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Lab personnel

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Research interests

  • Sympathetic excitation following acture myocardial infarction
    • Therapeutic effects of ghrelin in acute heart failure
    • Role of the peripheral chemoreflex in sympathetic excitation.
  • Regulation of the pulmonary vasculature
    • Endothelial control of the pulmonary vasculature
    • Sympathetic modulation
    • Pathological changes in the pathogenesis of pulmonary hypertension
    • Pulmonary vascular dysfunction in obesity

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Teaching

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Selected publications

Schwenke, D. O., Pearson, J. T., Umetani, K., Kangawa, K., & Shirai, M. (2007). Imaging of the pulmonary circulation in the closed-chest rat using synchrotron radiation microangiography. Journal of Applied Physiology, 102, 787-793.

Schwenke, D. O., Gray, E. A., Pearson, J. T., Sonobe, T., Ishibashi-Ueda, H., Campillo, I., … Shirai, M. (2011). Exogenous ghrelin improves blood flow distribution in pulmonary hypertension: Assessed using synchrotron radiation microangiography. Pflügers Archiv: European Journal of Physiology, 462(3), 397-406. doi: 10.1007/s00424-011-0992-8

Schwenke, D. O., Pearson, J. T., Sonobe, T., Ishibashi-Ueda, H., Shimouchi, A., Kangawa, K., … Shirai, M. (2011). Role of Rho-kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension. Journal of Applied Physiology, 110(4), 901-908. doi: 10.1152/japplphysiol.01318.2010

Schwenke, D. O., Pearson, J. T., Shimochi, A., Kangawa, K., Tsuchimochi, H., Umetani, K., … Cragg, P. A. (2009). Changes in pulmonary blood flow distribution in monocrotaline compared with hypoxia-induced models of pulmonary hypertension: Assessed using synchrotron radiation. Journal of Hypertension, 27(7), 1410-1419. doi: 10.1097/HJH.0b013e32832af6a1

Sonobe, T., Schwenke, D. O., Pearson, J. T., Yoshimoto, M., Fujii, Y., Umetani, K., & Shirai, M. (2011). Imaging of the closed-chest mouse pulmonary circulation using synchrotron radiation microangiography. Journal of Applied Physiology, 111(1), 75-80. doi: 10.1152/japplphysiol.00205.2011

Pearson, J. T., Schwenke, D. O., Jenkins, M. J., Edgley, A. J., Sonobe, T., Ishibashi-Ueda, H., … Shirai, M. (2010). Benefits of synchrotron microangiography for dynamic studies of smooth muscle and endothelial roles in the pathophysiology of vascular disease. AIP Conference Proceedings, 1266(1), 84-88. doi: 10.1063/1.3478204

Schwenke, D. O., Pearson, J. T., Kangawa, K., Cragg, P. A., & Shirai, M. (2010). Exogenous ghrelin accentuates the acute hypoxic ventilatory response after two weeks of chronic hypoxia in conscious rats. Acta Physiologica, 200(3), 279-287. doi: 10.1111/j.1748-1716.2010.02142.x

Shirai, M., Schwenke, D. O., Eppel, G. A., Evans, R. G., Edgley, A. J., Tsuchimochi, H., … Pearson, J. T. (2009). Synchrotron-based angiography for investigation of the regulation of vasomotor function in the microcirculation in vivo. Clinical & Experimental Pharmacology & Physiology, 36(1), 107-116. doi: 10.1111/j.1440-1681.2008.05073.x

Kishimoto, I., Tokudome, T., Schwenke, D. O., Takeshi, S., Hosoda, H., Nagaya, N., & Kangawa, K. (2009). Therapeutic potential of ghrelin in cardiac diseases. Expert Review of Endocrinology & Metabolism, 4(3), 283-289.

Schwenke, D. O., Pearson, J. T., Kangawa, K., Umetani, K., & Shirai, M. (2008). Changes in macrovessel pulmonary blood flow distribution following chronic hypoxia: Assessed using synchrotron radiation microangiography. Journal of Applied Physiology, 104(1), 88-96.

Schwenke, D. O., Tokudome, T., Kishimoto, I., Horio, T., Shirai, M., Cragg, P. A., & Kangawa, K. (2008). Early ghrelin treatment after myocardial infarction prevents an increase in cardiac sympathetic tone and reduces mortality. Endocrinology, 149(10), 5172-5176.

Schwenke, D. O., Tokudome, T., Shirai, M., Hosoda, H., Horio, T., Kishimoto, I., & Kangawa, K. (2008). Exogenous ghrelin attenuates the progression of chronic hypoxia-induced pulmonary hypertension in conscious rats. Endocrinology, 149(1), 237-244.

Schwenke, D. O., Bolter, C. P., & Cragg, P. A. (2007). Are the carotid bodies of the guinea-pig functional? Comparative Biochemistry & Physiology Part A, 146(2), 180-188.

Pearson, J. T., Shirai, M., Tsuchimochi, H., Schwenke, D. O., Ishida, T., Kangawa, K., … Yagi, N. (2007). Effects of sustained length-dependent activiation on in situ cross-bridge dynamics in rat hearts. Biophysical Journal, 93, 4319-4329.

Schwenke, D. O., Pearson, J. T., Tsuchimochi, H., Kangawa, K., & Shirai, M. (2007). Pulmonary vascular reactivity of spontaneously hypertensive rats is exacerbated in response to the central administration of exogenous nitrix oxide. Clinical & Experimental Pharmacology & Physiology, 34, 88-94.

Pearson, J. T., Shirai, M., Yokoyama, C., Tsuchimochi, H., Schwenke, D. O., Shimouchi, A., … Tanabe, T. (2007). α2-Adrenoreceptor mediated sympathoinhibition of heart rate during acute hypoxia is diminished in conscious prostacyclin synthase deficient mice. Pflügers Archiv: European Journal of Physiology, 454, 29-39. doi: 10.1007/s00424-006-0175-1

Schwenke, D. O., Pearson, J. T., Kangawa, K., & Shirai, M. (2006). Does central nitric oxide chronically modulate the acute hypoxic ventilatory response in conscious rats? Acta Physiologica, 186, 309-318.

Schwenke, D. O., Pearson, J. T., Mori, H., & Shirai, M. (2006). Does central nitric oxide elicit pulmonary hypertension in conscious rats? Respiratory Physiology & Neurobiology, 153, 250-260.

Schwenke, D. O., Pearson, J. T., Mori, H., & Shirai, M. (2006). Long-term monitoring of pulmonary arterial pressure in conscious, unrestrained mice. Journal of Pharmacological & Toxicological Methods, 53, 277-283.

Chapter in Book - Research

Brown, C. H., Han, S. Y., Moaddab, M., Scott, V., & Schwenke, D. O. (2015). Peptidergic control of oxytocin and vasopressin neurons and its role in reproduction and hypertension-associated plasticity. In W. E. Armstrong & J. G. Tasker (Eds.), Neurophysiology of neuroendocrine neurons. (pp. 63-84). Chichester, UK: Wiley Blackwell. doi: 10.1002/9781118606803.ch3

Cragg, P. A., & Schwenke, D. O. (1996). Role of carotid bodies in the guinea-pig. In P. Zapata, C. Eyzaguirre & R. W. Torrance (Eds.), Frontiers in Arterial Chemoreception. (pp. 377-381). New York: Plenum Press.

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Journal - Research Article

Bui, C. B., Kolodziej, M., Lamanna, E., Elgass, K., Sehgal, A., Rudloff, I., Schwenke, D. O., … Nold-Petry, C. A. (2019). Interleukin-1 receptor antagonist protects newborn mice against pulmonary hypertension. Frontiers in Immunology, 10, 1480. doi: 10.3389/fimmu.2019.01480

Korpal, A. K., Han, S. Y., Schwenke, D. O., & Brown, C. H. (2018). A switch from GABA inhibition to excitation of vasopressin neurones exacerbates the development angiotensin II-dependent hypertension. Journal of Neuroendocrinology, 30(8), e12564. doi: 10.1111/jne.12564

Pearson, J. T., Collie, N., Lamberts, R. R., Inagaki, T., Yoshimoto, M., Umetani, K., … Wilkins, G., Jones, P. P., … Schwenke, D. O. (2018). Ghrelin preserves ischemia-induced vasodilation of male rat coronary vessels following beta-adrenergic receptor blockade. Endocrinology, 159(4), 1763-1773. doi: 10.1210/en.2017-03070

Katare, R., Pearson, J. T., Lew, J. K.-S., Wei, M., Tsuchimouchi, H., Du, C.-K., … Schwenke, D. O. (2018). Progressive decrease in coronary vascular function associated with type 2 diabetic heart disease. Frontiers in Physiology, 9, 696. doi: 10.3389/fphys.2018.00696

Korpal, A. K., Brown, C. H., & Schwenke, D. O. (2018). Assessing the role of hypothalamic microglia and blood vessel disruption in the development of angiotensin II-dependent hypertension in Cyp1a1-Ren2 rats. Pflügers Archiv: European Journal of Physiology, 470(6), 883-895. doi: 10.1007/s00424-018-2128-x

Roy, R. K., Augustine, R. A., Brown, C. H., & Schwenke, D. O. (2018). Activation of oxytocin neurons in the paraventricular nucleus drives cardiac sympathetic nerve activation following myocardial infarction in rats. Communications Biology, 1, 160. doi: 10.1038/s42003-018-0169-5

Pearson, J. T., Yoshimoto, M., Chen, Y. C., Sultani, R., Edgley, A. J., Nakaoka, H., … Schwenke, D. O., … Shirai, M. (2017). Widespread coronary dysfunction in the absence of HDL receptor SR-B1 in an ischemic cardiomyopathy mouse model. Scientific Reports, 7, 18108. doi: 10.1038/s41598-017-18485-6

Hall, T. M., Gordon, C., Roy, R., & Schwenke, D. O. (2016). Delayed coronary reperfusion is ineffective at impeding the dynamic increase in cardiac efferent sympathetic nerve activity following myocardial ischemia. Basic Research in Cardiology, 111, 35. doi: 10.1007/s00395-016-0556-3

Diong, C., Jones, P. P., Tsuchimochi, H., Gray, E. A., Hughes, G., Inagaki, T., Bussey, C. T., … Schwenke, D. O. (2016). Sympathetic hyper-excitation in obesity and pulmonary hypertension: Physiological relevance to the 'obesity paradox'. International Journal of Obesity, 40, 938-946. doi: 10.1038/ijo.2016.33

Katare, R., Rawal, S., Munasinghe, P. E., Tsuchimochi, H., Inagaki, T., Fujii, Y., Dixit, P., … Schwenke, D. O. (2016). Ghrelin promotes functional angiogenesis in a mouse model of critical limb ischemia through activation of proangiogenic microRNAs. Endocrinology, 157(2), 432-445. doi: 10.1210/en.2015-1799

Chen, Y. C., Inagaki, T., Fujii, Y., Schwenke, D. O., Tsuchimochi, H., Edgley, A. J., … Pearson, J. T. (2016). Chronic intermittent hypoxia accelerates coronary microcirculatory dysfunction in insulin resistant Goto-Kakizaki rats. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 311, R426-R439. doi: 10.1152/ajpregu.00112.2016

Thaung, H. P. A., Baldi, J. C., Wang, H.-Y., Hughes, G., Cook, R. F., Bussey, C. T., Sheard, P. W., Bahn, A., Jones, P. P., Schwenke, D. O., & Lamberts, R. R. (2015). Increased efferent cardiac sympathetic nerve activity and defective intrinsic heart rate regulation in type 2 diabetes. Diabetes, 64(8), 2944-2956. doi: 10.2337/db14-0955

Shirai, M., Joe, N., Tsuchimochi, H., Sonobe, T., & Schwenke, D. O. (2015). Ghrelin supresses sympathetic hyper-excitation in acute heart failure in male rats: Assessing centrally and peripherally mediated pathways. Endocrinology, 156(9), 3309-3316. doi: 10.1210/en.2015-1333

Nagai, H., Kuwahira, I., Schwenke, D. O., Tsuchimochi, H., Nara, A., Ogura, S., … Shirai, M. (2015). Pulmonary macrophages attenuate hypoxic pulmonary vasoconstriction via β3AR/iNOS pathway in rats exposed to chronic intermittent hypoxia. PLoS ONE, 10(7), e0131923. doi: 10.1371/journal.pone.0131923

Sonobe, T., Tsuchimochi, H., Schwenke, D. O., Pearson, J. T., & Shirai, M. (2015). Treadmill running improves hindlimb arteriolar endothelial function in type 1 diabetic mice as visualized by X-ray microangiography. Cardiovascular Diabetology, 14, 51. doi: 10.1186/s12933-015-0217-0

Han, S. Y., Bouwer, G. T., Seymour, A. J., Korpal, A. K., Schwenke, D. O., & Brown, C. H. (2015). Induction of hypertension blunts baroreflex inhibition of vasopressin neurons in the rat. European Journal of Neuroscience, 42(9), 2690-2698. doi: 10.1111/ejn.13062

Ashley, Z., Schwenke, D. O., & Cragg, P. A. (2015). Hyperventilation in normoxia following myocardial infarction in rats: A shift in the set point of the hypoxic ventilatory response. Acta Physiologica, 214, 415-425. doi: 10.1111/apha.12527

Du, C.-K., Zhan, D.-Y., Morimoto, S., Akiyama, T., Schwenke, D. O., Hosoda, H., … Shirai, M. (2014). Survival benefit of ghrelin in the heart failure due to dilated cardiomyopathy. Pharmacology Research & Perspectives, 2(5), e00064. doi: 10.1002/prp2.64

Nagai, H., Kuwahira, I., Schwenke, D. O., Tsuchimochi, H., Nara, A., Inagaki, T., … Shirai, M. (2014). β2-adrenergic receptor-dependent attenuation of hypoxic pulmonary vasoconstriction prevents progression of pulmonary arterial hypertension in intermittent hypoxic rats. PLoS ONE, 9(10), e110693. doi: 10.1371/journal.pone.0110693

Shirai, M., Tsuchimochi, H., Nagai, H., Gray, E., Pearson, J. T., Sonobe, T., … Schwenke, D. O. (2014). Pulmonary vascular tone is dependent on the central modulation of sympathetic nerve activity following chronic intermittent hypoxia. Basic Research in Cardiology, 109, 432. doi: 10.1007/s00395-014-0432-y

Han, S. Y., Gray, E., Hughes, G., Brown, C. H., & Schwenke, D. O. (2014). Increased sympathetic drive during the onset of hypertension in conscious Cyp1a1-Ren2 rats. Pflügers Archiv: European Journal of Physiology, 466(3), 459-466. doi: 10.1007/s00424-013-1338-5

Gray, E. A., Tsuchimochi, H., Pearson, J. T., Sonobe, T., Fujii, Y., Yoshimoto, M., … Schwenke, D. O. (2013). Assessment of the serotonin pathway as a therapeutic target for pulmonary hypertension. Journal of Synchrotron Radiation, 20(Pt 5), 756-764. doi: 10.1107/s0909049513021213

Shirai, M., Schwenke, D. O., Tsuchimochi, H., Umetani, K., Yagi, N., & Pearson, J. T. (2013). Synchrotron radiation imaging for advancing our understanding of cardiovascular function. Circulation Research, 112(1), 209-221. doi: 10.1161/circresaha.111.300096

Shirai, M., Beard, M., Pearson, J. T., Sonobe, T., Tsuchimochi, H., Fujii, Y., Gray, E., … Schwenke, D. O. (2013). Impaired pulmonary blood flow distribution in congestive heart failure assessed using synchrotron radiation microangiography. Journal of Synchrotron Radiation, 20(3), 441-448. doi: 10.1107/S0909049513007413

Pearson, J. T., Jenkins, M. J., Edgley, A. J., Sonobe, T., Joshi, M., Waddingham, M. T., … Schwenke, D. O., … Shirai, M. (2013). Acute Rho-kinase inhibition improves coronary dysfunction in vivo, in the early diabetic microcirculation. Cardiovascular Diabetology, 12, 111. doi: 10.1186/1475-2840-12-111

Jenkins, M. J., Pearson, J. T., Schwenke, D. O., Edgley, A. J., Sonobe, T., Fujii, Y., … Shirai, M. (2013). Myosin heads are displaced from actin filaments in the in situ beating rat heart in early diabetes. Biophysical Journal, 104(5), 1065-1072. doi: 10.1016/j.bpj.2013.01.037

Umetani, K., Pearson, J. T., Schwenke, D. O., & Shirai, M. (2013). Synchrotron radiation intravital microscopy for preclinical imaging in rat and mouse hearts. Journal of the Institute of Image Information & Television Engineers, 67(8), J323-J325. doi: 10.3169/itej.67.J323

Schwenke, D. O., Tokudome, T., Kishimoto, I., Horio, T., Cragg, P. A., Shirai, M., & Kangawa, K. (2012). One dose of ghrelin prevents the acute and sustained increase in cardiac sympathetic tone after myocardial infarction. Endocrinology, 153(5), 2436-2443. doi: 10.1210/en.2011-2057

Schwenke, D. O., Gray, E. A., Pearson, J. T., Sonobe, T., Ishibashi-Ueda, H., Campillo, I., … Shirai, M. (2011). Exogenous ghrelin improves blood flow distribution in pulmonary hypertension: Assessed using synchrotron radiation microangiography. Pflügers Archiv: European Journal of Physiology, 462(3), 397-406. doi: 10.1007/s00424-011-0992-8

Sonobe, T., Schwenke, D. O., Pearson, J. T., Yoshimoto, M., Fujii, Y., Umetani, K., & Shirai, M. (2011). Imaging of the closed-chest mouse pulmonary circulation using synchrotron radiation microangiography. Journal of Applied Physiology, 111(1), 75-80. doi: 10.1152/japplphysiol.00205.2011

Schwenke, D. O., Pearson, J. T., Sonobe, T., Ishibashi-Ueda, H., Shimouchi, A., Kangawa, K., … Shirai, M. (2011). Role of Rho-kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension. Journal of Applied Physiology, 110(4), 901-908. doi: 10.1152/japplphysiol.01318.2010

Pearson, J. T., Schwenke, D. O., Jenkins, M. J., Edgley, A. J., Sonobe, T., Ishibashi-Ueda, H., … Shirai, M. (2010). Benefits of synchrotron microangiography for dynamic studies of smooth muscle and endothelial roles in the pathophysiology of vascular disease. AIP Conference Proceedings, 1266(1), 84-88. doi: 10.1063/1.3478204

Schwenke, D. O., Pearson, J. T., Kangawa, K., Cragg, P. A., & Shirai, M. (2010). Exogenous ghrelin accentuates the acute hypoxic ventilatory response after two weeks of chronic hypoxia in conscious rats. Acta Physiologica, 200(3), 279-287. doi: 10.1111/j.1748-1716.2010.02142.x

Shirai, M., Schwenke, D. O., Eppel, G. A., Evans, R. G., Edgley, A. J., Tsuchimochi, H., … Pearson, J. T. (2009). Synchrotron-based angiography for investigation of the regulation of vasomotor function in the microcirculation in vivo. Clinical & Experimental Pharmacology & Physiology, 36(1), 107-116. doi: 10.1111/j.1440-1681.2008.05073.x

Schwenke, D. O., Pearson, J. T., Shimochi, A., Kangawa, K., Tsuchimochi, H., Umetani, K., … Cragg, P. A. (2009). Changes in pulmonary blood flow distribution in monocrotaline compared with hypoxia-induced models of pulmonary hypertension: Assessed using synchrotron radiation. Journal of Hypertension, 27(7), 1410-1419. doi: 10.1097/HJH.0b013e32832af6a1

Kishimoto, I., Tokudome, T., Schwenke, D. O., Takeshi, S., Hosoda, H., Nagaya, N., & Kangawa, K. (2009). Therapeutic potential of ghrelin in cardiac diseases. Expert Review of Endocrinology & Metabolism, 4(3), 283-289.

Schwenke, D. O., Pearson, J. T., Kangawa, K., Umetani, K., & Shirai, M. (2008). Changes in macrovessel pulmonary blood flow distribution following chronic hypoxia: Assessed using synchrotron radiation microangiography. Journal of Applied Physiology, 104(1), 88-96.

Schwenke, D. O., Tokudome, T., Kishimoto, I., Horio, T., Shirai, M., Cragg, P. A., & Kangawa, K. (2008). Early ghrelin treatment after myocardial infarction prevents an increase in cardiac sympathetic tone and reduces mortality. Endocrinology, 149(10), 5172-5176.

Schwenke, D. O., Tokudome, T., Shirai, M., Hosoda, H., Horio, T., Kishimoto, I., & Kangawa, K. (2008). Exogenous ghrelin attenuates the progression of chronic hypoxia-induced pulmonary hypertension in conscious rats. Endocrinology, 149(1), 237-244.

Schwenke, D. O., Pearson, J. T., Umetani, K., Kangawa, K., & Shirai, M. (2007). Imaging of the pulmonary circulation in the closed-chest rat using synchrotron radiation microangiography. Journal of Applied Physiology, 102, 787-793.

Schwenke, D. O., Bolter, C. P., & Cragg, P. A. (2007). Are the carotid bodies of the guinea-pig functional? Comparative Biochemistry & Physiology Part A, 146(2), 180-188.

Pearson, J. T., Shirai, M., Tsuchimochi, H., Schwenke, D. O., Ishida, T., Kangawa, K., … Yagi, N. (2007). Effects of sustained length-dependent activiation on in situ cross-bridge dynamics in rat hearts. Biophysical Journal, 93, 4319-4329.

Schwenke, D. O., Pearson, J. T., Tsuchimochi, H., Kangawa, K., & Shirai, M. (2007). Pulmonary vascular reactivity of spontaneously hypertensive rats is exacerbated in response to the central administration of exogenous nitrix oxide. Clinical & Experimental Pharmacology & Physiology, 34, 88-94.

Pearson, J. T., Shirai, M., Yokoyama, C., Tsuchimochi, H., Schwenke, D. O., Shimouchi, A., … Tanabe, T. (2007). α2-Adrenoreceptor mediated sympathoinhibition of heart rate during acute hypoxia is diminished in conscious prostacyclin synthase deficient mice. Pflügers Archiv: European Journal of Physiology, 454, 29-39. doi: 10.1007/s00424-006-0175-1

Schwenke, D. O., Pearson, J. T., Mori, H., & Shirai, M. (2006). Long-term monitoring of pulmonary arterial pressure in conscious, unrestrained mice. Journal of Pharmacological & Toxicological Methods, 53, 277-283.

Schwenke, D. O., Pearson, J. T., Kangawa, K., & Shirai, M. (2006). Does central nitric oxide chronically modulate the acute hypoxic ventilatory response in conscious rats? Acta Physiologica, 186, 309-318.

Schwenke, D. O., Pearson, J. T., Mori, H., & Shirai, M. (2006). Does central nitric oxide elicit pulmonary hypertension in conscious rats? Respiratory Physiology & Neurobiology, 153, 250-260.

Aebli, N., Schwenke, D., Davis, G., Hii, T., Theis, J.-C., & Krebs, J. (2005). Polymethylmethacrylate causes prolonged pulmonary hypertension during fat embolism. Acta Orthopaedica, 76(6), 904-911.

Schwenke, D. O., & Cragg, P. A. (2004). Comparison of the depressive effects of four anesthetic regimens on ventilatory and cardiovascular variables in the guinea pig. Comparative Medicine, 54(1), 77-85.

Aebli, N., Krebs, J., Schwenke, D. O., Davis, G., & Theis, J.-C. (2003). Cardiovascular changes during multiple vertebroplasty with and without vent-hole: An experimental study in sheep. Spine, 28(14), 1504-1512.

Aebli, N., Krebs, J., Schwenke, D. O., Davis, G., & Theis, J.-C. (2003). Pressurization of vertebral bodies during vertebroplasty causes cardiovascular complications. Spine, 28(14), 1513-1520.

Aebli, N., Krebs, J., Stich, H., Schawalder, P., Walton, M. H., Schwenke, D. O., … Theis, J.-C. (2003). In vivo comparison of the osseointegration of vacuum plasma sprayed titanium- and hydroxyapatite-coated implants. Journal of Biomedical Materials Research Part A, 66A(2), 356-363.

Aebli, N., Krebs, J., Schwenke, D., Stich, H., Schawalder, P., & Theis, J.-C. (2003). Degradation of hydroxyapatite coating on a well-functioning femoral component. Journal of Bone & Joint Surgery (Br), 85-B(4), 499-503.

Schwenke, D. O., & Cragg, P. A. (2000). Carotid bodies and the sigh reflex in the conscious and anaesthetised guinea-pig. Advances in Experimental Medicine & Biology, 475, 801-813.

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Journal - Research Other

Lew, J. K. S., Pearson, J. T., Schwenke, D. O., & Katare, R. (2017). Exercise mediated protection of diabetic heart through modulation of microRNA mediated molecular pathways. Cardiovascular Diabetology, 16(1), 10. doi: 10.1186/s12933-016-0484-4

Neale, J. P. H., Pearson, J. T., Katare, R., & Schwenke, D. O. (2017). Ghrelin, microRNAs, and critical limb ischemia: Hungering for a novel treatment option. Frontiers in Endocrinology, 8, 350. doi: 10.3389/fendo.2017.00350

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Journal - Professional & Other Non-Research Articles

Schwenke, D. O., Umetani, K., & Shirai, M. (2008). Assessment of the pulmonary circulation in health and disease using synchrotron radiation microangiography. SPring-8 Research Frontiers, 52-53.

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Conference Contribution - Published proceedings: Full paper

Umetani, K., Pearson, J. T., Schwenke, D. O., & Shirai, M. (2013). Rat coronary microangiography system for preclinical imaging using synchrotron radiation. Proceedings of SPIE (Vol. 8668): Medical Imaging: Physics of Medical Imaging. 866864. doi: 10.1117/12.2006570

Umetani, K., Pearson, J. T., Schwenke, D. O., & Shirai, M. (2011). Development of synchrotron radiation x-ray intravital microscopy for in vivo imaging of rat heart vascular function. Proceedings of the 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS). (pp. 7791-7794). doi: 10.1109/IEMBS.2011.6091920

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Conference Contribution - Published proceedings: Abstract

Lew, J. K. S., Pearson, J. T., Katare, R., & Schwenke, D. O. (2018). High-intensity interval exercise attenuates cardiac remodelling in type-2 diabetes possibly through microRNAs restoration. Cardiovascular Research, 114(Suppl. 1), (pp. S60). doi: 10.1093/cvr/cvy060.164

Neale, J., Pearson, J., Tsuchimochi, H., Sonobe, T., Daniels, L., Katare, R., & Schwenke, D. (2018). Ghrelin deletion impairs postischaemic revascularisation in a murine model of critical limb ischaemia. European Heart Journal, 39(Suppl. 1), (pp. 1403). doi: 10.1093/eurheartj/ehy566.P6565

Neale, J., Pearson, J., Tsuchimochi, H., Sonobe, T., Daniels, L., Katare, R., & Schwenke, D. (2018). Ghrelin deletion impairs postischaemic revascularisation in a murine model of critical limb ischaemia. Heart, Lung & Circulation, 27(Suppl. 2), (pp. S492). doi: 10.1016/j.hlc.2018.06.1023

Brown, C. H., Korpal, A. K., Han, S. Y., & Schwenke, D. O. (2018). Vasopressin exacerbates the development of hypertension. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 339). Retrieved from http://www.icn2018.org/

Lew, J. K. S., Pearson, J. T., Katare, R., & Schwenke, D. O. (2018). Cardioprotection of moderate-intensity exercise is prognosis-dependent in type-2 diabetic mouse. Cardiovascular Research, 114(Suppl. 1), (pp. S105). doi: 10.1093/cvr/cvy060.304

Neale, J., Katare, R., & Schwenke, D. (2017). Can the 'hunger hormone' get a leg up on critical limb ischaemia? Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 61-62). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html

Bussey, C. T., Ashley, Z., Schwenke, D. O., & Lamberts, R. R. (2017). Increased right cardiac sympathetic and parasympathetic nerve activity in type 2 diabetes. New Zealand Medical Journal, 130(1467), (pp. 104). Retrieved from http://www.nzma.org.nz/journal

Lew, K. S., Pearson, J. T., Katare, R., & Schwenke, D. O. (2017). High-intensity interval exercise attenuates cardiac dysfunction and improves cardiac perfusion through restoration of microRNA-126 in type-2 diabetic mice. European Heart Journal, 38(Suppl. 1), (pp. 929). doi: 10.1093/eurheartj/ehx504.P4452

Korpal, A., Schwenke, D. O., & Brown, C. H. (2016). Vasopressin contributes to the development of angiotensin II-dependent hypertension. Proceedings of the Society for Neuroscience 46th Annual Meeting. 341.08/WW1. SfN. Retrieved from https://www.sfn.org/

Bussey, C. T., Ashley, Z., Schwenke, D. O., & Lamberts, R. R. (2016). Increased right cardiac sympathetic and parasympathetic nerve activity in type 2 diabetes. Proceedings of The Physiological Society, PCB038 . Retrieved from http://www.physoc.org

Zhan, D. Y., Du, C., Morimoto, S., Akiyama, T., Schwenke, D. O., Hosoda, H., … Shirai, M. (2015). The treatment benefit of ghrelin on a mouse model of inherited dilated cardiomyopathy caused by troponin mutation. Biophysical Journal, 108(2, Suppl. 1), (pp. 596a). doi: 10.1016/j.bpj.2014.11.3243

Roy, R. K., Brown, C. H., & Schwenke, D. O. (2015). Myocardial infarction increases Fos protein expression in the paraventricular and supraoptic nuclei. Proceedings of the 11th World Congress on Neurohypophysial Hormones (WCNH). (pp. 62-63). Retrieved from http://wcnh.otago.ac.nz/index.html

Korpal, A. K., Schwenke, D. O., & Brown, C. H. (2015). Induction of angiotensin II-dependent hypertension does not activate microglia in the hypothalamic supraoptic and paraventricular nuclei. Proceedings of the 11th World Congress on Neurohypophysial Hormones (WCNH). (pp. 40). Retrieved from http://wcnh.otago.ac.nz/index.html

Schwenke, D., Joe, N., Tsuchimochi, H., & Shirai, M. (2014). Ghrelin suppresses cardiac sympathetic tone following acute myocardial infarct: Mechanistic insight. FASEB Journal, 28(1, Suppl.), 1169.5. [Abstract]

Hall, T., Joe, N., & Schwenke, D. (2014). Optimising quantification of cardiac sympathetic nerve activity. New Zealand Medical Journal, 127(1395). Retrieved from http://www.nzma.org.nz/journal

Hall, T., & Schwenke, D. (2014). Effect of myocardial ischemia-reperfusion on cardiac sympathetic nerve activity in the rat. New Zealand Medical Journal, 127(1406). Retrieved from http://www.nzma.org.nz/journal

Hall, T., & Schwenke, D. (2014). Changes in sympathetic nerve activity following cardiac ischemia-reperfusion. Proceedings of the Medical Sciences Congress (MedSci). (pp. 32). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Korpal, A. K., Brown, C. H., & Schwenke, D. O. (2014). Neuroinflammation in the development of hypertension. Proceedings of the Medical Sciences Congress (MedSci). (pp. 31). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Roy, R. K., Brown, C. H., & Schwenke, D. O. (2014). Central modulation of cardiac sympathetic nerve activity following acute myocardial infarction. Proceedings of the Medical Sciences Congress (MedSci). (pp. 32). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Diong, C., Gray, E., Jones, P., & Schwenke, D. (2013). Increased sympathetic activity in obesity may protect against pulmonary hypertension. New Zealand Medical Journal, 126(1386). Retrieved from http://www.nzma.org.nz/journal

Han, S., Schwenke, D., & Brown, C. (2012). Induction of hypertension blunts baroreflex inhibition of vasopressin neuron activity in Cyp1a1-Ren2 (inducible hypertensive) rats. New Zealand Medical Journal, 125(1364). Retrieved from http://www.nzma.org.nz/journal

Thaung, A., Baldi, C., Schwenke, D., & Lamberts, R. (2012). Sympathetic modulation of cardiac function in diabetes: Paired in vivo and ex vivo study. New Zealand Medical Journal, 125(1367). Retrieved from http://www.nzma.org.nz/journal

Han, S., Schwenke, D. O., & Brown, C. H. (2012). Induction of hypertension increases supraoptic nucleus vasopressin neuron activity in Cyp1a1-Ren2 rats. Proceedings of the Society for Neuroscience 42nd Annual Meeting. SfN. Retrieved from http://www.sfn.org/index.aspx?pagename=abstracts_am2012

Sonobe, T., Tsuchimochi, H., Schwenke, D. O., & Shirai, M. (2012). Measurement of ventilatory parameters during voluntary wheel running in mice. Medicine & Science in Sports & Exercise, 44(5, Suppl. 2), (pp. 568). doi: 10.1249/01.mss.0000417529.22755.ed

Han, S., Schwenke, D., & Brown, C. (2011). Induction of hypertension increases vasopressin neuron activity in Cyp1a1-Ren2 rats. New Zealand Medical Journal, 124(1344). Retrieved from http://journal.nzma.org.nz/journal/124-1344/4919/content.pdf

Jenkins, M., Edgley, A., Sonobe, T., Brown, R., Fujii, Y., Kelly, D., … Schwenke, D., … Pearson, J. (2011). Dynamic synchrotron imaging of diabetic rat coronary microcirculation in vivo. Heart, Lung & Circulation, 20(Suppl. 2), (pp. S13-S14). doi: 10.1016/j.hlc.2011.05.033

Beard, M., Schwenke, D., Gray, E., & Campillo, I. (2011). Pulmonary hypertension is accentuated in heart failure: Assessed using synchrotron radiation microangiography. New Zealand Medical Journal, 124(1335). Retrieved from http://www.nzma.org.nz/journal/124-1335/4693/content.pdf

Sonobe, T., Schwenke, D., Pearson, J., Umetani, K., & Shirai, M. (2010). Visualization of the in vivo mouse pulmonary circulation using synchrotron radiation microangiography. Journal of Physiological Sciences, 60, (pp. S159). [Abstract]

Theis, J. C., Aebli, N., Davis, G., Krebs, J., & Schwenke, D. (2006). Fat embolism and cardiovascular changes following vertebroplasty in an animal model: Is the cement to blame? Journal of Bone & Joint Surgery (Br), 88-B(Suppl. I), (pp. 31). Retrieved from http://www.bjjprocs.boneandjoint.org.uk/content/88-B/SUPP_I/31.4.short

Aebli, N., Davis, G., Krebs, J., Schwenke, D., & Theis, J.-C. (2005). Fat embolism and cardiovascular changes following vertebroplasty in an animal model: Is the cement to blame? Journal of Bone & Joint Surgery (Br), 87B(Suppl. 1), (pp. 23). [Abstract]

Theis, J.-C., Schwenke, D., van Rij, S., Krebs, J., & Aebli, N. (2005). The use of intraosseous pressure as a measurement of intraosseous blood flow. Journal of Bone & Joint Surgery (Br), 87B(Suppl. 1), (pp. 26). [Abstract]

Bolter, C. P., Cragg, P. A., & Schwenke, D. O. (2001). Chemosensory activity in the carotid sinus nerve in the guinea-pig. Proceedings of the Physiological Society of New Zealand. 20, (pp. 24). [Abstract]

Schwenke, D. O., & Cragg, P. A. (2000). Does almitrine bismesylate accentuate the breathing responses to hypoxia, hypercapnia and sodium cyanide in the conscious guinea-pig? Proceedings of the Physiological Society of New Zealand. 19, (pp. 55). [Abstract]

Schwenke, D. O., & Cragg, P. A. (2000). Role of the carotid bodies in the breathing responses to hypoxia, hypercapnia and sodium cyanide in the presence of almitrine bismesylate in the anaesthetised guinea-pig. Proceedings of the Physiological Society of New Zealand. 19, (pp. 56). [Abstract]

Schwenke, D. O., & Cragg, P. A. (1999). Arterial blood pressure and blood gases of the concious guinea-pig during hypoxia and hypercapnia. Physiological Society of New Zealand. 18, (pp. 30). [Abstract]

Cragg, P. A., Schwenke, D. O., & McDonald, M. K. (1997). Hypoxic ventilatory roll-off: does it occur in the adult rat? Proceedings of the Physiological Society of New Zealand. 16. [Abstract]

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Conference Contribution - Poster Presentation (not in published proceedings)

Roy, R. K., Brown, C. H., & Schwenke, D. O. (2016, August-September). Magnocellular neuronal activation in response to acute myocardial infarction. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Wei, M. Y., Lew, J. K. S., Pearson, J. T., Katare, R., & Schwenke, D. O. (2016, August-September). Changes in coronary vascular function following the progression of diabetes: Assessed using Synchrotron Radiation microangiography. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Roy, R. K., Brown, C. H., & Schwenke, D. O. (2015, August-September). Central modulation of cardiac sympathetic nerve activity following acute myocardial infarction. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Korpal, A. K., Schwenke, D. O., & Brown, C. H. (2015, August-September). BDNF and TrkB expression are not changed in the hypothalamic supraoptic and paraventricular nuclei during the development of angiotensin II-dependent hypertension. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Thaung, H. P. A., Baldi, J. C., Schwenke, D. O., & Lamberts, R. R. (2012, September). Direct recording of sympathetic drive to the heart in vivo and cardiac responsiveness to β-adrenergic stimulation ex vivo in diabetic rats. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.

Han, S. Y., Schwenke, D. O., & Brown, C. H. (2011, August). Induction of hypertension increases vasopressin neuron activity in Cyp1a1-Ren2 (inducible hypertensive) rats. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Ashley, Z., Schwenke, D., & Cragg, P. (2011, September). Experimental myocardial infarction in rats: Altered autonomic balance with increased sympathetic nerve activity and reduced baroreflex sensitivity. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Han, S. Y., Schwenke, D. O., & Brown, C. H. (2010, November-December). Telemetric monitoring of blood pressure during induction of hypertension in Cyp1a1-Ren2 rats. Poster session presented at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

Schwenke, D. O., Gray, E. A., Pearson, J. T., Kangawa, K., Umetani, K., Sonobe, T., & Shirai, M. (2010, November-December). Ghrelin prevents adverse changes in pulmonary blood flow following the development of pulmonary arterial hypertension by modulating endogenous endothelin-1: Assessed using microangiography. Poster session presented at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

Schwenke, D. O., Pearson, J. T., Kangawa, K., Cragg, P. A., & Shirai, M. (2010, November-December). Exogenous ghrelin enhances the acute hypoxic ventilatory response after 2 weeks of chronic hypoxia. Poster session presented at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

Schwenke, D. O., Pearson, J. T., Shirai, M., & Cragg, P. A. (2008, November). Changes in pulmonary blood-flow distribution following chronic hypoxia: Assessed using synchrotron radiation microangiography. Poster session presented at the Medical Sciences Congress, Queenstown, New Zealand.

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Conference Contribution - Verbal presentation and other Conference outputs

Schwenke, D., Sopo'aga, F., Jutel, S., Mapusua, T., Walker, S., & Richards, R. (2018, September). Cardiovascular disease in Pacifica: Breaking down the disparities between ethnicities. Verbal presentation at the Samoa Conference 4: Our Heritage, Our Future, Apia, Samoa.

Lew, J. K.-S., Pearson, J., Katare, R., & Schwenke, D. (2017, September). High-intensity interval exercise attenuates cardiac dysfunction and restores cardiac microRNA-126/SPRED-1/VEGF pathway in type-2 diabetic mice. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Bussey, C. T., Ashley, Z., Schwenke, D. O., & Lamberts, R. R. (2017, September). Increased right cardiac sympathetic and parasympathetic nerve activity in type 2 diabetes. Invited presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Neale, J. P. H., Katare, R., & Schwenke, D. O. (2017, September). Ghrelin deletion impairs postischaemic revascularisation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Roy, R. K., Brown, C. H., & Schwenke, D. O. (2016, August). Magnocellular neuronal activation in response to acute myocardial infarction. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Wei, M. Y., Lew, J. K. S., Pearson, J. T., Katare, R., & Schwenke, D. O. (2016, August). Preventing changes in coronary blood flow associated with type 2 diabetic heart disease through exercise: Assessed using Synchrotron Radiation Microangiography. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Schwenke, D. O., Roy, R., & Brown, C. H. (2016, August-September). Identifying the neural network that triggers sympathetic activation following acute myocardial infarction. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Korpal, A. K., Schwenke, D. O., & Brown, C. H. (2016, August). Vasopressin secretion exacerbates the development of angiotensin II-dependent hypertension. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Neale, J. P. H., Katare, R., & Schwenke, D. (2016, August). Examining the role of endogenous ghrelin in vascular homeostasis using a murine model of hind-limb ischaemia. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Brown, C. H., Korpal, A. K., Han, S. Y., & Schwenke, D. O. (2016, August-September). Contribution of vasopressin neurons to the development of angiotensin-dependent hypertension. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Lew, K. S., Katare, R., & Schwenke, D. O. (2015, August-September). Moderate aerobic exercise prevents the onset of diabetic heart disease through modulation of cardiovascular miRNAs. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Schwenke, D. (2014, November). Ghrelin suppresses cardiac sympathetic tone following acute myocardial infarct. Verbal presentation at the HeartOtago First Australasian Symposium: Bench to Bedside and Back: New Advances in Cardiovascular Research, Dunedin, New Zealand.

Schwenke, D. O., Wilkins, G., & Baldi, C. (2013, August). Ghrelin: A novel therapeutic strategy for the early treatment of acute myocardial infarction: A clinical trial. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Diong, C. T., Gray, E. A., Jones, P., & Schwenke, D. O. (2013, August). Can sympathetic hyperexcitation in obesity protect against pulmonary hypertension? Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Han, S. Y., Schwenke, D. O., & Brown, C. H. (2013, August). Hypertension-induced plasticity in vasopressin neuron activity in Cyplal-Ren2 (inducible hypertensive) rats. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Ashley, Z., Schwenke, D., Tucker, K., & Cragg, P. (2011, August). Myocardial infarction increases chemoreflex sensitivity: A potential role in the prolonged sympathoexcitation? Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Schwenke, D. O., Pearson, J. T., Kangawa, K., Umetani, K., Sonobe, T., & Shirai, M. (2010, November-December). Role of Rho-kinase signaling in modulating blood flow distribution in pulmonary hypertension. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

Schwenke, D. O., Davis, G., Tokudome, T., Kishimoto, I., Kangawa, K., & Cragg, P. A. (2007, November). Exogenous ghrelin suppresses cardiac sympathetic tone following acute myocardial infarct in rats. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Schwenke, D. O., Pearson, J. T., Kangawa, K., & Shirai, M. (2007, November). Pulmonary vascular reactivity of spontaneously hypertensive rats is exacerbated in response to the central administration of exogenous nitric oxide. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Theis, J.-C., Krebs, J., Davis, G., Schwenke, D., & Aebli, N. (2002, May). Complications during vertebroplasty in sheep Stryker R's ″Controversies and challenges in spine surgery″. Verbal presentation at the Stryker R's ″Controversies and challenges in spine surgery″, Noosa Heads, Australia.

Theis, J.-C., Krebs, J., Davis, G., Schwenke, D., & Aebli, N. (2002, October). Fat embolism and acute hypotension during vertebroplasty in sheep. Verbal presentation at the 5th Combined Meeting of Spinal and Paediatric Sections of the Asia Pacific Orthopaedic Association, Singapore.

Theis, J.-C., Krebs, J., Davis, G., Schwenke, D., & Aebli, N. (2002, October). Cardiovascular changes caused by fat embolism during multiple vertebroplasties in sheep. Verbal presentation at the 5th Combined Meeting of Spinal and Paediatric Sections of the Asia Pacific Orthopaedic Association, Singapore.

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Web Site Conference Proceedings - prior to 2003

Bolter, C. P., Cragg, P. A., & Schwenke, D. O. (2001). Chemosensory activity from single or few-fibres of the carotid sinus nerve in the guinea-pig, 2. Retrieved from http://respiratory-research.com/content/2S1/P19

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