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Hamilton Lab

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Research interests

My main research interest is the molecular physiology, regulation and function of membrane ion channels of epithelial tissues. I have had a long-term interest in the molecular physiology and pharmacology of epithelial ion channels and K+ channels, specifically, the Ca2+-dependent, intermediate-conductance K+ channel, KCa3.1. Recently, my lab has been examining the anterograde and retrograde trafficking of KCa3.1 to and from the basolateral membrane of polarized epithelia. The cytoskeleton and accessory proteins play major roles in the trafficking of proteins throughout the cell and to and from the membrane. Additoinally, protein complexes such as the Exocyst and Retromer and SNARE proteins play significance roles in proper transport and targeting of ion channels and transporters to the appropriate membranes of epithelial cells.

We are using biotin-ligase acceptor peptide (BLAP) technology to tagged K+ channels in order to examine their cellular and membrane fate. This technique has allowed us to ask many important questions about the molecular physiology and trageting of KCa3.1 to the basolateral membrane of epithelial cells.

I employ electrophysiological (patch-clamp and short circuit current measurements) and molecular biochemical techniques (immunofluorescence, immunoprecipitation, co-immunoprecipitation, cell surface immunoprecipitation, gel electrophoresis, biotinylation, PCR) to address basic questions of cell physiology and biology of ion channels.

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Research topics

  • Molecular physiology of channels
  • Cellular and membrane trafficking of ion channels
  • The role of the Exocyst complex in the trafficking ion channels
  • SNARE protein regulation of ion channel activity via protein-protein interactions
  • The role of Retromer in the trafficking ion channels

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Current funding

  • 2017 Dean's Bequest Fund, University of Otago
  • 2017 Department of Physiology AIM Grant
  • 2016-2017 Lottery Grant (with A/P Fiona McDonald)

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Previous funding

  • 2016 Department of Physiology AIM Fund
  • 2015 University of Otago Research Grant (with A/P Fiona McDonald)
  • 2014-2015 Dean's Bequest Fund – University of Otago
  • 2013-2014 University of Otago Research Grant
  • 2013-2014 OSMS Strategic Grant

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Collaborators

  • Professor Yoshi Marunaka, Department of Molecular Cell Physiology Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  • Professor Daniel C. Devor, Department of Cell Biology and Physiology, School of Medicine, University of Pittsburgh, USA.
  • Professor Peter Hunter and Dr. David Nickerson, Auckland Bioengineering Institute, University of Auckland,
  • Dr Michael Butterworth, Department of Cell Biology and Physiology, School of Medicine, University of Pittsburgh, PA, USA.
  • A/Professor Fiona McDonald, Department of Physiology, University of Otago, NZ.
  • A/Professor Antoni Moore, Department of Surveying, University of Otago, NZ.

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Current students

  • Monique Scott, MSc student
  • Yoakim Eckhoff-Bjorngard, BBiomedSc Hons

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Previous students

  • Elliot Pilmore, PGDipSci and MSc student
  • Joshua April, PGDipSci student
  • Rachel Farquhar BBioMed Sci and MSc - now a PhD Candidate with Prof. Jamie Rossjohn, Department of Biochemistry and Molecular Biology, Monash University, Australia
  • Sibi Narayanana (PGDipSci)
  • Shih-Liang (Bob) Lee (BScHons and MSc) now a PhD Candidate at the School of Medicine, University of Sydney, Australia 

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Teaching

  • Convenor of PHSL 233
  • HUBS 192 Human Biology Studies II
  • PHSL 233 Cellular Gastrointestinal and Renal Physiology
  • PHSL 343 Cellular and Epithelial Physiology
  • PHSL 345 Physiological Aspects of Health and Disease
  • PHSL 473 Cellular Physiology
  • Med 2 - Physiology (Cases Studies)

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Selected publications

Hamilton, K. L., & Devor, D. C. (Eds.). (2020). Ion transport across epithelial tissues and disease: Ion channels and transporters of epithelia in health and disease (Vol. 2) (2nd ed.). Cham, Switzerland: Springer, 390p. doi: 10.1007/978-3-030-55310-4

Hamilton, K. L., & Devor, D. C. (Eds.). (2020). Basic epithelial ion transport principles and function: Ion channels and transporters of epithelia in health and disease (Vol. 1) (Second ed.). Cham, Swizterland: Springer, 563p. doi: 10.1007/978-3-030-52780-8

Hamilton, K. L. (2020). Techniques of epithelial transport physiology. In K. L. Hamilton & D. C. Devor (Eds.), Basic epithelial ion transport principles and function: Ion channels and transporters of epithelia in health and disease (Vol. 1). (Second ed.) (pp. 1-52). Cham, Swizterland: Springer. doi: 10.1007/978-3-030-52780-8_1

Nickerson, D. P., Noroozbabaee, L., Sarwar, D. M., Hamilton, K. L., & Hunter, P. J. (2020). Mathematical modeling of epithelial ion transport. In K. L. Hamilton & D. C. Devor (Eds.), Basic epithelial ion transport principles and function: Ion channels and transporters of epithelia in health and disease (Vol. 1). (Second ed.) (pp. 115-133). Cham, Swizterland: Springer. doi: 10.1007/978-3-030-52780-8_4

Cheung, T. T., Geda, A. C., Ware, A. W., Rasulov, S. R., Tenci, P., Hamilton, K. L., & McDonald, F. J. (2020). Retromer is involved in epithelial Na+ channel trafficking. American Journal of Physiology: Renal Physiology, 319, F895-F907. doi: 10.1152/ajprenal.00198.2019

Hamilton, K. L. (2020). AJP-Cell Physiology begins a Theme of Reviews on "New Frontiers in Protein Trafficking". American Journal of Physiology: Cell Physiology, 319, C402-C403. doi: 10.1152/ajpcell.00347.2020

Lozano-Gerona, J., Oliván-Viguera, A., Delgado-Wicke, P., Singh, V., Brown, B. M., Tapia-Casellas, E., … Hamilton, K. L., … Köhler, R. (2020). Conditional KCa3.1-transgene induction in murine skin produces pruritic eczematous dermatitis with severe epidermal hyperplasia and hyperkeratosis. PLoS ONE, 15(3), e0222619. doi: 10.1371/journal.pone.0222619

Valero, M. S., Ramón-Gimenez, M., Lozano-Gerona, J., Delgado-Wicke, P., Calmarza, P., Oliván-Viguera, A., … Hamilton, K. L., … Köhler, R. (2019). KCa3.1 transgene induction in murine intestinal epithelium causes duodenal chyme accumulation and impairs duodenal contractility. International Journal of Molecular Sciences, 20(5), 1193. doi: 10.3390/ijms20051193

Bertuccio, C. A., Wang, T. T., Hamilton, K. L., Rodriguez-Gil, D. J., Condliffe, S. B., & Devor, D. C. (2018). Plasma membrane insertion of KCa2.3 (SK3) is dependent upon the SNARE proteins, syntaxin-4 and SNAP23. PLoS ONE, 13(5). doi: 10.1371/journal.pone.0196717

Olivan-Viguera, A., Garcia-Otin, A. L., Lozano-Gerona, J., Abarca-Lachen, E., Garcia-Malinis, A. J., Hamilton, K. L., … Köhler, R. (2018). Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes. PLoS ONE, 13(1), e0190307. doi: 10.1371/journal.pone.0190307

Delpire, E., Hamilton, K. L., Hawke, T. J., Isenberg, J. S., Lotersztajn, S., Yuan, J. X.-J., & Adams, J. C. (2018). AJP-Cell Physiology begins landmark reviews in cell physiology: An editorial from the senior editors of AJP-Cell Physiology. American Journal of Physiology: Cell Physiology, 314(1), C1. doi: 10.1152/ajpcell.00256.2017

Lee, B. S.-L., Devor, D. C., & Hamilton, K. L. (2017). Modulation of retrograde trafficking of KCa3.1 in a polarized epithelium. Frontiers in Physiology, 8, 489. doi: 10.3389/fphys.2017.00489

Farquhar, R. E., Rodrigues, E., & Hamilton, K. L. (2017). The role of the cytoskeleton and Myosin-Vc in the targeting of KCa3.1 to the basolateral membrane of polarized epithelial cells. Frontiers in Physiology, 7, 639. doi: 10.3389/fphys.2016.00639

Hamilton, K. L., & Moore, A. B. (2016). 50 years of renal physiology from one man and the perfused tubule: Maurice B. Burg. American Journal of Physiology: Renal Physiology, 311(2), F291-F304. doi: 10.1152/ajprenal.00198.2016

Hamilton, K. L., & Devor, D. C. (Eds.). (2016). Ion channels and transporters of epithelia in health and disease. New York: Springer, 1019p. doi: 10.1007/978-1-4939-3366-2

Devor, D. C., Bertuccio, C. A., & Hamilton, K. L. (2016). KCa3.1 in epithelia. In K. L. Hamilton & D. C. Devor (Eds.), Ion channels and transporters of epithelia in health and disease. (pp. 659-705). New York: Springer. doi: 10.1007/978-1-4939-3366-2_20

Nickerson, D. P., Hamilton, K. L., & Hunter, P. J. (2016). Mathematical modeling of epithelial ion transport. In K. L. Hamilton & D. C. Devor (Eds.), Ion channels and transporters of epithelia in health and disease. (pp. 265-278). New York: Springer. doi: 10.1007/978-1-4939-3366-2_6

Hamilton, K. L. (2016). New life in overactive bladder: Focus on "Novel regulatory mechanism in human urinary bladder: Central role of transient receptor potential melastatin 4 channels in detrusor smooth muscle function". American Journal of Physiology: Cell Physiology, 310(7), C597-C599. doi: 10.1152/ajpcell.00039.2016

Pilmore, E., & Hamilton, K. L. (2015). The role of microRNAs in the regulation of K+ channels in epithelial tissue. Frontiers in Physiology, 6, 352. doi: 10.3389/fphys.2015.00352

Sun, H., Niisato, N., Nishio, K., Hamilton, K. L., & Marunaka, Y. (2014). Distinct action of flavonoids, myricetin and quercetin, on epithelial Cl- secretion: Useful tools as regulators of Cl- secretion. BioMed Research International, 2014, 902735. doi: 10.1155/2014/902735

Bertuccio, C. A., Lee, S.-L., Wu, G., Butterworth, M. B., Hamilton, K. L., & Devor, D. C. (2014). Anterograde trafficking of KCa3.1 in polarized epithelia is Rab1- and Rab8-dependent and recycling endosome-independent. PLoS ONE, 9(3), e92013. doi: 10.1371/journal.pone.0092013

Hamilton, K. L. (2014). Even an old technique is suitable in the molecular world of science: The everted sac preparation - turns 60 years old. American Journal of Physiology: Cell Physiology, 306(8), C715-C720. doi: 10.1152/ajpcell.00041.2014

Hamilton, K. L. (2014). Cleavage: What’s up with prostasin and ENaC these days? American Journal of Physiology: Renal Physiology, 307(11), F1196-F1197. doi: 10.1152/ajprenal.00522.2014

Hamilton, K. L., & Butt, A. G. (2013). Glucose transport into everted sacs of the small intestine of mice. Advances in Physiology Education, 37(4), 415-426. doi: 10.1152/advan.00017.2013

Hamilton, K. L. (2013). Robert K. Crane: Na+-glucose cotransporter to cure? Frontiers in Physiology, 4, 53. doi: 10.3389/fphys.2013.00053

Edited Book - Research

Hamilton, K. L., & Devor, D. C. (Eds.). (2020). Ion transport across epithelial tissues and disease: Ion channels and transporters of epithelia in health and disease (Vol. 2) (2nd ed.). Cham, Switzerland: Springer, 390p. doi: 10.1007/978-3-030-55310-4

Hamilton, K. L., & Devor, D. C. (Eds.). (2020). Basic epithelial ion transport principles and function: Ion channels and transporters of epithelia in health and disease (Vol. 1) (Second ed.). Cham, Swizterland: Springer, 563p. doi: 10.1007/978-3-030-52780-8

Hamilton, K. L., & Devor, D. C. (Eds.). (2016). Ion channels and transporters of epithelia in health and disease. New York: Springer, 1019p. doi: 10.1007/978-1-4939-3366-2

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Chapter in Book - Research

Nickerson, D. P., Noroozbabaee, L., Sarwar, D. M., Hamilton, K. L., & Hunter, P. J. (2020). Mathematical modeling of epithelial ion transport. In K. L. Hamilton & D. C. Devor (Eds.), Basic epithelial ion transport principles and function: Ion channels and transporters of epithelia in health and disease (Vol. 1). (Second ed.) (pp. 115-133). Cham, Swizterland: Springer. doi: 10.1007/978-3-030-52780-8_4

Hamilton, K. L. (2020). Techniques of epithelial transport physiology. In K. L. Hamilton & D. C. Devor (Eds.), Basic epithelial ion transport principles and function: Ion channels and transporters of epithelia in health and disease (Vol. 1). (Second ed.) (pp. 1-52). Cham, Swizterland: Springer. doi: 10.1007/978-3-030-52780-8_1

Devor, D. C., Bertuccio, C. A., & Hamilton, K. L. (2016). KCa3.1 in epithelia. In K. L. Hamilton & D. C. Devor (Eds.), Ion channels and transporters of epithelia in health and disease. (pp. 659-705). New York: Springer. doi: 10.1007/978-1-4939-3366-2_20

Nickerson, D. P., Hamilton, K. L., & Hunter, P. J. (2016). Mathematical modeling of epithelial ion transport. In K. L. Hamilton & D. C. Devor (Eds.), Ion channels and transporters of epithelia in health and disease. (pp. 265-278). New York: Springer. doi: 10.1007/978-1-4939-3366-2_6

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Journal - Research Article

Cheung, T. T., Geda, A. C., Ware, A. W., Rasulov, S. R., Tenci, P., Hamilton, K. L., & McDonald, F. J. (2020). Retromer is involved in epithelial Na+ channel trafficking. American Journal of Physiology: Renal Physiology, 319, F895-F907. doi: 10.1152/ajprenal.00198.2019

Lozano-Gerona, J., Oliván-Viguera, A., Delgado-Wicke, P., Singh, V., Brown, B. M., Tapia-Casellas, E., … Hamilton, K. L., … Köhler, R. (2020). Conditional KCa3.1-transgene induction in murine skin produces pruritic eczematous dermatitis with severe epidermal hyperplasia and hyperkeratosis. PLoS ONE, 15(3), e0222619. doi: 10.1371/journal.pone.0222619

Valero, M. S., Ramón-Gimenez, M., Lozano-Gerona, J., Delgado-Wicke, P., Calmarza, P., Oliván-Viguera, A., … Hamilton, K. L., … Köhler, R. (2019). KCa3.1 transgene induction in murine intestinal epithelium causes duodenal chyme accumulation and impairs duodenal contractility. International Journal of Molecular Sciences, 20(5), 1193. doi: 10.3390/ijms20051193

Bertuccio, C. A., Wang, T. T., Hamilton, K. L., Rodriguez-Gil, D. J., Condliffe, S. B., & Devor, D. C. (2018). Plasma membrane insertion of KCa2.3 (SK3) is dependent upon the SNARE proteins, syntaxin-4 and SNAP23. PLoS ONE, 13(5). doi: 10.1371/journal.pone.0196717

Olivan-Viguera, A., Garcia-Otin, A. L., Lozano-Gerona, J., Abarca-Lachen, E., Garcia-Malinis, A. J., Hamilton, K. L., … Köhler, R. (2018). Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes. PLoS ONE, 13(1), e0190307. doi: 10.1371/journal.pone.0190307

Farquhar, R. E., Rodrigues, E., & Hamilton, K. L. (2017). The role of the cytoskeleton and Myosin-Vc in the targeting of KCa3.1 to the basolateral membrane of polarized epithelial cells. Frontiers in Physiology, 7, 639. doi: 10.3389/fphys.2016.00639

Lee, B. S.-L., Devor, D. C., & Hamilton, K. L. (2017). Modulation of retrograde trafficking of KCa3.1 in a polarized epithelium. Frontiers in Physiology, 8, 489. doi: 10.3389/fphys.2017.00489

Hamilton, K. L., & Moore, A. B. (2016). 50 years of renal physiology from one man and the perfused tubule: Maurice B. Burg. American Journal of Physiology: Renal Physiology, 311(2), F291-F304. doi: 10.1152/ajprenal.00198.2016

Pilmore, E., & Hamilton, K. L. (2015). The role of microRNAs in the regulation of K+ channels in epithelial tissue. Frontiers in Physiology, 6, 352. doi: 10.3389/fphys.2015.00352

Sun, H., Niisato, N., Nishio, K., Hamilton, K. L., & Marunaka, Y. (2014). Distinct action of flavonoids, myricetin and quercetin, on epithelial Cl- secretion: Useful tools as regulators of Cl- secretion. BioMed Research International, 2014, 902735. doi: 10.1155/2014/902735

Bertuccio, C. A., Lee, S.-L., Wu, G., Butterworth, M. B., Hamilton, K. L., & Devor, D. C. (2014). Anterograde trafficking of KCa3.1 in polarized epithelia is Rab1- and Rab8-dependent and recycling endosome-independent. PLoS ONE, 9(3), e92013. doi: 10.1371/journal.pone.0092013

Hamilton, K. L. (2014). Even an old technique is suitable in the molecular world of science: The everted sac preparation - turns 60 years old. American Journal of Physiology: Cell Physiology, 306(8), C715-C720. doi: 10.1152/ajpcell.00041.2014

Hamilton, K. L., & Butt, A. G. (2013). Glucose transport into everted sacs of the small intestine of mice. Advances in Physiology Education, 37(4), 415-426. doi: 10.1152/advan.00017.2013

Hamilton, K. L., & Devor, D. C. (2012). Basolateral membrane K+ channels in renal epithelial cells. American Journal of Physiology: Renal Physiology, 302(9), F1069-F1081. doi: 10.1152/ajprenal.00646.2011

Hamilton, K. L., & Pao, A. C. (2012). βPix is a new player in renal physiology. Frontiers in Physiology, 3, 268. doi: 10.3389/fphys.2012.00268

Balut, C. M., Hamilton, K. L., & Devor, D. C. (2012). Trafficking of intermediate (KCa3.1) and small (KCa2.x) conductance, Ca2+-activated K+ channels: A novel target for medicinal chemistry efforts? ChemMedChem, 7(10), 1741-1755. doi: 10.1002/cmdc.201200226

Hamilton, K. L. (2012). BLAP-tags, TUBEs and DUB-Chips: Combined novel technologies will advance molecular epithelial physiology. Frontiers in Physiology, 3, 137. doi: 10.3389/fphys.2012.00137

Nickerson, D. P., Terkildsen, J. R., Hamilton, K. L., & Hunter, P. J. (2011). A tool for multi-scale modelling of the renal nephron. Interface Focus, 1, 417-425. doi: 10.1098/rsfs.2010.0032

Millership, J. E., Devor, D. C., Hamilton, K. L., Balut, C. M., Bruce, J. I. E., & Fearon, I. M. (2011). Calcium-activated K+ channels increase cell proliferation independent of K+ conductance. American Journal of Physiology: Cell Physiology, 300(4), C792-C802. doi: 10.1152/ajpcell.00274.2010

Chao, P.-C., & Hamilton, K. L. (2009). Genistein stimulates electrogenic Cl- secretion via phosphodiesterase modulation in the mouse jejunum. American Journal of Physiology: Cell Physiology, 297(3), C688-C698. doi: 10.1152/ajpcell.00152.2009

Jones, H. M., Bailey, M. A., Baty, C. J., MacGregor, G. G., Syme, C. A., Hamilton, K. L., & Devor, D. C. (2007). An NH2-terminal multi-basic RKR motif is required for the ATP-dependent regulation of hlK1. Channels, 1(2), 80-91.

Hamilton, K. L., & Kiessling, M. (2006). DCEBIO stimulates Cl- secretion in the mouse jejunum. American Journal of Physiology: Cell Physiology, 290, C152-C164. doi: 10.1152/ajpcell.00187.2005

Jones, H. M., Hamilton, K. L., & Devor, D. C. (2005). Role of an S4-S5 linker lysine in the trafficking of the Ca2+ -activated K+ channels IK1 and SK3. Journal of Biological Chemistry, 280(44), 37257-37265.

Baker, M. J., & Hamilton, K. L. (2004). Genistein stimulates electrogenic Cl- secretion in mouse jejunum. American Journal of Physiology: Cell Physiology, 287, C1636-C1645.

Jones, H. M., Hamilton, K. L., Papworth, G. D., Syme, C. A., Watkins, S. C., Bradbury, N. A., & Devor, D. C. (2004). Role of the NH2 terminus in the assembly and trafficking of the intermediate conductance Ca2+-activated K+ channel hIK1. Journal of Biological Chemistry, 279(15), 15531-15540.

Syme, C. A., Hamilton, K. L., Jones, H. M., Gerlach, A. C., Giltinan, L., Papworth, G. D., … Devor, D. C. (2003). Trafficking of the Ca2+ -activated K+ channel, hIK1, is dependent upon a C-terminal leucine zipper. Journal of Biological Chemistry, 278(10), 8476-8486.

Hamilton, K. L., Syme, C. A., & Devor, D. C. (2003). Molecular localization of the inhibitory arachidonic acid binding site to the pore of hIK1. Journal of Biological Chemistry, 278, 16690-16697.

Hamilton, K. L., Butt, A. G., Cheng, S., & Carter, D. J. (2002). Methoxsalen stimulates electrogenic Cl- secretion in the mouse jejunum. Experimental Physiology, 87(4), 437-445.

Taylor, J., Hamilton, K. L., & Butt, A. G. (2001). HCO3- potentiates the cAMP-dependent secretory response of the human distal colon through a DIDS-sensitive pathway. Pflügers Archiv: European Journal of Physiology, 442(2), 256-262.

Samson, A., Hamilton, K. L., & Butt, A. G. (2000). Effect of somatostatin on electrogenic ion transport in the duodenum and colon of the mouse, Mus domesticus. Comparative Biochemistry & Physiology Part A, 125A, 459-468.

Hamilton, K. L., & Butt, A. G. (2000). The molecular basis of renal tubular transport disorders. Comparative Biochemistry & Physiology Part A, 126A, 305-321.

Hamilton, K. L., Meads, L., & Butt, A. G. (1999). 1-EBIO stimulates C1 secretion by activating a basolateral K channel in the mouse jejunum. Pflügers Archiv: European Journal of Physiology, 439, 158-166.

Butt, A. G., & Hamilton, K. L. (1998). Ion channels in isolated mouse jejunal crypts. Pflügers Archiv: European Journal of Physiology, 435, 528-538.

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Journal - Research Other

Hamilton, K. L. (2020). AJP-Cell Physiology begins a Theme of Reviews on "New Frontiers in Protein Trafficking". American Journal of Physiology: Cell Physiology, 319, C402-C403. doi: 10.1152/ajpcell.00347.2020

Delpire, E., Hamilton, K. L., Hawke, T. J., Isenberg, J. S., Lotersztajn, S., Yuan, J. X.-J., & Adams, J. C. (2018). AJP-Cell Physiology begins landmark reviews in cell physiology: An editorial from the senior editors of AJP-Cell Physiology. American Journal of Physiology: Cell Physiology, 314(1), C1. doi: 10.1152/ajpcell.00256.2017

Hamilton, K. L. (2016). New life in overactive bladder: Focus on "Novel regulatory mechanism in human urinary bladder: Central role of transient receptor potential melastatin 4 channels in detrusor smooth muscle function". American Journal of Physiology: Cell Physiology, 310(7), C597-C599. doi: 10.1152/ajpcell.00039.2016

Hamilton, K. L. (2014). Cleavage: What’s up with prostasin and ENaC these days? American Journal of Physiology: Renal Physiology, 307(11), F1196-F1197. doi: 10.1152/ajprenal.00522.2014

Hamilton, K. L. (2013). Cyclosporine A and lovastatin: The Good and the bad, but who will be the winner? American Journal of Physiology: Renal Physiology, 305(5), F643-F644. doi: 10.1152/ajprenal.00321.2013

Hamilton, K. L. (2013). Robert K. Crane: Na+-glucose cotransporter to cure? Frontiers in Physiology, 4, 53. doi: 10.3389/fphys.2013.00053

Hamilton, K. L. (2011). Ussing's ″little chamber″: 60 years+ old and counting. Frontiers in Physiology, 2, 6. doi: 10.3389/fphys.2011.00006

Hamilton, K. L. (2010). BLAP-tagged channel technology: A new direction trafficking toward epithelial physiology. Frontiers in Physiology, 1, 162. doi: 10.3389/fphys.2010.00162

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Conference Contribution - Published proceedings: Abstract

Scott, M. L., Cheung, T. T., Hamilton, K. L., & McDonald, F. J. (2020). Sorting nexins 1, 2, 3 and 17 regulate epithelial sodium channel trafficking. FASEB Journal, 34(Suppl. 1). doi: 10.1096/fasebj.2020.34.s1.07065

Lozano-Gerona, J., Olivan-Viguera, A., Delgado-Wicke, P., Singh, V., Brown, B., Tapia-Casellas, E., … Hamilton, K. L., … Köhler, R. (2019). KCa3.1-overexpression in skin causes pruritic eczema and epidermal hyperplasia. Journal of Investigative Dermatology, 139(5, Suppl.), (pp. S51). doi: 10.1016/j.jid.2019.03.373

Hamilton, K. L., Farquhar, R. E., Eckhoff-Björngard, Y., Cheung, T., & McDonald, F. J. (2019). Interactions between SNARE and exocyst complex proteins with KCa3. 1 in the tethering and fusion of KCa3. 1-containing vesicles to the basolateral membrane of epithelial cells. FASEB Journal, 33(Suppl. 1), 824.16. doi: 10.1096/fasebj.2019.33.1_supplement.824.16

Scott, M. L., Cheung, T. T., Hamilton, K. L., & McDonald, F. J. (2018). Recycling of the epithelial sodium channel requires SNX1 and SNX2. New Zealand Medical Journal, 131(1470), (pp. 110). Retrieved from https://www.nzma.org.nz/journal

Farquhar, R., & Hamilton, K. L. (2017). The role of SNARE proteins in targeting KCa3.1 to the basolateral membrane of epithelial cells. FASEB Journal, 31(Suppl. 1), 1007.25. [Abstract]

Hamilton, K., Farquhar, R., Lee, S.-L., & Devor, D. (2015). Anterograde trafficking of KCa3.1 by cytoskeletal elements and accessory proteins in a polarized epithelium. FASEB Journal, 29(1, Suppl.), 844.16. Retrieved from http://www.fasebj.org/content/29/1_Supplement/844.16.abstract

Nickerson, D., Hamilton, K., Beard, D., & Hunter, P. (2015). Computational tools for the creation, simulation, and dissemination of epithelial cell models. FASEB Journal, 29(1, Suppl.), 814.16. Retrieved from http://www.fasebj.org/content/29/1_Supplement/814.16.abstract

Nickerson, D., Hamilton, K., Beard, D., & Hunter, P. (2014). Epithelial cell modeling: Standards-based simulation experiments. FASEB Journal, 28(1, Suppl.), 1180.4. [Abstract]

Lee, S.-L., Devor, D., & Hamilton, K. (2014). Modulation of KCa3.1 by ubiquitylation in a polarized epithelium. FASEB Journal, 28(1, Suppl.), 893.2. [Abstract]

Nickerson, D. P., Hamilton, K. L., Terkildsen, J., & Hunter, P. J. (2013). Generalized epithelial transport modeling: Computational physiology. FASEB Journal, 27(Meeting Abstract Suppl.), 1217.12. [Abstract]

Bukhari, W., Condliffe, S., & Hamilton, K. (2013). Detection of endogenous syntaxin-4 and VAMP3 in Fischer rat thyroid (FRT) epithelial cells. New Zealand Medical Journal, 126(1374). Retrieved from http://www.nzma.org.nz/journal

Hamilton, K. L., & Devor, D. C. (2012). Molecular determinant of KCa3.1 that affects cell proliferation? FASEB Journal, 26(Meeting Abstract Suppl.), 884.11. [Abstract]

Terkildsen, J., Nickerson, D., Hamilton, K., & Hunter, P. (2011). Mathematical modelling of the proximal portion of the nephron. FASEB Journal, 25(Meeting Abstract Suppl.), 1129.5. [Abstract]

Lee, S.-L., Devor, D. C., & Hamilton, K. L. (2011). Role of cytoskeletal elements in the trafficking of KCa3.1. FASEB Journal, 25(Meeting Abstract Suppl.), 860.14. [Abstract]

Winter, B. J., Balut, C. M., Butterworth, M. B., Gao, Y., Devor, D. C., & Hamilton, K. L. (2011). Basolateral trafficking of KCa3.1 in a polarized epithelium. FASEB Journal, 25(Meeting Abstract Suppl.), 860.13. [Abstract]

McKenzie, J., & Hamilton, K. L. (2010). Possible role of adaptor proteins in the trafficking of hIK1. FASEB Journal, 24(Meeting Abstract Suppl.), 608.1. [Abstract]

Terkildsen, J., Nickerson, D., Hamilton, K., & Hunter, P. (2010). Visualizing multiscale models of the nephron. FASEB Journal, 24(Meeting Abstract Suppl.), 1065.10. [Abstract]

Chao, T., Hamilton, K. L., Hessian, P. A., & Butt, G. (2009). The conductive properties of exponentially dividing LNCaP prostate cancer cells. FASEB Journal, 23(Meeting Abstract Suppl.), 1000.12. [Abstract]

Hamilton, K. L., & Devor, D. C. (2009). Trafficking of biotin-ligase-tagged KCNE3 (MiRP2) potassium channels. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]

Chao, P.-C., & Hamilton, K. L. (2008). hIK1 pottasium channel in the G1 phase of the cell cycle (Preliminary report). FASEB Journal, 22(Meeting Abstracts), 937.10. [Abstract]

Chao, P.-C., & Hamilton, K. L. (2008). hIK1 potassium channel in the G1 phase of the cell cycle (Preliminary report). FASEB Journal, 22(Meeting Abstract Suppl.), 937.1. [Abstract]

Chao, P.-C., & Hamilton, K. L. (2007). Genistein stimulates C1 secretion by modulating phosphodiesterase 3 in the mouse jejunum. FASEB Journal, 21(Meeting Abstract Suppl.), 772.9. [Abstract]

Kiessling, M., & Hamilton, K. L. (2006). DCEBIO stimulates C1- secretion in the mouse jejunum via a cAMP-dependent manner. FASEB Journal, 20(4), 215.4, (pp. A325). [Abstract]

Jones, H. M., Syme, C. A., Bailey, M. A., Hamilton, K., & Devor, D. C. (2005). An NH2-terminal multi-basic RKR motif is required for the ATP-dependent regulation of hIKl. Biophysical Journal. 88, (pp. 469A). [Abstract]

Jones, H. M., Syme, C. A., Bailey, M. A., Hamilton, K. L., & Devor, D. C. (2005). An NH2-terminal multi-basic RKR motif is required for the ATP-dependent regulation of hIKl. FASEB Journal, 19, (pp. A1170-A1171). [Abstract]

Hamilton, K. L., & Kiessling, M. (2005). DCEBIO activates Cl secretion by the mouse jejunum. FASEB Journal, 19, (pp. A1181). [Abstract]

Hamilton, K. L., & Kiessling, M. (2004). Effects of DCEBIO on CI- secretion of the mouse jejunum. Proceedings of the Physiological Society of New Zealand. (pp. 41). [Abstract]

Jones, H. M., Papworth, G. D., Watkins, S. C., Hamilton, K. L., & Devor, D. C. (2004). Role of the S4-S5 linker in the trafficking of hIK1. Biophysical Journal. 86(Supplement), 2863-Pos, (pp. 552a). [Abstract]

Jones, H. M., Papworth, G. D., Watkins, S. C., Hamilton, K. L., & Devor, D. C. (2004). hIK1 trafficking and function is dependent on the S4-S5 linker region. Federation of American Societies for Experimental Biology Journal. 18, (pp. A1044). [Abstract]

Chao, P. C. T., & Hamilton, K. L. (2004). The role of genistein in the CI- secretory response of the mouse jejunum. Proceedings of the Physiological Society of New Zealand. (pp. 43). [Abstract]

Jones, H. J., Hamilton, K. L., Papworth, G. D., Watkins, S. C., & Devor, D. C. (2003). NH3- terminal leucines are required for the correct trafficking of hIK1. Biophysical Journal, 84, (pp. A559). [Abstract]

Hamilton, K. L., Syme, C. A., & Devor, D. C. (2003). Molecular localization of the inhibitory arachidonic acid binding site to the pore of hIK1. Biophysical Journal, 84, (pp. A529). [Abstract]

Jones, H. J., Hamilton, K. L., Papworth, G. D., Watkins, S. C., & Devor, D. C. (2003). NH3- terminal leucines are required for the correct trafficking of hIK1. FASEB Journal, 17, (pp. A916). [Abstract]

Hamilton, K. L., Syme, C. A., & Devor, D. C. (2003). Molecular localization of the inhibitory arachidonic acid binding site to the pore of hIK1. FASEB Journal, 17, (pp. A916). [Abstract]

Hamilton, K. L., & Baker, M. J. (2002). The effects of genistein on Cl secretion in the mouse jejunum. FASEB Journal. 16, (pp. A481). Bethesda: Federation of American Societies for Experimental Biology. [Abstract]

Syme, C. A., Gerlach, A. C., Giltinan, L., Hamilton, K. L., Bradbury, N. A., Watkins, S. C., & Devor, D. C. (2002). Trafficking of the Ca2+-activated K+ channel, hIK1 is dependent upon a COOH-terminal leucine zipper. 1st Annual Pittsburgh Symposium on Intracellular Membrane Traffic. (pp. 27). [Abstract]

Syme, C. A., Papworth, G. D., Hamilton, K. L., Jones, H. M., Watkins, S. C., Bradbury, N. A., & Devor, D. C. (2002). Novel role for a multibasic motif in trafficking of an ion channel, hIK1. 1st Annual Pittsburgh Symposium on Intracellular Membrane Traffic. [Abstract]

Syme, C. A., Papworth, G. D., Hamilton, K. L., Jones, H. M., Watkins, S. C., Bradbury, N. A., & Devor, D. C. (2002). Novel role for a multibasic motif in trafficking of an ion channel, hIK1. Journal of General Physiology. 120, (pp. 14a-15a). New York: Rockefeller University Press. [Abstract]

Syme, C. A., Gerlach, A. C., Giltinan, L., Hamilton, K. L., Bradbury, N. A., Watkins, S. C., & Devor, D. C. (2002). Trafficking of the Ca2+-activated K+ channel, hIK1 is dependent upon a COOH-terminal leucine zipper. Journal of General Physiology. 120, (pp. 15a). New York: Rockefeller University Press. [Abstract]

Carter, D. J., Hamilton, K. L., & Butt, A. G. (2001). The role of the Ca2+-dependent, intermediate-conductance K+ channel (IKCa) in the 1-ethyl-2-benzimidazolone (1-EBIO) mediated secretory response in the mouse jejunum. Proceedings of the Physiological Society of New Zealand. 20, (pp. 34). [Abstract]

Hamilton, K. L., Butt, A. G., Cheng, S. J.-S., & Carter, D. J. (2001). Effects of methoxsalen on Cl- secretion of the mouse jejunum. Proceedings of the Physiological Society of New Zealand. 20, (pp. 56). [Abstract]

Hamilton, K. L., Butt, A. G., Cheng, S., & Carter, D. J. (2000). Effects of methoxsalen on ion transport of the mouse jejunum. Proceedings of the Physiological Society of New Zealand. 19, (pp. 66). [Abstract]

Carter, D. J., Hamilton, K. L., & Butt, A. G. (2000). Pharmacologically distinct K+ channels are involved in cAMP- and Ca2+-mediated secretion in the mouse jejunum. Federation of American Societies for Experimental Biology Journal. 14, (pp. A112). [Abstract]

Hamilton, K. L., Meads, L., & Butt, A. G. (1999). 1-EBIO activates a K channel involved in C1 secretion in the mouse jejunum. In E. Board (Ed.), FASEB Journal. 13, (pp. A58). Bethesda, USA: Federation of American Societies for Experimental Biology. [Abstract]

Butt, A. G., Taylor, J., & Hamilton, K. L. (1999). HCO3 contributes to the secretory response of the human colon via a DIDS sensitive pathway. Journal of Physiology. 517, (pp. 16P-17P). Manchester, England: British Physiological Society. [Abstract]

Hamilton, K. L., Meads, L., & Butt, A. G. (1999). 1-ethyl-2-benzimidazolone activates a K+ channel involved in C1 secretion in the murine jejunum. Proceedings of the Physiological Society of New Zealand. 18, (pp. 44). [Abstract]

Carter, D. J., Hamilton, K. L., & Butt, A. G. (1999). Pharmacologically distinct K+ channels are involved in the cAMP-and Ca2+-mediated secretion in the mouse jejunum. Proceedings of the Physiological Society of New Zealand. 18, (pp. 45). [Abstract]

Carter, D. J., Hamilton, K. L., & Butt, A. G. (1997). Contribution of C1 conductance to potential volume regulation by mouse jejunal crypt cells. Proceedings of the Physiological Society of New Zealand. 16, (pp. 24). [Abstract]

Butt, A. G., Taylor, J. L., Hamilton, K. L., & Harvey, B. J. (1997). The relationship between intracellular Ca2+ activity and C1 secretion in the human colon. Proceedings of the Physiological Society of New Zealand. 16, (pp. 22). [Abstract]

Kirkness, S. J., Hamilton, K. L., & Butt, A. G. (1997). Secretion of HCO3- by the mouse jejunum. Proceedings of the Physiological Society of New Zealand. 16, (pp. 23). [Abstract]

Hamilton, K. L., & Butt, A. G. (1997). Are basolateral nonselective cation channels and C1 channels involved in the C1 secretory response of mouse jejunal crypts? Proceedings of the Physiological Society of New Zealand. 16, (pp. 22). [Abstract]

Taylor, J. L., Hamilton, K. L., & Butt, A. G. (1997). HCO3- modifies the cAMP-dependent secretory response of human colon in the Ussing chamber. Proceedings of the Physiological Society of New Zealand. 16, (pp. 23). [Abstract]

Hamilton, K. L., & Butt, A. G. (1997). Properties of two K channels of the basolateral membrane of isolated mouse jejunal crypts. In E. Board (Ed.), FASEB Journal. 11, (pp. A25). Bethesda, USA: Federation of American Societies for Experimental Biology. [Abstract]

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Conference Contribution - Poster Presentation (not in published proceedings)

Walters, C., Hamilton, K. L., & McDonald, F. J. (2019, September). The effect of Rab7 on the trafficking of the epithelial sodium channel. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Cheung, T. T., Geda, A., Pilmore, E., Hamilton, K. L., & McDonald, F. J. (2016, December). How is epithelial ion transport maintained? Implications for hypertension. Poster session presented at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.

Lee, S.-L., Devor, D. C., & Hamilton, K. L. (2011, August). Role of microtubules and microfilaments in the trafficking of KCa3.1. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Terkildsen, J. R., Nickerson, D. P., Hamilton, K. L., Hunter, P. J., & Crampin, E. J. (2011, August). Modelling SGLT kinetics in the kidney. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Terkildsen, J., Nickerson, D., Hamilton, K., & Hunter, P. (2010, November-December). Mathematical modelling of the distal nephron. Poster session presented at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

Winter, B., Balut, C. M., Butterworth, M. B., Devor, D. C., & Hamilton, K. L. (2010, November-December). Trafficking of KCa3.1 in a polarized epithelium. Poster session presented at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

Terkildsen, J., Nickerson, D., Hamilton, K., & Hunter, P. (2010, August-September). Visualising multiscale models of the nephron. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Chao, T., Hamilton, K., Hessian, P., & Butt, G. (2008, November). The conductive properties of exponentially dividing LNCaP prostate cancer cells. Poster session presented at the Medical Sciences Congress, Queenstown, New Zealand.

Krause, C., Chao, P.-C., & Hamilton, K. L. (2006, November-December). The role of the human-intermediate conductance K+ channel (hIK1) in breast and prostate cancer. Poster session presented at the Medical Sciences Congress, Rotorua, New Zealand.

Kiessling, M., & Hamilton, K. L. (2005, December). DCEBIO stimulates Cl- secretion in the mouse jejunum via a cAMP-dependent manner. Poster session presented at the Medical Sciences Congress, Queenstown, New Zealand.

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Conference Contribution - Verbal presentation and other Conference outputs

Scott, M. L., Cheung, T. T., Hamilton, K. L., & McDonald, F. J. (2018, August). Endosomal SNX proteins are required for recycling of the epithelial sodium channel. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

McDonald, F. J., Cheung, T. T., Geda, A., Pilmore, E., & Hamilton, K. L. (2016, December). Recycling of epithelial ion channels by Retromer with implications for water and salt homeostasis. Verbal presentation at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.

Farquhar, R., Rodrigues, E., & Hamilton, K. L. (2016, August). The role of the cytoskeleton and myosin-Vc in the trafficking of KCa3.1 to the basolateral membrane of polarised epithelial cells. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Lee, S.-L., Winter, B., Devor, D. C., & Hamilton, K. L. (2013, August). Ubiquitin-dependent degradation of KCa3.1 in a polarised epithelium. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Nickerson, D., Terkildsen, J., Hamilton, K., & Hunter, P. (2010, November-December). An interface for interacting with multiscale models of the nephron. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

Chao, P. C., & Hamilton, K. L. (2007, November). Synchronizing LNCaP cells in various phases of the cell cycle (Preliminary Report). Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Jones, H. M., Bailey, M. A., Baty, C. J., MacGregor, G. G., Syme, C. A., Hamilton, K. L., & Devor, D. C. (2006, November-December). An NH2-terminal multi-basic RKR motif is crucial for the ATP-dependent regulation of hIK1. Verbal presentation at the Medical Sciences Congress, Rotorua, New Zealand.

Chao, P. C. T., & Hamilton, K. L. (2005, December). Genistein stimulates Cl- secretion partially by modulating specific phosphodiesterases in the mouse jejunum. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

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