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Dr Cesar Alcala

Cesar Alcala-OrozcoPostdoctoral Fellow

BSc (Biotech Engineering | ITESM), MSc (Regenerative Biology and Medicine | TU Dresden), PhD (Otago)

Email cesar.alcala@otago.ac.nz

Cesar Alcala joined the Christchurch Regenerative Medicine and Tissues Engineering (CReaTE) group after completing his PhD with the same group.

Cesar’s expertise lies in nanocomposite biomaterials and their use in biofabrication of 3D-printed tissues.

His current focus is a project using advanced 3D bioprinting/bio-assembly strategies to engineer hybrid constructs for musculoskeletal regeneration, specifically targeting bone and cartilage engineering.

Research interests

  • 3D bioprinted scaffolds and novel hydrogel bioinks as platforms for cell encapsulation to generate complex hybrid constructs
  • Assessing nanocomposites for their ability to signal cells during tissue development and for biological functionality
  • Tissue engineering of skeletal tissues
  • Novel biofabrication technologies

Awards

  • Molecular Biology Meeting travel award at the Queenstown Research Week (2019)
  • ASBTE travel award for the ECR & Strategy Workshop in Sydney (2019)
  • International Society of Biofabrication travel award for the International Conference on Biofabrication in Wurzburg (2018)
  • University of Otago travel award for the International Conference on Biofabrication in Wurzburg (2018)
  • CMDH Researcher award (Second Runner-up) at the MedTech CoRE Conference in Auckland (2017)

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Publications

Cui, X., Soliman, B. G., Alcala-Orozco, C. R., Li, J., Vis, M. A. M., Santos, M., … Woodfield, T. B. F., … Lim, K. S. (2020). Rapid photocrosslinking of silk hydrogels with high cell density and enhanced shape fidelity. Advanced Healthcare Materials, 9, 1901667. doi: 10.1002/adhm.201901667

Baptista, M., Jouhkdar, H., Alcala-Orozco, C. R., Lau, K., Jiang, S., Cui, X., … Woodfield, T. B. F., Lim, K. S., & Rnjak-Kovacina, J. (2020). Silk fibroin photo-lyogels containing microchannels as a biomaterial platform for in situ tissue engineering. Biomaterials Science. Advance online publication. doi: 10.1039/d0bm01010c

Alcala-Orozco, C. R., Mutreja, I., Cui, X., Kumar, D., Hooper, G. J., Lim, K. S., & Woodfield, T. B. F. (2020). Design and characterisation of multi-functional strontium-gelatin nanocomposite bioinks with improved print fidelity and osteogenic capacity. Bioprinting, 18, e00073. doi: 10.1016/j.bprint.2019.e00073

Cidonio, G., Alcala-Orozco, C. R., Lim, K. S., Glinka, M., Mutreja, I., Kim, Y.-H., … Woodfield, T. B. F., & Oreffo, R. O. C. (2019). Osteogenic and angiogenic tissue formation in high fidelity nanocomposite Laponite-gelatin bioinks. Biofabrication, 11, 035027. doi: 10.1088/1758-5090/ab19fd

Tang, F., Baptista, M., Lin, X., Jiang, S., Alcala-Orozco, C., Whitelock, J., Lim, K., … Rnjak-Kovacina, J. (2019). Biometric materials toward enhanced bioengineered tissue vascularisation. Proceedings of the European Society for Biomaterials (ESB) 30th Annual Conference and the German Society for Biomaterials (DGBM) 26th Annual Conference. X-OS37-04. Retrieved from https://www.esb2019.org/

Journal - Research Article

Cui, X., Soliman, B. G., Alcala-Orozco, C. R., Li, J., Vis, M. A. M., Santos, M., … Woodfield, T. B. F., … Lim, K. S. (2020). Rapid photocrosslinking of silk hydrogels with high cell density and enhanced shape fidelity. Advanced Healthcare Materials, 9, 1901667. doi: 10.1002/adhm.201901667

Alcala-Orozco, C. R., Mutreja, I., Cui, X., Kumar, D., Hooper, G. J., Lim, K. S., & Woodfield, T. B. F. (2020). Design and characterisation of multi-functional strontium-gelatin nanocomposite bioinks with improved print fidelity and osteogenic capacity. Bioprinting, 18, e00073. doi: 10.1016/j.bprint.2019.e00073

Baptista, M., Jouhkdar, H., Alcala-Orozco, C. R., Lau, K., Jiang, S., Cui, X., … Woodfield, T. B. F., Lim, K. S., & Rnjak-Kovacina, J. (2020). Silk fibroin photo-lyogels containing microchannels as a biomaterial platform for in situ tissue engineering. Biomaterials Science. Advance online publication. doi: 10.1039/d0bm01010c

Cidonio, G., Alcala-Orozco, C. R., Lim, K. S., Glinka, M., Mutreja, I., Kim, Y.-H., … Woodfield, T. B. F., & Oreffo, R. O. C. (2019). Osteogenic and angiogenic tissue formation in high fidelity nanocomposite Laponite-gelatin bioinks. Biofabrication, 11, 035027. doi: 10.1088/1758-5090/ab19fd

Lim, K. S., Levato, R., Costa, P. F., Castilho, M. D., Alcala-Orozco, C. R., van Dorenmalen, K. M. A., … Hooper, G. J., … Woodfield, T. B. F. (2018). Bio-resin for high resolution lithography-based biofabrication of complex cell laden constructs. Biofabrication, 10, 034101. doi: 10.1088/1758-5090/aac00c

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Conference Contribution - Published proceedings: Abstract

Tang, F., Baptista, M., Lin, X., Jiang, S., Alcala-Orozco, C., Whitelock, J., Lim, K., … Rnjak-Kovacina, J. (2019). Biometric materials toward enhanced bioengineered tissue vascularisation. Proceedings of the European Society for Biomaterials (ESB) 30th Annual Conference and the German Society for Biomaterials (DGBM) 26th Annual Conference. X-OS37-04. Retrieved from https://www.esb2019.org/

Cui, S., Li, J., Alcala-Orozco, C., Woodfield, T., Rnjak-Kovacina, J., & Lim, K. (2019). Rapid visible light crosslinking of silk hydrogels for cartilage tissue engineering. Proceedings of the European Society for Biomaterials (ESB) 30th Annual Conference and the German Society for Biomaterials (DGBM) 26th Annual Conference. X-OS19-04. Retrieved from https://www.esb2019.org/

Alcala Orozco, C., Mutreja, I., Lim, K., Hooper, G., & Woodfield, T. (2018). Strontium-based nanocomposite bioinks for improved osteogenic differentiation of mesenchymal stromal cells. Proceedings of the Australasian Society for Biomaterials and Tissue Engineering (ASBTE) 26th Annual Conference. (pp. 53). Retrieved from https://www.asbte.org

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Conference Contribution - Poster Presentation (not in published proceedings)

Alcala-Orozco, C. R., Mutreja, I., Cui, X., Hooper, G. J., Lim, K. S., & Woodfield, T. B. F. (2019, April). Strontium-based nanocomposite bioink for 3D bioprinting of high shape-fidelity osteoconductive scaffolds. Poster session presented at the Australasian Society for Biomaterials and Tissue Engineering (ASBTE) Early Career Researcher Workshop, Sydney, Australia.

Cidonio, G., Alcala-Orozco, C. R., Glinka, M., Mutreja, I., Kim, Y., Dawson, J. L., Lim, K. S., Woodfield, T. B. F., & Oreffo, R. O. C. (2018, October). A nanocomposite bioink to sustain human skeletal stem cell viability and drug delivery. Poster session presented at the International Society for Biofabrication Annual Meeting, Würzburg, Germany.

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Conference Contribution - Verbal presentation and other Conference outputs

Woodfield, T. B. F., Lim, K. S., Lindberg, G. C. J., Cui, S., Alcala-Orozco, C., & Hooper, G. J. (2019, August-September). Biofabrication of the musculoskeletal tissue niche: Tissue spheroid and bioink platiforms. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Alcala-Orozco, C. R., Cidonio, G., Lim, K. S., Dawson, J., Oreffo, R. O. C., & Woodfield, T. B. F. (2019, August-September). High fidelity bioprinting of nanocomposite bioinks supporting osteogenic and angiogenic tissue formation. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Lam Po Tang, E. J., Alcala-Orozco, C. R., Nielsen, P. M. F., Taberner, A. J., Woodfield, T. B. F., & Lim, K. S. (2019, August-September). The effects of different buffers on the physico-mechanical properties of gelatin-methacryloyl (GelMA) hydrogels. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Alcala-Orozco, C. R., Mutreja, I., Lim, K. S., Lindberg, G., Hooper, G. J., & Woodfield, T. (2018, October). Strontium-based nanocomposite bioink for 3D-bioprinting of scaffolds with long-term shape retention and improved osteogenic differentiation of mesenchymal stromal cells. Verbal presentation at the International Society for Biofabrication Annual Meeting, Würzburg, Germany.

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