A postgraduate research opportunity at the University of Otago.
Details
- Academic background
- Health Sciences
- Host campus
- Dunedin
- Qualifications
- Postgraduate Diploma, Honours, Master’s
- Department
- Pathology (Dunedin)
- Supervisors
- Dr Kunyu Li, Professor Antony Braithwaite
Overview
The p53 was originally known to function as a tumour suppressor gene that prevents cellular transformation and cancer development. Recent studies have shown that the p53 family also plays a regulatory role in the immune response. Our previous studies show that one of its isoforms, namely Δ133p53, has a pro-inflammatory function in both cancer and autoimmune conditions.
This project aims to determine the contribution of Δ133p53 isoform in Inflammatory Bowel Disease (IBD), using both a mouse model of colitis and samples from IBD patients.
Students with substantial knowledge in IBD, inflammation, and immunology are desired.
