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Professor Neil McNaughton

Neil McNaughton

Email neil.mcnaughton@otago.ac.nz
Tel 64 3 479 7634

Professor Neil McNaughton has been extensively involved in the development of Neuroscience at Otago. He was involved in the setting up of the undergraduate Neuroscience programme (the only one of its kind in New Zealand) and was director of the programme from 1991–2008. He was director of the Neuroscience Research Centre from 1991–1997 and the Neural Systems Structure and Function Research Theme from 1997–2005. He was one of the founders of the Australasian Winter Conference on Brain research and the Treasurer from 1983–1997 and a committee member until 2009.

He has acted as an External Assessor for Personal Chairs, Awards and Promotions for the Institute of Psychiatry, London; University of Hong Kong; University of Hawaii; NHMRC Australia Fellowship; Australian National University; and National University of Singapore. He has refereed grants for 15 grant awarding bodies and papers for 48 journals.

Neil joined the Department in 1982. He has over 30 years of university teaching experience, teaching at both graduate and undergraduate levels. He has over 40 years work experience as a Neuroscience researcher in the UK, Canada and New Zealand. His research interests are multidisciplinary. He has authored 111 papers, 5 major reviews, 2 books, and 30 book chapters; and edited 4 book-length works.

Research Interests

  • Neurobiology of State and Trait Anxiety and Temporal-Frontal Lobe Interactions

Find out more about Professor McNaughton's research interests

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Publications

Silva, C., & McNaughton, N. (2019). Are periaqueductal grey and dorsal raphe the foundation of appetitive and aversive control? A comprehensive review. Progress in Neurobiology. Advance online publication. doi: 10.1016/j.pneurobio.2019.02.001

Glue, P., Neehoff, S., Sabadel, A., Broughton, L., Le Nedelec, M., Shadli, S., McNaughton, N., & Medlicott, N. J. (2019). Effects of ketamine in patients with treatment-refractory generalized anxiety and social anxiety disorders: Exploratory double-blind psychoactive-controlled replication study. Journal of Psychopharmacology. Advance online publication. doi: 10.1177/0269881119874457

Shadli, S. M., High, O., Byers, B., Gibbs, P., Steller, R., Glue, P., & McNaughton, N. (2019). Human anxiety-specific "theta" occurs with selective stopping and localizes to right inferior frontal gyrus. Behavioral Neuroscience. Advance online publication. doi: 10.1037/bne0000316

Shadli, S. M., McIntosh, J., & McNaughton, N. (2019). Anxiety process "theta" biomarker in the stop signal task eliminated by a preceding relaxation test. Behavioral Neuroscience. Advance online publication. doi: 10.1037/bne0000328

Wang, Y., McCane, B., McNaughton, N., Huang, Z., Shadli, S., & Neo, P. (2019). AnxietyDecoder: An EEG-based anxiety predictor using a 3-D convolutional neural network. Proceedings of the International Joint Conference on Neural Networks. 19344. IEEE. doi: 10.1109/IJCNN.2019.8851782

Authored Book - Research

Gray, J. A., & McNaughton, N. (2000). The Neuropsychology of Anxiety: An Enquiry into the Functions of the Septo-Hippocampal System (Second Edition). Oxford, UK: Oxford University Press, 424p.

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Chapter in Book - Research

Corr, P. J., McNaughton, N., Wilson, M. R., Hutchison, A., Burch, G., & Poropat, A. (2017). Neuroscience of motivation and organizational behavior: Putting the reinforcement Sensitivity Theory (RST) to Work. In S.-I. Kim, J. Reeve & M. Bong (Eds.), Recent developments in neuroscience research on human motivation: Advances in motivation and achievement (Vol. 19). (pp. 65-92). Bingley, UK: Emerald Group. doi: 10.1108/S0749-742320160000019010

McNaughton, N., DeYoung, C. G., & Corr, P. J. (2016). Approach/Avoidance. In J. R. Absher & J. Cloutier (Eds.), Neuroimaging personality, social cognition, and character. (pp. 25-49). London, UK: Academic Press. doi: 10.1016/B978-0-12-800935-2.00002-6

Corr, P. J., & McNaughton, N. (2015). Neural mechanisms of low trait anxiety and risk for externalizing behavior. In T. P. Beauchaine & S. P. Hinshaw (Eds.), The Oxford handbook of externalizing spectrum disorders. Oxford University Press. doi: 10.1093/oxfordhb/9780199324675.013.1

McNaughton, N. (2010). Approach-avoidance conflict. In I. B. Weiner & W. E. Craighead (Eds.), The Corsini encyclopedia of psychology (Vol. 1). (4th ed.) (pp. 138-139). Hoboken, NJ: John Wiley & Sons.

McNaughton, N., & Corr, P. J. (2009). Central theories of motivation and emotion. In G. G. Berntson & J. T. Cacioppo (Eds.), Handbook of neuroscience for the behavioral sciences. (pp. 710-730). Hoboken, NJ: John Wiley & Sons.

McNaughton, N. (2008). The neurobiology of anxiety: Potential for co-morbidity of anxiety and substance use disorders. In S. H. Stewart & P. J. Conrod (Eds.), Anxiety and substance use disorders: The vicious cycle of comorbidity. (pp. 19-33). NY: Springer. doi: 10.1007/978-0-387-74290-8_2

McNaughton, N., & Zangrossi, Jr, H. (2008). Theoretical approaches to the modeling of anxiety in animals. In R. J. Blanchard, D. C. Blanchard, G. Griebel & D. J. Nutt (Eds.), Handbook of anxiety and fear (Vol. 17). (pp. 11-27). Amsterdam: Academic Press. doi: 10.1016/S1569-7339(07)00002-1

Corr, P. J., & McNaughton, N. (2008). Reinforcement sensitivity theory and personality. In P. J. Corr (Ed.), The reinforcement sensitivity theory of personality. (pp. 155-187). Cambridge University Press.

McNaughton, N., & Corr, P. J. (2008). Animal cognition and human personality. In P. J. Corr (Ed.), The reinforcement sensitivity theory of personality. (pp. 95-119). Cambridge University Press.

McNaughton, N., & Corr, P. J. (2008). The neuropsychology of fear and anxiety: A foundation for reinforcement sensitivity theory. In P. J. Corr (Ed.), The reinforcement sensitivity theory of personality. (pp. 44-94). Cambridge University Press.

McNaughton, N. (2002). Aminergic transmitter systems. In H. D'haenen, J. A. den Boer & P. Willner (Eds.), Biological Psychiatry, Volume 1. (Volume ed.) (pp. 895-913). Chichester: John Wiley & Sons, Ltd.

McNaughton, N. (2001). Approach-avoidance conflict. In W. E. Craighead & C. B. Nemeroff (Eds.), The Corsini Encyclopedia of Psychology and Behavioral Science. (3rd Edition, Volume 1). (pp. 126-127). NY: John Wiley & Sons.

McNaughton, N. (2000). Implications of the neuropsychology of anxiety for the functional role of LTP in the hippocampus. In C. Hölscher (Ed.), Neuronal Mechanisms of Memory Formation: Concepts of Long-Term Potentiation and Beyond. (pp. 362-378). Cambridge, UK: Cambridge University Press.

Gray, J. A., & McNaughton, N. (1996). The neuropsychology of anxiety: reprise. In D. A. Hope (Ed.), Perspectives on Anxiety, Panic and Fear. (pp. 61-134). Lincoln, Nebraska: University of Nebraska Press.

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Chapter in Book - Other

Gray, J., & McNaughton, N. (2004). Ansiedad: La conexión hipocámpica. In J. Vallejo, L. Sánchez Planell, C. Diez-Quevedo & J. M. Menchón (Eds.), La neurosis de angustia en el siglo XXI. (pp. 61-84). Barcelona: Ars Medica.

McNaughton, N. (2004). The neuropsychology of defence: Implications for syndromes and pharmacotherapy. In M. Maj, H. S. Akiskal, J. J. López-Ibor & A. Okasha (Eds.), Phobias. (pp. 148-152). John Wiley & Sons.

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Journal - Research Article

Silva, C., & McNaughton, N. (2019). Are periaqueductal grey and dorsal raphe the foundation of appetitive and aversive control? A comprehensive review. Progress in Neurobiology. Advance online publication. doi: 10.1016/j.pneurobio.2019.02.001

Shadli, S. M., McIntosh, J., & McNaughton, N. (2019). Anxiety process "theta" biomarker in the stop signal task eliminated by a preceding relaxation test. Behavioral Neuroscience. Advance online publication. doi: 10.1037/bne0000328

Shadli, S. M., High, O., Byers, B., Gibbs, P., Steller, R., Glue, P., & McNaughton, N. (2019). Human anxiety-specific "theta" occurs with selective stopping and localizes to right inferior frontal gyrus. Behavioral Neuroscience. Advance online publication. doi: 10.1037/bne0000316

Glue, P., Neehoff, S., Sabadel, A., Broughton, L., Le Nedelec, M., Shadli, S., McNaughton, N., & Medlicott, N. J. (2019). Effects of ketamine in patients with treatment-refractory generalized anxiety and social anxiety disorders: Exploratory double-blind psychoactive-controlled replication study. Journal of Psychopharmacology. Advance online publication. doi: 10.1177/0269881119874457

Glue, P., Neehoff, S. M., Medlicott, N. J., Gray, A., Kibby, G., & McNaughton, N. (2018). Safety and efficacy of maintenance ketamine treatment in patients with treatment-refractory generalised anxiety and social anxiety disorders. Journal of Psychopharmacology, 32(6), 663-667. doi: 10.1177/0269881118762073

Shadli, S. M., Kawe, T., Martin, D., McNaughton, N., Neehoff, S., & Glue, P. (2018). Ketamine effects on EEG during therapy of treatment-resistant generalized anxiety and social anxiety. International Journal of Neuropsychopharmacology. Advance online publication. doi: 10.1093/ijnp/pyy032

Ulrich, K., Spriggs, M. J., Abraham, W. C., Dalrymple-Alford, J. C., & McNaughton, N. (2018). Environmental enrichment increases prefrontal EEG power and synchrony with the hippocampus in rats with anterior thalamus lesions. Hippocampus. Advance online publication. doi: 10.1002/hipo.23022

Young, C. K., Ruan, M., & McNaughton, N. (2017). A critical assessment of directed connectivity estimates with artificially imposed causality in the supramammillary-septo-hippocampal circuit. Frontiers in Systems Neuroscience, 11, 72. doi: 10.3389/fnsys.2017.00072

Zhang, S., McIntosh, J., Shadli, S. M., Neo, P. S.-H., Huang, Z., & McNaughton, N. (2017). Removing eye blink artefacts from EEG: A single-channel physiology-based method. Journal of Neuroscience Methods, 291, 213-220. doi: 10.1016/j.jneumeth.2017.08.031

Glue, P., Medlicott, N. J., Harland, S., Neehoff, S., Anderson-Fahey, B., Le Nedelec, M., Gray, A., & McNaughton, N. (2017). Ketamine's dose-related effects on anxiety symptoms in patients with treatment refractory anxiety disorders. Journal of Psychopharmacology, 31(10), 1302-1305. doi: 10.1177/0269881117705089

Frost, R., & McNaughton, N. (2017). The neural basis of delay discounting: A review and preliminary model. Neuroscience & Biobehavioral Reviews, 79, 48-65. doi: 10.1016/j.neubiorev.2017.04.022

Ruan, M., Young, C. K., & McNaughton, N. (2017). Bi-directional theta modulation between the septo-hippocampal system and the mammillary area in free-moving rats. Frontiers in Neural Circuits, 11, 62. doi: 10.3389/fncir.2017.00062

Shadli, S. M., Smith, M. J., Glue, P., & McNaughton, N. (2016). Testing an anxiety process biomarker: Generalisation from an auditory to a visual stimulus. Biological Psychology, 117, 50-55. doi: 10.1016/j.biopsycho.2016.02.011

Tyree, S. M., Munn, R. G. K., & McNaughton, N. (2016). Anxiolytic-like effects of leptin on fixed interval responding. Pharmacology Biochemistry & Behavior, 148, 15-20. doi: 10.1016/j.pbb.2016.05.005

McNaughton, N., & Corr, P. J. (2016). Mechanisms of comorbidity, continuity, and discontinuity in anxiety-related disorders. Development & Psychopathology, 28(4, Pt. 1), 1053-1069. doi: 10.1017/s0954579416000699

Dalrymple-Alford, J. C., Harland, B., Loukavenko, E. A., Perry, B., Mercer, S., Collings, D. A., Ulrich, K., Abraham, W. C., McNaughton, N., & Wolff, M. (2015). Anterior thalamic nuclei lesions and recovery of function: Relevance to cognitive thalamus. Neuroscience & Biobehavioral Reviews, 54, 145-160. doi: 10.1016/j.neubiorev.2014.12.007

Munn, R. G. K., Tyree, S. M., McNaughton, N., & Bilkey, D. K. (2015). The frequency of hippocampal theta rhythm is modulated on a circadian period and is entrained by food availability. Frontiers in Behavioral Neuroscience, 9, 61. doi: 10.3389/fnbeh.2015.00061

Shadli, S. M., Glue, P., McIntosh, J., & McNaughton, N. (2015). An improved human anxiety process biomarker: Characterization of frequency band, personality and pharmacology. Translational Psychiatry, 5, e699. doi: 10.1038/tp.2015.188

McNaughton, N. (2014). Development of a theoretically-derived human anxiety syndrome biomarker. Translational Neuroscience, 5(2), 137-146. doi: 10.2478/s13380-014-0220-z

Ulrich, K., Aitken, P. N., Abraham, W. C., Dalrymple-Alford, J. C., & McNaughton, N. (2014). Effects of thalamic lesions on repeated re-learning of a spatial working memory task. Behavioural Brain Research, 261, 56-59. doi: 10.1016/j.bbr.2013.12.002

Harland, B. C., Collings, D. A., McNaughton, N., Abraham, W. C., & Dalrymple-Alford, J. C. (2014). Anterior thalamic lesions reduce spine density in both hippocampal CA1 and retrosplenial cortex, but enrichment rescues CA1 spines only. Hippocampus, 24, 1232-1247. doi: 10.1002/hipo.22309

McNaughton, N., Swart, C., Neo, P., Bates, V., & Glue, P. (2013). Anti-anxiety drugs reduce conflict-specific “theta”: A possible human anxiety-specific biomarker. Journal of Affective Disorders, 148(1), 104-111. doi: 10.1016/j.jad.2012.11.057

Stevenson, M., & McNaughton, N. (2013). A comparison of phenylketonuria with attention deficit hyperactivity disorder: Do markedly different aetiologies deliver common phenotypes? Brain Research Bulletin, 99, 63-83. doi: 10.1016/j.brainresbull.2013.10.003

Corr, P. J., DeYoung, C. G., & McNaughton, N. (2013). Motivation and personality: A neuropsychological perspective. Social & Personality Psychology Compass, 7(3), 158-175. doi: 10.1111/spc3.12016

Corr, P. J., & McNaughton, N. (2012). Neuroscience and approach/avoidance personality traits: A two stage (valuation–motivation) approach. Neuroscience & Biobehavioral Reviews, 36, 2339-2354. doi: 10.1016/j.neubiorev.2012.09.013

Neo, P., Carter, D., Zheng, Y., Smith, P., Darlington, C., & McNaughton, N. (2012). Septal elicitation of hippocampal theta rhythm did not repair cognitive and emotional deficits resulting from vestibular lesions. Hippocampus, 22(5), 1176-1187. doi: 10.1002/hipo.20963

Hall, P. J., Chong, C. W., McNaughton, N., & Corr, P. J. (2011). An economic perspective on the Reinforcement Sensitivity Theory of personality. Personality & Individual Differences, 51(3), 242-247. doi: 10.1016/j.paid.2010.06.023

McNaughton, N. (2011). Trait anxiety, trait fear and emotionality: The perspective from non-human studies. Personality & Individual Differences, 50(7), 898-906. doi: 10.1016/j.paid.2010.07.011

Neo, P. S.-H., Thurlow, J. K., & McNaughton, N. (2011). Stopping, goal-conflict, trait anxiety and frontal rhythmic power in the stop-signal task. Cognitive, Affective, & Behavioral Neuroscience, 11(4), 485-493. doi: 10.3758/s13415-011-0046-x

McNaughton, N. (2011). Fear, anxiety and their disorders: Past, present and future neural theories. Psychology & Neuroscience, 4(2), 173-181. doi: 10.3922/j.psns.2011.2.002

Neo, P. S.-H., & McNaughton, N. (2011). Frontal theta power linked to neuroticism and avoidance. Cognitive, Affective, & Behavioral Neuroscience, 11(3), 396-403. doi: 10.3758/s13415-011-0038-x

Ruan, M., Young, C. K., & McNaughton, N. (2010). Minimal driving of hippocampal theta by the supramammillary nucleus during water maze learning. Hippocampus, 21(10), 1074-1081. doi: 10.1002/hipo.20821

Young, C., & McNaughton, N. (2009). Coupling of theta oscillations between anterior and posterior midline cortex and with the hippocampus in freely behaving rats. Cerebral Cortex, 19(1), 24-40. doi: 10.1093/cercor/bhn055

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