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Investigating the interplay between calcium and reactive oxygen species in skeletal muscle function

A postgraduate research opportunity at the University of Otago.

Details

Academic background
Sciences, Health Sciences
Host campus
Dunedin
Qualifications
Master’s, PhD
Department
Physiology
Supervisor
Dr Tanya Cully

Overview

The Cully research lab has postgraduate projects focusing on the interplay between calcium and reactive oxygen species signalling in healthy and diseased skeletal muscle. Calcium is known to have a critical role in the degenerative phase of many muscular diseases that leads to muscle degeneration, frequent attempts at regeneration or even total muscle breakdown. A leaky calcium channel in skeletal muscle can be a result of the influence of reactive oxygen species (ROS) which can promote damage and inflammation in the muscle.

Projects will focus on rodent models and utilise several techniques, such as biochemical measurements, DNA electroporation, molecular biology and microscopy. We will seek to understand the role of two ROS producing isoforms and their influence on calcium handling in skeletal muscle of different animal models, to gain a greater understanding of these processes as well as potential drug targets.

Contact

Tanya Cully
Email   tanya.cully@otago.ac.nz