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Lab personnel

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Research interests

My principal research interest is in how calcium cycling is controlled in cardiac myocytes. In particular, my focus is on the mechanisms by which calcium release from intra-cellular stores (sarcoplasmic reticulum, SR) is controlled by the cardiac ryanodine receptor (RyR2). The aim of my research is to characterize how the activity of RyR2 is altered both physiologically and in disease. This is achieved using a broad spectrum of assays from molecular biology and single channel recordings, through to isolated cardiac myocytes and ultimately whole animal models.

Keywords

Arrhythmia, RyR2, calcium, sarcoplasmic reticulum, RyR1, malignant hyperthermia

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Current funding

  • 2016–2019 Royal Society of New Zealand Marsden Fund
  • 2015–2017 Heart Foundation of New Zealand
  • 2015 Lottery Health Equipment Grant
  • 2014–2015 University of Otago Research Grant

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Previous funding

  • 2013 Healthcare Otago Trust
  • 2013 Heart Foundation of New Zealand
  • 2012–2013 Otago Medical Research Foundation, Laurenson Award
  • 2011–2014 Royal Society of New Zealand Marsden Fund
  • 2011–2012 Lottery Health Research

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Collaborators

  • Badrilla Ltd (characterisation of phosphor-specific cardiac antibodies)

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Publications

Gardner, R. J. M., Crozier, I. G., Binfield, A. L., Love, D. R., Lehnert, K., Gibson, K., … Jones, P. P., … Kennedy, M. A., & Skinner, J. R. (2019). Penetrance and expressivity of the R858H CACNA1C variant in a five-generation pedigree segregating an arrhythmogenic channelopathy. Molecular Genetics & Genomic Medicine, 7(1), e00476. doi: 10.1002/mgg3.476

Aitken-Buck, H. M., Babakr, A. A., Coffey, S., Jones, P. P., Tse, R. D., & Lamberts, R. R. (2019). Epicardial adipocyte size does not correlate with body mass index. Cardiovascular Pathology. Advance online publication. doi: 10.1016/j.carpath.2019.07.003

Aitken-Buck, H. M., Moharram, M., Babakr, A., van Hout, I., Fomison-Nurse, I., Reijers, R., … Williams, M., Jones, P., Coffey, S., & Lamberts, R. (2019). Increasing general adiposity is not associated with hypertrophy of epicardial adipocytes in cardiac surgery patients. Heart, Lung & Circulation, 28(Suppl. 4), (pp. S177). doi: 10.1016/j.hlc.2019.06.101

Moharram, M., Aitken-Buck, H., Van Hout, I., Reijers, R., Williams, M., Whalley, G., Jones, P., Lamberts, R., & Coffey, S. (2019). Impact of ethnicity on the correlation between body mass index and epicardial adipose tissue. Heart, Lung & Circulation, 28(Suppl. 4), (pp. S251). doi: 10.1016/j.hlc.2019.06.276

Pearson, J. T., Collie, N., Lamberts, R. R., Inagaki, T., Yoshimoto, M., Umetani, K., … Wilkins, G., Jones, P. P., … Schwenke, D. O. (2018). Ghrelin preserves ischemia-induced vasodilation of male rat coronary vessels following beta-adrenergic receptor blockade. Endocrinology, 159(4), 1763-1773. doi: 10.1210/en.2017-03070

Chakraborty, A. D., Gonano, L. A., Munro, M. L., Smith, L. J., Thekkedam, C., Staudacher, V., Gamble, A. B., … Jones, P. P. (2018). Activation of RyR2 by class I kinase inhibitors. British Journal of Pharmacology. Advance online publication. doi: 10.1111/bph.14562

Daniels, L. J., Wallace, R. S., Nicholson, O. M., Wilson, G. A., McDonald, F. J., Jones, P. P., Baldi, J. C., Lamberts, R. R., & Erickson, J. R. (2018). Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats. Cardiovascular Diabetology, 17, 89. doi: 10.1186/s12933-018-0732-x

Jones, P. P., MacQuaide, N., & Louch, W. E. (2018). Dyadic plasticity in cardiomyocytes. Frontiers in Physiology, 9, 1773. doi: 10.3389/fphys.2018.01773

Babakr, A. A., Fomison-Nurse, I. C., Jones, P. P., & Lamberts, R. R. (2018). Does human epicardial adipose tissue enhance atrial fibrillation induced by beta adrenergic stimulation in human cardiac muscles? Cardiovascular Research, 114(Suppl. 1), (pp. S11). doi: 10.1093/cvr/cvy060.018

Lamberts, R. R., Babakr, A. A., Fomison-Nurse, I. C., & Jones, P. P. (2018). Effect of human epicardial adipose tissue on calcium-overload-induced atrial fibrillation in human cardiac muscles. Cardiovascular Research, 114(Suppl. 1), (pp. S34). doi: 10.1093/cvr/cvy060.093

Babakr, A., Fomison-Nurse, I., Van Hout, I., Davis, P., Sugunesegran, R., Crouch, G., … Coffey, S., Bunton, R., Jones, P., & Lamberts, R. (2018). Human epicardial adipose tissue promotes atrial fibrillation through β1-but not β3-adrenergic receptors. Heart, Lung & Circulation, 27(Suppl. 2), (pp. S168). doi: 10.1016/j.hlc.2018.06.283

Gonano, L. A., & Jones, P. P. (2017). FK506-binding proteins 12 and 12.6 (FKBPs) as regulators of cardiac Ryanodine Receptors: Insights from new functional and structural knowledge. Channels, 11(5), 415-425. doi: 10.1080/19336950.2017.1344799

Jones, P. P., Guo, W., & Chen, S. R. W. (2017). Control of cardiac ryanodine receptor by sarcoplasmic reticulum luminal Ca2+. Journal of General Physiology, 149(9), 867-875. doi: 10.1085/jgp.201711805

Jones, P., Chakraborty, A., Gonano, L. A., & Dulhunty, A. (2017). Arrhythmogenic ATP-based kinase inhibitors directly increase the activity of RyR2. Heart, Lung & Circulation, 26(Suppl. 2), (pp. S158). doi: 10.1016/j.hlc.2017.06.262

Chakraborty, A., Gonano, L., McLay, J., Dulhunty, A., & Jones, P. (2017). Arrhythmogenic ATP based kinase inhibitors directly increase the activity of RyR2. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 11). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html

Parveen, S., Lamberts, R., & Jones, P. (2017). Understanding heart rate generation in type 2 diabetes. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 70-71). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html

Parveen, S., Lamberts, R. R., & Jones, P. P. (2017, September). Understanding altered heart rate generation in type 2 diabetes. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

van Hout, I., Nicholson, O., Erickson, J. R., Lamberts, R. R., & Jones, P. P. (2017, September). Alterations in calcium handling proteins in diabetic and non-diabetic patient with or without post-operative atrial fibrillation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Babakr, A. A., Fomison-Nurse, I. C., Jones, P. P., & Lamberts, R. R. (2017, September). Does epicardial adipose tissue make the human heart more susceptible to atrial fibrillation? Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Waddell, H. M. M., Zhang, J. Z., Hoeksema, K. J., McLachlan, J. J., McLay, J. C., & Jones, P. P. (2016). Oxidation of RyR2 has a biphasic effect on the threshold for store overload-induced calcium release. Biophysical Journal, 110(11), 2386-2396. doi: 10.1016/j.bpj.2016.04.036

Xiao, Z., Guo, W., Sun, B., Hunt, D. J., Wei, J., Liu, Y., … Jones, P. P., … Chen, S. R. W. (2016). Enhanced cytosolic Ca2+ activation underlies a common defect of central domain cardiac ryanodine receptor mutations linked to arrhythmias. Journal of Biological Chemistry, 291(47), 24528-24537. doi: 10.1074/jbc.M116.756528

Zhang, J. Z., Waddell, H. M. M., Wu, E., Dholakia, J., Okolo, C. A., McLay, J. C., & Jones, P. P. (2016). FKBPs facilitate the termination of spontaneous Ca2+ release in wild-type RyR2 but not CPVT mutant RyR2. Biochemical Journal, 473(14), 2049-2060. doi: 10.1042/bcj20160389

Diong, C., Jones, P. P., Tsuchimochi, H., Gray, E. A., Hughes, G., Inagaki, T., Bussey, C. T., … Schwenke, D. O. (2016). Sympathetic hyper-excitation in obesity and pulmonary hypertension: Physiological relevance to the 'obesity paradox'. International Journal of Obesity, 40, 938-946. doi: 10.1038/ijo.2016.33

Babakr, A., Lamberts, R., & Jones, P. (2016, August-September). How does epicardial adipose tissue make the human heart more susceptible to atrial fibrillation? Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Gonano, L. A., Sepúlveda, M., Morell, M., Tottef, T., Jones, P. P., Back, T. G., … Petroff, M. V. (2016, August). Carvedilol and its non-ß-blocking analog VK-II-86 prevent digitalis-induced Ca++ waves in cardiac myocytes. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Journal - Research Article

Gardner, R. J. M., Crozier, I. G., Binfield, A. L., Love, D. R., Lehnert, K., Gibson, K., … Jones, P. P., … Kennedy, M. A., & Skinner, J. R. (2019). Penetrance and expressivity of the R858H CACNA1C variant in a five-generation pedigree segregating an arrhythmogenic channelopathy. Molecular Genetics & Genomic Medicine, 7(1), e00476. doi: 10.1002/mgg3.476

Aitken-Buck, H. M., Babakr, A. A., Coffey, S., Jones, P. P., Tse, R. D., & Lamberts, R. R. (2019). Epicardial adipocyte size does not correlate with body mass index. Cardiovascular Pathology. Advance online publication. doi: 10.1016/j.carpath.2019.07.003

Pearson, J. T., Collie, N., Lamberts, R. R., Inagaki, T., Yoshimoto, M., Umetani, K., … Wilkins, G., Jones, P. P., … Schwenke, D. O. (2018). Ghrelin preserves ischemia-induced vasodilation of male rat coronary vessels following beta-adrenergic receptor blockade. Endocrinology, 159(4), 1763-1773. doi: 10.1210/en.2017-03070

Daniels, L. J., Wallace, R. S., Nicholson, O. M., Wilson, G. A., McDonald, F. J., Jones, P. P., Baldi, J. C., Lamberts, R. R., & Erickson, J. R. (2018). Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats. Cardiovascular Diabetology, 17, 89. doi: 10.1186/s12933-018-0732-x

Chakraborty, A. D., Gonano, L. A., Munro, M. L., Smith, L. J., Thekkedam, C., Staudacher, V., Gamble, A. B., … Jones, P. P. (2018). Activation of RyR2 by class I kinase inhibitors. British Journal of Pharmacology. Advance online publication. doi: 10.1111/bph.14562

Gonano, L. A., & Jones, P. P. (2017). FK506-binding proteins 12 and 12.6 (FKBPs) as regulators of cardiac Ryanodine Receptors: Insights from new functional and structural knowledge. Channels, 11(5), 415-425. doi: 10.1080/19336950.2017.1344799

Waddell, H. M. M., Zhang, J. Z., Hoeksema, K. J., McLachlan, J. J., McLay, J. C., & Jones, P. P. (2016). Oxidation of RyR2 has a biphasic effect on the threshold for store overload-induced calcium release. Biophysical Journal, 110(11), 2386-2396. doi: 10.1016/j.bpj.2016.04.036

Diong, C., Jones, P. P., Tsuchimochi, H., Gray, E. A., Hughes, G., Inagaki, T., Bussey, C. T., … Schwenke, D. O. (2016). Sympathetic hyper-excitation in obesity and pulmonary hypertension: Physiological relevance to the 'obesity paradox'. International Journal of Obesity, 40, 938-946. doi: 10.1038/ijo.2016.33

Zhang, J. Z., Waddell, H. M. M., Wu, E., Dholakia, J., Okolo, C. A., McLay, J. C., & Jones, P. P. (2016). FKBPs facilitate the termination of spontaneous Ca2+ release in wild-type RyR2 but not CPVT mutant RyR2. Biochemical Journal, 473(14), 2049-2060. doi: 10.1042/bcj20160389

Xiao, Z., Guo, W., Sun, B., Hunt, D. J., Wei, J., Liu, Y., … Jones, P. P., … Chen, S. R. W. (2016). Enhanced cytosolic Ca2+ activation underlies a common defect of central domain cardiac ryanodine receptor mutations linked to arrhythmias. Journal of Biological Chemistry, 291(47), 24528-24537. doi: 10.1074/jbc.M116.756528

Thaung, H. P. A., Baldi, J. C., Wang, H.-Y., Hughes, G., Cook, R. F., Bussey, C. T., Sheard, P. W., Bahn, A., Jones, P. P., Schwenke, D. O., & Lamberts, R. R. (2015). Increased efferent cardiac sympathetic nerve activity and defective intrinsic heart rate regulation in type 2 diabetes. Diabetes, 64(8), 2944-2956. doi: 10.2337/db14-0955

Liu, Y., Sun, B., Xiao, Z., Wang, R., Guo, W., Zhang, J. Z., … Jones, P. P., … Chen, S. R. W. (2015). Roles of the NH2-terminal domains of cardiac ryanodine receptor in Ca2+ release activation and termination. Journal of Biological Chemistry, 290(12), 7736-7746. doi: 10.1074/jbc.M114.618827

Mi, T., Xiao, Z., Guo, W., Tang, Y., Hiess, F., Xiao, J., … Zhang, J. Z., … Jones, P. P., & Chen, S. R. W. (2015). Role of Cys3602 in the function and regulation of the cardiac ryanodine receptor. Biochemical Journal, 467(1), 177-190. doi: 10.1042/BJ20141263

Bussey, C. T., Hughes, G., Saxena, P., Galvin, I. F., Bunton, R. W., Noye, M. K., Coffey, S., Williams, M. J. A., Baldi, J. C., Jones, P. P., & Lamberts, R. R. (2015). Chamber-specific changes in calcium-handling proteins in the type 2 diabetic human heart with preserved ejection fraction. International Journal of Cardiology, 193, 53-55. doi: 10.1016/j.ijcard.2015.05.053

Thaung, H. P. A., Yao, Y., Bussey, C. T., Hughes, G., Jones, P. P., Bahn, A., Sammut, I. A., & Lamberts, R. R. (2015). Chronic bilateral renal denervation reduces cardiac hypertrophic remodelling but not β-adrenergic responsiveness in hypertensive type 1 diabetic rats. Experimental Physiology, 100(6), 628-639. doi: 10.1113/EP085021

Chen, W., Wang, R., Chen, B., Zhong, X., Kong, H., Bai, Y., … Jones, P. P., … Chen, S. R. W. (2014). The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias. Nature Medicine, 20(2), 184-192. doi: 10.1038/nm.3440

Lamberts, R. R., Lingam, S. J., Wang, H.-Y., Bollen, I. A. E., Hughes, G., Galvin, I. F., Bunton, R. W., Bahn, A., Katare, R., Baldi, J. C., Williams, M. J. A., Saxena, P., Coffey, S., & Jones, P. P. (2014). Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction. Cardiovascular Diabetology, 13, 72. doi: 10.1186/1475-2840-13-72

Zhang, J. Z., McLay, J. C., & Jones, P. P. (2014). The arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca2+ release due to an impaired ability to buffer store Ca2+. Journal of Molecular & Cellular Cardiology, 74, 22-31. doi: 10.1016/j.yjmcc.2014.04.019

Bai, Y., Jones, P. P., Guo, J., Zhong, X., Clark, R. B., Zhou, Q., … Chen, S. R. W. (2013). Phospholamban knockout breaks arrhythmogenic Ca2+ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice. Circulation Research, 113, 517-526. doi: 10.1161/circresaha.113.301678

Liu, Y., Kimlicka, L., Heiss, F., Tian, X., Wang, R., Zhang, L., Jones, P. P., … Chen, S. R. W. (2013). The CPVT-associated RyR2 mutation G230C enhances store overloadinduced Ca2+ release and destabilizes the N-terminal domains. Biochemical Journal, 454(1), 123-131. doi: 10.1042/BJ20130594

Wang, R., Zhong, X., Meng, X., Koop, A., Tian, X., Jones, P. P., … Chen, S. R. W. (2011). Localization of the dantrolene-binding sequence near the FK506-binding protein-binding site in the three-dimensional structure of the ryanodine receptor. Journal of Biological Chemistry, 286(14), 12202-12212. doi: 10.1074/jbc.M110.194316

Zhou, Q., Xiao, J., Jiang, D., Wang, R., Vembaiyan, K., Wang, A., … Jones, P. P., … Chen, S. R. W. (2011). Carvedilol and its new analogs suppress arrhythmogenic store overload—induced Ca2+ release. Nature Medicine, 17, 1003-1009. doi: 10.1038/nm.2406

Beca, S., Helliwell, P. B., Simpson, J. A., Zhao, D., Farman, G. P., Jones, P. P., … Backx, P. H. (2011). Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-Type Ca2+ current. Circulation Research, 109(9), 1024-1030. doi: 10.1161/CIRCRESAHA.111.250464

Jiang, D., Jones, P. P., Davis, D. R., Gow, R., Green, M. S., Birnie, D. H., … Gollob, M. H. (2010). Characterization of a novel mutation in the cardiac ryanodine receptor that results in catecholaminergic polymorphic ventricular tachycardia. Channels, 4(4), 12666. doi: 10.4161/chan.4.4.12666

Mufti, R. E., Brett, S. E., Tran, C. H. T., El-Rahman, R. A., Anfinogenova, Y., El-Yazbi, A., … Jones, P. P., … Welsh, D. G. (2010). Intravascular pressure augments cerebral arterial constriction by inducing voltage-insensitive Ca2+ waves. Journal of Physiology, 588(20), 3983-4005. doi: 10.1113/jphysiol.2010.193300

Jones, P. P., Jiang, D., Bolstad, J., Hunt, D. J., Zhang, L., Demaurex, N., & Chen, S. R. W. (2008). Endoplasmic reticulum Ca2+ measurements reveal that the cardiac ryanodine receptor mutations linked to cardiac arrhythmia and sudden death alter the threshold for store-overload-induced Ca2+ release. Biochemical Journal, 412, 171-178. doi: 10.1042/BJ20071287

Kong, H., Jones, P. P., Koop, A., Zhang, L., Duff, H. J., & Chen, S. R. W. (2008). Caffeine induces Ca2+ release by reducing the threshold for luminal Ca2+ activation of the ryanodine receptor. Biochemical Journal, 414, 441-452. doi: 10.1042/BJ20080489

Jiang, D., Chen, W., Xiao, J., Wang, R., Kong, H., & Jones, P. P. (2008). Reduced threshold for luminal Ca2+ activation of RyR1 underlies a causal mechanism of porcine malignant hyperthermia. Journal of Biological Chemistry, 283(30), 20813-20820. doi: 10.1074/jbc.M801944200

Jones, P. P., Meng, X., Xiao, B., Cai, S., Bolstad, J., Wagenknecht, T., … Chen, S. R. W. (2008). Localization of PKA phosphorylation site, Ser2030, in the three-dimensional structure of cardiac ryanodine receptor. Biochemical Journal, 410, 261-270. doi: 10.1042/BJ20071257

Hunt, D. J., Jones, P. P., Wang, R., Chen, W., Bolstad, J., Chen, K., … Chen, S. R. W. (2007). K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochemical Journal, 404, 431-438. doi: 10.1042/BJ20070135

Xiao, J., Tian, X., Jones, P. P., Bolstad, J., Kong, H., Wang, R., … Chen, S. R. W. (2007). Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias. Journal of Biological Chemistry, 282(48), 34828-34838. doi: 10.1074/jbc.M707423200

Xiao, B., Tian, X., Xie, W., Jones, P. P., Cai, S., Wang, X., … Chen, S. R. W. (2007). Functional consequence of protein kinase A-dependent phosphorylation of the cardiac ryanodine receptor: Sensitization of store overload-induced Ca2+ release. Journal of Biological Chemistry, 282(41), 30256-30264. doi: 10.1074/jbc.M703510200

Jones, P. P., Bazzazi, H., Kargacin, G. J., & Colyer, J. (2006). Inhibition of cAMP-dependent protein kinase under conditions occurring in the cardiac dyad during a Ca2+ transient. Biophysical Journal, 91, 433-443. doi: 10.1529/biophysj.106.083931

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Journal - Research Other

Jones, P. P., MacQuaide, N., & Louch, W. E. (2018). Dyadic plasticity in cardiomyocytes. Frontiers in Physiology, 9, 1773. doi: 10.3389/fphys.2018.01773

Jones, P. P., Guo, W., & Chen, S. R. W. (2017). Control of cardiac ryanodine receptor by sarcoplasmic reticulum luminal Ca2+. Journal of General Physiology, 149(9), 867-875. doi: 10.1085/jgp.201711805

Jones, P. P., & Braun, A. P. (2009). Store operated Ca2+ entry (SOCE) [Commentary]. Channels, 3(1), 1-2. doi: 10.4161/chan.3.1.7983

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Conference Contribution - Published proceedings: Full paper

Zhang, J. Z., Waddell, H. M. M., & Jones, P. P. (2015). Regulation of RyR2 by sarcoplasmic reticulum Ca2+. Clinical & Experimental Pharmacology & Physiology, 42(6), (pp. 720-726). doi: 10.1111/1440-1681.12364

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Conference Contribution - Published proceedings: Abstract

Aitken-Buck, H. M., Moharram, M., Babakr, A., van Hout, I., Fomison-Nurse, I., Reijers, R., … Williams, M., Jones, P., Coffey, S., & Lamberts, R. (2019). Increasing general adiposity is not associated with hypertrophy of epicardial adipocytes in cardiac surgery patients. Heart, Lung & Circulation, 28(Suppl. 4), (pp. S177). doi: 10.1016/j.hlc.2019.06.101

Moharram, M., Aitken-Buck, H., Van Hout, I., Reijers, R., Williams, M., Whalley, G., Jones, P., Lamberts, R., & Coffey, S. (2019). Impact of ethnicity on the correlation between body mass index and epicardial adipose tissue. Heart, Lung & Circulation, 28(Suppl. 4), (pp. S251). doi: 10.1016/j.hlc.2019.06.276

Babakr, A. A., Fomison-Nurse, I. C., Jones, P. P., & Lamberts, R. R. (2018). Does human epicardial adipose tissue enhance atrial fibrillation induced by beta adrenergic stimulation in human cardiac muscles? Cardiovascular Research, 114(Suppl. 1), (pp. S11). doi: 10.1093/cvr/cvy060.018

Babakr, A., Fomison-Nurse, I., Van Hout, I., Davis, P., Sugunesegran, R., Crouch, G., … Coffey, S., Bunton, R., Jones, P., & Lamberts, R. (2018). Human epicardial adipose tissue promotes atrial fibrillation through β1-but not β3-adrenergic receptors. Heart, Lung & Circulation, 27(Suppl. 2), (pp. S168). doi: 10.1016/j.hlc.2018.06.283

Lamberts, R. R., Babakr, A. A., Fomison-Nurse, I. C., & Jones, P. P. (2018). Effect of human epicardial adipose tissue on calcium-overload-induced atrial fibrillation in human cardiac muscles. Cardiovascular Research, 114(Suppl. 1), (pp. S34). doi: 10.1093/cvr/cvy060.093

Jones, P., Chakraborty, A., Gonano, L. A., & Dulhunty, A. (2017). Arrhythmogenic ATP-based kinase inhibitors directly increase the activity of RyR2. Heart, Lung & Circulation, 26(Suppl. 2), (pp. S158). doi: 10.1016/j.hlc.2017.06.262

Parveen, S., Lamberts, R., & Jones, P. (2017). Understanding heart rate generation in type 2 diabetes. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 70-71). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html

Chakraborty, A., Gonano, L., McLay, J., Dulhunty, A., & Jones, P. (2017). Arrhythmogenic ATP based kinase inhibitors directly increase the activity of RyR2. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 11). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html

Lamberts, R. R., Hughes, G., Bussey, C. T., Saxena, P., Galvin, I. F., Noye, M. K., Coffey, S., Williams, M. J. A., Baldi, J. C., Jones, P. P., on behalf of HeartOtago. (2015). Left ventricular calcium-handling proteins in the type 2 diabetic human heart with preserved ejection fraction. European Heart Journal, 36(Suppl. 1), (pp. 312-313). doi: 10.1093/eurheartj/ehv399

Zhang, J. Z., McLay, J., & Jones, P. P. (2014). Regulation of cardiac ryanodine receptor by histidine rich Ca2+ binding protein. Proceedings of the Medical Sciences Congress (MedSci). (pp. 17). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Jones, P. P., Bai, Y., Guo, J., Zhong, X., Clark, R. B., Zhou, Q., … Chen, S. R. (2014). Phospholamban knockout breaks arrhythmogenic Ca2+ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice. Proceedings of the Medical Sciences Congress (MedSci). (pp. 7). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Diong, C., Gray, E., Jones, P., & Schwenke, D. (2013). Increased sympathetic activity in obesity may protect against pulmonary hypertension. New Zealand Medical Journal, 126(1386). Retrieved from http://www.nzma.org.nz/journal

Lamberts, R., Lingam, S., Wang, S., Saxena, P., Galvin, I., Bunton, R., Williams, M., Coffey, S., Baldi, J., & Jones, P. (2013). Impaired functional relaxation despite upregulated calcium handling proteins in human diabetic myocardium. Heart, Lung & Circulation, 22(Suppl. 1), (pp. S57). doi: 10.1016/j.hlc.2013.05.137

Zhang, J., McLay, J., & Jones, P. (2013). Histidine-rich Ca2+ binding protein inhibits the propensity for store overload-induced Ca2+ release (SOICR). Heart, Lung & Circulation, 22(Suuppl. 1), (pp. S78). doi: 10.1016/j.hlc.2013.05.186

Deo, M., McLay, J., & Jones, P. (2012). Triadin decreases the propensity for Store Overload Induced Calcium Release (SOICR). New Zealand Medical Journal, 125(1367). Retrieved from http://www.nzma.org.nz/journal

Lingam, S. J., Saxena, P., Coffey, S., Baldi, J. C., Lamberts, R. R., & Jones, P. P. (2012). Hastened relaxation in a non-failing diabetic heart. Proceedings of the Medical Sciences Congress (MedSci). (pp. 67). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf

Jones, P. P. (2012). From dyes to proteins, imaging subcellular calcium events. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 30th International Australasian Winter Conference on Brain Research. 30, (pp. 70). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2012.html

Deo, M., Wu, E., McLay, J., & Jones, P. P. (2012). Proteins associated with the cardiac ryanodine receptor alter the threshold for store overload-induced calcium release. Heart, Lung & Circulation, 21(12), (pp. 860). doi: 10.1016/j.hlc.2012.08.023

Lingam, S., Saxena, P., Coffey, S., Williams, M., Baldi, J., Lamberts, R., & Jones, P. (2012). Improved atrial relaxation in human type 2 diabetes mellitus. New Zealand Medical Journal, 125(1367). Retrieved from http://www.nzma.org.nz/journal

Deo, M., McLay, J., & Jones, P. P. (2012). The RyR2 binding protein triadin decreases the propensity for store overload induced Ca2+ release. Proceedings of the Medical Sciences Congress (MedSci). (pp. 66). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf

Jones, P., Bai, Y., Vallmitjana, A., Wang, R., Clark, R., Zhou, Q., … Chen, S. (2012). Disrupting Ca2+ waves, but not Ca2+ leak, protects against cardiac arrhythmia. Heart, Lung & Circulation, 21(Suppl. 1), (pp. S78). doi: 10.1016/j.hlc.2012.05.198

Mufti, R., Welsh, S. B., El-Rahman, R. A., Jones, P., Chen, W., & Welsh, D. (2010). The role of IP3 receptors in generating calcium waves and cerebral myogenic tone. FASEB Journal, 24(Meeting Abstracts), 1033.3. [Abstract]

Chen, S. R. W., Chen, W., Tian, X., Wang, R., Kong, H., O'Mara, M. L., Jones, P. P., … Tieleman, D. P. (2009). Molecular basis of luminal Ca2+ gating of the cardiac ryanodine receptor. Biophysical Journal. 96(3, Suppl. 1), (pp. 551a). doi: 10.1016/j.bpj.2008.12.2984

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Conference Contribution - Poster Presentation (not in published proceedings)

Parveen, S., Lamberts, R. R., & Jones, P. P. (2017, September). Understanding altered heart rate generation in type 2 diabetes. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Babakr, A., Lamberts, R., & Jones, P. (2016, August-September). How does epicardial adipose tissue make the human heart more susceptible to atrial fibrillation? Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Gonano, L. A., Sepúlveda, M., Morell, M., Tottef, T., Jones, P. P., Back, T. G., … Petroff, M. V. (2016, August). Carvedilol and its non-ß-blocking analog VK-II-86 prevent digitalis-induced Ca++ waves in cardiac myocytes. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Okolo, C. A., McLachlan, J. J., McLay, J., Erickson, J. R., & Jones, P. P. (2016, August). O-GlcNAcylation regulates RyR2 function directly. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Denny, A., Jones, P. P., Erickson, J. R., & Heather, A. K. (2016, August). Oxidised CaMKII: A novel mechanism in the pathophysiology of FSHD. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Chakraborty, A., McLay, J., & Jones, P. (2016, August). Regulation of RyR2 by protein kinase CK2. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Denny, A., Erickson, J. R., Jones, P. P., & Heather, A. K. (2016, August-September). RyR2 leak and CaMKII post-translational modifications in the heart: Can this explain the altered Ca2+ handling in FSHD? Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Okolo, C. A., McLachlan, J. J., McLay, J. C., Erickson, J. R., & Jones, P. P. (2016, August-September). O-GlcNAcylation regulates RyR2 function directly. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Waddell, H. M. M., McLay, J. C., & Jones, P. P. (2013, August). Oxidation of the cardiac ryanodine receptor reduces the threshold for spontaneous calcium release. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Hoeksema, K. J., McLay, J. C., & Jones, P. P. (2013, August). Assessing the efficacy of a new class of anti-arrhythmics in human atrial samples. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Zhang, J., McLay, J., & Jones, P. P. (2012, September). Histidine-rich CA2+ binding protein (HRC) attenuates the propensity for store overload-induced CA2+ release (SOICR). Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.

Lingam, S. J., Saxena, P., Coffey, S., Williams, M. J. A., Baldi, J. C., Lamberts, R. R., & Jones, P. P. (2012, September). Improved atrial relaxation in human type 2 diabetes mellitus. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.

Deo, M., McLay, J., & Jones, P. P. (2012, September). Luminal regulation of the RYR2 by triadin reduces the propensity for store overload induced calcium release. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.

Zhou, Q., Xiao, J., Jiang, D., Wang, R., Vembaiyan, K., Wang, A., … Jones, P. P., … Chen, S. R. W. (2011, August). Unique action of carvedilol and its novel analogues: Suppression of store-overload-induced Ca2+ release. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

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Conference Contribution - Verbal presentation and other Conference outputs

van Hout, I., Nicholson, O., Erickson, J. R., Lamberts, R. R., & Jones, P. P. (2017, September). Alterations in calcium handling proteins in diabetic and non-diabetic patient with or without post-operative atrial fibrillation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Babakr, A. A., Fomison-Nurse, I. C., Jones, P. P., & Lamberts, R. R. (2017, September). Does epicardial adipose tissue make the human heart more susceptible to atrial fibrillation? Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Chakraborty, A. D., McLay, J., & Jones, P. (2016, August-September). Regulation of RyR2 by protein kinase CK2. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Gonano, L. A., Sepúlveda, M., Morell, M., Tottef, T., Jones, P. P., Back, T. G., … Petroff, M. V. (2016, August-September). RyR2 dysfunction and digitalis toxicity. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

McLachlan, J., & Jones, P. (2016, August). Development of RyR2-based redox sensor for H2O2 quantification in cardiac dyad microdomain. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Jones, P. (2016, August-September). FKBPs facilitate the termination of spontaneous Ca2+ release in wild type RyR2 but not CPVT mutant RyR2. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Jones, P. (2014, November). Role of RyR2 in arrhythmia. Verbal presentation at the HeartOtago First Australasian Symposium: Bench to Bedside and Back: New Advances in Cardiovascular Research, Dunedin, New Zealand.

Diong, C. T., Gray, E. A., Jones, P., & Schwenke, D. O. (2013, August). Can sympathetic hyperexcitation in obesity protect against pulmonary hypertension? Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Lingam, S. J., Wang, S. H. Y., Saxena, P., Galvin, I. F., Bunton, R. W., Williams, M. J. A., Coffey, S., Baldi, J. C., Jones, P. P., & Lamberts, R. R. (2013, August). Relaxation in human diabetic myocardium. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Jones, P. P. (2012, August). From dyes to proteins: Imaging subcellular calcium events. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Jones, P. (2011, September). Regulation of RyR2 and its implications in arrhythmia. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Chen, S. R. W., Wang, R., Clark, R. B., Zhou, Q., & Jones, P. P. (2010, November-December). Increased calcium leak alone is not sufficient to cause arrhythmia. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

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