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Research interests

  • Cellular mechanisms and regulation of ion transport in the mammalian intestine
  • Intestinal secretion of mucus and bicarbonate
  • The role of NOD2 mutations in Crohn's disease
  • The interaction of bacteria with the intestinal epithelium.

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Projects

  • The effect of inflammation on intestinal bicarbonate and mucus secretion
  • The impact of NOD2 mutations associated with Crohn's disease on the properties of the intestinal epithelium
  • The effect of NOD2 mutations on the response of the intestinal epithelium to commensal bacteria
  • The effect of outer membrane vesicles from gram-negative bacteria on intestinal epithelial cells.

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Current funding

  • University of Otago Research Grant
  • Otago Medical Research Foundation
  • Anderson Trust
  • Gastroenterology Society
  • Dean's Fund University of Otago

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Collaborators

  • Professor Michael Schultz, Gastroenterology section, Department of Medicine, Dunedin School of Medicine, University of Otago
  • Associate Professor Ros Kemp, Department of Microbiology and Immunology, University of Otago
  • Associate Professor Jacqui Keenan, Department of Surgery, University of Otago, Christchurch

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Teaching

  • Cellular Physiology
  • Gastrointestinal Physiology
  • Epithelial Transport

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Selected publications

Kemp, R., Angus, H., Butt, G., & Schultz, M. (2020). Understanding human Crohn's disease: T cell immunoprofiling and in vitro primary intestinal epithelial monolayer models. Journal of Immunology, 204(1, Suppl.), 224.4. [Abstract]

Angus, H. C. K., Butt, A. G., Schultz, M., & Kemp, R. A. (2020). Intestinal organoids as a tool for inflammatory bowel disease research. Frontiers in Medicine, 6, 334. doi: 10.3389/fmed.2019.00334

Sayoc-Becerra, A., Krishnan, M., Fan, S., Jimenez, J., Hernandez, R., Gibson, K., … Butt, G., & McCole, D. F. (2020). The JAK-inhibitor tofacitinib rescues human intestinal epithelial cells and colonoids from cytokine-induced barrier dysfunction. Inflammatory Bowel Diseases, 26(3), 407-422. doi: 10.1093/ibd/izz266

Angus, H. C. K., Aluzaite, K., Butt, G. A., Schultz, M., & Kemp, R. A. (2018, August). Novel investigation of Crohn's disease T cell phenotypes and functionality in an in vitro human colonoid model. Verbal presentation at the Queenstown Molecular Biology (QMB) and Australasian Society for Immunology New Zealand Branch (ASI-NZ) Joint Meeting, Queenstown, New Zealand.

Angus, H., Norton, S., Dunn, E., Aluzaite, K., Gadeock, S., Butt, G., & Kemp, R. (2017). Development of in vitro models for human Crohn's disease. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 4). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html

Angus, H., Aluzaite, K., Schultz, M., Butt, G., & Kemp, R. (2017, July). Investigation into T cell-mediated Crohn's disease. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.

Samuel, G., Gadeock, S., Schultz, M., & Butt, G. (2017). The differential response of human epithelial derived colonic organoids to TLR agonists. FASEB Journal, 31(Suppl. 1), 1049.6. [Abstract]

Chao, P.-C., & Butt, A. G. (2017). cAMP-dependent secretagogues stimulate the NaHCO3 cotransporter in the villous epithelium of the brushtail possum, Trichosurus vulpecula. Journal of Comparative Physiology B, 187(7), 1019-1028. doi: 10.1007/s00360-017-1063-z

Gadeock, S., Schultz, M., & Butt, A. (2017). Increased permeability is an inherent defect in the colonic epithelium of Crohn’s disease patients. New Zealand Medical Journal, 130(1460), (pp. 95-96). Retrieved from http://www.nzma.org.nz/journal

Rodrigues, E., Schultz, M., & Butt, A. G. (2016). Bacteria modulate goblet cell development in the colon: A mechanism compromised in Crohn’s disease. New Zealand Medical Journal, 129(1442), (pp. 97-98). Retrieved from https://www.nzma.org.nz/journal

van Hout, I., Rodrigues, E., Slobbe, L., Schultz, M., & Butt, G. (2016). The effects of bacterial components on colonic stem cell proliferation. New Zealand Medical Journal, 129(1441), (pp. 107-108). Retrieved from http://www.nzma.org.nz/journal

Dunn, E. T. J., Taylor, E. S., Stebbings, S., Schultz, M., Butt, A. G., & Kemp, R. A. (2016). Distinct immune signatures in the colon of Crohn's disease and ankylosing spondylitis patients in the absence of inflammation. Immunology & Cell Biology, 94(5), 421-429. doi: 10.1038/icb.2015.112

Gadeock, S., Schultz, M., & Butt, G. (2016). TNF-α and IFN-γ induce a biphasic change in the distribution and expression of tight junction proteins in human colonic enteroids. FASEB Journal, 30(1, Suppl.), 1250.2. Retrieved from http://www.fasebj.org/content/30/1_Supplement/1250.2.abstract

Alsop, T.-A., McLeod, B. J., & Butt, A. G. (2016). Variations in epithelial Na+ transport and epithelial sodium channel localisation in the vaginal cul-de-sac of the brushtail possum, Trichosurus vulpecula, during the oestrous cycle. Reproduction, Fertility & Development, 28(3), 328-336. doi: 10.1071/RD13277

Butt, G. (2015, August-September). Organoids: A new kid on the block. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

van Hout, I., Rodrigues, E., Slobbe, L., Schultz, M., & Butt, A. G. (2015, August-September). Modulation of colonic stem cell proliferation by bacterial components. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Samuel, G., Rodrigues, E., Slobbe, L., Schultz, M., & Butt, A. G. (2015, August-September). The expression of functional toll like receptors in human colonic organoids. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Rodrigues, E., Slobbe, L., Samuel, G., Gadeock, S., Schultz, M., & Butt, A. G. (2015, August-September). Chronic exposure to LPS modified lineage development via the TLR4 dependent pathway in human colonic enteroids. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Gadeock, S., Schultz, M., & Butt, A. G. (2015, August-September). TNF-α induces a biphasic change in the expression and distribution of tight junction proteins in human colonic enteroids. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Schultz, M., Lai, C. C., Lindstrom, A. L., Stein, K., Donaldson, G., Thompson-Fawcett, M., & Butt, A. G. (2015). Aggravation of established colitis in specific pathogen-free IL-10 knockout mice by restraint stress is not mediated by increased colonic permeability. Journal of Crohn's & Colitis, 9(9), 754-762. doi: 10.1093/ecco-jcc/jjv098

Rodrigues, E., Slobbe, L., Schultz, M., & Butt, G. (2015). Chronic exposure to microbial stimuli affects the development of the intestinal epithelium in human colonic enteroids. FASEB Journal, 29(1, Suppl.), 999.7. Retrieved from http://www.fasebj.org/content/29/1_Supplement/999.7.abstract

Rodrigues, E., Slobbe, L., Schultz, M., & Butt, A. G. (2014, November). Chronic exposure to LPS induces goblet cell differentiation in human colonic organoids. Poster session presented at the New Zealand Society of Gastroenterology & New Zealand Nurses Organisation Gastroenterology Section Annual Scientific Meeting, Auckland, New Zealand.

Gadeock, S., Schultz, M., & Butt, G. (2014, November). Colonoids: A model of the colonic epithelium in IBD. Poster session presented at the New Zealand Society of Gastroenterology & New Zealand Nurses Organisation Gastroenterology Section Annual Scientific Meeting, Auckland, New Zealand.

Samuel, M., Rodrigues, E., Slobbe, L., Schultz, M., & Butt, G. (2014, November). The expression of toll like receptors in human colonic organoids, three-dimensional cultures of the colonic epithelium. Poster session presented at the New Zealand Society of Gastroenterology & New Zealand Nurses Organisation Gastroenterology Section Annual Scientific Meeting, Auckland, New Zealand.

Fan, L., Schultz, M., & Butt, G. (2014, November). Inflammation reduces the activity of the NaHCO3 cotransporter, NBCe1, in the surface cells of the proximal colon of IL10-/- mice. Poster session presented at the New Zealand Society of Gastroenterology & New Zealand Nurses Organisation Gastroenterology Section Annual Scientific Meeting, Auckland, New Zealand.

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