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Lab personnel

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Previous lab personnel

  • Yongfeng Liu, currently postdoctoral fellow Center for Cardiovascular Sciences, Albany Medical Center, USA with Prof Harold Singer
  • Ying Ke, Currently postdoctoral fellow with Associate Professor Jamie Vandenberg at Victor Chang Cardiac Research Institute, Sydney
  • Dominik Wiemuth, Currently postdoctoral fellow with Professor Stefan Grunder, University of Aachen, Germany
  • Joy McIntosh, Currently postdoctoral fellow with Professor Ken McNatty, Victoria University of Wellington
  • Meino Rohlfs, Currently postdoctoral fellow with Dr Michael Schleicher, Ludwig-Maximilians-University, Munich, Germany

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Research interests

How do proteins find their way to their correct location in a cell? What factors control this "protein trafficking" process? Using the epithelial sodium channel (ENaC), essential for kidney control of blood pressure, we have shown that ubiquitin pathway proteins control the number of ENaCs at the cell surface resulting in changes in Na+ absorption. As part of a protein interaction screen we discovered that COMMD family proteins also regulate ENaC trafficking. The mechanisms and implications of this pathway are under investigation.

Pancreatic acinar cells are responsible for digestive enzyme secretion subsequently necessary for breakdown of ingested food. Unregulated activation of digestive enzymes in the acinar cells of the pancreas can cause cell damage, in a process called pancreatitis. The COMMD10 protein is highly expressed in pancreas and has links to the protein secretory pathway; we are currently investigating the role of COMMD10 in the production and secretion of digestive enzymes from pancreatic acinar cells.

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Expertise

  • Protein-protein interaction assays, Ussing chamber, molecular and cellular biology

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Projects

  • Regulation of ENaC by COMMD protein family members
  • Regulation of ENaC by ubiquitin pathway proteins: Nedd8, XIAP
  • Interaction of COMMD1 with the insulin signalling pathway

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Current funding

  • University of Otago Research Grant

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Collaborators

  • Associate Professor Ezra Burstein, University of Texas Southerwestern Medical Center
  • Professor Peter Snyder, University of Iowa, USA
  • Dr Shaun Lott, School of Biological Sciences, University of Auckland, NZ
  • Associate Professor Teesdale-Spittle, School of Biological Sciences, Victoria University of Wellington, NZ

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Teaching

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Selected publications

Cheung, T. T., Ismail, N. A. S., Moir, R., Arora, N., McDonald, F. J., & Condliffe, S. B. (2019). Annexin II light chain p11 interacts with ENaC to increase functional activity at the membrane. Frontiers in Physiology, 10, 7. doi: 10.3389/fphys.2019.00007

Daniels, L. J., Wallace, R. S., Nicholson, O. M., Wilson, G. A., McDonald, F. J., Jones, P. P., Baldi, J. C., Lamberts, R. R., & Erickson, J. R. (2018). Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats. Cardiovascular Diabetology, 17, 89. doi: 10.1186/s12933-018-0732-x

Ware, A. W., Cheung, T. T., Rasulov, S., Burstein, E., & McDonald, F. J. (2018). Epithelial Na+ Channel: Reciprocal control by COMMD10 and Nedd4-2. Frontiers in Physiology, 9, 793. doi: 10.3389/fphys.2018.00793

Healy, M. D., Hospenthal, M. K., Hall, R. J., Chandra, M., Chilton, M., Tillu, V., … McDonald, F. J., … Ghai, R. (2018). Structural insights into the architecture and membrane interactions of the conserved COMMD proteins. eLIFE, 7, e35898. doi: 10.7554/eLife.35898

Ashley, Z., Mugloo, S., McDonald, F. J., & Fronius, M. (2018). Epithelial Na+ channel differentially contributes to shear stress-mediated vascular responsiveness in carotid and mesenteric arteries from mice. American Journal of Physiology: Heart & Circulatory Physiology, 314(5), H1022-H1032. doi: 10.1152/ajpheart.00506.2017

Denny, P., McDonald, F., Empson, R., Kelly, P., & Petersen, A. (2018). Empirical support for a causal relationship between gamification and learning outcomes. Proceedings of the CHI Conference on Human Factors in Computing Systems. 311. New York, NY: ACM. doi: 10.1145/3173574.3173885

Scott, M. L., Cheung, T. T., Hamilton, K. L., & McDonald, F. J. (2018). Recycling of the epithelial sodium channel requires SNX1 and SNX2. New Zealand Medical Journal, 131(1470), (pp. 110). Retrieved from https://www.nzma.org.nz/journal

Ware, A. W., & McDonald, F. J. (2017). COMMD10: A novel regulator of ENaC endocytosis. New Zealand Medical Journal, 130(1460), (pp. 97). Retrieved from http://www.nzma.org.nz/journal

Reynolds, J., Oranje, J. M., Spronken-Smith, R. A., & McDonald, F. J. (2017). The challenges of leading large scale curriculum change from a student-centred framework. Proceedings of the Talking Teaching Conference. Retrieved from https://akoacademy.ac.nz/programme

Mugloo, S., Ashley, Z., Leader, C., Bahn, A., Sammut, I. A., Walker, R., McDonald, F. J., & Fronius, M. (2017, September). Hypertension is associated with increased ENaC expression in the arteries of Cyp1a1-Ren2 rats. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Daniels, L. J., Lamberts, R. R., McDonald, F., Pereira, L., Bers, D. M., & Erickson, J. R. (2017, September). The role of calcium calmodulin dependent protein kinase II in type 2 diabetic cardiac dysfunction. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Ashley, Z., Leader, C., Sammut, I., McDonald, F., Walker, R., & Fronius, M. (2016). The flow detection role of the vascular epithelial sodium channel (ENaC) in an experimental model of hypertension: The novel target for spironolactone therapy? Journal of Hypertension, 34(Suppl. 2), (pp. e103). [Abstract]

Ware, A., Burstein, E., & McDonald, F. (2016). COMMD10: A novel regulator of ENaC trafficking? FASEB Journal, 30(Suppl. 1), 1223.8. doi: 10.1096/fj.1530-6860

McDonald, F., & Bahn, A. (2016). New technologies in teaching and learning. Proceedings of the First Year Biology Educators' Colloquium (FYBC). (pp. 7). Retrieved from http://www.otago.ac.nz/fybec/programme-and-speakers/index.html

Cheung, T. T., Geda, A., Pilmore, E., Hamilton, K. L., & McDonald, F. J. (2016, December). How is epithelial ion transport maintained? Implications for hypertension. Poster session presented at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.

Mugloo, S., Leader, C., Sammut, I. A., Walker, R., McDonald, F. J., & Fronius, M. (2016, August). Characterising ENaC expression in vasculature. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Daniels, L. J., Lamberts, R. R., McDonald, F. J., & Erickson, J. R. (2016, August). CaMKII inhibition restores contractile performance in cardiac muscle from a rat model of type 2 diabetes. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Daniels, L. J., McDonald, F. J., Lamberts, R. R., & Erickson, J. R. (2016, August-September). The effects of CaMKII inhibition on post-rest behavior and spontaneous contractions in isolated Zucker diabetic fatty rat cardiac muscle. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Ashley, Z., Leader, C., Sammut, I., McDonald, F., Walker, R., & Fronius, M. (2016, December). Role of ENaC in the dysfunction of resistance arteries in hypertension with/without the confounding factor of myocardial infarction. Verbal presentation at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.

Mugloo, S., Ashley, Z., Leader, C., Bahn, A., Sammut, I., Walker, R., McDonald, F., & Fronius, M. (2016, December). Epithelial Sodium Channel (ENaC): An emerging regulator of vascular physiology. Verbal presentation at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.

Ware, A. W., & McDonald, F. J. (2016, December). COMMD10: A novel regulator of ENaC endocytosis and recycling. Verbal presentation at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.

Jennings, M., Ashley, Z., Leader, C., McDonald, F., Sammut, I., Walker, R., & Fronius, M. (2016, December). The ultrastructure of mesenteric arteries in a hypertensive rat model. Verbal presentation at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.

McDonald, F. J., Cheung, T. T., Geda, A., Pilmore, E., & Hamilton, K. L. (2016, December). Recycling of epithelial ion channels by Retromer with implications for water and salt homeostasis. Verbal presentation at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.

Daniels, L., Bell, J. R., Delbridge, L. M. D., McDonald, F. J., Lamberts, R. R., & Erickson, J. R. (2015). The role of CaMKII in diabetic heart dysfunction. Heart Failure Reviews, 20(5), 589-600. doi: 10.1007/s10741-015-9498-3

Taura, M., Kudo, E., Kariya, R., Goto, H., Matsuda, K., Hattori, S., … McDonald, F., … Okada, S. (2015). COMMD1/Murr1 reinforces HIV-1 latent infection through IκB-α stabilization. Journal of Virology, 89(5), 2643-2658. doi: 10.1128/jvi.03105-14

Journal - Research Article

Cheung, T. T., Ismail, N. A. S., Moir, R., Arora, N., McDonald, F. J., & Condliffe, S. B. (2019). Annexin II light chain p11 interacts with ENaC to increase functional activity at the membrane. Frontiers in Physiology, 10, 7. doi: 10.3389/fphys.2019.00007

Daniels, L. J., Wallace, R. S., Nicholson, O. M., Wilson, G. A., McDonald, F. J., Jones, P. P., Baldi, J. C., Lamberts, R. R., & Erickson, J. R. (2018). Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats. Cardiovascular Diabetology, 17, 89. doi: 10.1186/s12933-018-0732-x

Ashley, Z., Mugloo, S., McDonald, F. J., & Fronius, M. (2018). Epithelial Na+ channel differentially contributes to shear stress-mediated vascular responsiveness in carotid and mesenteric arteries from mice. American Journal of Physiology: Heart & Circulatory Physiology, 314(5), H1022-H1032. doi: 10.1152/ajpheart.00506.2017

Healy, M. D., Hospenthal, M. K., Hall, R. J., Chandra, M., Chilton, M., Tillu, V., … McDonald, F. J., … Ghai, R. (2018). Structural insights into the architecture and membrane interactions of the conserved COMMD proteins. eLIFE, 7, e35898. doi: 10.7554/eLife.35898

Ware, A. W., Cheung, T. T., Rasulov, S., Burstein, E., & McDonald, F. J. (2018). Epithelial Na+ Channel: Reciprocal control by COMMD10 and Nedd4-2. Frontiers in Physiology, 9, 793. doi: 10.3389/fphys.2018.00793

Daniels, L., Bell, J. R., Delbridge, L. M. D., McDonald, F. J., Lamberts, R. R., & Erickson, J. R. (2015). The role of CaMKII in diabetic heart dysfunction. Heart Failure Reviews, 20(5), 589-600. doi: 10.1007/s10741-015-9498-3

Taura, M., Kudo, E., Kariya, R., Goto, H., Matsuda, K., Hattori, S., … McDonald, F., … Okada, S. (2015). COMMD1/Murr1 reinforces HIV-1 latent infection through IκB-α stabilization. Journal of Virology, 89(5), 2643-2658. doi: 10.1128/jvi.03105-14

Bobby, R., Medini, K., Neudecker, P., Verne Lee, T., Brimble, M. A., McDonald, F. J., … Dingley, A. J. (2013). Structure and dynamics of human Nedd4-1 WW3 in complex with the αENaC PY motif. Biochimica et Biophysica Acta: Proteins & Proteomics, 1834(8), 1632-1641. doi: 10.1016/j.bbapap.2013.04.031

Liu, Y. F., Swart, M., Ke, Y., Ly, K., & McDonald, F. J. (2013). Functional interaction of COMMD3 and COMMD9 with the epithelial sodium channel. American Journal of Physiology: Renal Physiology, 305(1), F80-F89. doi: 10.1152/ajprenal.00158.2013

Starokadomskyy, P., Gluck, N., Li, H., Chen, B., Wallis, M., Maine, G. N., … McDonald, F. J., … Burstein, E. (2013). CCDC22 deficiency in humans blunts activation of proinflammatory NF-κβ signaling. Journal of Clinical Investigation, 123(5), 2244-2256. doi: 10.1172/JCI66466

Ly, K., McIntosh, C. J., Biasio, W., Liu, Y., Ke, Y., Olson, D. R., … McDonald, F. J. (2013). Regulation of the delta and alpha epithelial sodium channel (ENaC) by ubiquitination and Nedd8. Journal of Cellular Physiology, 228, 2190-2201. doi: 10.1002/jcp.24390

Chang, T., Ke, Y., Ly, K., & McDonald, F. J. (2011). COMMD1 regulates the delta epithelial sodium channel (δENaC) through trafficking and ubiquitination. Biochemical & Biophysical Research Communications, 411(3), 506-511. doi: 10.1016/j.bbrc.2011.06.149

Wiemuth, D., Lott, J. S., Ly, K., Ke, Y., Teesdale-Spittle, P., Snyder, P. M., & McDonald, F. J. (2010). Interaction of Serum- and Glucocorticoid regulated Kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation. PLoS ONE, 5(8), e12163. doi: 10.1371/journal.pone.0012163

Walker, R., Spronken-Smith, R., Bond, C., McDonald, F., Reynolds, J., & McMartin, A. (2010). The impact of curriculum change on health sciences first year students' approaches to learning. Instructional Science, 38(6), 707-722. doi: 10.1007/s11251-009-9092-y

Ke, Y., Butt, A. G., Swart, M., Liu, Y.-f., & McDonald, F. J. (2010). COMMD1 down-regulates the epithelial sodium channel through Nedd4-2. American Journal of Physiology: Renal Physiology, 298, F1445-F1456. doi: 10.1152/ajprenal.00257.2009

Bedford, J. J., Weggery, S., Ellis, G., McDonald, F. J., Joyce, P. R., Leader, J. P., & Walker, R. J. (2008). Lithium-induced nephrogenic diabetes insipidus: Renal effects of amiloride. Clinical Journal of the American Society of Nephrology, 3(5), 1324-1331.

Wiemuth, D., Ke, Y., Rohlfs, M., & McDonald, F. J. (2007). Epithelial sodium channel (ENaC) is multi-ubiquitinated at the cell surface. Biochemical Journal, 405, 147-155.

Bromhead, C., Miller, J. H., & McDonald, F. J. (2006). Regulation of T-cadherin by hormones, glucocorticoid and EGF. Gene, 374, 58-67.

Walker, R. J., Weggery, S., Bedford, J. J., McDonald, F. J., Ellis, G., & Leader, J. P. (2005). Lithium-induced reduction in urinary concentrating ability and urinary aquaporin 2 (AQP2) excretion in healthy volunteers. Kidney International, 67, 291-294.

Kivell, B. M., Day, D. J., McDonald, F. J., & Miller, J. H. (2004). Developmental expression of μ and δ opioid receptors in the rat brainstem: Evidence for a postnatal switch in μ isoform expression. Developmental Brain Research, 148, 185-196.

Kivell, B. M., Day, D. J., McDonald, F. J., & Miller, J. H. (2004). Mu and delta opioid receptor immunoreactivity and mu receptor regulation in brainstem cells cultured from late fetal and early postnatal rats. Developmental Brain Research, 149, 9-19.

Biasio, W., Chang, T., McIntosh, C. J., & McDonald, F. J. (2004). Identification of Murr1 as a regulator of the human δ epithelial sodium channel. Journal of Biological Chemistry, 279(7), 5429-5434.

Morrison, P. S., Dobbie, G., & McDonald, F. J. (2003). Research collaboration among university scientists. Higher Education Research & Development, 22(3), 275-296.

Lott, J. S., Coddington-Lawson, S. J., Teesdale-Spittle, P. H., & McDonald, F. J. (2002). A single WW domain is the predominant mediator of the interaction between the human ubiquitin-protein ligase Nedd4 and the human epithelial sodium channel. Biochemical Journal, 361, 481-488.

McDonald, F. J., Western, A. H., McNeil, J. D., Thomas, B. C., Olson, D., & Snyder, P. (2002). Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na+ channel. American Journal of Physiology: Renal Physiology, 283, 431-436.

McDonald, F. J. (2002). Regulation of the epithelial sodium channel by the ubiquitin pathway: implications for hypertension. New Zealand BioScience, 11(3), 8-10.

Kivell, B. M., McDonald, F. J., & Miller, J. H. (2001). Method for serum-free culture of late fetal and early postnatal rat brainstem neurons. Brain Research Protocols, 6(3), 91-99. doi: 10.1016/S1385-299X(00)00037-4

Snyder, P. M., Olson, D. R., McDonald, F. J., & Bucher, D. B. (2001). Multiple WW domains, but not the C2 domain, are required for inhibition of the epithelial Na+ channel by human Nedd4. Journal of Biological Chemistry, 276(30), 28321-28326.

Farr, T. J., Coddington-Lawson, S. J., Snyder, P. M., & McDonald, F. J. (2000). Human Nedd4 interacts with the human epthithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits. Biochemical Journal, 345, 503-509.

Kivell, B. M., McDonald, F. J., & Miller, J. H. (2000). Serum-free culture of rat post-natal and fetal brainstem neurons. Developmental Brain Research, 120, 199-210.

McDonald, F. J., Yang, B., Hrstka, R. F., Drummond, H. A., Tarr, D. E., McCray, P. B., … Williamson, R. A. (1999). Disruption of the β subunit of the epithelial Na+ channel in mice: Hyperkalemia and neonatal death associated with a pseudohypoaldosteronism phenotype. PNAS, 96(4), 1727-1731.

McDonald, F. J. (1997). Salt intake and high blood pressure. New Zealand Science Review, 54(3-4), 47-52.

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Journal - Research Other

McDonald, F. J. (2013). COMMD1 and ion transport proteins: What is the COMMection? Focus on "COMMD1 interacts with the COOH terminus of NKCC! in Calu-3 airway epithelial cells to modulate NKCC1 ubiquitination". American Journal of Physiology: Cell Physiology, 305(2), C129-C130. doi: 10.1152/ajpcell.00128.2013

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Journal - Professional & Other Non-Research Articles

McDonald, F. J. (2008). A new SGK1 knockout mouse. American Journal of Physiology: Renal Physiology, 294(6), F1296-F1297. doi: 10.1152/ajprenal.90245.2008

McDonald, F. J. (2001). From molecule to malady: a report on the XXXIV International Congress of Physiological Sciences held in Christchurch during 26-31 August, 2001. New Zealand Science Review, 58(3), 78.

Rohlfs, M., McIntosh, C. J., & McDonald, F. J. (2001). Regulation of the epithelial sodium channel by ubiquitination and endocytosis. 40th Annual Report of the Wellington Research Foundation Inc., 8-9.

Lott, J. S., Coddington-Lawson, S. J., & McDonald, F. J. (1999). Structural studies on the interaction of human Nedd4 with the epithelial Na+ channel. Annual Report of the Wellington Medical Research Foundation Inc, 10-11.

Miller, J. H., Day, D., McDonald, F. J., Chikka, A., Colman, A., Kivell, B. M., & Mrkusich, E. (1999). Developmental expression of opioids in the rat brainstem. 40th Annual Report of the Wellington Medical Research Foundation Inc., 10-11.

McDonald, F. J., & Farr, T. J. (1997). Identifying proteins which bind to the epithelial sodium channel. 37th Report of the Wellington Medical Research Foundation Inc., 61-62.

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Conference Contribution - Published proceedings: Full paper

Denny, P., McDonald, F., Empson, R., Kelly, P., & Petersen, A. (2018). Empirical support for a causal relationship between gamification and learning outcomes. Proceedings of the CHI Conference on Human Factors in Computing Systems. 311. New York, NY: ACM. doi: 10.1145/3173574.3173885

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Conference Contribution - Published proceedings: Abstract

Scott, M. L., Cheung, T. T., Hamilton, K. L., & McDonald, F. J. (2018). Recycling of the epithelial sodium channel requires SNX1 and SNX2. New Zealand Medical Journal, 131(1470), (pp. 110). Retrieved from https://www.nzma.org.nz/journal

Ware, A. W., & McDonald, F. J. (2017). COMMD10: A novel regulator of ENaC endocytosis. New Zealand Medical Journal, 130(1460), (pp. 97). Retrieved from http://www.nzma.org.nz/journal

Reynolds, J., Oranje, J. M., Spronken-Smith, R. A., & McDonald, F. J. (2017). The challenges of leading large scale curriculum change from a student-centred framework. Proceedings of the Talking Teaching Conference. Retrieved from https://akoacademy.ac.nz/programme

Ashley, Z., Leader, C., Sammut, I., McDonald, F., Walker, R., & Fronius, M. (2016). The flow detection role of the vascular epithelial sodium channel (ENaC) in an experimental model of hypertension: The novel target for spironolactone therapy? Journal of Hypertension, 34(Suppl. 2), (pp. e103). [Abstract]

McDonald, F., & Bahn, A. (2016). New technologies in teaching and learning. Proceedings of the First Year Biology Educators' Colloquium (FYBC). (pp. 7). Retrieved from http://www.otago.ac.nz/fybec/programme-and-speakers/index.html

Ware, A., Burstein, E., & McDonald, F. (2016). COMMD10: A novel regulator of ENaC trafficking? FASEB Journal, 30(Suppl. 1), 1223.8. doi: 10.1096/fj.1530-6860

Malahay, I., Cheung, T., Bright, L., & McDonald, F. (2014). COMMD10 is important for zymogen granule formation in AR42J pancreatic acinar cells. New Zealand Medical Journal, 127(1395). Retrieved from http://www.nzma.org.nz/journal

McDonald, F., Reynolds, J., Spronken-Smith, R., & Bixley, A. (2013). A longitudinal study of deep, surface and strategic approaches to learning. In J. McDonald, S.-K. Loke, A. McLean & M. Rajoo (Eds.), Proceedings of the Spotlight on Teaching and Learning Colloquium. (pp. 22). Dunedin, New Zealand: HEDC, University of Otago. [Abstract]

McDonald Cowles, F., Liu, Y., Hospenthal, M., Swart, M., Ke, Y., & Lott, S. (2011). Three COMMD family proteins are located in collecting duct cells and regulate ENaC. Proceedings of the 7th International Symposium on Aldosterone and the ENaC/Degenerin Family of Ion Channels: Molecular Mechanisms and Pathophysiology. (pp. 26). Retrieved from http://the-aps.org/mm/Conferences/APS-Conferences/2011-Conferences/ENaC

Liu, Y., Swart, M., & McDonald, F. J. (2010). Interaction of COMMD family proteins with the epithelial sodium channel. FASEB Journal, 24, 611.13. [Abstract]

McDonald, F. J., Swart, M., & Ke, Y. (2010). Insulin stimulation of the epithelial sodium channel is inhibited by COMMD1. FASEB Journal, 24, 611.13. [Abstract]

McDonald, F. J., Swart, M., & Ke, Y. (2009). Insulin stimulation of the epithelial sodium channel is inhibited by COMMD1. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]

Swart, M., Liu, Y., Ke, Y., & McDonald, F. J. (2009). Cellular localisation of the COMMD1 and 3 proteins. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]

Glass, L., & McDonald, F. (2009). COMMD2 interacts with the epithelial sodium channel ENaC. New Zealand Medical Journal, 122(1306). Retrieved from http://journal.nzma.org.nz/journal/122-1306/3899/content.pdf

Liu, H., Ke, Y., & McDonald, F. J. (2009). Investigation of the stabilising effect of COMMD1 on SGK1. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]

Liu, H.-J., Ke, Y., & McDonald, F. (2009). Investigation of the stabilising effect of COMMD1 on SGK1. New Zealand Medical Journal, 122(1306). Retrieved from http://journal.nzma.org.nz/journal/122-1306/3899/content.pdf

Walker, R., McMartin, A., McDonald, F., Reynolds, J., Spronken-Smith, R., & Bond, C. (2008). Approaches to learning in first year health science. Proceedings of the Higher Education Research and Development Society of Australasia 31st Annual International Conference. HERDSA. Retrieved from http://conference.herdsa.org.au/2008/program.cfm

Walker, R., Bond, C., Spronken-Smith, R., McDonald, F., Reynolds, J., & McMartin, A. (2008). Student learning experiences in first year health science: Change in curriculum, change in approach? In C. Bond & R. Spronken-Smith (Eds.), Proceedings of the Spotlight on Teaching at Otago Conference. (pp. 43). Dunedin, New Zealand: HEDC, University of Otago. [Abstract]

Chang, T., & McDonald, F. J. (2007). COMMD1 downregulates δ epithelial sodium channel (δENaC) through trafficking and ubiquitination. FASEB Journal, 21(6), lb465, (pp. LB99). [Abstract]

Ke, Y., Chang, T., & McDonald, F. (2007). Mechanisms by which the copper metabolism gene MURR1 domain 1 (COMMD1) protein down-regulates human epithelial sodium channel activity. New Zealand Medical Journal, 120(1262). Retrieved from http://journal.nzma.org.nz/journal/120-1262/2740/content.pdf

Chang, T., & McDonald, F. J. (2006). Murr1/COMMD1 colocalises with delta epithelial sodium channel (δENaC) and regulates its ubiquitination. New Zealand Medical Journal, 119(1237). Retrieved from http://journal.nzma.org.nz/journal/119-1237/2062/content.pdf

Ke, Y., Chang, T., & McDonald, F. (2006). Murr1, a novel regulator of epithelial sodium channel activity. Proceedings of the Australian Society for Biochemistry and Molecular Biology (ComBio). Retrieved from http://www.asbmb.org.au/combio2006/abstracts/edited/KE-20060623115838.rtf

Chang, T., & McDonald, F. J. (2005). The study of delta epithelial sodium channel (δENaC) and its modulator Murr1/COMMD1. Proceedings of the Medical Sciences Congress. (pp. 68-69). [Abstract]

McDonald, F. J., & Wiemuth, D. (2005). Interactions of SGK, the epithelial sodium channel (ENaC), and ubiquitin ligases Nedd4 and Nedd4-2. Proceedings of the Medical Sciences Congress. (pp. 42). [Abstract]

Wiemuth, D., & McDonald, F. J. (2005). Interactions between the serum- and glucocorticoid regulated kinase (SGK), the epithelial sodium channel (ENaC) and the ubiquitin ligases Nedd4 and Nedd4-2. FEBS Journal, 272(Suppl.1), (pp. 162). doi: 10.1111/j.1742-4658.2005.4739_4.x

Ke, Y., Chang, T., & McDonald, F. (2005). Murr1, a novel regulator of epithelial sodium channel activity. Proceedings of the Medical Sciences Congress. (pp. 71-72). [Abstract]

Chang, T., & McDonald, F. J. (2005). Interaction of delta epithelial sodium channel and its modulator Murr1. Proceedings of the ComBio Conference. (pp. 41). [Abstract]

Chang, T., Biasio, W., & McDonald, F. J. (2004). Interaction between the delta subunit of epithelial sodium channel (δENaC) and a copper-toxicosis related protein Murr1. Proceedings of the Medical Sciences Congress: Celebrating New Zealand Health Research. (A28), (pp. 36). [Abstract]

Chang, T., Biasio, W., & McDonald, F. J. (2004). Interaction between the delta subunit of epithelial sodium channel (δENaC) and a copper-toxicosis related protein Murr1. Proceedings of the 14th Annual Queenstown Molecular Biology Meeting. (104). [Abstract]

Wiemuth, D., & McDonald, F. J. (2004). The serum- and glucocorticoid regulated kinase (SGK) binds to different WW-domains of the ubiquitin ligases Nedd4 and Nedd4-2. Proceedings of the 14th Annual Queenstown Molecular Biology Meeting. (13). [Abstract]

Biasio, W., Strauss, M., & McDonald, F. J. (2002). Identification of proteins binding to the {delta} subunit of the human epithelial sodium channel. European Journal of Biochemistry Supplement. 269, (pp. 60-61). Oxford: Blackwell Publishing. [Abstract]

McIntosh, J., Page, R., Miller, J., Snyder, P., & McDonald, F. J. (2002). Nedd8, a potential regulator of the human epithelial sodium channel. Non-traditional functions of ubiquitin and ubiquitin-like proteins. Colorado Springs. 91, (pp. 33). [Abstract]

Day, D., Kivell, B. M., McDonald, F. J., & Miller, J. H. (2001). Mu and delta opioid receptor immunocytochemistry in SH-SY5Y cells and cells cultured from the rat brainstem. Proceedings of the Physiological Society of New Zealand. 20, (pp. 43). [Abstract]

McDonald, F. J., Coddington-Lawson, S. J., Teesdale-Spittle, P. H., & Lott, J. S. (2001). Binding of the human Nedd4 WW domains to the human epithelial sodium channel. Proceedings of the Physiological Society of New Zealand. 20, (pp. 71). [Abstract]

Bromhead, C., Grebe, S. K., Miller, J. H., Bethwaite, P. B., Tie, A. M., Teague, C. A., & McDonald, F. J. (2001). T-cadherin expression is regulated in EGF, estradiol and dexamethasone in human osteosarcoma cells. Molecular Biology of the Cell (special supplement). 12(November), (pp. 480a). [Abstract]

Kivell, B. M., McDonald, F. J., & Miller, J. H. (2000). Immunocytochemistry of mu opioid receptors in cells cultured from the rat brainstem. Proceedings of the Physiological Society of New Zealand. 19. [Abstract]

Coddington-Lawson, S. J., & McDonald, F. J. (1999). Identification of Nedd4 binding proteins by MALDI-TOF mass spectrometry. Proceedings of the Physiological Society of New Zealand. 18. [Abstract]

Kivell, B. M., Miller, J. H., & McDonald, F. J. (1999). Serum-free culture of rat postnatal and fetal brainstem neurons. Proceedings of the Physiological Society of New Zealand. 18. [Abstract]

McDonald, F. J., Coddington-Lawson, S. J., Snyder, P., & Lott, J. S. (1999). Interaction and regulation of the human epithelial sodium channel by E3 ubiquitin-protein ligases. Proceedings of the Physiological Society of New Zealand. 18. [Abstract]

McDonald, F. J., Farr, T. J., Coddington, S. J., & Welsh, M. J. (1997). Binding proteins of the epithelial sodium channel. The Physiologist. 40(5). [Abstract]

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Conference Contribution - Poster Presentation (not in published proceedings)

Cheung, T. T., Geda, A., Pilmore, E., Hamilton, K. L., & McDonald, F. J. (2016, December). How is epithelial ion transport maintained? Implications for hypertension. Poster session presented at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.

Mugloo, S., Leader, C., Sammut, I. A., Walker, R., McDonald, F. J., & Fronius, M. (2016, August). Characterising ENaC expression in vasculature. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Ware, A. W., Burstein, E., & McDonald, F. J. (2015, August-September). COMMD10: A novel regulator of the protein trafficking pathway? Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

McDonald, F., Chang, T., Ke, Y., & Ly, K. (2008, August-September). δENaC ubiquitination and regulation by COMMD1. Poster session presented at the Queenstown Molecular Biology Meetings, Queenstown, New Zealand.

Liu, Y., & McDonald, F. (2008, August-September). Interaction of COMMD family proteins with the epithelial sodium channel. Poster session presented at the Queenstown Molecular Biology Meetings, Queenstown, New Zealand.

Ke, Y., & McDonald, F. (2008, August-September). Mechanism by which COMMD1 down-regulates human epithelial sodium channel activity. Poster session presented at the Queenstown Molecular Biology Meetings, Queenstown, New Zealand.

Ke, Y., Chang, T., & McDonald, F. (2007, October). Mechanisms by which COMMD1 down-regulates human epithelial sodium channel activity. Poster session presented at the 6th International Symposium on ″Aldosterone and ENaC: From gene to disease″, Zermatt, Switzerland.

Liu, Y.-F., Swart, M., & McDonald, F. J. (2007, November). Interaction of COMMD family proteins with the epithelial sodium channel. Poster session presented at the Medical Sciences Congress, Queenstown, New Zealand.

McDonald, F. J., Lott, J. S., Rohlfs, M., & Wiemuth, D. (2006, August-September). Epithelial sodium channel (ENaC) interaction with Nedd4-2, SGK and ubiquitin. Poster session presented at the Queenstown Signal Transduction Meeting, New Zealand.

Fleming, R. I., McDonald, F. J., & Lott, J. S. (2006, August-September). How structural biology affects your blood pressure: Understanding epithelial sodium channel regulation. Poster session presented at the Queenstown Signal Transduction Meeting, New Zealand.

Crook, A., McDonald, F. J., & Lott, J. S. (2006, August-September). COMMD proteins: A unique family structurally and functionally related to MURR1. Poster session presented at the Queenstown Signal Transduction Meeting, New Zealand.

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Conference Contribution - Verbal presentation and other Conference outputs

Mugloo, S., Ashley, Z., Leader, C., Bahn, A., Sammut, I. A., Walker, R., McDonald, F. J., & Fronius, M. (2017, September). Hypertension is associated with increased ENaC expression in the arteries of Cyp1a1-Ren2 rats. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Daniels, L. J., Lamberts, R. R., McDonald, F., Pereira, L., Bers, D. M., & Erickson, J. R. (2017, September). The role of calcium calmodulin dependent protein kinase II in type 2 diabetic cardiac dysfunction. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Daniels, L. J., Lamberts, R. R., McDonald, F. J., & Erickson, J. R. (2016, August). CaMKII inhibition restores contractile performance in cardiac muscle from a rat model of type 2 diabetes. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

McDonald, F. J., Cheung, T. T., Geda, A., Pilmore, E., & Hamilton, K. L. (2016, December). Recycling of epithelial ion channels by Retromer with implications for water and salt homeostasis. Verbal presentation at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.

Jennings, M., Ashley, Z., Leader, C., McDonald, F., Sammut, I., Walker, R., & Fronius, M. (2016, December). The ultrastructure of mesenteric arteries in a hypertensive rat model. Verbal presentation at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.

Ware, A. W., & McDonald, F. J. (2016, December). COMMD10: A novel regulator of ENaC endocytosis and recycling. Verbal presentation at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.

Mugloo, S., Ashley, Z., Leader, C., Bahn, A., Sammut, I., Walker, R., McDonald, F., & Fronius, M. (2016, December). Epithelial Sodium Channel (ENaC): An emerging regulator of vascular physiology. Verbal presentation at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.

Ashley, Z., Leader, C., Sammut, I., McDonald, F., Walker, R., & Fronius, M. (2016, December). Role of ENaC in the dysfunction of resistance arteries in hypertension with/without the confounding factor of myocardial infarction. Verbal presentation at the Joint International Meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network: Translational Medicine: Innovations in Renal Research, Blenheim, New Zealand.

Daniels, L. J., McDonald, F. J., Lamberts, R. R., & Erickson, J. R. (2016, August-September). The effects of CaMKII inhibition on post-rest behavior and spontaneous contractions in isolated Zucker diabetic fatty rat cardiac muscle. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

McDonald, F. (2014, August). Multiple COMMD proteins alter the trafficking of the epithelial sodium channel, ENaC. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

McDonald, F. J., Swart, M., & Ke, Y. (2010, August-September). Insulin stimulation of the epithelial sodium channel is inhibited by COMMD1. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

McDonald, F. J., Chang, T., Ke, Y., & Ly, K. (2007, October). δ-ENaC ubiquitination and regulation by COMMD1. Verbal presentation at the 6th International Symposium on ″Aldosterone and ENaC: From gene to disease″, Zermatt, Switzerland.

McDonald, F. J., & Ke, Y. (2007, November). Mechanisms by which COMMD1 down-regulates human epithelial sodium channel activity. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Ly, K., & McDonald, F. J. (2007, November). Ubiquitination of delta epithelial sodium channel (δENaC). Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

McDonald, F., Chang, T., Ke, Y., Ly, K., Swart, M., & Wiemuth, D. (2006, November-December). Hypertension and the kidney. Verbal presentation at the Medical Sciences Congress, Rotorua, New Zealand.

Ly, K., & McDonald, F. (2006, November-December). Investigation of delta Epithelial Sodium Channel (δENaC) ubiquitination. Verbal presentation at the Medical Sciences Congress, Rotorua, New Zealand.

Swart, M., Crook, A., Lott, S., & McDonald, F. (2006, November-December). Interaction of COMMD family members with δENAC. Verbal presentation at the Medical Sciences Congress, Rotorua, New Zealand.

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