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Katare Lab

Lab personnel

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Research interests

  • Molecular mechanisms involved in the development of cardiovascular complications in diabetes.
  • Role of microRNAs in cardiovascular diseases.
  • Development of novel genetic and stem cell therapies for the treatment of ischemic and non-ischemic cardiovascular complications

Keywords

microRNA; gene therapy; stem cells; chronic heart failure; Diabetes Mellitus; cardiomyopathy; tissue engineering.

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Projects

  • Pathological role of microRNAs in the development of diabetic cardiomyopathy
  • Circulating microRNAs as potential biomarkers for early diagnosis of cardiovascular complications
  • Gender differences in diabetic heart – why females are more prone to complications
  • Investigating the role of suicidal autophagy in diabetic hearts
  • Treatment of ischemic hearts with resident cardiac stem cells
  • Development of engineered heart tissue using cardiac and mesenchymal stem cells

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Current funding

  • 2013–2015 Lottery Health Board project grant
  • 2013–2015 New Zealand Society for the Study of Diabetes project (Sanofi) grant
  • 2013–2014 Maurice & Phyllis Paykel Trust grant-in-ai
  • 2013–2014 University of Otago research grant
  • 2013–2014 Otago School of Medical Sciences Dean's Bequest grant
  • 2012–2013 Heart Foundation New Zealand small project grant
  • 2012–2013 Otago Medical Research Foundation project grant

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Previous funding

  • 2010–2012 British Heart Foundation project grant
  • 2007–2010 Diabetes UK project grant
  • 2004–2007 Ministry of Science and Education, Japan
  • 2002–2004 Industrial grant with Mitsubishi Pharmaceuticals, Japan

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Collaborators

  • Associate Professor Patrick Manning, Department of Medicine, University of Otago
  • Professor Vicky Cameron, Christchurch Heart Institute, University of Otago
  • Dr Andrew Bahn, Department of Physiology, University of Otago
  • Professor Paolo Madeddu, Bristol Heart Institute, University of Bristol, United Kingdom
  • Professor Costanza Emanueli, Bristol Heart Institute, University of Bristol, United Kingdom
  • Professor Saadeh Suleiman, Department of Cardiovascular Physiology, University of Bristol, United Kingdom
  • Dr Antonio Beltrami, Department of Pathology, University of Udine, Italy
  • Dr Daniela Cesselli, Department of Pathology, University of Udine, Italy
  • Professor Sato Takayuki, Department of Physiology, Kochi University, Japan
  • Dr Kakinuma Yoshihiko, Department of Physiology, Kochi University, Japan
  • Professor Ando Motonori, Laboratory of Cell Physiology, Department of Science Education, Okayama University, Japan

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Publications

Hebbard, C., Lee, B., Katare, R., & Garikipati, V. N. S. (2021). Diabetes, heart failure, and COVID-19: An update. Frontiers in Physiology, 12, 706185. doi: 10.3389/fphys.2021.706185

Bellae Papannarao, J., Schwenke, D. O., Manning, P., & Katare, R. (2021). Upregulated miR-200c is associated with downregulation of the functional receptor for severe acute respiratory syndrome coronavirus 2 ACE2 in individuals with obesity [Brief communication]. International Journal of Obesity. Advance online publication. doi: 10.1038/s41366-021-00984-2

Reily-Bell, M., Bahn, A., & Katare, R. (2021). Reactive oxygen species-mediated diabetic heart disease: Mechanisms and therapies. Antioxidants & Redox Signaling. Advance online publication. doi: 10.1089/ars.2021.0098

Kovanur Sampath, K., Mani, R., Katare, R., Neale, J., Cotter, J., & Tumilty, S. (2021). Thoracic spinal manipulation effect on neuroendocrine response in people with Achilles tendinopathy: A randomized crossover trial. Journal of Manipulative & Physiological Therapeutics. Advance online publication. doi: 10.1016/j.jmpt.2021.06.001

Bir, S., Chandrasekera, D., Van Hout, I., Lequeux, S., Coffey, S., Bunton, R. W., Davis, P., Williams, M. J. A., & Katare, R. (2021). Use of exosomes to deliver proangiogenic microRNAs and reduce the microvascular complications of diabetes mellitus. Proceedings of the 44th New Zealand Society for the Study of Diabetes (NZSSD) Annual Scientific Meeting. Retrieved from https://www.ivvy.com.au/event/NZSSD2021

Chamorro-Jorganes, A., Sweaad, W. K., Katare, R., Besnier, M., Anwar, M., Beazley-Long, N., … Chandrasekera, D., … Emanueli, C. (2021). METTL3 regulates angiogenesis by modulating let-7e-5p and miRNA-18a-5p expression in endothelial cells. Arteriosclerosis, Thrombosis, & Vascular Biology. Advance online publication. doi: 10.1161/atvbaha.121.316180

Purvis, N., Kumari, S., Chandrasekera, D., Bellae Papannarao, J., Gandhi, S., van Hout, I., Coffey, S., Bunton, R., Sugunesegran, R., Parry, D., Davis, P., Williams, M. J. A., Bahn, A., & Katare, R. (2021). Diabetes induces dysregulation of microRNAs associated with survival, proliferation and self-renewal in cardiac progenitor cells. Diabetologia. Advance online publication. doi: 10.1007/s00125-021-05405-7

Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., … Hughes, S. M., … Katare, R. G., … Tong, C.-K. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. Advance online publication. doi: 10.1080/15548627.2020.1797280

Khadka, P., Sinha, S., Tucker, I. G., Dummer, J., Hill, P. C., Katare, R., & Das, S. C. (2021). Pharmacokinetics of rifampicin after repeated intra-tracheal administration of amorphous and crystalline powder formulations to Sprague Dawley rats. European Journal of Pharmaceutics & Biopharmaceutics. Advance online publication. doi: 10.1016/j.ejpb.2021.02.011

Saw, E. L., Pearson, J. T., Schwenke, D. O., Munasinghe, P. E., Tsuchimochi, H., Rawal, S., Coffey, S., … Bunton, R., Van Hout, I., … Williams, M. J. A., … Fronius, M., & Katare, R. (2021). Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications. Cardiovascular Diabetology, 20, 50. doi: 10.1186/s12933-021-01231-8

Daniels, L. J., Annandale, M., Koutsifeli, P., Li, X., Bussey, C. T., van Hout, I., Bunton, R. W., … Coffey, S., Katare, R., Lamberts, R. R., … Mellor, K. M. (2021). Elevated myocardial fructose and sorbitol levels are associated with diastolic dysfunction in diabetic patients, and cardiomyocyte lipid inclusions in vitro [Brief communication]. Nutrition & Diabetes, 11, 8. doi: 10.1038/s41387-021-00150-7

Khadka, P., Sinha, S., Tucker, I. G., Dummer, J., Hill, P. C., Katare, R., & Das, S. C. (2021). Studies on the safety and the tissue distribution of inhaled high-dose amorphous and crystalline rifampicin in a rat model. International Journal of Pharmaceutics, 597, 120345. doi: 10.1016/j.ijpharm.2021.120345

Avolio, E., Katare, R., Thomas, A. C., Caporali, A., Schwenke, D., Meloni, M., … Madeddu, P. (2020). Cardiac pericytes can be pharmacologically redirected towards a smooth muscle phenotype to enhance the revascularisation of the ischemic heart. European Journal of Heart Failure, 23(Suppl. 1), (pp. 13). doi: 10.1002/ejhf.2100

Avolio, E., Mangialardi, G., Slater, S. C., Alvino, V. V., Gu, Y., Cathery, W., … Katare, R., … Madeddu, P. (2020). Secreted Protein Acidic and Cysteine Rich matricellular protein is enriched in the bioactive fraction of the human vascular pericyte secretome. Antioxidants & Redox Signaling. Advance online publication. doi: 10.1089/ars.2019.7969

McQuaig, R., Dixit, P., Yamauchi, A., Van Hout, I., Bellae Papannarao, J., Bunton, R., Parry, D., … Katare, R. (2020). Combination of cardiac progenitor cells from the right atrium and left ventricle exhibits synergistic paracrine effects in vitro. Cell Transplantation. Advance online publication. doi: 10.1177/0963689720972328

Neale, J. P. H., Pearson, J. T., Thomas, K. N., Tsuchimochi, H., Hosoda, H., Kojima, M., … Jones, G. T., Denny, A. P., Daniels, L. J., Chandrasekera, D., Liu, P., van Rij, A. M., Katare, R., & Schwenke, D. O. (2020). Dysregulation of ghrelin in diabetes impairs the vascular reparative response to hindlimb ischemia in a mouse model; Clinical relevance to peripheral artery disease. Scientific Reports, 10, 13651. doi: 10.1038/s41598-020-70391-6

Lew, J. K.-S., Pearson, J. T., Saw, E., Tsuchimochi, H., Wei, M., Ghosh, N., … Katare, R., & Schwenke, D. O. (2020). Exercise regulates microRNAs to preserve coronary and cardiac function in the diabetic heart. Circulation Research, 127, 1384-1400. doi: 10.1161/circresaha.120.317604

Khadka, P., Hill, P. C., Zhang, B., Katare, R., Dummer, J., & Das, S. C. (2020). A study on polymorphic forms of rifampicin for inhaled high dose delivery in tuberculosis treatment. International Journal of Pharmaceutics, 587, 119602. doi: 10.1016/j.ijpharm.2020.119602

Chandrasekera, D. N. K., Neale, J. P. H., van Hout, I., Rawal, S., Coffey, S., Jones, G. T., … Manning, P., Williams, M. J. A., & Katare, R. (2020). Upregulation of microRNA-532 enhances cardiomyocyte apoptosis in the diabetic heart. Apoptosis, 25(5-6), 388-399. doi: 10.1007/s10495-020-01609-1

Paul, S., Ali, A., & Katare, R. (2020). Molecular complexities underlying the vascular complications of diabetes mellitus: A comprehensive review. Journal of Diabetes & Its Complications, 34, 107613. doi: 10.1016/j.jdiacomp.2020.107613

Khadka, P., Sinha, S., Tucker, I. G., Dummer, J., Hill, P. C., Katare, R., & Das, S. C. (2020). Safety of a single high-dose inhaled rifampicin in Sprague Dawley rats. Journal of Aerosol Medicine & Pulmonary Drug Delivery, 33(2), (pp. A11). doi: 10.1089/jamp.2020.ab01.abstracts

Schwenke, D., Lew, J. K.-S., Pearson, J., Tsuchimouchi, H., & Katare, R. (2020). Early exercise intervention preserves coronary and cardiac function in the diabetic heart: Emerging role of microRNAs. Journal of Molecular & Cellular Cardiology, 140, Suppl., (pp. 5-6). doi: 10.1016/j.yjmcc.2019.11.009

SawKatare, E. E. L., Rawal, S., Pearson, J., Schwenke, D., Kakinuma, Y., Fronius, M., & Katare, R. (2020). Diabetes induced dysregulation of cardiac non-neuronal cholinergic system impairs heart metabolism. Journal of Molecular & Cellular Cardiology, 140, Suppl., (pp. 14). doi: 10.1016/j.yjmcc.2019.11.031

Knoepp, F., Ashley, Z., Barth, D., Baldin, J.-P., Jennings, M., Kazantseva, M., Saw, E. L., Katare, R., … Fronius, M. (2020). Shear force sensing of epithelial Na+ channel (ENaC) relies on N-glycosylated asparagines in the palm and knuckle domains of αENaC. PNAS, 117(1), 717-726. doi: 10.1073/pnas.1911243117

Chandrasekera, D. N. K., Bunton, R., Galvin, I., & Katare, R. (2019, September). Understanding the role of altered microRNA cargo in pericardial fluid exosomes in the diabetic heart. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

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