Bradykinesia induced by dopamine D2 receptor blockade is associated with reduced motor cortex activity in the rat. Journal of Neuroscience, 25(24), 5700-5709.

Bosch-Bouju, C., Smither, R. A., Hyland, B. I., & Parr-Brownlie, L. C. (2014). Reduced reach-related modulation of motor thalamus neural activity in a rat model of Parkinson's disease. Journal of Neuroscience, 34(48), 15836-15850. doi: 10.1523/jneurosci.0893-14.2014

Igelstrom, K. M., Herbison, A. E., & Hyland, B. I. (2010). Enhanced c-Fos expression in superior colliculus, paraventricular thalamus and septum during learning of cue-reward association. Neuroscience, 168(3), 706-714. doi: 10.1016/j.neuroscience.2010.04.018

Perk, C. G., Wickens, J. R., & Hyland, B. I. (2015). Differing properties of putative fast-spiking interneurons in the striatum of two rat strains. Neuroscience, 294, 215-226. doi: 10.1016/j.neuroscience.2015.02.051

Blakemore, R. L., Hyland, B. I., Hammond-Tooke, G. D., & Anson, J. G. (2013). Distinct modulation of event-related potentials during motor preparation in patients with motor conversion disorder. PLoS ONE, 8(4), e62539. doi: 10.1371/journal.pone.0062539

Wickens, J. R., Hyland, B. I., & Tripp, G. (2011). Animal models to guide clinical drug development in ADHD: Lost in translation? British Journal of Pharmacology, 164, 1107-1128. doi: 10.1111/j.1476-5381.2011.01412.x

Wickens, J. R., Budd, C. S., Hyland, B. I., & Arbuthnott, G. W. (2007). Striatal contributions to reward and decision making: Making sense of regional variations in a reiterated processing matrix. Annals of the New York Academy of Sciences, 1104, 192-212.

Sutherland, K. R., Alsop, B., McNaughton, N., Hyland, B. I., Tripp, G., & Wickens, J. R. (2009). Sensitivity to delay of reinforcement in two animal models of attention deficit hyperactivity disorder (ADHD). Behavioural Brain Research, 205(2), 372-376. doi: 10.1016/j.bbr.2009.07.011

Aggarwal, M., Hyland, B. I., & Wickens, J. R. (2012). Neural control of dopamine neurotransmission: Implications for reinforcement learning. European Journal of Neuroscience, 35(7), 1115-1123. doi: 10.1111/j.1460-9568.2012.08055.x

Villa, A. E., Tetko, I. V., Hyland, B. I., & Najem, A. (1999). Spatiotemporal activity patterns of rat cortical neurons predict responses in a conditioned task. PNAS, 96, 1106-1111.

Reynolds, J. N. J., Hyland, B. I., & Wickens, J. R. (2004). Modulation of an afterhyperpolarization by the substantia nigra induces pauses in the tonic firing of striatal cholinergic interneurons. Journal of Neuroscience, 24(44), 9870-9877.

Kazennikov, O., Hyland, B. I., Corboz, M., Babalian, A., Rouiller, E. M., & Wiesendanger, M. (1999). Neural activity of supplementary and primary motor areas in monkeys and its relation to bimanual and unimanual movement sequences. Neuroscience, 89(3), 661-674.

Jarratt, H. L., & Hyland, B. I. (1999). Neuronal activity in rat red nucleus during forelimb reach-to-grasp movements. Neuroscience, 88(2), 629-642.

Wickens, J. R., Hyland, B. I., & Tripp, G. (2006). Frontostriatal mechanisms in reinforcement: Implications for ADHD. In E. Bezard (Ed.), Recent breakthroughs in basal ganglia research. (pp. 65-80). New York: Nova Science.

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