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Katare Lab

Lab personnel

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Research interests

  • Molecular mechanisms involved in the development of cardiovascular complications in diabetes.
  • Role of microRNAs in cardiovascular diseases.
  • Development of novel genetic and stem cell therapies for the treatment of ischemic and non-ischemic cardiovascular complications

Keywords

microRNA; gene therapy; stem cells; chronic heart failure; Diabetes Mellitus; cardiomyopathy; tissue engineering.

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Projects

  • Pathological role of microRNAs in the development of diabetic cardiomyopathy
  • Circulating microRNAs as potential biomarkers for early diagnosis of cardiovascular complications
  • Gender differences in diabetic heart – why females are more prone to complications
  • Investigating the role of suicidal autophagy in diabetic hearts
  • Treatment of ischemic hearts with resident cardiac stem cells
  • Development of engineered heart tissue using cardiac and mesenchymal stem cells

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Current funding

  • 2013–2015 Lottery Health Board project grant
  • 2013–2015 New Zealand Society for the Study of Diabetes project (Sanofi) grant
  • 2013–2014 Maurice & Phyllis Paykel Trust grant-in-ai
  • 2013–2014 University of Otago research grant
  • 2013–2014 Otago School of Medical Sciences Dean's Bequest grant
  • 2012–2013 Heart Foundation New Zealand small project grant
  • 2012–2013 Otago Medical Research Foundation project grant

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Previous funding

  • 2010–2012 British Heart Foundation project grant
  • 2007–2010 Diabetes UK project grant
  • 2004–2007 Ministry of Science and Education, Japan
  • 2002–2004 Industrial grant with Mitsubishi Pharmaceuticals, Japan

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Collaborators

  • Associate Professor Patrick Manning, Department of Medicine, University of Otago
  • Professor Vicky Cameron, Christchurch Heart Institute, University of Otago
  • Dr Andrew Bahn, Department of Physiology, University of Otago
  • Professor Paolo Madeddu, Bristol Heart Institute, University of Bristol, United Kingdom
  • Professor Costanza Emanueli, Bristol Heart Institute, University of Bristol, United Kingdom
  • Professor Saadeh Suleiman, Department of Cardiovascular Physiology, University of Bristol, United Kingdom
  • Dr Antonio Beltrami, Department of Pathology, University of Udine, Italy
  • Dr Daniela Cesselli, Department of Pathology, University of Udine, Italy
  • Professor Sato Takayuki, Department of Physiology, Kochi University, Japan
  • Dr Kakinuma Yoshihiko, Department of Physiology, Kochi University, Japan
  • Professor Ando Motonori, Laboratory of Cell Physiology, Department of Science Education, Okayama University, Japan

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Publications

Katare, R., Pearson, J. T., Lew, J. K.-S., Wei, M., Tsuchimouchi, H., Du, C.-K., … Schwenke, D. O. (2018). Progressive decrease in coronary vascular function associated with type 2 diabetic heart disease. Frontiers in Physiology, 9, 696. doi: 10.3389/fphys.2018.00696

Manning, P., Munasinghe, P. E., Bellae Papannarao, J., Gray, A. R., Sutherland, W., & Katare, R. (2018). Acute weight loss restores dysregulated circulating microRNAs in obese individuals. Journal of Clinical Endocrinology & Metabolism. Advance online publication. doi: 10.1210/jc.2018-00684

Fomison-Nurse, I., Saw, E. E. L., Gandhi, S., Munasinghe, P. E., van Hout, I., Williams, M. J. A., Galvin, I., Bunton, R., Davis, P., Cameron, V., & Katare, R. (2018). Diabetes induces the activation of pro-ageing miR-34a in the heart, but has differential effects on cardiomyocytes and cardiac progenitor cells. Cell Death & Differentiation. Advance online publication. doi: 10.1038/s41418-017-0047-6

Campagnolo, P., Katare, R., & Madeddu, P. (2018). Realities and misconceptions on the pericytes role in tissue repair. Regenerative Medicine, 13(2), 119-122. doi: 10.2217/rme-2017-0091

Ghosh, N., & Katare, R. (2018). Molecular mechanism of diabetic cardiomyopathy and modulation of microRNA function by synthetic oligonucleotides. Cardiovascular Diabetology, 17, 43. doi: 10.1186/s12933-018-0684-1

Lew, J. K. S., Pearson, J. T., Katare, R., & Schwenke, D. O. (2018). High-intensity interval exercise attenuates cardiac remodelling in type-2 diabetes possibly through microRNAs restoration. Cardiovascular Research, 114(Suppl. 1), (pp. S60). doi: 10.1093/cvr/cvy060.164

Lew, J. K. S., Pearson, J. T., Katare, R., & Schwenke, D. O. (2018). Cardioprotection of moderate-intensity exercise is prognosis-dependent in type-2 diabetic mouse. Cardiovascular Research, 114(Suppl. 1), (pp. S105). doi: 10.1093/cvr/cvy060.304

Saw, E., Rawal, S., Bunton, R., Galvin, I., Davis, P., Fronius, M., & Katare, R. (2018). Non-neuronal cholinergic system in the diabetic heart. Heart, Lung & Circulation, 27(Suppl. 2), (pp. S115). doi: 10.1016/j.hlc.2018.06.161

Neale, J., Pearson, J., Tsuchimochi, H., Sonobe, T., Daniels, L., Katare, R., & Schwenke, D. (2018). Ghrelin deletion impairs postischaemic revascularisation in a murine model of critical limb ischaemia. Heart, Lung & Circulation, 27(Suppl. 2), (pp. S492). doi: 10.1016/j.hlc.2018.06.1023

Dixit, P., Donnelly, H., Edamatsu, M., Galvin, I., Bunton, R., & Katare, R. (2017). Progenitor cells from atria, ventricle and peripheral blood of the same patients exhibit functional differences associated with cardiac repair. International Journal of Cardiology, 228, 412-421. doi: 10.1016/j.ijcard.2016.11.178

Akerman, A. P., Lucas, S. J. E., Katare, R., & Cotter, J. D. (2017). Heat and dehydration additively enhance cardiovascular outcomes following orthostatically-stressful calisthenics exercise. Frontiers in Physiology, 8, 756. doi: 10.3389/fphys.2017.00756

Rawal, S., Munasinghe, E. P., Nagesh, P. T., Lew, J. K. S., Jones, G. T., Williams, M. J. A., Davis, P., Bunton, R. W., Galvin, I. F., Manning, P., Lamberts, R. R., & Katare, R. (2017). Downregulation of miR-15a/b accelerates fibrotic remodelling in the Type-2 diabetic human and mouse heart. Clinical Science, 131(9), 847-863. doi: 10.1042/cs20160916

Rawal, S., Munasinghe, P. E., Shindikar, A., Paulin, J., Cameron, V., Manning, P., Williams, M. J. A., Jones, G. T., Bunton, R., Galvin, I., & Katare, R. (2017). Down-regulation of proangiogenic microRNA-126 and microRNA-132 are early modulators of diabetic cardiac microangiopathy. Cardiovascular Research, 113(1), 90-101. doi: 10.1093/cvr/cvw235

Sampath, K. K., Botnmark, E., Mani, R., Cotter, J. D., Katare, R., Munasinghe, P. E., & Tumilty, S. (2017). Neuro-endocrine response following a thoracic spinal manipulation in healthy men. Journal of Orthopaedic & Sports Physical Therapy, 47(9), 617-627. doi: 10.2519/jospt.2017.7348

Satthenapalli, V. R., Lamberts, R. R., & Katare, R. G. (2017). Challenges in regenerating the diabetic heart: A comprehensive review. Stem Cells, 35(9), 2009-2026. doi: 10.1002/stem.2661

Lew, J. K. S., Pearson, J. T., Schwenke, D. O., & Katare, R. (2017). Exercise mediated protection of diabetic heart through modulation of microRNA mediated molecular pathways. Cardiovascular Diabetology, 16(1), 10. doi: 10.1186/s12933-016-0484-4

Munasinghe, P. E., & Katare, R. (2017). Reply to the letter to editor "Autophagy may be impelled by collected fatty acids in type 2 diabetic myocardial cells". International Journal of Cardiology, 229, 4. doi: 10.1016/j.ijcard.2016.12.007

Neale, J. P. H., Pearson, J. T., Katare, R., & Schwenke, D. O. (2017). Ghrelin, microRNAs, and critical limb ischemia: Hungering for a novel treatment option. Frontiers in Endocrinology, 8, 350. doi: 10.3389/fendo.2017.00350

Ram, T. P., Fomison-Nurse, I., Gandhi, S., Coffey, S., Saxena, P., Galvin, I., Bunton, R., Williams, M. J. A., Lamberts, R. R., & Katare, R. (2017). The diagnostic sensitivity of circulating cardio-enriched microRNAs is increased after normalization of high-density lipoprotein levels [Short communication]. International Journal of Cardiology, 236, 498-500. doi: 10.1016/j.ijcard.2017.01.119

Neale, J., Katare, R., & Schwenke, D. (2017). Can the 'hunger hormone' get a leg up on critical limb ischaemia? Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 61-62). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html

Lew, K. S., Pearson, J. T., Katare, R., & Schwenke, D. O. (2017). High-intensity interval exercise attenuates cardiac dysfunction and improves cardiac perfusion through restoration of microRNA-126 in type-2 diabetic mice. European Heart Journal, 38(Suppl. 1), (pp. 929). doi: 10.1093/eurheartj/ehx504.P4452

Lee, S., & Katare, R. (2017). Effect of glucose on enhancing maturation of heart muscle cells. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 49-50). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html

Purvis, N., Katare, R., & Bahn, A. (2017). The pathophysiological role of mircoRNAs in diabetic cardiac stem cells. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 72). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html

Satthenapalli, V. R., Hore, T. A., Lamberts, R. R., & Katare, R. (2017, September). Ventricle-specific cardiomyocyte differentiation of mouse embryonic stem cells. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Katare, R., Rawal, S., Munasinghe, P. E., Tsuchimochi, H., Inagaki, T., Fujii, Y., Dixit, P., … Schwenke, D. O. (2016). Ghrelin promotes functional angiogenesis in a mouse model of critical limb ischemia through activation of proangiogenic microRNAs. Endocrinology, 157(2), 432-445. doi: 10.1210/en.2015-1799

Journal - Research Article

Katare, R., Pearson, J. T., Lew, J. K.-S., Wei, M., Tsuchimouchi, H., Du, C.-K., … Schwenke, D. O. (2018). Progressive decrease in coronary vascular function associated with type 2 diabetic heart disease. Frontiers in Physiology, 9, 696. doi: 10.3389/fphys.2018.00696

Fomison-Nurse, I., Saw, E. E. L., Gandhi, S., Munasinghe, P. E., van Hout, I., Williams, M. J. A., Galvin, I., Bunton, R., Davis, P., Cameron, V., & Katare, R. (2018). Diabetes induces the activation of pro-ageing miR-34a in the heart, but has differential effects on cardiomyocytes and cardiac progenitor cells. Cell Death & Differentiation. Advance online publication. doi: 10.1038/s41418-017-0047-6

Manning, P., Munasinghe, P. E., Bellae Papannarao, J., Gray, A. R., Sutherland, W., & Katare, R. (2018). Acute weight loss restores dysregulated circulating microRNAs in obese individuals. Journal of Clinical Endocrinology & Metabolism. Advance online publication. doi: 10.1210/jc.2018-00684

Dixit, P., Donnelly, H., Edamatsu, M., Galvin, I., Bunton, R., & Katare, R. (2017). Progenitor cells from atria, ventricle and peripheral blood of the same patients exhibit functional differences associated with cardiac repair. International Journal of Cardiology, 228, 412-421. doi: 10.1016/j.ijcard.2016.11.178

Satthenapalli, V. R., Lamberts, R. R., & Katare, R. G. (2017). Challenges in regenerating the diabetic heart: A comprehensive review. Stem Cells, 35(9), 2009-2026. doi: 10.1002/stem.2661

Sampath, K. K., Botnmark, E., Mani, R., Cotter, J. D., Katare, R., Munasinghe, P. E., & Tumilty, S. (2017). Neuro-endocrine response following a thoracic spinal manipulation in healthy men. Journal of Orthopaedic & Sports Physical Therapy, 47(9), 617-627. doi: 10.2519/jospt.2017.7348

Rawal, S., Munasinghe, P. E., Shindikar, A., Paulin, J., Cameron, V., Manning, P., Williams, M. J. A., Jones, G. T., Bunton, R., Galvin, I., & Katare, R. (2017). Down-regulation of proangiogenic microRNA-126 and microRNA-132 are early modulators of diabetic cardiac microangiopathy. Cardiovascular Research, 113(1), 90-101. doi: 10.1093/cvr/cvw235

Rawal, S., Munasinghe, E. P., Nagesh, P. T., Lew, J. K. S., Jones, G. T., Williams, M. J. A., Davis, P., Bunton, R. W., Galvin, I. F., Manning, P., Lamberts, R. R., & Katare, R. (2017). Downregulation of miR-15a/b accelerates fibrotic remodelling in the Type-2 diabetic human and mouse heart. Clinical Science, 131(9), 847-863. doi: 10.1042/cs20160916

Akerman, A. P., Lucas, S. J. E., Katare, R., & Cotter, J. D. (2017). Heat and dehydration additively enhance cardiovascular outcomes following orthostatically-stressful calisthenics exercise. Frontiers in Physiology, 8, 756. doi: 10.3389/fphys.2017.00756

Katare, R., Rawal, S., Munasinghe, P. E., Tsuchimochi, H., Inagaki, T., Fujii, Y., Dixit, P., … Schwenke, D. O. (2016). Ghrelin promotes functional angiogenesis in a mouse model of critical limb ischemia through activation of proangiogenic microRNAs. Endocrinology, 157(2), 432-445. doi: 10.1210/en.2015-1799

Munasinghe, P. E., Riu, F., Dixit, P., Edamatsu, M., Saxena, P., Hamer, N. S. J., Galvin, I. F., Bunton, R. W., Lequeux, S., Jones, G., Lamberts, R. R., … Katare, R. (2016). Type-2 diabetes increases autophagy in the human heart through promotion of Beclin-1 mediated pathway. International Journal of Cardiology, 202, 13-20. doi: 10.1016/j.ijcard.2015.08.111

Rawal, S., Parshu Ram, T., Coffey, S., Williams, M. J. A., Saxena, P., Bunton, R. W., Galvin, I. F., & Katare, R. (2016). Differential expression pattern of cardiovascular microRNAs in the human type-2 diabetic heart with normal ejection fraction. International Journal of Cardiology, 202, 40-43. doi: 10.1016/j.ijcard.2015.08.161

Dixit, P., & Katare, R. (2015). Challenges in identifying the best source of stem cells for cardiac regeneration therapy. Stem Cell Research & Therapy, 6, 26. doi: 10.1186/s13287-015-0010-8

Purvis, N., Bahn, A., & Katare, R. (2015). The role of microRNAs in cardiac stem cells. Stem Cells International, 2015(2015), 194894. doi: 10.1155/2015/194894

Gubernator, M., Slater, S. C., Spencer, H. L., Spiteri, I., Sottoriva, A., Riu, F., … Katare, R., … Madeddu, P. (2015). Epigenetic profile of human adventitial progenitor cells correlates with therapeutic outcomes in a mouse model of limb ischemia. Arteriosclerosis, Thrombosis, & Vascular Biology, 35, 675-688. doi: 10.1161/ATVBAHA.114.304989

Caporali, A., Meloni, M., Nailor, A., Mitić, T., Shantikumar, S., Riu, F., … Katare, R., … Emanueli, C. (2015). p75NTR-dependent activation of NF-κB regulates microRNA-503 transcription and pericyte-endothelial crosstalk in diabetes after limb ischaemia. Nature Communications, 6(8024). doi: 10.1038/ncomms9024

Avolio, E., Meloni, M., Spencer, H. L., Riu, F., Katare, R., Mangialardi, G., … Madeddu, P. (2015). Combined intramyocardial delivery of human pericytes and cardiac stem cells additively improves the healing of mouse infarcted hearts through stimulation of vascular and muscular repair. Circulation Research, 116, e81-e94. doi: 10.1161/circresaha.115.306146

Aiba, T., Noda, T., Hidaka, I., Inagaki, M., Katare, R. G., Ando, M., … Sugimachi, M. (2015). Acetylcholine suppresses ventricular arrhythmias and improves conduction and connexin-43 properties during myocardial ischemia in isolated rabbit hearts. Journal of Cardiovascular Electrophysiology, 26, 678-685. doi: 10.1111/jce.12663

Ascione, R., Rowlinson, J., Avolio, E., Katare, R., Meloni, M., Spencer, H. L., … Madeddu, P. (2015). Migration towards SDF-1 selects angiogenin-expressing bone marrow monocytes endowed with cardiac reparative activity in patients with previous myocardial infarction. Stem Cell Research & Therapy, 6, 53. doi: 10.1186/s13287-015-0028-y

Munasinghe, P. E., Riu, F., Dixit, P., Edamatsu, M., Saxena, P., Hamer, N. S. J., Galvin, I. F., Bunton, R. W., Lequeux, S., Jones, G., Lamberts, R., … Katare, R. (2015). Data supporting the activation of autophagy genes in the diabetic heart. Data in Brief, 5, 269-275. doi: 10.1016/j.dib.2015.09.003

Rawal, S., Manning, P., & Katare, R. (2014). Cardiovascular microRNAs: As modulators and diagnostic biomarkers of diabetic heart disease. Cardiovascular Diabetology, 13, 44. doi: 10.1186/1475-2840-13-44

Moore, A., Shindikar, A., Fomison-Nurse, I., Riu, F., Munasinghe, P. E., Parshu Ram, T., Saxena, P., Coffey, S., Bunton, R. W., Galvin, I. F., Williams, M. J. A., … Katare, R. (2014). Rapid onset of cardiomyopathy in STZ-induced female diabetic mice involves the downregulation of pro-survival Pim-1. Cardiovascular Diabetology, 13, 68. doi: 10.1186/1475-2840-13-68

Lamberts, R. R., Lingam, S. J., Wang, H.-Y., Bollen, I. A. E., Hughes, G., Galvin, I. F., Bunton, R. W., Bahn, A., Katare, R., Baldi, J. C., Williams, M. J. A., Saxena, P., Coffey, S., & Jones, P. P. (2014). Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction. Cardiovascular Diabetology, 13, 72. doi: 10.1186/1475-2840-13-72

Avolio, E., Gianfranceschi, G., Cesselli, D., Caragnano, A., Athanasakis, E., Katare, R., … Beltrami, A. P. (2014). Ex vivo molecular rejuvenation improves the therapeutic activity of senescent human cardiac stem cells in a mouse model of myocardial infarction. Stem Cells, 32(9), 2373-2385. doi: 10.1002/stem.1728

Katare, R., Stroemer, P., Hicks, C., Stevanato, L., Patel, S., Corteling, R., … Madeddu, P. (2014). Clinical-grade human neural stem cells promote reparative neovascularization in mouse models of hindlimb ischemia. Arteriosclerosis, Thrombosis, & Vascular Biology, 34, 408-418. doi: 10.1161/ATVBAHA.113.302592

Katare, R., Riu, F., Rowlinson, J., Lewis, A., Holden, R., Meloni, M., … Madeddu, P. (2013). Perivascular delivery of encapsulated mesenchymal stem cells improves postischemic angiogenesis via paracrine activation of VEGF-A. Arteriosclerosis, Thrombosis, & Vascular Biology, 33, 1872-1880. doi: 10.1161/atvbaha.113.301217

Aditi, Mahajan, N., Rawal, S., & Katare, R. (2013). An insight in to the pathogenesis of diabetic vascular diseases: Role of oxidative stress and antioxidants. Pharmaceutica Analytica Acta, 4(10), 273. doi: 10.4172/2153-2435.1000273

Katare, R. G., & Madeddu, P. (2013). Pericytes from human veins for treatment of myocardial ischemia. Trends in Cardiovascular Medicine, 23, 66-70. doi: 10.1016/j.tcm.2012.09.002

Katare, R., Oikawa, A., Cesselli, D., Beltrami, A. P., Avolio, E., Muthukrishnan, D., Munasinghe, P. E., … Madeddu, P. (2013). Boosting the pentose phosphate pathway restores cardiac progenitor cell availability in diabetes. Cardiovascular Research, 97(1), 55-65. doi: 10.1093/cvr/cvs291

Mangialardi, G., Katare, R., Oikawa, A., Meloni, M., Reni, C., Emanueli, C., & Madeddu, P. (2013). Diabetes causes bone marrow endothelial barrier dysfunction by activation of the RhoA-Rho-associated kinase signaling pathway. Arteriosclerosis, Thrombosis, & Vascular Biology, 33, 555-564. doi: 10.1161/ATVBAHA.112.300424

Amadesi, S., Reni, C., Katare, R., Meloni, M., Oikawa, A., Beltrami, A. P., … Madeddu, P. (2012). Role for substance P-based nociceptive signaling in progenitor cell activation and angiogenesis during ischemia in nice and in human subject. Circulation, 125, 1774-1786. doi: 10.1161/CIRCULATIONAHA.111.089763

Katare, R., Riu, F., Mitchell, K., Gubernator, M., Campagnolo, P., Cui, Y., … Madeddu, P. (2011). Transplantation of human pericyte progenitor cells improves the repair of infarcted heart through activation of an angiogenic program involving micro-RNA-132. Circulation Research, 109, 894-906. doi: 10.1161/CIRCRESAHA.111.251546

Spinetti, G., Fortunato, O., Cordella, D., Portararo, P., Kränkel, N., Katare, R., … Madeddu, P. (2011). Tissue kallikrein is essential for invasive capacity of circulating proangiogenic cells. Circulation Research, 108, 284-293. doi: 10.1161/CIRCRESAHA.110.236786

Katare, R., Caporali, A., Zentilin, L., Avolio, E., Sala-Newby, G., Oikawa, A., … Madeddu, P. (2011). Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling. Circulation Research, 108, 1238-1251. doi: 10.1161/CIRCRESAHA.110.239111

Katare, R. G., Caporali, A., Oikawa, A., Meloni, M., Emanueli, C., & Maddedu, P. (2010). Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1—mediated survival pathway. Circulation: Heart Failure, 3(2), 294-305. doi: 10.1161/CIRCHEARTFAILURE.109.903450

Katare, R. G., Ando, M., Kakinuma, Y., Arikawa, M., Yamasaki, F., & Sato, T. (2010). Differential regulation of TNF receptors by vagal nerve stimulation protects heart against acute ischemic injury. Journal of Molecular & Cellular Cardiology, 49(2), 234-244. doi: 10.1016/j.yjmcc.2010.03.007

Oikawa, A., Siragusa, M., Quaini, F., Mangialardi, G., Katare, R. G., Caporali, A., … Madeddu, P. (2010). Diabetes mellitus induces bone marrow microangiopathy. Arteriosclerosis, Thrombosis, & Vascular Biology, 30, 498-508. doi: 10.1161/ATVBAHA.109.200154

Handa, T., Katare, R. G., Nishimori, H., Wariishi, S., Fukutomi, T., Yamamoto, M., … Sato, T. (2010). New device for intraoperative graft assessment: HyperEye charge-coupled device camera system. General Thoracic & Cardiovascular Surgery, 58, 68-77. doi: 10.1007/s11748-009-0536-8

Meloni, M., Caporali, A., Graiani, G., Lagrasta, C., Katare, R., van Linthout, S., … Emanueli, C. (2010). Nerve growth factor promotes cardiac repair following myocardial infarction. Circulation Research, 106, 1275-1284. doi: 10.1161/CIRCRESAHA.109.210088

Campagnolo, P., Cesselli, D., Al Haj Zen, A., Beltrami, A. P., Kränkel, N., Katare, R., … Madeddu, P. (2010). Human adult vena saphena contains perivascular progenitor cells endowed with clonogenic and proangiogenic potential. Circulation, 121, 1735-1745. doi: 10.1161/CIRCULATIONAHA.109.899252

Kakinuma, Y., Furihata, M., Akiyama, T., Arikawa, M., Handa, T., Katare, R. G., & Sato, T. (2010). Donepezil, an acetylcholinesterase inhibitor against Alzheimer's dementia, promotes angiogenesis in an ischemic hindlimb model. Journal of Molecular & Cellular Cardiology, 48(4), 680-693. doi: 10.1016/j.yjmcc.2009.11.010

Siragusa, M., Katare, R., Meloni, M., Damilano, F., Hirsch, E., Emanueli, C., & Madeddu, P. (2010). Involvement of phosphoinositide 3-kinase γ in angiogenesis and healing of experimental myocardial infarction in mice. Circulation Research, 106, 757-768. doi: 10.1161/CIRCRESAHA.109.207449

Katare, R. G., Ando, M., Kakinuma, Y., & Sato, T. (2010). Engineered heart tissue: A novel tool to study the ischemic changes of the heart in vitro. PLoS ONE, 5(2), e9275. doi: 10.1371/journal.pone.0009275

Katare, R., Caporali, A., Emanueli, C., & Madeddu, P. (2010). Benfotiamine improves functional recovery of the infarcted heart via activation of pro-survival G6PD/Akt signaling pathway and modulation of neurohormonal response. Journal of Molecular & Cellular Cardiology, 49, 625-638. doi: 10.1016/j.yjmcc.2010.05.014

Katare, R. G., Kakinuma, Y., Arikawa, M., Yamasaki, F., & Sato, T. (2009). Chronic intermittent fasting improves the survival following large myocardial ischemia by activation of BDNF/VEGF/PI3K signaling pathway. Journal of Molecular & Cellular Cardiology, 46, 405-412. doi: 10.1016/j.yjmcc.2008.10.027

Handa, T., Katare, R. G., Kakinuma, Y., Arikawa, M., Ando, M., Sasaguri, S., … Sato, T. (2009). Anti-Alzheimer's drug, Donepezil, markedly improves long-term survival after chronic heart failure in mice. Journal of Cardiac Failure, 15(9), 805-811. doi: 10.1016/j.cardfail.2009.05.008

Katare, R. G., Ando, M., Kakinuma, Y., Arikawa, M., Handa, T., Yamasaki, F., & Sato, T. (2009). Vagal nerve stimulation prevents reperfusion injury through inhibition of opening of mitochondrial permeability transition pore independent of the bradycardiac effect. Journal of Thoracic & Cardiovascular Surgery, 137(1), 223-231. doi: 10.1016/j.jtcvs.2008.08.020

Handa, T., Katare, R. G., Sasaguri, S., & Sato, T. (2009). Preliminary experience for the evaluation of the intraoperative graft patency with real color charge-coupled device camera system: An advanced device for simultaneous capturing of color and near-infrared images during coronary artery bypass graft. Interactive Cardiovascular & Thoracic Surgery, 9, 150-154. doi: 10.1510/icvts.2008.201418

Stone, O. A., Richer, C., Emanueli, C., van Weel, V., Quax, P. H. A., Katare, R., … Madeddu, P. (2009). Critical role of tissue kallikrein in vessel formation and maturation: Implications for therapeutic revascularization. Arteriosclerosis, Thrombosis, & Vascular Biology, 29, 657-664. doi: 10.1161/ATVBAHA.108.182139

Barcelos, L. S., Duplaa, C., Kränkel, N., Graiani, G., Invernici, G., Katare, R., … Madeddu, P. (2009). Human CD133+ progenitor cells promote the healing of diabetic ischemic ulcers by paracrine stimulation of angiogenesis and activation of Wnt signaling. Circulation Research, 104, 1095-1102. doi: 10.1161/CIRCRESAHA.108.192138

Kakinuma, Y., Katare, R. G., Arikawa, M., Muramoto, K., Yamasaki, F., & Sato, T. (2008). A HIF-1alpha-related gene involved in cell protection from hypoxia by suppression of mitochondrial function. FEBS Letters, 582, 332-340. doi: 10.1016/j.febslet.2007.12.026

Radhakrishnan, G., Suzuki, R., Maeda, H., Yamamoto, M., Hirose, N., Katare, R. G., … Sasaguri, S. (2008). Inhibition of neointimal hyperplasia developement by MCI-186 is correlated with downregulation of nuclear factor-κB pathway. Circulation Journal, 72, 800-806.

Yamamoto, M., Hironori, M., Hirose, N., Yamamoto, M., Nakagawa, A., Radhakrishnan, G., Katare, R. G., … Sasaguri, S. (2008). Biphasic elevation of bilirubin oxidation during myocardial ischemia reperfusion. Circulation Journal, 72(9), 1520-1527.

Kränkel, N., Katare, R. G., Siragusa, M., Barcelos, L. S., Campagnolo, P., Mangialardi, G., … Madeddu, P. (2008). Role of kinin B2 receptor signaling in the recruitment of circulating progenitor cells with neovascularization potential. Circulation Research, 103, 1335-1343. doi: 10.1161/CIRCRESAHA.108.179952

Katare, R. G., Zhitian, Z., Sodeoka, M., & Sasaguri, S. (2007). Novel bisindolylmaleimide derivative inhibits mitochondrial permeability transition pore and protects the heart from reperfusion injury. Canadian Journal of Physiology & Pharmacology, 85(10), 979-985. doi: 10.1139/Y07-071

Kuwabara, M., Kakinuma, Y., Katare, R. G., Ando, M., Yamasaki, F., Doi, Y., & Sato, T. (2007). Granulocyte colony-stimulating factor activates Wnt signal to sustain gap junction function through recruitment of β-catenin and cadherin. FEBS Letters, 581, 4821-4830. doi: 10.1016/j.febslet.2007.09.007

Yamamoto, M., Maeda, H., Hirose, N., Radhakrishnan, G., Katare, R. G., Hayashi, Y., … Sasaguri, S. (2007). Bilirubin oxidation provoked by nitric oxide radicals predicts the progression of acute cardiac allograft rejection. American Journal of Transplantation, 7, 1897-1906. doi: 10.1111/j.1600-6143.2007.01868.x

Katare, R. G., Zhitian, Z., Sodeoka, M., & Sasaguri, S. (2007). A novel bisindolylmaleimide derivative enhances functional recovery of heart after long-term hypothermic heart preservation. Transplantation, 83(12), 1588-1594. doi: 10.1097/01.tp.0000267019.93796.aa

Zhang, Y., Kakinuma, Y., Ando, M., Katare, R. G., Yamasaki, F., Sugiura, T., & Sato, T. (2006). Acetylcholine inhibits the hypoxia-induced reduction of connexin43 protein in rat cardiomyocytes. Journal of Pharmacological Sciences, 101, 214-222. doi: 10.1254/jphs. FP0051023

Kuwabara, M., Kakinuma, Y., Ando, M., Katare, R. G., Yamasaki, F., Doi, Y., & Sato, T. (2006). Nitric oxide stimulates vascular endothelial growth factor production in cardiomyocytes involved in angiogenesis. Journal of Physiological Sciences, 56(1), 95-101. doi: 10.2170/physiolsci.RP002305

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Journal - Research Other

Campagnolo, P., Katare, R., & Madeddu, P. (2018). Realities and misconceptions on the pericytes role in tissue repair. Regenerative Medicine, 13(2), 119-122. doi: 10.2217/rme-2017-0091

Ghosh, N., & Katare, R. (2018). Molecular mechanism of diabetic cardiomyopathy and modulation of microRNA function by synthetic oligonucleotides. Cardiovascular Diabetology, 17, 43. doi: 10.1186/s12933-018-0684-1

Lew, J. K. S., Pearson, J. T., Schwenke, D. O., & Katare, R. (2017). Exercise mediated protection of diabetic heart through modulation of microRNA mediated molecular pathways. Cardiovascular Diabetology, 16(1), 10. doi: 10.1186/s12933-016-0484-4

Munasinghe, P. E., & Katare, R. (2017). Reply to the letter to editor "Autophagy may be impelled by collected fatty acids in type 2 diabetic myocardial cells". International Journal of Cardiology, 229, 4. doi: 10.1016/j.ijcard.2016.12.007

Neale, J. P. H., Pearson, J. T., Katare, R., & Schwenke, D. O. (2017). Ghrelin, microRNAs, and critical limb ischemia: Hungering for a novel treatment option. Frontiers in Endocrinology, 8, 350. doi: 10.3389/fendo.2017.00350

Ram, T. P., Fomison-Nurse, I., Gandhi, S., Coffey, S., Saxena, P., Galvin, I., Bunton, R., Williams, M. J. A., Lamberts, R. R., & Katare, R. (2017). The diagnostic sensitivity of circulating cardio-enriched microRNAs is increased after normalization of high-density lipoprotein levels [Short communication]. International Journal of Cardiology, 236, 498-500. doi: 10.1016/j.ijcard.2017.01.119

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Conference Contribution - Published proceedings: Abstract

Lew, J. K. S., Pearson, J. T., Katare, R., & Schwenke, D. O. (2018). High-intensity interval exercise attenuates cardiac remodelling in type-2 diabetes possibly through microRNAs restoration. Cardiovascular Research, 114(Suppl. 1), (pp. S60). doi: 10.1093/cvr/cvy060.164

Neale, J., Pearson, J., Tsuchimochi, H., Sonobe, T., Daniels, L., Katare, R., & Schwenke, D. (2018). Ghrelin deletion impairs postischaemic revascularisation in a murine model of critical limb ischaemia. Heart, Lung & Circulation, 27(Suppl. 2), (pp. S492). doi: 10.1016/j.hlc.2018.06.1023

Saw, E., Rawal, S., Bunton, R., Galvin, I., Davis, P., Fronius, M., & Katare, R. (2018). Non-neuronal cholinergic system in the diabetic heart. Heart, Lung & Circulation, 27(Suppl. 2), (pp. S115). doi: 10.1016/j.hlc.2018.06.161

Lew, J. K. S., Pearson, J. T., Katare, R., & Schwenke, D. O. (2018). Cardioprotection of moderate-intensity exercise is prognosis-dependent in type-2 diabetic mouse. Cardiovascular Research, 114(Suppl. 1), (pp. S105). doi: 10.1093/cvr/cvy060.304

Neale, J., Katare, R., & Schwenke, D. (2017). Can the 'hunger hormone' get a leg up on critical limb ischaemia? Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 61-62). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html

Purvis, N., Katare, R., & Bahn, A. (2017). The pathophysiological role of mircoRNAs in diabetic cardiac stem cells. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 72). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html

Lee, S., & Katare, R. (2017). Effect of glucose on enhancing maturation of heart muscle cells. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 49-50). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html

Lew, K. S., Pearson, J. T., Katare, R., & Schwenke, D. O. (2017). High-intensity interval exercise attenuates cardiac dysfunction and improves cardiac perfusion through restoration of microRNA-126 in type-2 diabetic mice. European Heart Journal, 38(Suppl. 1), (pp. 929). doi: 10.1093/eurheartj/ehx504.P4452

Akerman, A. P., Lucas, S. J. E., Baldi, C. J., Katare, R., & Cotter, J. D. (2015). Haematological adaptations to High Intensity Interval Training (HIIT) in temperate and hot environments. Extreme Physiology & Medicine, 4(Suppl. 4), A145. doi: 10.1186/2046-7648-4-S1-A145

Rawal, S., Munasinghe, E., Manning, P., & Katare, R. (2015). Cardiovascular microRNAs in diagnosis and therapeutic intervention of diabetic heart disease. New Zealand Medical Journal, 128(1425). Retrieved from http://www.nzma.org.nz/journal

Rawal, S., Munasinghe, E., Shindikar, A., Manning, P., & Katare, R. (2015). Orchestrated role of cardiovascular microRNAs in diabetic cardiomyopathy. Heart, Lung & Circulation, 24(Suppl. 3), (pp. S214). doi: 10.1016/j.hlc.2015.06.246

Gandhi, S., Fomison-Nurse, I., Cameron, V., & Katare, R. (2015). Circulating miR-34a as biomarker for diabetes mellitus. New Zealand Medical Journal, 128(1421). Retrieved from https://www.nzma.org.nz/journal

Donnelly, H., Dixit, P., Bunton, R., Galvin, I., & Katare, R. (2014). Exploiting the physiological and functional difference between stem cells isolated from human atria and left ventricle. Proceedings of the Medical Sciences Congress (MedSci). (pp. 33). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Dixit, P., Donnelly, H., Galvin, I., Bunton, R., & Katare, R. (2014). Comparison of in vitro functional properties of human cardiac and extra-cardiac stem cells. Proceedings of the Medical Sciences Congress (MedSci). (pp. 46). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Munasinghe, E., Fomison-Nurse, I., Hughes, G., Saxena, P., Bunton, R., Galvin, I., & Katare, R. (2014). Pathological autophagy augments cell death in the diabetic heart. Heart, Lung & Circulation, 23(Suppl. 1), (pp. e35). doi: 10.1016/j.hlc.2014.04.217

Purvis, N., Bahn, A., & Katare, R. (2014). The pathophysiological role of microRNAs in diabetic cardiac stem cells. Proceedings of the Medical Sciences Congress (MedSci). (pp. 34). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Purvis, N., Bahn, A., & Katare, R. (2014). The pathophysiological role of microRNAs in diabetic cardiac stem cells. New Zealand Medical Journal, 127(1406). Retrieved from http://www.nzma.org.nz/journal

Fomison-Nurse, I., Saxena, P., Coffey, S., Menon, A., Bunton, R., Galvin, I., Bahn, A., Williams, M., Cameron, V., & Katare, R. (2014). Diabetes causes the activation of the pro-ageing miRNA-34a in the human heart. Heart, Lung & Circulation, 23(Suppl. 1), (pp. e24). doi: 10.1016/j.hlc.2014.04.188

Rawal, S., Paulin, J., Munasinghe, E., Manning, P., & Katare, R. (2014). Circulating cardiovascular microRNAs as diagnostic biomarkers for early diagnosis of diabetic heart disease. Heart, Lung & Circulation, 23(Suppl. 1), (pp. e38-e39). doi: 10.1016/j.hlc.2014.04.227

Munasinghe, E., Rawal, S., Fomison-Nurse, I., & Katare, R. (2014). Pathological autophagy augments cell death in the diabetic heart. Proceedings of the Medical Sciences Congress (MedSci). (pp. 35). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Parshu Ram, T., & Katare, R. (2014). Therapeutic inhibition of cardiac specific microRNAs-1 and -208 to improve the function and survival of human cardiac myocytes exposed to hypoxia and high glucose. Proceedings of the Medical Sciences Congress (MedSci). (pp. 43). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Fomison-Nurse, I., Saxena, P., Menon, A., Bunton, R., Galvin, I., Bahn, A., Cameron, V., & Katare, R. (2014). Diabetes causes the activation of the pro-ageing microRNA-34a in the human heart. Proceedings of the Medical Sciences Congress (MedSci). (pp. 45). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Rawal, S., Shindikar, A., & Katare, R. (2014). Cardiac-specific microRNAs as early modulators of diabetic heart disease. Proceedings of the Medical Sciences Congress (MedSci). (pp. 44). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Katare, R. (2012). Identifying the molecular mechanisms involved in the development of diabetic cardiomyopathy. Proceedings of the Medical Sciences Congress (MedSci). (pp. 6). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf

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Conference Contribution - Poster Presentation (not in published proceedings)

Satthenapalli, V. R., Hore, T. A., Lamberts, R. R., & Katare, R. (2017, September). Ventricle-specific cardiomyocyte differentiation of mouse embryonic stem cells. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Satthenapalli, R., Hore, T. A., Lamberts, R. R., & Katare, R. (2016, August). Ventricular specific cardiomyocyte differentiation of mouse embryonic stem cells through modulation of molecular pathways. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Chandrasekera, D., Fomison-Nurse, I., Rawal, S., Bunton, R., Galvin, I., & Katare, R. (2016, August-September). Effect of diabetes on pro-apoptotic microRNA-532 in heart. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Wei, M. Y., Lew, J. K. S., Pearson, J. T., Katare, R., & Schwenke, D. O. (2016, August-September). Changes in coronary vascular function following the progression of diabetes: Assessed using Synchrotron Radiation microangiography. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Cheakhun, C., Dixit, P., Katare, R., & Bahn, A. (2016, August). Role of uric acid in cardiac stem cell function. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Rawal, S., Munasinghe, P. E., Cameron, V., Manning, P., Williams, M. J. A., Jones, G. T., Bunton, R., Galvin, I., & Katare, R. (2016, August). microRNA-126 and microRNA-132 are the early modulators of diabetic microangiopathy in heart. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Vehikite, L., & Katare, R. (2015, August-September). The effect of remote ischemic preconditioning on cardiac specific microRNAs in the diabetic heart. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Gandhi, S., & Katare, R. (2015, August-September). Identifying the functional role of microRNA-34a in diabetic cardiac stem cells. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Moore, A., Shindikar, A., Fomison-Nurse, I., & Katare, R. (2013, August). Rapid onset of cardiomyopathy in female diabetics. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Fomison-Nurse, I., Saxena, P., Menon, A., Bunton, R., Galvin, I., Bahn, A., & Katare, R. (2013, August). Diabetes causes the activation of the pro-ageing miRNA-34a in the human heart. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Rawal, S., Manning, P., Munasinghe, P., & Katare, R. (2013, August). Circulating cardiac-specific microRNAs as diagnostic biomarkers for early diagnosis of diabetic heart disease. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Parshu Ram, T., Fomison-Nurse, I., Munasinghe, P., Saxena, P., Menon, A., Bunton, R., Galvin, I., & Katare, R. (2013, August). The correlation between circulating and tissue levels of miR-1, miR126, miR-133 and miR-208 in cardiovascular disease. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

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Conference Contribution - Verbal presentation and other Conference outputs

Wei, M. Y., Lew, J. K. S., Pearson, J. T., Katare, R., & Schwenke, D. O. (2016, August). Preventing changes in coronary blood flow associated with type 2 diabetic heart disease through exercise: Assessed using Synchrotron Radiation Microangiography. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Katare, R. (2016, August-September). Circulating cardiovascular microRNAs as diagnostic biomarkers for early diagnosis of diabetic heart disease. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Neale, J. P. H., Katare, R., & Schwenke, D. (2016, August). Examining the role of endogenous ghrelin in vascular homeostasis using a murine model of hind-limb ischaemia. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Chandrasekera, D., Fomison-Nurse, I., Rawal, S., Bunton, R., Galvin, I., & Katare, R. (2016, August). Effect of diabetes on pro-apoptotic microRNA-532 in heart. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Katare, R. (2016, August). Diabetes increases autophagy in the human heart through promotion of Beclin-1 mediated pathway. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Rawal, S., Munasinghe, E., Manning, P., & Katare, R. (2015, August-September). Cardiovascular microRNAs in diagnosis and therapeutic intervention of diabetic heart disease. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Lew, K. S., Katare, R., & Schwenke, D. O. (2015, August-September). Moderate aerobic exercise prevents the onset of diabetic heart disease through modulation of cardiovascular miRNAs. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Katare, R. (2014, November). Circulating microRNAs as non-invasive diagnostic biomarkers for diabetic heart disease. Invited presentation at the Devices for Diagnostics and Drug Delivery (D4) Conference, Dunedin, New Zealand.

Katare, R. (2014, November). Circulating microRNAs as potential diagnostic biomarkers for diabetic heart disease. Verbal presentation at the HeartOtago First Australasian Symposium: Bench to Bedside and Back: New Advances in Cardiovascular Research, Dunedin, New Zealand.

Moore, A., Shindikar, A., Fomison-Nurse, I., & Katare, R. (2013, August). Rapid onset of cardiomyopathy in female diabetics. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Fomison-Nurse, I., Saxena, P., Menon, A., Bunton, R., Galvin, I., Bahn, A., & Katare, R. (2013, August). Diabetes causes the activation of the pro-ageing miRNA-34a in the human heart. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Parshu Ram, T., Fomison-Nurse, I., Munasinghe, P., Saxena, P., Menon, A., Bunton, R., Galvin, I., & Katare, R. (2013, August). The correlation between circulating and tissue levels of miR-1, miR-126, miR-133 and miR-208 in cardiovascular disease. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

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