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A postgraduate research opportunity at the University of Otago.

Details

Close date
No date set
Academic background
Health Sciences, Sciences
Host campus
Dunedin
Qualification
Postgraduate Diploma, Master's, Honours
Department
Pathology (Dunedin)
Supervisor
Dr Glen Reid, Dr Cath Drummond

Overview

Mutant forms of the oncogene KRAS are common drivers of non-small cell lung cancers (NSCLC).

Recently, sotorasib and adagrasib – targeted agents that specifically inhibit the KRASG12C mutant – have been approved for treating patients. Unfortunately, while many respond to this therapy, resistance invariably occurs.

This project will investigate how variable KRAS expression levels in different subpopulations of NSCLC cells contribute to their initial survival when treated with KRAS inhibitors.

Contact

Glen Reid
Emailglen.reid@otago.ac.nz

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