Lab personnel
- Associate Professor Pete Jones Associate Professor, Deputy (HOD) Research
- Dr Shane Ohline Postdoctoral Fellow
- Callum Tanner Assistant Research Fellow
- Isabelle van Hout Assistant Research Fellow
Research interests
My principal research interest is in how calcium cycling is controlled in cardiac myocytes. In particular, my focus is on the mechanisms by which calcium release from intra-cellular stores (sarcoplasmic reticulum, SR) is controlled by the cardiac ryanodine receptor (RyR2). The aim of my research is to characterize how the activity of RyR2 is altered both physiologically and in disease. This is achieved using a broad spectrum of assays from molecular biology and single channel recordings, through to isolated cardiac myocytes and ultimately whole animal models.
Keywords
Arrhythmia, RyR2, calcium, sarcoplasmic reticulum, RyR1, malignant hyperthermia
Current funding
- 2016–2019 Royal Society of New Zealand Marsden Fund
- 2015–2017 Heart Foundation of New Zealand
- 2015 Lottery Health Equipment Grant
- 2014–2015 University of Otago Research Grant
Previous funding
- 2013 Healthcare Otago Trust
- 2013 Heart Foundation of New Zealand
- 2012–2013 Otago Medical Research Foundation, Laurenson Award
- 2011–2014 Royal Society of New Zealand Marsden Fund
- 2011–2012 Lottery Health Research
Collaborators
- Badrilla Ltd (characterisation of phosphor-specific cardiac antibodies)
Publications
Frisk, M., Le, C., Shen, X., Røe, Å., Hou, Y., Manfra, O., … van Hout, I., … Lamberts, R. R., … Coffey, S., … Jones, P. P., … Louch, W. E. (2021). Etiology-dependent impairment of diastolic cardiomyocyte calcium homeostasis in heart failure with preserved ejection fraction. JACC, 77(4), 405-419. doi: 10.1016/j.jacc.2020.11.044
Aitken-Buck, H. M., Babakr, A. A., Fomison-Nurse, I. C., van Hout, I., Davis, P. J., Bunton, R. W., Williams, M. J. A., Coffey, S., Jones, P. P., & Lamberts, R. R. (2020). Inotropic and lusitropic, but not arrhythmogenic, effects of adipocytokine resistin on human atrial myocardium. American Journal of Physiology: Endocrinology & Metabolism. Advance online publication. doi: 10.1152/ajpendo.00202.2020
Moharram, M. A., Aitken-Buck, H. M., Reijers, R., van Hout, I., Williams, M. J. A., Jones, P. P., Whalley, G. A., Lamberts, R. R., & Coffey, S. (2020). Correlation between epicardial adipose tissue and body mass index in New Zealand ethnic populations. New Zealand Medical Journal, 133(1516), 22-32. Retrieved from https://www.nzma.org.nz/journal
Babakr, A. A., Fomison-Nurse, I. C., van Hout, I., Aitken-Buck, H. M., Sugunesegran, R., Davis, P. J., Bunton, R. W., Williams, M. J. A., Coffey, S., Stiles, M. K., Jones, P. P., & Lamberts, R. R. (2020). Acute interaction between human epicardial adipose tissue and human atrial myocardium induce arrhythmic susceptibility. American Journal of Physiology: Endocrinology & Metabolism, 318, E164-E172. doi: 10.1152/ajpendo.00374.2019
McNeill, S., Giles, N. M., Preston, D., Jones, P. P., Crowley, J. D., & Giles, G. I. (2020). The quadruply stranded metallo-supramolecular helicate [Pd2 (hextrz)4]4+ acts as a molecular mimic of cytolytic peptides. Chemical Research in Toxicology, 33, 1822-1834. doi: 10.1021/acs.chemrestox.0c00061
Loehfelm, A., Elder, M. K., Boucsein, A., Jones, P. P., Williams, J. M., & Tups, A. (2020). Docosahexaenoic acid prevents palmitate-induced insulin-dependent impairments of neuronal health. FASEB Journal, 34, 4635-4652. doi: 10.1096/fj.201902517R
Aitken-Buck, H. M., Krause, J., Zeller, T., Jones, P. P., & Lamberts, R. R. (2020). Long-chain acylcarnitines and cardiac excitation-contraction coupling: Links to arrhythmias. Frontiers in Physiology, 11, 577856. doi: 10.3389/fphys.2020.577856
Munro, M. L., & Jones, P. P. (2020). Too much of a good thing? Establishing a role of excessive RyR2 dephosphorylation in heart disease. Journal of Physiology, 598(6), 1115-1116. doi: 10.1113/jp279569
Moharram, M., van Hout, I., Jones, P., Lamberts, R., Whalley, G., Williams, M., & Coffey, S. (2020). Speckle tracking strain analysis for the detection of changes in left ventricular function in patients with hypertension. Heart, Lung & Circulation, 29(Suppl. 1), (pp. S18). doi: 10.1016/j.hlc.2020.05.048
Frisk, M., Le, C., Hou, Y., Røe, Å., Dahl, C., Shen, X., … Jones, P., & Louch, W. (2020). T-tubule disruption is a prominent feature of HFrEF but not HFpEF. Journal of Molecular & Cellular Cardiology, 140, Suppl., (pp. 26). doi: 10.1016/j.yjmcc.2019.11.060
Hou, Y., Laasmaa, M., Li, J., Manfra, O., Shen, X., Jones, P. P., … Louch, W. E. (2020). Correlating calcium sparks and ryanodine receptor localization in live cardiomyocytes. Biophysical Journal, 118(3, Suppl. 1), (pp. 567a). doi: 10.1016/j.bpj.2019.11.3088
Gonano, L. A., Chakraborty, A. D., Aitken-Buck, H., Vila Petroff, M., & Jones, P. P. (2020). Phosphorylation of cardiac ryanodine receptors by protein kinase G: Evaluation of its impact on store overload-induced calcium release. Journal of Molecular & Cellular Cardiology, 140, Suppl., (pp. 49). doi: 10.1016/j.yjmcc.2019.11.117
Aitken-Buck, H. M., Moharram, M., Babakr, A. A., Reijers, R., Van Hout, I., Fomison-Nurse, I. C., Sugunesegran, R., … Bunton, R. W., Williams, M. J. A., … Jones, P. P., Coffey, S., & Lamberts, R. R. (2019). Relationship between epicardial adipose tissue thickness and epicardial adipocyte size with increasing body mass index. Adipocyte, 8(1), 412-420. doi: 10.1080/21623945.2019.1701387
Aitken-Buck, H. M., Babakr, A. A., Coffey, S., Jones, P. P., Tse, R. D., & Lamberts, R. R. (2019). Epicardial adipocyte size does not correlate with body mass index. Cardiovascular Pathology, 43, 107144. doi: 10.1016/j.carpath.2019.07.003
Chakraborty, A. D., Gonano, L. A., Munro, M. L., Smith, L. J., Thekkedam, C., Staudacher, V., Gamble, A. B., … Jones, P. P. (2019). Activation of RyR2 by class I kinase inhibitors. British Journal of Pharmacology, 176, 773-786. doi: 10.1111/bph.14562
Gardner, R. J. M., Crozier, I. G., Binfield, A. L., Love, D. R., Lehnert, K., Gibson, K., … Jones, P. P., … Kennedy, M. A., & Skinner, J. R. (2019). Penetrance and expressivity of the R858H CACNA1C variant in a five-generation pedigree segregating an arrhythmogenic channelopathy. Molecular Genetics & Genomic Medicine, 7(1), e00476. doi: 10.1002/mgg3.476
Aitken-Buck, H. M., Moharram, M., Babakr, A., van Hout, I., Fomison-Nurse, I., Reijers, R., … Williams, M., Jones, P., Coffey, S., & Lamberts, R. (2019). Increasing general adiposity is not associated with hypertrophy of epicardial adipocytes in cardiac surgery patients. Heart, Lung & Circulation, 28(Suppl. 4), (pp. S177). doi: 10.1016/j.hlc.2019.06.101
Moharram, M., Aitken-Buck, H., Van Hout, I., Reijers, R., Williams, M., Whalley, G., Jones, P., Lamberts, R., & Coffey, S. (2019). Impact of ethnicity on the correlation between body mass index and epicardial adipose tissue. Heart, Lung & Circulation, 28(Suppl. 4), (pp. S251). doi: 10.1016/j.hlc.2019.06.276
Parveen, S., Lamberts, R., & Jones, P. (2019). Clock changes in the type 2 diabetic sinoatrial node. Heart, Lung & Circulation, 28(Suppl. 4), (pp. S206). doi: 10.1016/j.hlc.2019.06.169
Hinton, L., Jones, P., & Munro, M. (2019, September). Role protein kinase CK2 in regulation of the cardiac Ryanodine Receptor. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Munro, M. L., van Hout, I., Sugunesegran, R., Bhagwat, K., Davis, P. J., Bunton, R. W., Coffey, S., … Jones, P. P. (2019, September). Resolving the role of dyadic organisation in cardiac dysfunction. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Aitken-Buck, H. M., van Hout, I., Davis, P. J., Coffey, S., Krause, J., Zeller, T., Jones, P. P., & Lamberts, R. R. (2019, September). Long-chain acylcarnitines as acute modulators of human atrial muscle function. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Pearson, J. T., Collie, N., Lamberts, R. R., Inagaki, T., Yoshimoto, M., Umetani, K., … Wilkins, G., Jones, P. P., … Schwenke, D. O. (2018). Ghrelin preserves ischemia-induced vasodilation of male rat coronary vessels following beta-adrenergic receptor blockade. Endocrinology, 159(4), 1763-1773. doi: 10.1210/en.2017-03070
Daniels, L. J., Wallace, R. S., Nicholson, O. M., Wilson, G. A., McDonald, F. J., Jones, P. P., Baldi, J. C., Lamberts, R. R., & Erickson, J. R. (2018). Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats. Cardiovascular Diabetology, 17, 89. doi: 10.1186/s12933-018-0732-x
Jones, P. P., MacQuaide, N., & Louch, W. E. (2018). Dyadic plasticity in cardiomyocytes. Frontiers in Physiology, 9, 1773. doi: 10.3389/fphys.2018.01773
Journal - Research Article
Frisk, M., Le, C., Shen, X., Røe, Å., Hou, Y., Manfra, O., … van Hout, I., … Lamberts, R. R., … Coffey, S., … Jones, P. P., … Louch, W. E. (2021). Etiology-dependent impairment of diastolic cardiomyocyte calcium homeostasis in heart failure with preserved ejection fraction. JACC, 77(4), 405-419. doi: 10.1016/j.jacc.2020.11.044
Aitken-Buck, H. M., Babakr, A. A., Fomison-Nurse, I. C., van Hout, I., Davis, P. J., Bunton, R. W., Williams, M. J. A., Coffey, S., Jones, P. P., & Lamberts, R. R. (2020). Inotropic and lusitropic, but not arrhythmogenic, effects of adipocytokine resistin on human atrial myocardium. American Journal of Physiology: Endocrinology & Metabolism. Advance online publication. doi: 10.1152/ajpendo.00202.2020
Loehfelm, A., Elder, M. K., Boucsein, A., Jones, P. P., Williams, J. M., & Tups, A. (2020). Docosahexaenoic acid prevents palmitate-induced insulin-dependent impairments of neuronal health. FASEB Journal, 34, 4635-4652. doi: 10.1096/fj.201902517R
McNeill, S., Giles, N. M., Preston, D., Jones, P. P., Crowley, J. D., & Giles, G. I. (2020). The quadruply stranded metallo-supramolecular helicate [Pd2 (hextrz)4]4+ acts as a molecular mimic of cytolytic peptides. Chemical Research in Toxicology, 33, 1822-1834. doi: 10.1021/acs.chemrestox.0c00061
Babakr, A. A., Fomison-Nurse, I. C., van Hout, I., Aitken-Buck, H. M., Sugunesegran, R., Davis, P. J., Bunton, R. W., Williams, M. J. A., Coffey, S., Stiles, M. K., Jones, P. P., & Lamberts, R. R. (2020). Acute interaction between human epicardial adipose tissue and human atrial myocardium induce arrhythmic susceptibility. American Journal of Physiology: Endocrinology & Metabolism, 318, E164-E172. doi: 10.1152/ajpendo.00374.2019
Moharram, M. A., Aitken-Buck, H. M., Reijers, R., van Hout, I., Williams, M. J. A., Jones, P. P., Whalley, G. A., Lamberts, R. R., & Coffey, S. (2020). Correlation between epicardial adipose tissue and body mass index in New Zealand ethnic populations. New Zealand Medical Journal, 133(1516), 22-32. Retrieved from https://www.nzma.org.nz/journal
Aitken-Buck, H. M., Moharram, M., Babakr, A. A., Reijers, R., Van Hout, I., Fomison-Nurse, I. C., Sugunesegran, R., … Bunton, R. W., Williams, M. J. A., … Jones, P. P., Coffey, S., & Lamberts, R. R. (2019). Relationship between epicardial adipose tissue thickness and epicardial adipocyte size with increasing body mass index. Adipocyte, 8(1), 412-420. doi: 10.1080/21623945.2019.1701387
Gardner, R. J. M., Crozier, I. G., Binfield, A. L., Love, D. R., Lehnert, K., Gibson, K., … Jones, P. P., … Kennedy, M. A., & Skinner, J. R. (2019). Penetrance and expressivity of the R858H CACNA1C variant in a five-generation pedigree segregating an arrhythmogenic channelopathy. Molecular Genetics & Genomic Medicine, 7(1), e00476. doi: 10.1002/mgg3.476
Chakraborty, A. D., Gonano, L. A., Munro, M. L., Smith, L. J., Thekkedam, C., Staudacher, V., Gamble, A. B., … Jones, P. P. (2019). Activation of RyR2 by class I kinase inhibitors. British Journal of Pharmacology, 176, 773-786. doi: 10.1111/bph.14562
Aitken-Buck, H. M., Babakr, A. A., Coffey, S., Jones, P. P., Tse, R. D., & Lamberts, R. R. (2019). Epicardial adipocyte size does not correlate with body mass index. Cardiovascular Pathology, 43, 107144. doi: 10.1016/j.carpath.2019.07.003
Pearson, J. T., Collie, N., Lamberts, R. R., Inagaki, T., Yoshimoto, M., Umetani, K., … Wilkins, G., Jones, P. P., … Schwenke, D. O. (2018). Ghrelin preserves ischemia-induced vasodilation of male rat coronary vessels following beta-adrenergic receptor blockade. Endocrinology, 159(4), 1763-1773. doi: 10.1210/en.2017-03070
Daniels, L. J., Wallace, R. S., Nicholson, O. M., Wilson, G. A., McDonald, F. J., Jones, P. P., Baldi, J. C., Lamberts, R. R., & Erickson, J. R. (2018). Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats. Cardiovascular Diabetology, 17, 89. doi: 10.1186/s12933-018-0732-x
Gonano, L. A., & Jones, P. P. (2017). FK506-binding proteins 12 and 12.6 (FKBPs) as regulators of cardiac Ryanodine Receptors: Insights from new functional and structural knowledge. Channels, 11(5), 415-425. doi: 10.1080/19336950.2017.1344799
Diong, C., Jones, P. P., Tsuchimochi, H., Gray, E. A., Hughes, G., Inagaki, T., Bussey, C. T., … Schwenke, D. O. (2016). Sympathetic hyper-excitation in obesity and pulmonary hypertension: Physiological relevance to the 'obesity paradox'. International Journal of Obesity, 40, 938-946. doi: 10.1038/ijo.2016.33
Waddell, H. M. M., Zhang, J. Z., Hoeksema, K. J., McLachlan, J. J., McLay, J. C., & Jones, P. P. (2016). Oxidation of RyR2 has a biphasic effect on the threshold for store overload-induced calcium release. Biophysical Journal, 110(11), 2386-2396. doi: 10.1016/j.bpj.2016.04.036
Zhang, J. Z., Waddell, H. M. M., Wu, E., Dholakia, J., Okolo, C. A., McLay, J. C., & Jones, P. P. (2016). FKBPs facilitate the termination of spontaneous Ca2+ release in wild-type RyR2 but not CPVT mutant RyR2. Biochemical Journal, 473(14), 2049-2060. doi: 10.1042/bcj20160389
Xiao, Z., Guo, W., Sun, B., Hunt, D. J., Wei, J., Liu, Y., … Jones, P. P., … Chen, S. R. W. (2016). Enhanced cytosolic Ca2+ activation underlies a common defect of central domain cardiac ryanodine receptor mutations linked to arrhythmias. Journal of Biological Chemistry, 291(47), 24528-24537. doi: 10.1074/jbc.M116.756528
Thaung, H. P. A., Baldi, J. C., Wang, H.-Y., Hughes, G., Cook, R. F., Bussey, C. T., Sheard, P. W., Bahn, A., Jones, P. P., Schwenke, D. O., & Lamberts, R. R. (2015). Increased efferent cardiac sympathetic nerve activity and defective intrinsic heart rate regulation in type 2 diabetes. Diabetes, 64(8), 2944-2956. doi: 10.2337/db14-0955
Liu, Y., Sun, B., Xiao, Z., Wang, R., Guo, W., Zhang, J. Z., … Jones, P. P., … Chen, S. R. W. (2015). Roles of the NH2-terminal domains of cardiac ryanodine receptor in Ca2+ release activation and termination. Journal of Biological Chemistry, 290(12), 7736-7746. doi: 10.1074/jbc.M114.618827
Mi, T., Xiao, Z., Guo, W., Tang, Y., Hiess, F., Xiao, J., … Zhang, J. Z., … Jones, P. P., & Chen, S. R. W. (2015). Role of Cys3602 in the function and regulation of the cardiac ryanodine receptor. Biochemical Journal, 467(1), 177-190. doi: 10.1042/BJ20141263
Thaung, H. P. A., Yao, Y., Bussey, C. T., Hughes, G., Jones, P. P., Bahn, A., Sammut, I. A., & Lamberts, R. R. (2015). Chronic bilateral renal denervation reduces cardiac hypertrophic remodelling but not β-adrenergic responsiveness in hypertensive type 1 diabetic rats. Experimental Physiology, 100(6), 628-639. doi: 10.1113/EP085021
Bussey, C. T., Hughes, G., Saxena, P., Galvin, I. F., Bunton, R. W., Noye, M. K., Coffey, S., Williams, M. J. A., Baldi, J. C., Jones, P. P., & Lamberts, R. R. (2015). Chamber-specific changes in calcium-handling proteins in the type 2 diabetic human heart with preserved ejection fraction. International Journal of Cardiology, 193, 53-55. doi: 10.1016/j.ijcard.2015.05.053
Chen, W., Wang, R., Chen, B., Zhong, X., Kong, H., Bai, Y., … Jones, P. P., … Chen, S. R. W. (2014). The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias. Nature Medicine, 20(2), 184-192. doi: 10.1038/nm.3440
Lamberts, R. R., Lingam, S. J., Wang, H.-Y., Bollen, I. A. E., Hughes, G., Galvin, I. F., Bunton, R. W., Bahn, A., Katare, R., Baldi, J. C., Williams, M. J. A., Saxena, P., Coffey, S., & Jones, P. P. (2014). Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction. Cardiovascular Diabetology, 13, 72. doi: 10.1186/1475-2840-13-72
Zhang, J. Z., McLay, J. C., & Jones, P. P. (2014). The arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca2+ release due to an impaired ability to buffer store Ca2+. Journal of Molecular & Cellular Cardiology, 74, 22-31. doi: 10.1016/j.yjmcc.2014.04.019
Bai, Y., Jones, P. P., Guo, J., Zhong, X., Clark, R. B., Zhou, Q., … Chen, S. R. W. (2013). Phospholamban knockout breaks arrhythmogenic Ca2+ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice. Circulation Research, 113, 517-526. doi: 10.1161/circresaha.113.301678
Liu, Y., Kimlicka, L., Heiss, F., Tian, X., Wang, R., Zhang, L., Jones, P. P., … Chen, S. R. W. (2013). The CPVT-associated RyR2 mutation G230C enhances store overloadinduced Ca2+ release and destabilizes the N-terminal domains. Biochemical Journal, 454(1), 123-131. doi: 10.1042/BJ20130594
Wang, R., Zhong, X., Meng, X., Koop, A., Tian, X., Jones, P. P., … Chen, S. R. W. (2011). Localization of the dantrolene-binding sequence near the FK506-binding protein-binding site in the three-dimensional structure of the ryanodine receptor. Journal of Biological Chemistry, 286(14), 12202-12212. doi: 10.1074/jbc.M110.194316
Zhou, Q., Xiao, J., Jiang, D., Wang, R., Vembaiyan, K., Wang, A., … Jones, P. P., … Chen, S. R. W. (2011). Carvedilol and its new analogs suppress arrhythmogenic store overload—induced Ca2+ release. Nature Medicine, 17, 1003-1009. doi: 10.1038/nm.2406
Beca, S., Helliwell, P. B., Simpson, J. A., Zhao, D., Farman, G. P., Jones, P. P., … Backx, P. H. (2011). Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-Type Ca2+ current. Circulation Research, 109(9), 1024-1030. doi: 10.1161/CIRCRESAHA.111.250464
Mufti, R. E., Brett, S. E., Tran, C. H. T., El-Rahman, R. A., Anfinogenova, Y., El-Yazbi, A., … Jones, P. P., … Welsh, D. G. (2010). Intravascular pressure augments cerebral arterial constriction by inducing voltage-insensitive Ca2+ waves. Journal of Physiology, 588(20), 3983-4005. doi: 10.1113/jphysiol.2010.193300
Jiang, D., Jones, P. P., Davis, D. R., Gow, R., Green, M. S., Birnie, D. H., … Gollob, M. H. (2010). Characterization of a novel mutation in the cardiac ryanodine receptor that results in catecholaminergic polymorphic ventricular tachycardia. Channels, 4(4), 12666. doi: 10.4161/chan.4.4.12666
Kong, H., Jones, P. P., Koop, A., Zhang, L., Duff, H. J., & Chen, S. R. W. (2008). Caffeine induces Ca2+ release by reducing the threshold for luminal Ca2+ activation of the ryanodine receptor. Biochemical Journal, 414, 441-452. doi: 10.1042/BJ20080489
Jones, P. P., Jiang, D., Bolstad, J., Hunt, D. J., Zhang, L., Demaurex, N., & Chen, S. R. W. (2008). Endoplasmic reticulum Ca2+ measurements reveal that the cardiac ryanodine receptor mutations linked to cardiac arrhythmia and sudden death alter the threshold for store-overload-induced Ca2+ release. Biochemical Journal, 412, 171-178. doi: 10.1042/BJ20071287
Jiang, D., Chen, W., Xiao, J., Wang, R., Kong, H., & Jones, P. P. (2008). Reduced threshold for luminal Ca2+ activation of RyR1 underlies a causal mechanism of porcine malignant hyperthermia. Journal of Biological Chemistry, 283(30), 20813-20820. doi: 10.1074/jbc.M801944200
Jones, P. P., Meng, X., Xiao, B., Cai, S., Bolstad, J., Wagenknecht, T., … Chen, S. R. W. (2008). Localization of PKA phosphorylation site, Ser2030, in the three-dimensional structure of cardiac ryanodine receptor. Biochemical Journal, 410, 261-270. doi: 10.1042/BJ20071257
Hunt, D. J., Jones, P. P., Wang, R., Chen, W., Bolstad, J., Chen, K., … Chen, S. R. W. (2007). K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochemical Journal, 404, 431-438. doi: 10.1042/BJ20070135
Xiao, J., Tian, X., Jones, P. P., Bolstad, J., Kong, H., Wang, R., … Chen, S. R. W. (2007). Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias. Journal of Biological Chemistry, 282(48), 34828-34838. doi: 10.1074/jbc.M707423200
Xiao, B., Tian, X., Xie, W., Jones, P. P., Cai, S., Wang, X., … Chen, S. R. W. (2007). Functional consequence of protein kinase A-dependent phosphorylation of the cardiac ryanodine receptor: Sensitization of store overload-induced Ca2+ release. Journal of Biological Chemistry, 282(41), 30256-30264. doi: 10.1074/jbc.M703510200
Jones, P. P., Bazzazi, H., Kargacin, G. J., & Colyer, J. (2006). Inhibition of cAMP-dependent protein kinase under conditions occurring in the cardiac dyad during a Ca2+ transient. Biophysical Journal, 91, 433-443. doi: 10.1529/biophysj.106.083931
Journal - Research Other
Aitken-Buck, H. M., Krause, J., Zeller, T., Jones, P. P., & Lamberts, R. R. (2020). Long-chain acylcarnitines and cardiac excitation-contraction coupling: Links to arrhythmias. Frontiers in Physiology, 11, 577856. doi: 10.3389/fphys.2020.577856
Munro, M. L., & Jones, P. P. (2020). Too much of a good thing? Establishing a role of excessive RyR2 dephosphorylation in heart disease. Journal of Physiology, 598(6), 1115-1116. doi: 10.1113/jp279569
Jones, P. P., MacQuaide, N., & Louch, W. E. (2018). Dyadic plasticity in cardiomyocytes. Frontiers in Physiology, 9, 1773. doi: 10.3389/fphys.2018.01773
Jones, P. P., Guo, W., & Chen, S. R. W. (2017). Control of cardiac ryanodine receptor by sarcoplasmic reticulum luminal Ca2+. Journal of General Physiology, 149(9), 867-875. doi: 10.1085/jgp.201711805
Jones, P. P., & Braun, A. P. (2009). Store operated Ca2+ entry (SOCE) [Commentary]. Channels, 3(1), 1-2. doi: 10.4161/chan.3.1.7983
Conference Contribution - Published proceedings: Full paper
Zhang, J. Z., Waddell, H. M. M., & Jones, P. P. (2015). Regulation of RyR2 by sarcoplasmic reticulum Ca2+. Clinical & Experimental Pharmacology & Physiology, 42(6), (pp. 720-726). doi: 10.1111/1440-1681.12364
Conference Contribution - Published proceedings: Abstract
Moharram, M., van Hout, I., Jones, P., Lamberts, R., Whalley, G., Williams, M., & Coffey, S. (2020). Speckle tracking strain analysis for the detection of changes in left ventricular function in patients with hypertension. Heart, Lung & Circulation, 29(Suppl. 1), (pp. S18). doi: 10.1016/j.hlc.2020.05.048
Gonano, L. A., Chakraborty, A. D., Aitken-Buck, H., Vila Petroff, M., & Jones, P. P. (2020). Phosphorylation of cardiac ryanodine receptors by protein kinase G: Evaluation of its impact on store overload-induced calcium release. Journal of Molecular & Cellular Cardiology, 140, Suppl., (pp. 49). doi: 10.1016/j.yjmcc.2019.11.117
Hou, Y., Laasmaa, M., Li, J., Manfra, O., Shen, X., Jones, P. P., … Louch, W. E. (2020). Correlating calcium sparks and ryanodine receptor localization in live cardiomyocytes. Biophysical Journal, 118(3, Suppl. 1), (pp. 567a). doi: 10.1016/j.bpj.2019.11.3088
Frisk, M., Le, C., Hou, Y., Røe, Å., Dahl, C., Shen, X., … Jones, P., & Louch, W. (2020). T-tubule disruption is a prominent feature of HFrEF but not HFpEF. Journal of Molecular & Cellular Cardiology, 140, Suppl., (pp. 26). doi: 10.1016/j.yjmcc.2019.11.060
Aitken-Buck, H. M., Moharram, M., Babakr, A., van Hout, I., Fomison-Nurse, I., Reijers, R., … Williams, M., Jones, P., Coffey, S., & Lamberts, R. (2019). Increasing general adiposity is not associated with hypertrophy of epicardial adipocytes in cardiac surgery patients. Heart, Lung & Circulation, 28(Suppl. 4), (pp. S177). doi: 10.1016/j.hlc.2019.06.101
Parveen, S., Lamberts, R., & Jones, P. (2019). Clock changes in the type 2 diabetic sinoatrial node. Heart, Lung & Circulation, 28(Suppl. 4), (pp. S206). doi: 10.1016/j.hlc.2019.06.169
Moharram, M., Aitken-Buck, H., Van Hout, I., Reijers, R., Williams, M., Whalley, G., Jones, P., Lamberts, R., & Coffey, S. (2019). Impact of ethnicity on the correlation between body mass index and epicardial adipose tissue. Heart, Lung & Circulation, 28(Suppl. 4), (pp. S251). doi: 10.1016/j.hlc.2019.06.276
Babakr, A. A., Fomison-Nurse, I. C., Jones, P. P., & Lamberts, R. R. (2018). Does human epicardial adipose tissue enhance atrial fibrillation induced by beta adrenergic stimulation in human cardiac muscles? Cardiovascular Research, 114(Suppl. 1), (pp. S11). doi: 10.1093/cvr/cvy060.018
Babakr, A., Fomison-Nurse, I., Van Hout, I., Davis, P., Sugunesegran, R., Crouch, G., … Coffey, S., Bunton, R., Jones, P., & Lamberts, R. (2018). Human epicardial adipose tissue promotes atrial fibrillation through β1-but not β3-adrenergic receptors. Heart, Lung & Circulation, 27(Suppl. 2), (pp. S168). doi: 10.1016/j.hlc.2018.06.283
Lamberts, R. R., Babakr, A. A., Fomison-Nurse, I. C., & Jones, P. P. (2018). Effect of human epicardial adipose tissue on calcium-overload-induced atrial fibrillation in human cardiac muscles. Cardiovascular Research, 114(Suppl. 1), (pp. S34). doi: 10.1093/cvr/cvy060.093
Jones, P., Chakraborty, A., Gonano, L. A., & Dulhunty, A. (2017). Arrhythmogenic ATP-based kinase inhibitors directly increase the activity of RyR2. Heart, Lung & Circulation, 26(Suppl. 2), (pp. S158). doi: 10.1016/j.hlc.2017.06.262
Parveen, S., Lamberts, R., & Jones, P. (2017). Understanding heart rate generation in type 2 diabetes. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 70-71). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html
Chakraborty, A., Gonano, L., McLay, J., Dulhunty, A., & Jones, P. (2017). Arrhythmogenic ATP based kinase inhibitors directly increase the activity of RyR2. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 11). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html
Lamberts, R. R., Hughes, G., Bussey, C. T., Saxena, P., Galvin, I. F., Noye, M. K., Coffey, S., Williams, M. J. A., Baldi, J. C., Jones, P. P., on behalf of HeartOtago. (2015). Left ventricular calcium-handling proteins in the type 2 diabetic human heart with preserved ejection fraction. European Heart Journal, 36(Suppl. 1), (pp. 312-313). doi: 10.1093/eurheartj/ehv399
Zhang, J. Z., McLay, J., & Jones, P. P. (2014). Regulation of cardiac ryanodine receptor by histidine rich Ca2+ binding protein. Proceedings of the Medical Sciences Congress (MedSci). (pp. 17). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts
Jones, P. P., Bai, Y., Guo, J., Zhong, X., Clark, R. B., Zhou, Q., … Chen, S. R. (2014). Phospholamban knockout breaks arrhythmogenic Ca2+ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice. Proceedings of the Medical Sciences Congress (MedSci). (pp. 7). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts
Lamberts, R., Lingam, S., Wang, S., Saxena, P., Galvin, I., Bunton, R., Williams, M., Coffey, S., Baldi, J., & Jones, P. (2013). Impaired functional relaxation despite upregulated calcium handling proteins in human diabetic myocardium. Heart, Lung & Circulation, 22(Suppl. 1), (pp. S57). doi: 10.1016/j.hlc.2013.05.137
Zhang, J., McLay, J., & Jones, P. (2013). Histidine-rich Ca2+ binding protein inhibits the propensity for store overload-induced Ca2+ release (SOICR). Heart, Lung & Circulation, 22(Suuppl. 1), (pp. S78). doi: 10.1016/j.hlc.2013.05.186
Diong, C., Gray, E., Jones, P., & Schwenke, D. (2013). Increased sympathetic activity in obesity may protect against pulmonary hypertension. New Zealand Medical Journal, 126(1386). Retrieved from http://www.nzma.org.nz/journal
Deo, M., McLay, J., & Jones, P. (2012). Triadin decreases the propensity for Store Overload Induced Calcium Release (SOICR). New Zealand Medical Journal, 125(1367). Retrieved from http://www.nzma.org.nz/journal
Lingam, S. J., Saxena, P., Coffey, S., Baldi, J. C., Lamberts, R. R., & Jones, P. P. (2012). Hastened relaxation in a non-failing diabetic heart. Proceedings of the Medical Sciences Congress (MedSci). (pp. 67). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf
Deo, M., Wu, E., McLay, J., & Jones, P. P. (2012). Proteins associated with the cardiac ryanodine receptor alter the threshold for store overload-induced calcium release. Heart, Lung & Circulation, 21(12), (pp. 860). doi: 10.1016/j.hlc.2012.08.023
Jones, P. P. (2012). From dyes to proteins, imaging subcellular calcium events. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 30th International Australasian Winter Conference on Brain Research. 30, (pp. 70). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2012.html
Lingam, S. J., Saxena, P., Coffey, S., Williams, M. J. A., Baldi, J. C., Lamberts, R. R., & Jones, P. P. (2012). Protein expression of SERCA2a and PLB in diabetes. Proceedings of the Oxygen Theme Meeting. (pp. 34). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf
Lingam, S., Saxena, P., Coffey, S., Williams, M., Baldi, J., Lamberts, R., & Jones, P. (2012). Improved atrial relaxation in human type 2 diabetes mellitus. New Zealand Medical Journal, 125(1367). Retrieved from http://www.nzma.org.nz/journal
Deo, M., McLay, J., & Jones, P. P. (2012). The RyR2 binding protein triadin decreases the propensity for store overload induced Ca2+ release. Proceedings of the Oxygen Theme Meeting. (pp. 30). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf
Deo, M., McLay, J., & Jones, P. P. (2012). The RyR2 binding protein triadin decreases the propensity for store overload induced Ca2+ release. Proceedings of the Medical Sciences Congress (MedSci). (pp. 66). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf
Jones, P., Bai, Y., Vallmitjana, A., Wang, R., Clark, R., Zhou, Q., … Chen, S. (2012). Disrupting Ca2+ waves, but not Ca2+ leak, protects against cardiac arrhythmia. Heart, Lung & Circulation, 21(Suppl. 1), (pp. S78). doi: 10.1016/j.hlc.2012.05.198
Mufti, R., Welsh, S. B., El-Rahman, R. A., Jones, P., Chen, W., & Welsh, D. (2010). The role of IP3 receptors in generating calcium waves and cerebral myogenic tone. FASEB Journal, 24(Meeting Abstracts), 1033.3. [Abstract]
Chen, S. R. W., Chen, W., Tian, X., Wang, R., Kong, H., O'Mara, M. L., Jones, P. P., … Tieleman, D. P. (2009). Molecular basis of luminal Ca2+ gating of the cardiac ryanodine receptor. Biophysical Journal. 96(3, Suppl. 1), (pp. 551a). doi: 10.1016/j.bpj.2008.12.2984
Conference Contribution - Poster Presentation (not in published proceedings)
Hinton, L., Jones, P., & Munro, M. (2019, September). Role protein kinase CK2 in regulation of the cardiac Ryanodine Receptor. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Parveen, S., Lamberts, R. R., & Jones, P. P. (2017, September). Understanding altered heart rate generation in type 2 diabetes. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Denny, A., Jones, P. P., Erickson, J. R., & Heather, A. K. (2016, August). Oxidised CaMKII: A novel mechanism in the pathophysiology of FSHD. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
Okolo, C. A., McLachlan, J. J., McLay, J., Erickson, J. R., & Jones, P. P. (2016, August). O-GlcNAcylation regulates RyR2 function directly. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
Gonano, L. A., Sepúlveda, M., Morell, M., Tottef, T., Jones, P. P., Back, T. G., … Petroff, M. V. (2016, August). Carvedilol and its non-ß-blocking analog VK-II-86 prevent digitalis-induced Ca++ waves in cardiac myocytes. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
Babakr, A., Lamberts, R., & Jones, P. (2016, August-September). How does epicardial adipose tissue make the human heart more susceptible to atrial fibrillation? Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Chakraborty, A., McLay, J., & Jones, P. (2016, August). Regulation of RyR2 by protein kinase CK2. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
Denny, A., Erickson, J. R., Jones, P. P., & Heather, A. K. (2016, August-September). RyR2 leak and CaMKII post-translational modifications in the heart: Can this explain the altered Ca2+ handling in FSHD? Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Okolo, C. A., McLachlan, J. J., McLay, J. C., Erickson, J. R., & Jones, P. P. (2016, August-September). O-GlcNAcylation regulates RyR2 function directly. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Waddell, H. M. M., McLay, J. C., & Jones, P. P. (2013, August). Oxidation of the cardiac ryanodine receptor reduces the threshold for spontaneous calcium release. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Hoeksema, K. J., McLay, J. C., & Jones, P. P. (2013, August). Assessing the efficacy of a new class of anti-arrhythmics in human atrial samples. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Lingam, S. J., Saxena, P., Coffey, S., Williams, M. J. A., Baldi, J. C., Lamberts, R. R., & Jones, P. P. (2012, September). Improved atrial relaxation in human type 2 diabetes mellitus. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.
Zhang, J., McLay, J., & Jones, P. P. (2012, September). Histidine-rich CA2+ binding protein (HRC) attenuates the propensity for store overload-induced CA2+ release (SOICR). Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.
Deo, M., McLay, J., & Jones, P. P. (2012, September). Luminal regulation of the RYR2 by triadin reduces the propensity for store overload induced calcium release. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.
Zhou, Q., Xiao, J., Jiang, D., Wang, R., Vembaiyan, K., Wang, A., … Jones, P. P., … Chen, S. R. W. (2011, August). Unique action of carvedilol and its novel analogues: Suppression of store-overload-induced Ca2+ release. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Munro, M. L., van Hout, I., Sugunesegran, R., Bhagwat, K., Davis, P. J., Bunton, R. W., Coffey, S., … Jones, P. P. (2019, September). Resolving the role of dyadic organisation in cardiac dysfunction. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Aitken-Buck, H. M., van Hout, I., Davis, P. J., Coffey, S., Krause, J., Zeller, T., Jones, P. P., & Lamberts, R. R. (2019, September). Long-chain acylcarnitines as acute modulators of human atrial muscle function. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Okolo, C. A., McLay, J. C., McLachlan, J. J., Munro, M., Tanner, C., Chakraborty, A. D., Erickson, J. R., & Jones, P. P. (2018, August). Regulation of RyR2 by O-linked glycosylation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Munro, M. L., Jayasinghe, I. D., Crossman, D. J., Baddeley, D., Soeller, C., & Jones, P. P. (2018, August). Super resolved calcium channel organisation in the heart. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
van Hout, I., Nicholson, O., Erickson, J. R., Lamberts, R. R., & Jones, P. P. (2017, September). Alterations in calcium handling proteins in diabetic and non-diabetic patient with or without post-operative atrial fibrillation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Babakr, A. A., Fomison-Nurse, I. C., Jones, P. P., & Lamberts, R. R. (2017, September). Does epicardial adipose tissue make the human heart more susceptible to atrial fibrillation? Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Chakraborty, A. D., Gonano, L. A., Mclay, J. C., Dulhunty, A., & Jones, P. P. (2017, September). Arrhythmogenic ATP based kinase inhibitors directly increase the activity of RyR2. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Chakraborty, A. D., McLay, J., & Jones, P. (2016, August-September). Regulation of RyR2 by protein kinase CK2. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Gonano, L. A., Sepúlveda, M., Morell, M., Tottef, T., Jones, P. P., Back, T. G., … Petroff, M. V. (2016, August-September). RyR2 dysfunction and digitalis toxicity. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
McLachlan, J., & Jones, P. (2016, August). Development of RyR2-based redox sensor for H2O2 quantification in cardiac dyad microdomain. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
Jones, P. (2016, August-September). FKBPs facilitate the termination of spontaneous Ca2+ release in wild type RyR2 but not CPVT mutant RyR2. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Jones, P. (2014, November). Role of RyR2 in arrhythmia. Verbal presentation at the HeartOtago First Australasian Symposium: Bench to Bedside and Back: New Advances in Cardiovascular Research, Dunedin, New Zealand.
Diong, C. T., Gray, E. A., Jones, P., & Schwenke, D. O. (2013, August). Can sympathetic hyperexcitation in obesity protect against pulmonary hypertension? Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Lingam, S. J., Wang, S. H. Y., Saxena, P., Galvin, I. F., Bunton, R. W., Williams, M. J. A., Coffey, S., Baldi, J. C., Jones, P. P., & Lamberts, R. R. (2013, August). Relaxation in human diabetic myocardium. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Jones, P. P. (2012, August). From dyes to proteins: Imaging subcellular calcium events. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Jones, P. (2011, September). Regulation of RyR2 and its implications in arrhythmia. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Chen, S. R. W., Wang, R., Clark, R. B., Zhou, Q., & Jones, P. P. (2010, November-December). Increased calcium leak alone is not sufficient to cause arrhythmia. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.