My research focuses on investigating the mechanisms that underlie heart failure and vascular disease particularly in the context of hypertension and diabetes. To this end, we have developed a number of novel tools to assess cardiovascular signaling pathways.
- FRET-based biosensors to measure kinase activity and localization in living cells
- Custom antibodies to measure biochemical modifications of proteins
- A variety of animal models with enhanced or reduced susceptibility to cardiovascular pathology.
With this research, we hope to contribute new understanding to the molecular basis of cardiovascular signaling that will culminate in potential clinical therapies for heart disease and atherosclerosis.
- Identifying the mechanism by which CaMKII regulates cellular signaling in the diabetic heart
- The role of CaMKII in vascular physiology and pathology
- Nitric oxide as a mediator of cardiac signaling
- Health Research Council Project Grant
- Royal Society of New Zealand Marsden Fast Start Research Grant
- University of Otago Research Grant
- American Heart Association Scientist Development Grant
- National Institute of Health T32 Fellowship
Roberts-Craig, F. T., Worthington, L. P., O'Hara, S. P., Erickson, J. R., Heather, A. K., & Ashley, Z. (2022). CaMKII splice variants in vascular smooth muscle cells: The next step or redundancy? International Journal of Molecular Sciences, 23, 7916. doi: 10.3390/ijms23147916