A postgraduate research opportunity at the University of Otago.
- Academic background
- Sciences, Health Sciences
- Host campus
- Master’s, PhD
- Associate Professor Regis Lamberts, Associate Professor Phil Sheard
Old age is accompanied by many changes to body function, some of which are driven by loss of cells that cannot be replaced. The main tissues experiencing loss of irreplaceable cells are the nervous system and the myocardium. Whilst we know a good deal about the impact of ageing on the central nervous system, we know much less about how age influences the heart and its nervous input. Therefore, a PhD project is available with the aim of determining whether, when, how, and why cardiac myocytes and autonomic neurons die with advancing age.
The project will use histology and immunohistochemistry to characterise and quantify cellular changes in myocytes and autonomic neurons, and echocardiography to correlate these changes to cardiac function. The project will use human and animal tissues, will include investigation of the potential impact of obesity, and may include investigation of whether any processes are different among Māori.