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Lab personnel

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Research interests

Sarcopenia - age-related loss of muscle mass and strength

Sarcopenia is the widely described phenomenon of age-related loss of muscle mass and strength. The functional impairments that arise from progressive weakness have profound implications for the elderly, and therefore for modern society. Sarcopenia manifests as a death of muscle fibers and decrease in cross sectional area of surviving fibers, the triggers for this progressive loss of muscle remain largely unknown. We are particularly interested in the role the motor nerve terminal may play in driving sarcopenia, since progressive withdrawal of the motor nerve from the muscle fibre also seems to be a conspicuous feature of elderly muscle. We are currently examining age-related changes to the neuromuscular junction with a view to using this information to establish whether motor nerve withdrawal is a cause of muscle fibre death, or a consequence of it.

We use electrophysiology, electron microscopy, confocal microscopy, fluorescence and transmitted light microscopy, histochemistry, immunohistochemistry, and anterograde and retrograde cell tracing techniques.

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Selected publications

Gillon, A., Nielsen, K., Steel, C., Cornwall, J., & Sheard, P. (2018). Exercise attenuates age-associated changes in motoneuron number, nucleocytoplasmic transport proteins and neuromuscular health. GeoScience. Advance online publication. doi: 10.1007/s11357-018-0020-4

Nielsen, K. B., Lal, N. N., & Sheard, P. W. (2018). Age-related remodelling of the myotendinous junction in the mouse soleus muscle. Experimental Gerontology, 104, 52-59. doi: 10.1016/j.exger.2018.01.021

Tan, C. L., Sheard, P. W., & Jasoni, C. L. (2018). Developing neurites from mouse basal forebrain gonadotropin-releasing hormone neurons use Sonic hedgehog to modulate their growth. International Journal of Developmental Neuroscience. Advance online publication. doi: 10.1016/j.ijdevneu.2018.05.005

Hennebry, A., Oldham, J., Shavlakadze, T., Grounds, M. D., Sheard, P., Fiorotto, M. L., … McMahon, C. D. (2017). IGF1 stimulates greater muscle hypertrophy in the absence of myostatin in male mice. Journal of Endocrinology, 234(2), 187-200. doi: 10.1530/joe-17-0032

Nielsen, K., & Sheard, P. (2017). The protective role of endurance exercise in age-related loss of muscle mass. Australasian Journal on Ageing, 36(Suppl. 1), (pp. 21). doi: 10.1111/ajag.12395

Sheard, P., Brady, J., Nielsen, K., & Cornwall, J. (2017). Age and exercise-related changes in Neurotrophin-r and Neuregulin amongst mouse lumbar motoneurons. Australasian Journal on Ageing, 36(Suppl. 1), (pp. 20). doi: 10.1111/ajag.12395

Cornwall, J., Lal, N., Slatter, T., Rowlands, D., & Sheard, P. (2017). Autophagic dysfunction has a key role in age-related myofibre death. Australasian Journal on Ageing, 36(Suppl. 1), (pp. 20). doi: 10.1111/ajag.12395

Cornwall, J., Farrell, S. F., & Sheard, P. W. (2016). Fibre types of human suboccipital muscles. European Journal of Anatomy, 20(1), 31-36.

White, Z., Terrill, J., White, R. B., McMahon, C., Sheard, P., Grounds, M. D., & Shavlakadze, T. (2016). Voluntary resistance wheel exercise from mid-life prevents sarcopenia and increases markers of mitochondrial function and autophagy in muscles of old male and female C57BL/6J mice. Skeletal Muscle, 6(1), 45. doi: 10.1186/s13395-016-0117-3

Davies, T. M., Sheard, P. W., & Cornwall, J. (2016). Comment on Makino et al. and observations on spatial modeling. Anatomical Science International, 91(4), 423-424. doi: 10.1007/s12565-016-0347-9

Thaung, H. P. A., Baldi, J. C., Wang, H.-Y., Hughes, G., Cook, R. F., Bussey, C. T., Sheard, P. W., Bahn, A., Jones, P. P., Schwenke, D. O., & Lamberts, R. R. (2015). Increased efferent cardiac sympathetic nerve activity and defective intrinsic heart rate regulation in type 2 diabetes. Diabetes, 64(8), 2944-2956. doi: 10.2337/db14-0955

Lal, N., & Sheard, P. (2015). Dying myofibers in elderly mouse skeletal muscles are characterized by the appearance of dystrophin-encircled vacuoles. Biogerontology, 16, 443-459. doi: 10.1007/s10522-015-9565-0

Gillon, A., & Sheard, P. (2015). Elderly mouse skeletal muscle fibres have a diminished capacity to upregulate NCAM production in response to denervation. Biogerontology, 16(6), 811-823. doi: 10.1007/s10522-015-9608-6

Brady, J., & Sheard, P. (2015). Implementation of internal intensity controls for semi-quantitative fluorescence immunohistochemistry. Proceedings of the 27th National Conference on Microscopy. Retrieved from http://microscopy2015.otago.ac.nz/index.html

Brady, J., Lal, N., & Sheard, P. (2015). Introducing an algorithm with user-defined parameters for improving consistency of immunofluorescence analysis. Proceedings of the 27th National Conference on Microscopy. Retrieved from http://microscopy2015.otago.ac.nz/index.html

Lal, N., Cornwall, J., & Sheard, P. (2015). Elderly dying myofibers are characterized by Dystrophin Encircle Vacuoles and invaginations with Intracellular Localization (DEVILs). Clinical Anatomy, 28(7), (pp. 945-946). doi: 10.1002/ca.22520

Brady, J., Gillon, A., Lal, N., & Sheard, P. (2015). Age-related declines in synaptic proteins, agrin and rapsyn, and their relevance to sarcopenia. Clinical Anatomy, 28(7), (pp. 940). doi: 10.1002/ca.22520

Hellyer, S. D., Selwood, A. I., van Ginkel, R., Munday, R., Sheard, P., Miles, C. O., … Kerr, D. S. (2014). In vitro labelling of muscle type nicotinic receptors using a fluorophore-conjugated pinnatoxin F derivative. Toxicon, 87, 17-25. doi: 10.1016/j.toxicon.2014.05.013

McMahon, C. D., Chai, R., Radley-Crabb, H. G., Watson, T., Matthews, K. G., Sheard, P. W., … Shavlakadze, T. (2014). Lifelong exercise and locally produced insulin-like growth factor-1 (IGF-1) have a modest influence on reducing age-related muscle wasting in mice. Scandinavian Journal of Medicine & Science in Sports, 24(6), e423-e435. doi: 10.1111/sms.12200

Rowlands, D. S., Page, R. A., Sukala, W. R., Giri, M., Ghimbovschi, S. D., Hayat, I., … Leikis, M., Sheard, P. W., Wakefield, St. J., … Krebs, J., … Hoffman, E. P. (2014). Multi-omic integrated networks connect DNA methylation and miRNA with skeletal muscle plasticity to chronic exercise in Type 2 diabetic obesity. Physiological Genomics, 46(20), 747-765. doi: 10.1152/physiolgenomics.00024.2014

Lal, N., Sheard, P., & Cornwall, J. (2014). Age-related myofibre death in human skeletal muscle may be evident by the appearance of vacuolated myofibres. Annals of Anatomy, 196(Suppl.), (pp. 106). doi: 10.1016/j.aanat.2014.05.035

Cornwall, J., & Sheard, P. (2014). Fibre types in human suboccipital muscles. Annals of Anatomy, 196(Suppl.), (pp. 88). doi: 10.1016/j.aanat.2014.05.035

Lal, N., & Sheard, P. (2014, September). Autophagic dysfunction accompanies myofibre death with age and predominantly affects the innervated myofibres in elderly mouse skeletal muscles. Verbal presentation at the New Zealand Association of Gerontology Conference: The Age of Ageing, Dunedin, New Zealand.

Gillon, A. P., & Sheard, P. W. (2014, September). A role for terminal Schwann cells in age related degeneration of the motor nerve terminal? Verbal presentation at the New Zealand Association of Gerontology Conference: The Age of Ageing, Dunedin, New Zealand.

Brady, J., Gillon, A. P., & Sheard, P. W. (2014, September). Altered expression of the synaptic proteins agrin and rapsyn with age: Implications for sarcopenia. Verbal presentation at the New Zealand Association of Gerontology Conference: The Age of Ageing, Dunedin, New Zealand.

Intellectual Property

Turney, S., & Sheard, P. W. (2009). System and methods for thick specimen imaging using a microscope-based tissue sectioning device. (WO/2009/048524).

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Chapter in Book - Research

Sayer, R. J., Bray, J. J., Mills, R. G., & Sheard, P. W. (1999). Introduction to the Nervous System. In J. J. Bray, P. A. Cragg, A. D. C. Macknight & R. G. Mills (Eds.), Lecture Notes on Human Physiology. (pp. 39-64). London: Blackwell Science.

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Journal - Research Article

Gillon, A., Nielsen, K., Steel, C., Cornwall, J., & Sheard, P. (2018). Exercise attenuates age-associated changes in motoneuron number, nucleocytoplasmic transport proteins and neuromuscular health. GeoScience. Advance online publication. doi: 10.1007/s11357-018-0020-4

Tan, C. L., Sheard, P. W., & Jasoni, C. L. (2018). Developing neurites from mouse basal forebrain gonadotropin-releasing hormone neurons use Sonic hedgehog to modulate their growth. International Journal of Developmental Neuroscience. Advance online publication. doi: 10.1016/j.ijdevneu.2018.05.005

Nielsen, K. B., Lal, N. N., & Sheard, P. W. (2018). Age-related remodelling of the myotendinous junction in the mouse soleus muscle. Experimental Gerontology, 104, 52-59. doi: 10.1016/j.exger.2018.01.021

Hennebry, A., Oldham, J., Shavlakadze, T., Grounds, M. D., Sheard, P., Fiorotto, M. L., … McMahon, C. D. (2017). IGF1 stimulates greater muscle hypertrophy in the absence of myostatin in male mice. Journal of Endocrinology, 234(2), 187-200. doi: 10.1530/joe-17-0032

Cornwall, J., Farrell, S. F., & Sheard, P. W. (2016). Fibre types of human suboccipital muscles. European Journal of Anatomy, 20(1), 31-36.

White, Z., Terrill, J., White, R. B., McMahon, C., Sheard, P., Grounds, M. D., & Shavlakadze, T. (2016). Voluntary resistance wheel exercise from mid-life prevents sarcopenia and increases markers of mitochondrial function and autophagy in muscles of old male and female C57BL/6J mice. Skeletal Muscle, 6(1), 45. doi: 10.1186/s13395-016-0117-3

Thaung, H. P. A., Baldi, J. C., Wang, H.-Y., Hughes, G., Cook, R. F., Bussey, C. T., Sheard, P. W., Bahn, A., Jones, P. P., Schwenke, D. O., & Lamberts, R. R. (2015). Increased efferent cardiac sympathetic nerve activity and defective intrinsic heart rate regulation in type 2 diabetes. Diabetes, 64(8), 2944-2956. doi: 10.2337/db14-0955

Gillon, A., & Sheard, P. (2015). Elderly mouse skeletal muscle fibres have a diminished capacity to upregulate NCAM production in response to denervation. Biogerontology, 16(6), 811-823. doi: 10.1007/s10522-015-9608-6

Lal, N., & Sheard, P. (2015). Dying myofibers in elderly mouse skeletal muscles are characterized by the appearance of dystrophin-encircled vacuoles. Biogerontology, 16, 443-459. doi: 10.1007/s10522-015-9565-0

Hellyer, S. D., Selwood, A. I., van Ginkel, R., Munday, R., Sheard, P., Miles, C. O., … Kerr, D. S. (2014). In vitro labelling of muscle type nicotinic receptors using a fluorophore-conjugated pinnatoxin F derivative. Toxicon, 87, 17-25. doi: 10.1016/j.toxicon.2014.05.013

Rowlands, D. S., Page, R. A., Sukala, W. R., Giri, M., Ghimbovschi, S. D., Hayat, I., … Leikis, M., Sheard, P. W., Wakefield, St. J., … Krebs, J., … Hoffman, E. P. (2014). Multi-omic integrated networks connect DNA methylation and miRNA with skeletal muscle plasticity to chronic exercise in Type 2 diabetic obesity. Physiological Genomics, 46(20), 747-765. doi: 10.1152/physiolgenomics.00024.2014

McMahon, C. D., Chai, R., Radley-Crabb, H. G., Watson, T., Matthews, K. G., Sheard, P. W., … Shavlakadze, T. (2014). Lifelong exercise and locally produced insulin-like growth factor-1 (IGF-1) have a modest influence on reducing age-related muscle wasting in mice. Scandinavian Journal of Medicine & Science in Sports, 24(6), e423-e435. doi: 10.1111/sms.12200

Davies, T. M., Cornwall, J., & Sheard, P. W. (2013). Modelling dichotomously marked muscle fibre configurations. Statistics in Medicine, 32(24), 4240-4258. doi: 10.1002/sim.5806

Sheard, P. W., & Anderson, R. D. (2012). Age-related loss of muscle fibres is highly variable amongst mouse skeletal muscles. Biogerontology, 13(2), 157-167. doi: 10.1007/s10522-011-9365-0

Sheard, P. W., Bewick, G. S., Woolley, A. G., Shaw, J., Fisher, L., Fong, S. W., & Duxson, M. J. (2010). Investigation of neuromuscular abnormalities in neurotrophin-3-deficient mice. European Journal of Neuroscience, 31(1), 29-41. doi: 10.1111/j.1460-9568.2009.07032.x

Woolley, A. G., Tait, K. J., Hurren, B. J., Fisher, L., Sheard, P. W., & Duxson, M. J. (2008). Developmental loss of NT-3 in vivo results in reduced levels of myelin-specific proteins, a reduced extent of myelination and increased apoptosis of Schwann cells. GLIA, 56(3), 306-317. doi: 10.1002/glia.20614

Li, C., Stanton, J.-A. L., Robertson, T. M., Suttie, J. M., Sheard, P. W., Harris, A. J., & Clark, D. E. (2007). Nerve growth factor mRNA expression in the regenerating antler tip of red deer (Cervus elaphus). PLoS ONE, 2(1), e148. Retrieved from http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0000148

Woolley, A. G., Sheard, P. W., & Duxson, M. J. (2005). Neurotrophin-3 null mutant mice display a postnatal motor neuropathy. European Journal of Neuroscience, 21, 2100-2110.

Sun, C.-K., Zhang, X.-Y., Sheard, P. W., Mabuchi, A., & Wheatley, A. M. (2005). Change in mitochondrial membrane potential is the key mechanism in early warm hepatic ischemia-reperfusion injury. Microvascular Research, 70, 102-110.

Homer, C., Knight, D. A., Hananeia, L., Sheard, P., Risk, J., Lasham, A., Royds, J. A., & Braithwaite, A. W. (2005). Y-box factor YB1 controls p53 apoptotic function. Oncogene, 24, 8314-8325. Retrieved from http://www.nature.com/onc/journal/v24/n56/abs/1208998a.html

Mabuchi, A., Mullaney, I., Sheard, P. W., Hessian, P. A., Mallard, B. L., Tawadrous, M. N., … Wheatley, A. M. (2004). Role of hepatic stellate cell/hepatocyte interaction and activation of hepatic stellate cells in the early phase of liver regeneration in the rat. Journal of Hepatology, 40, 910-916.

Mabuchi, A., Mullaney, I., Sheard, P., Hessian, P., Zimmermann, A., Senoo, H., & Wheatley, A. M. (2004). Role of hepatic stellate cells in the early phase of liver regeneration in rat: Formation of tight adhesion to parenchymal cells. Comparative Hepatology, 3(Suppl. 1), S29.

Paul, A. C., Sheard, P. W., & Duxson, M. J. (2004). Development of a mammalian series-fibered muscle. Anatomical Record Part A, 278A, 571-578.

Maclennan, K. M., Zheng, Y., Sheard, P. W., Williams, S. M., Darlington, C. L., & Smith, P. F. (2003). Adrenalectomy-induced cell death in the dentate gyrus: Further characterisation using TUNEL and effects of the Ginkgo biloba extract, EGb 761 and ginkgolide B. Hippocampus, 13, 212-225.

Zhang, Y.-F., Homer, C., Edwards, S. J., Hananeia, L., Lasham, A., Royds, J., Sheard, P., & Braithwaite, A. W. (2003). Nuclear localization of Y-box factor YB1 requires wild-type p53. Oncogene, 22, 2782-2794. doi: 10.1038/sj.onc.1206357

Sheard, P. W., Paul, A., & Duxson, M. J. (2002). Intramuscular force transmission. Advances in Experimental Medicine & Biology, 508, 495-499.

Sheard, P. W., Musaad, K., & Duxson, M. J. (2002). Distribution of neurotrophin receptors in the mouse neuromuscular system. International Journal of Developmental Biology, 46, 569-575.

Paul, A. C., Sheard, P. W., Kaufman, S. J., & Duxson, M. J. (2002). Localization of α7 integrins and dystrophin suggests potential for both lateral and longitudinal transmission of tension in large mammalian muscles. Cell & Tissue Research, 308, 255-265.

Sheard, P. W. (2000). Tension delivery from short fibers in long muscles. Exercise & Sport Sciences Reviews, 28(2), 51-56.

Scarlett, J. L., Sheard, P. W., Hughes, G., Ledgerwood, E. C., Ku, H.-H., & Murphy, M. P. (2000). Changes in mitochondrial membrane potential during staurosporine-induced apoptosis in Jurkat cells. FEBS Letters, 475, 267-272.

Young, M., Paul, A., Rodda, J., Duxson, M. J., & Sheard, P. W. (2000). Examination of intrafascicular muscle fiber terminations: Implications for tension delivery in series-fibered muscles. Journal of Morphology, 245, 130-145.

James, A. M., Sheard, P. W., Wei, Y.-H., & Murphy, M. P. (1999). Decreased ATP synthesis is phenotypically expressed during increased energy demand in fibroblasts containing mitochondrial tRNA mutations: Implications for neurodegenerative and mitochondrial DNA diseases. European Journal of Biochemistry, 259, 462-469.

Sheard, P. W., McHannigan, P., & Duxson, M. J. (1999). Single and paired motor unit performance in skeletal muscles: Comparison between simple and series-fibred muscles from the rat and the guinea pig. Basic & Applied Myology, 9(2), 79-87.

Woolley, A., Sheard, P. W., Dodds, K. G., & Duxson, M. J. (1999). Alpha motoneurons are present in normal numbers but with reduced soma size in neurotrophin-3 knockout mice. Neuroscience Letters, 272, 107-110.

Porteous, W. K., James, A. M., Sheard, P. W., Porteous, C., Packer, M., Hyslop, S. J., Melton, J. V., … Murphy, M. P. (1998). Bioenergetic consequences of accumulating the common 4977-bp mitochondrial DNA deletion. European Journal of Biochemistry, 257, 192-201.

Sheard, P. W., & Duxson, M. J. (1997). The transient existence of "en passant" nerve terminals in normal embryonic rat skeletal muscle. Brain Research. Developmental Brain Research, 98(2), 259-264.

Beazley, L. D., Sheard, P. W., Tennant, M., Starac, D., & Dunlop, S. A. (1997). Optic nerve regenerates but does not restore topographic projections in the lizard Ctenophorus ornatus. Journal of Comparative Neurology, 377(1), 105-120.

Sheard, P. W., Oettli, H. E., Johnson, A. J., & Duxson, M. J. (1997). Variations in oxidative enzyme type profiles among prenatal rat lumbar motoneurons. Brain Research. Developmental Brain Research, 103(1), 67-75.

Sheard, P. W., & Duxson, M. J. (1996). Composition of newly forming motor units in prenatal rat intercostal muscle. Developmental Dynamics, 205, 196-212.

Duxson, M. J., & Sheard, P. W. (1995). Formation of new myotubes occurs exclusively at the multiple innervation zones of an embryonic large muscle. Developmental Dynamics, 204, 391-405.

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Journal - Professional & Other Non-Research Articles

Davies, T. M., Sheard, P. W., & Cornwall, J. (2016). Comment on Makino et al. and observations on spatial modeling. Anatomical Science International, 91(4), 423-424. doi: 10.1007/s12565-016-0347-9

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Conference Contribution - Published proceedings: Abstract

Nielsen, K., & Sheard, P. (2017). The protective role of endurance exercise in age-related loss of muscle mass. Australasian Journal on Ageing, 36(Suppl. 1), (pp. 21). doi: 10.1111/ajag.12395

Cornwall, J., Lal, N., Slatter, T., Rowlands, D., & Sheard, P. (2017). Autophagic dysfunction has a key role in age-related myofibre death. Australasian Journal on Ageing, 36(Suppl. 1), (pp. 20). doi: 10.1111/ajag.12395

Sheard, P., Brady, J., Nielsen, K., & Cornwall, J. (2017). Age and exercise-related changes in Neurotrophin-r and Neuregulin amongst mouse lumbar motoneurons. Australasian Journal on Ageing, 36(Suppl. 1), (pp. 20). doi: 10.1111/ajag.12395

Brady, J., & Sheard, P. (2015). Implementation of internal intensity controls for semi-quantitative fluorescence immunohistochemistry. Proceedings of the 27th National Conference on Microscopy. Retrieved from http://microscopy2015.otago.ac.nz/index.html

Brady, J., Gillon, A., Lal, N., & Sheard, P. (2015). Age-related declines in synaptic proteins, agrin and rapsyn, and their relevance to sarcopenia. Clinical Anatomy, 28(7), (pp. 940). doi: 10.1002/ca.22520

Lal, N., Cornwall, J., & Sheard, P. (2015). Elderly dying myofibers are characterized by Dystrophin Encircle Vacuoles and invaginations with Intracellular Localization (DEVILs). Clinical Anatomy, 28(7), (pp. 945-946). doi: 10.1002/ca.22520

Brady, J., Lal, N., & Sheard, P. (2015). Introducing an algorithm with user-defined parameters for improving consistency of immunofluorescence analysis. Proceedings of the 27th National Conference on Microscopy. Retrieved from http://microscopy2015.otago.ac.nz/index.html

Lal, N., Sheard, P., & Cornwall, J. (2014). Age-related myofibre death in human skeletal muscle may be evident by the appearance of vacuolated myofibres. Annals of Anatomy, 196(Suppl.), (pp. 106). doi: 10.1016/j.aanat.2014.05.035

Cornwall, J., & Sheard, P. (2014). Fibre types in human suboccipital muscles. Annals of Anatomy, 196(Suppl.), (pp. 88). doi: 10.1016/j.aanat.2014.05.035

Davies, T. M., Sheard, P. W., & Cornwall, J. (2013). Development of a novel statistical method to test spatial distribution of skeletal muscle fiber types. Clinical Anatomy, 26, (pp. 643). doi: 10.1002/ca.22235

Cornwall, J., & Sheard, P. (2012). Spatial aggregation of Type II fibres in human cervical muslces. Clinical Anatomy, 25(4), (pp. 533). doi: 10.1002/ca.22049

Tan, C., Sheard, P. W., & Jasoni, C. L. (2012). Sonic hedgehog stimulates gonadotropin releasing-hormone neuron axon growth. Proceedings of the Society for Neuroscience 42nd Annual Meeting. SfN. Retrieved from http://www.sfn.org/index.aspx?pagename=abstracts_am2012

Hennebry, A., Watson, T., Shavlakadze, T., Grounds, M. D., Sheard, P., Fiorotto, M., & McMahon, C. D. (2012). Overexpression of IGF-1 stimulates greater muscle development in the absence of myostatin, but reduces lifespan. Proceedings of the Medical Sciences Congress (MedSci). (pp. 39). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf

Cornwall, J., & Sheard, P. (2011). Spatial aggregation of type II fibres in human cervical muscles. Proceedings of the 8th Annual Conference of the Australian and New Zealand Association of Clinical Anatomists (ANZACA): New Insights: Implications for Clinical Practice. (pp. 22). Retrieved from http://anzaca.otago.ac.nz/images/anzaca2011/anzaca2011_abstracts.pdf

Woolley, A., Sheard, P. W., & Duxson, M. J. (2002). Effects of NT-3 deficit on mouse neuromuscular development. Proceedings of the Third (2002) Asia Pacific Symposium on Neural Regeneration. (pp. 64). [Abstract]

Sheard, P. W., Paul, A., McHannigan, P., Young, M. A., & Duxson, M. J. (2001). Intramuscular force transmission. In S. Gandevia, U. Proske & D. Stuart (Eds.), International Union of Physiological Sciences Satellite Meeting on Movement and Sensation. (pp. S57). [Abstract]

Sheard, P. W., Shaw, J., & Duxson, M. J. (2000). Impaired neuromuscular performance among neurotropin-3 deficient mice. Proceedings of the Physiological Society of New Zealand. 19, (pp. 19). [Abstract]

Shaw, J., Duxson, M. J., & Sheard, P. W. (2000). Improved neuromuscular performance following nerve crush in neurotrophin-3 deficient mice. Proceedings of the University of Otago Medical School. 78(1), (pp. 16). Dunedin, New Zealand: University Print. [Abstract]

Paul, A. C., Sheard, P. W., & Duxson, M. J. (1998). Mechanisms of tension transmission in mammalian muscles with series-fibred architecture. Proceedings of the University of Otago Medical School. 76, (pp. 10). [Abstract]

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Conference Contribution - Poster Presentation (not in published proceedings)

Bewick, G. S., & Sheard, P. W. (2006, August). Abnormal synaptic vesicle dynamics at the motor nerve terminals of neurotrophin-3 deficient mice. Poster session presented at the Scottish Neuroscience Group Meeting, Dundee, Scotland.

Sheard, P. W., & Bewick, G. S. (2005, December). Abnormal synaptic vesicle dynamics at the motor nerve terminals of neurotrophin-3 deficient mice. Poster session presented at the Medical Sciences Congress, Queenstown, New Zealand.

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Conference Contribution - Verbal presentation and other Conference outputs

Lal, N., & Sheard, P. (2014, September). Autophagic dysfunction accompanies myofibre death with age and predominantly affects the innervated myofibres in elderly mouse skeletal muscles. Verbal presentation at the New Zealand Association of Gerontology Conference: The Age of Ageing, Dunedin, New Zealand.

Gillon, A. P., & Sheard, P. W. (2014, September). A role for terminal Schwann cells in age related degeneration of the motor nerve terminal? Verbal presentation at the New Zealand Association of Gerontology Conference: The Age of Ageing, Dunedin, New Zealand.

Brady, J., Gillon, A. P., & Sheard, P. W. (2014, September). Altered expression of the synaptic proteins agrin and rapsyn with age: Implications for sarcopenia. Verbal presentation at the New Zealand Association of Gerontology Conference: The Age of Ageing, Dunedin, New Zealand.

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Web Site Conference Proceedings - prior to 2003

Mabuchi, A., Mullaney, I., Sheard, P. W., Hessian, P. A., Zimmermann, A., Senoo, H., & Wheatley, A. M. (2002). Role of hepatic stellate cells in the early phase of liver regeneration in rat: formation of tight adhesions to parenchymal cells. Retrieved from http://www.comparative-hepatology.com/

Mabuchi, A., Mullaney, I., Sheard, P. W., Hessian, P. A., Zimmermann, A., Senoo, H., & Wheatley, A. M. (2002). Role of hepatic stellate cells in the early phase of liver regeneration in rat: formation of tight adhesions to parenchymal cells. Retrieved from http://www.comparative-hepatology.com/

More publications...

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