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Katare Lab

Lab personnel

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Research interests

  • Molecular mechanisms involved in the development of cardiovascular complications in diabetes.
  • Role of microRNAs in cardiovascular diseases.
  • Development of novel genetic and stem cell therapies for the treatment of ischemic and non-ischemic cardiovascular complications

Keywords

microRNA; gene therapy; stem cells; chronic heart failure; Diabetes Mellitus; cardiomyopathy; tissue engineering.

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Projects

  • Pathological role of microRNAs in the development of diabetic cardiomyopathy
  • Circulating microRNAs as potential biomarkers for early diagnosis of cardiovascular complications
  • Gender differences in diabetic heart – why females are more prone to complications
  • Investigating the role of suicidal autophagy in diabetic hearts
  • Treatment of ischemic hearts with resident cardiac stem cells
  • Development of engineered heart tissue using cardiac and mesenchymal stem cells

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Current funding

  • 2013–2015 Lottery Health Board project grant
  • 2013–2015 New Zealand Society for the Study of Diabetes project (Sanofi) grant
  • 2013–2014 Maurice & Phyllis Paykel Trust grant-in-ai
  • 2013–2014 University of Otago research grant
  • 2013–2014 Otago School of Medical Sciences Dean's Bequest grant
  • 2012–2013 Heart Foundation New Zealand small project grant
  • 2012–2013 Otago Medical Research Foundation project grant

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Previous funding

  • 2010–2012 British Heart Foundation project grant
  • 2007–2010 Diabetes UK project grant
  • 2004–2007 Ministry of Science and Education, Japan
  • 2002–2004 Industrial grant with Mitsubishi Pharmaceuticals, Japan

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Collaborators

  • Associate Professor Patrick Manning, Department of Medicine, University of Otago
  • Professor Vicky Cameron, Christchurch Heart Institute, University of Otago
  • Dr Andrew Bahn, Department of Physiology, University of Otago
  • Professor Paolo Madeddu, Bristol Heart Institute, University of Bristol, United Kingdom
  • Professor Costanza Emanueli, Bristol Heart Institute, University of Bristol, United Kingdom
  • Professor Saadeh Suleiman, Department of Cardiovascular Physiology, University of Bristol, United Kingdom
  • Dr Antonio Beltrami, Department of Pathology, University of Udine, Italy
  • Dr Daniela Cesselli, Department of Pathology, University of Udine, Italy
  • Professor Sato Takayuki, Department of Physiology, Kochi University, Japan
  • Dr Kakinuma Yoshihiko, Department of Physiology, Kochi University, Japan
  • Professor Ando Motonori, Laboratory of Cell Physiology, Department of Science Education, Okayama University, Japan

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Publications

Chandrasekera, D., Shah, R., van Hout, I., de Jonge, W., Bunton, R., Parry, D., Davis, P., & Katare, R. (2023). Combination of precipitation and size exclusion chromatography as an effective method for exosome like extracellular vesicle isolation from pericardial fluids. Nanotheranostics, 7(4), 345-352. doi: 10.7150/ntno.82939

Tonkin, D., Yee-Goh, A., & Katare, R. (2023). Healing the ischaemic heart: A critical review of stem cell therapies. Reviews in Cardiovascular Medicine, 24(4), 122. doi: 10.31083/j.rcm2404122

Varghese, L. N., Schwenke, D. O., & Katare, R. (2023). Role of noncoding RNAs in cardiac ageing. Frontiers in Cardiovascular Medicine, 10, 1142575. doi: 10.3389/fcvm.2023.1142575

Khadka, P., Dummer, J., Hill, P. C., Katare, R., & Das, S. C. (2023). A review of formulations and preclinical studies of inhaled rifampicin for its clinical translation. Drug Delivery & Translational Research, 13, 1246-1271. doi: 10.1007/s13346-022-01238-y

Farrell, G., Bell, M., Chapple, C., Kennedy, E., Sampath, K., Gisselman, A. S., … Katare, R., & Tumilty, S. (2023). Autonomic nervous system and endocrine system response to upper and lower cervical spine mobilization in healthy male adults: A randomized crossover trial. Journal of Manual & Manipulative Therapy. Advance online publication. doi: 10.1080/10669817.2023.2177071

Shah, R., Walker, G., Katare, R., & Das, S. (2022, November). Spray-freeze drying: An emerging technique for producing inhalable microparticles of thermosensitive bioactives. Verbal presentation at the School of Pharmacy Research Day, Dunedin, New Zealand.

Shah, R. M., Katare, R., Walker, G., & Das, S. C. (2022, November). Physicochemical characterization of exosome-mimetic nanoparticles for chronic obstructive pulmonary disease. Poster session presented at the New Zealand Controlled Release Society (NZCRS) Symposium, Auckland, New Zealand.

Shah, R., Walker, G., Katare, R., & Das, S. C. (2022, November). Spray-freeze drying: A hybrid particle engineering technique for producing highly porous and aerosolizable dry powder. Verbal presentation at the Bioengineering@Otago Showcase, [Online].

Ghosh, N., Fenton, S., Chatterjee, A., Schwenke, D., & Katare, R. (2022). In vivo knockdown of pro-apoptotic miR-320 restores cardiac function and angiogenesis in a mouse model of type 2 diabetes. Circulation, 146(Suppl. 1), 13062. doi: 10.1161/circ.146.suppl_1.13062

Katare, R. (2022, August). Modulation of microRNAs: A mechanistic approach for the treatment of diabetic heart disease. Verbal presentation at the Metabolic & Cardiovascular Disease Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Tonkin, D., Williams, M., Schwenke, D., & Katare, R. (2022, August-September). Effects of synthetic miRNA cocktail for activation of endogenous progenitor cells in the diabetic heart. Poster session presented at the New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

'Uluaki'afua, K., Adhia, D., Mani, R., & Katare, R. (2022, August-September). Elucidating the role of miRNAs underlying chronic pain in rheumatoid arthritis. Poster session presented at the New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Paul, S., Ali, A., & Katare, R. (2022, August-September). Investigating the effectiveness of a novel therapeutic to improve diabetic wound healing. Poster session presented at the New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Reily-Bell, M., Gamble, A., & Katare, R. (2022, August-September). Investigating CRISPR/Cas13 as a novel tool for the knockdown of miRNA upregulated in diabetic heart disease (DHD). Poster session presented at the New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Fenton, S., Augustine, R., Katare, R., & Schwenke, D. O. (2022, August-September). miRNA-138 drives tau protein dysfunction in diabetic cardiac autonomic neuropathy. Verbal presentation at the New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Chau, A., Fenton, S., Pearson, J., Katare, R., & Schwenke, D. O. (2022, August-September). miRNA-138 as a novel therapeutic target for cardiac autonomic neuropathy in diabetes. Verbal presentation at the New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Roberts, E., Tohu, P., Fenton, S., Katare, R., & Schwenke, D. (2022, August-September). Can loss of a 'hunger' hormone increase cardiovascular disease in Pacific people? Verbal presentation at the New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Shah, R. M., Walker, G. F., Katare, R., & Das, S. C. (2022, August-September). Differential regulation of microRNAs associated with COPD in smokers. Verbal presentation at the New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Chandrasekera, D. N. K., van Hout, I., Bunton, R., Parry, D., & Katare, R. (2022, August-September). A novel protocol for the enrichment of exosomes yield from biological fluids. Verbal presentation at the New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Ghosh, N., Fenton, S., van Hout, I., Jones, G. T., Coffey, S., Williams, M. J. A., Sugunesegran, R., Parry, D., … Schwenke, D. O., Chatterjee, A., & Katare, R. (2022). Therapeutic knockdown of miR-320 improves deteriorated cardiac function in a pre-clinical model of non-ischemic diabetic heart disease. Molecular Therapy: Nucleic Acids, 29, 330-342. doi: 10.1016/j.omtn.2022.07.007

Chandrasekera, D., & Katare, R. (2022). Exosomal microRNAs in diabetic heart disease. Cardiovascular Diabetology, 21, 122. doi: 10.1186/s12933-022-01544-2

Yee-Goh, A. S., Yamauchi, A., van Hout, I., Bellae Papannarao, J., Sugunesegran, R., Parry, D., Davis, P., & Katare, R. (2022). Cardiac progenitor cells and adipocyte stem cells from same patients exhibit in vitro functional differences. International Journal of Molecular Sciences, 23, 5588. doi: 10.3390/ijms23105588

Satthenapalli, R., Lee, S., Bellae Papannarao, J., Hore, T. A., Chakraborty, A., Jones, P. P., Lamberts, R. R., & Katare, R. (2022). Stage-specific regulation of signalling pathways to differentiate pluripotent stem cells to cardiomyocytes with ventricular lineage. Stem Cell Research & Therapy, 13(1), 185. doi: 10.1186/s13287-022-02845-9

Avolio, E., Katare, R., Thomas, A. C., Caporali, A., Schwenke, D., Carrabba, M., … Madeddu, P. (2022). Cardiac pericyte reprogramming by MEK inhibition promotes arteriologenesis and angiogenesis of the ischemic heart. Journal of Clinical Investigation. Advance online publication. doi: 10.1172/jci152308

Waddingham, M. T., Tsuchimochi, H., Sonobe, T., Asano, R., Jin, H., Ow, C. P. C., Schwenke, D. O., Katare, R., … Pearson, J. T. (2022). Using synchrotron radiation imaging techniques to elucidate the actions of hexarelin in the heart of small animal models. Frontiers in Physiology, 12, 766818. doi: 10.3389/fphys.2021.766818

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