Qualifications BDS MDSc PhD FRCPath FFOP(RCPA) FRACDS FICD FADI
Position - Retired from Dean, Faculty of Dentistry, and Professor of Periodontology in December 2013
Research summary Primary dentistry and oral health
Professor Seymour's research had two major themes:
- The relationship between oral disease and systemic conditions, primarily atherosclerosis
- The immunopathology of periodontal and oral mucosal diseases using immunological and molecular techniques
Investigations of the relationship between periodontal disease and atherosclerosis focused on molecular mimicry as the link. This work was central to a major collaboration with the University of Queensland, Australia, and the University of Niigata, Japan.
Investigations of the immunopathology of oral diseases focused on relating the nature of the inflammatory infiltrate together with the cytokine and gene expression profiles. An emerging theme in this research was the effect of environmental factors such as smoking and the use of bisphosphonates on gingival gene expression profiles.
Ng, L. K., Rich, A. M., Hussaini, H. M., Thomson, W. M., Fisher, A. L., Horne, L. S., & Seymour,G. J. (2011). Toll-like receptor 2 is present in the microenvironment of oral squamous cell carcinoma. British Journal of Cancer, 104(3), 460-463. doi: 10.1038/sj.bjc.6606057.
Rose-Hill, S., Ford, P. J., Leishman, S. J., Do, H. L., Palmer, J. E., Heng, N. C. K., Seymour, G. J., Cullinan, M. P. (2011). Improved periodontal health and cardiovascular risk. Australian Dental Journal, 56(4), 352-357. doi:10.1111/j.1834-7819.2011.01363.x.
Cullinan, M. P., Palmer, J. E., Carle, A. D., West, M. J., & Seymour, G. J. (2012). Long term use of triclosan toothpaste and thyroid function. Science of the Total Environment, 416, 75-79. doi: 10.1016/j.scitotenv.2011.11.063.
Leishman, S. J., Ford, P. J., Do, H. L., Palmer, J. E., Heng, N. C. K., West, M. J., Seymour, G. J., Cullinan, M. P. (2012). Periodontal pathogen load and increased antibody response to heat shock protein 60 in patients with cardiovascular disease. Journal of Clinical Periodontology, 39(10), 923-930. doi: 10.1111/j.1600-051X.2012.01934.x.