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Munro Lab

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Research interests

I am interested in how the cardiac ultrastructure impacts the function of the heart, in particular the organisation of specialised structures known as the dyad and transverse tubules. I am investigating how these structures are remodelled in atrial fibrillation and heart failure, and whether specific proteins can be targeted to restore cardiac organisation and function in heart disease.

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Projects

  • Restoration of calcium balance by calsequestrin in atrial fibrillation

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Current funding

  • 2019–2022: Heart Foundation of New Zealand Research Fellowship
  • 2020–2022: Health Research Council Emerging Researcher First Grant

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Previous funding

  • Heart Foundation of New Zealand small project grant

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Publications

Sibbles, E. T., Waddell, H. M. M., Mereacre, V., Jones, P. P., & Munro, M. L. (2022). The function and regulation of calsequestrin-2: Implications in calcium-mediated arrhythmias. Biophysical Reviews. Advance online publication. doi: 10.1007/s12551-021-00914-6

Munro, M. L., van Hout, I., Aitken-Buck, H., Sugunesegran, R., Bhagwat, K., Davis, P. J., Lamberts, R. R., Coffey, S., … Jones, P. P. (2021). Human atrial fibrillation is not associated with remodeling of ryanodine receptor clusters. Frontiers in Cell & Developmental Biology, 9, 633704. doi: 10.3389/fcell.2021.633704

Munro, M. L., & Jones, P. P. (2020). Too much of a good thing? Establishing a role of excessive RyR2 dephosphorylation in heart disease. Journal of Physiology, 598(6), 1115-1116. doi: 10.1113/jp279569

Munro, M. L., van Hout, I., Sugunesegran, R., Bhagwat, K., Davis, P. J., Bunton, R. W., Coffey, S., … Jones, P. P. (2019, September). Resolving the role of dyadic organisation in cardiac dysfunction. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Hinton, L., Jones, P., & Munro, M. (2019, September). Role protein kinase CK2 in regulation of the cardiac Ryanodine Receptor. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.