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Cardiovascular and respiratory physiology

Overview

Many laboratories with the Department of Physiology conduct research concerned with the regulation of cardiovascular and respiratory function in both health and disease.

Specific areas of interest include:

  • How hormonal, neuronal, and intrinsic processes control the heart
  • Understanding the vasculature of the lungs
  • Describing calcium regulation of heart rhythms
  • Identifying pathogenic mechanisms operating in diseases such as obesity, diabetes, heart failure, hypertension, and cardiac arrhythmia

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Cardiovascular and respiratory physiology research techniques

We use a range of whole animal, whole organ, cellular, molecular, and genetic techniques to investigate heart, lung, and blood vessel function.

Researchers in this group have expertise in the following techniques:

  • Animal models of disease (eg diabetes, cardiac arrhythmias, myocardial and limb ischemia, obesity, vascular calcification)
  • Cardiac haemodynamics (eg echocardiography)
  • Cell culture (eg stem cells, cell differentiation)
  • Cell signalling (eg phosphorylation, oxidation, inflammation)
  • Genetic modulation of the heart (e.g., microRNA, hereditary mutations)
  • Histochemistry (eg atherosclerosis plaque assessment, collagen deposition)
  • Isolated and innervated heart preparations (eg Langendorff, trabeculae)
  • Microangiography
  • Protein analysis (eg immunohistochemistry, western blotting)
  • Radiotelemetry (eg sympathetic nerve activity, blood pressure)
  • Tissue engineering (eg iPSC derived cardiac progenitor cells)

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