Associate Professor Mani Ekambaram
| Position | Associate Professor |
|---|---|
| Department | Department of Oral Sciences |
| Qualifications | BDS(India) MDS PhD(HK) FDSRCSEd MPaedDent RCSEd MRACDS(Paed) |
| Research summary | Enamel remineralisation and adhesion, dentine adhesion, MIH, paediatric oral health |
| Teaching | Paediatric Dentistry at undergraduate and postgraduate levels |
Research
Associate Professor Mani's research expertise is in remineralisation of early enamel caries lesions, enamel and dentine adhesion, molar incisor hypomineralisation (MIH), and paediatric oral health.
Through his research, he has established a niche in experimental strategies for enhancing dentine bond durability, enhancing bonding to developmentally hypomineralised enamel, studying the remineralisation potential of various contemporary remineralisation agents on early enamel carious lesions. Additionally, his ongoing research projects are aiming at other novel experimental strategies to remineralise such lesions.
Associate Professor Mani has ongoing research collaborations with The University of Hong Kong and University of Western Australia. His research interest also includes prevention and management of early childhood caries.
Publications
Sardana, D., Galland, B., Wheeler, B. J., Yiu, C. K. Y., & Ekambaram, M. (2023). Effect of sleep on development of early childhood caries: A systematic review. European Archives of Paediatric Dentistry, 24, 1-14. doi: 10.1007/s40368-022-00753-3
Imran, E., Cooper, P. R., Ratnayake, J., Ekambaram, M., & Mei, M. L. (2023). Potential beneficial effects of hydroxyapatite nanoparticles on caries lesions in vitro: A review of the literature. Dentistry Journal, 11, 40. doi: 10.3390/dj11020040
Mar, K., Ekambaram, M., Li, K. C., Zwirner, J., & Mei, M. L. (2023). The influence of saliva and blood contamination on bonding between resin-modified glass ionomer cements and resin composite. Operative Dentistry. Advance online publication. doi: 10.2341/21-173-l
Wong, P. Y. W., Lim, S. L., Loi, S. T. Y., Mei, M. L., Li, K. C., Aziz, S., & Ekambaram, M. (2023). A comparative study of two chemical models for creating subsurface caries lesions on aprismatic and prismatic enamel. Journal of Oral Science, 65(1), 20-23. doi: 10.2334/josnusd.22-0311
Lam, P. P. Y., Chua, H., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2022). Does early childhood caries increase caries development among school children and adolescents? A systematic review and meta-analysis. International Journal of Environmental Research & Public Health, 19, 13459. doi: 10.3390/ijerph192013459
Mar, K., Ekambaram, M., Li, K. C., Zwirner, J., & Mei, M. L. (2023). The influence of saliva and blood contamination on bonding between resin-modified glass ionomer cements and resin composite. Operative Dentistry. Advance online publication. doi: 10.2341/21-173-l
Journal - Research Article
Wong, P. Y. W., Lim, S. L., Loi, S. T. Y., Mei, M. L., Li, K. C., Aziz, S., & Ekambaram, M. (2023). A comparative study of two chemical models for creating subsurface caries lesions on aprismatic and prismatic enamel. Journal of Oral Science, 65(1), 20-23. doi: 10.2334/josnusd.22-0311
Journal - Research Article
Lam, P. P. Y., Chua, H., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2022). Does early childhood caries increase caries development among school children and adolescents? A systematic review and meta-analysis. International Journal of Environmental Research & Public Health, 19, 13459. doi: 10.3390/ijerph192013459
Journal - Research Article
Lam, P. P. Y., Chua, H., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2022). Risk predictors of Early Childhood Caries increment: A systematic review and meta-analysis. Journal of Evidence-Based Dental Practice. Advance online publication. doi: 10.1016/j.jebdp.2022.101732
Journal - Research Article
Lee, Y.-L., Li, K. C., Yiu, C. K. Y., Boyd, D. H., & Ekambaram, M. (2022). Evaluation of developmentally hypomineralised enamel after surface pretreatment with Papacarie Duo gel and different etching modes: An in vitro SEM and AFM study. European Archives of Paediatric Dentistry, 23, 117-131. doi: 10.1007/s40368-021-00671-w
Journal - Research Article
Sardana, D., Ekambaram, M., Yang, Y., McGrath, C. P., & Yiu, C. K. Y. (2022). Caries-preventive effectiveness of two different fluoride varnishes: A randomised clinical trial in patients with multi-bracketed fixed orthodontic appliances. International Journal of Paediatric Dentistry. Advance online publication. doi: 10.1111/ipd.13013
Journal - Research Article
Sardana, D., Li, K. Y., Ekambaram, M., Yang, Y., McGrath, C. P., & Yiu, C. K. Y. (2022). Validation of clinical photography and a laser fluorescence device for assessment of enamel demineralization during multi-bracketed fixed orthodontic treatment. Photodiagnosis & Photodynamic Therapy, 38, 102828. doi: 10.1016/j.pdpdt.2022.102828
Journal - Research Article
Al-Kindi, F., Al-Harrasi, R., Coimbatore, H., Aziz, S., Thomson, W. M., & Ekambaram, M. (2021). The selection and clinical application of dental adhesives by general dental practitioners in New Zealand. New Zealand Dental Journal, 117(2), 74-79.
Journal - Research Article
Bijle, M. N., Abdalla, M. M., Ashraf, U., Ekambaram, M., & Yiu, C. K. Y. (2021). Enamel remineralization potential of arginine-fluoride varnish in a multi-species bacterial pH-cycling model. Journal of Dentistry, 104, 103528. doi: 10.1016/j.jdent.2020.103528
Journal - Research Article
Bijle, M. N., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2021). Combined effect of arginine and fluoride on the growth of Lactobacillus rhamnosus GG. Scientific Reports, 11, 973. doi: 10.1038/s41598-020-79684-2
Journal - Research Article
bin Haji Awang Masri, A. A., Khang, K. K. Y., Low Wei Shen, L., Ekambaram, M., & Loch, C. (2021). Knowledge of dental enamel defects among undergraduate dental students a cross sectional survey. European Journal of Dental Education, 25, 711-716. doi: 10.1111/eje.12650
Journal - Research Article
Cheng, M. S., Hsu, K.-H., Thomson, W. M., & Ekambaram, M. (2021). General dental practitioners’ opinions on universal publicly-funded dental care in New Zealand. New Zealand Dental Journal, 117(1), 35-39.
Journal - Research Article
Lam, P. P. Y., Sardana, D., Luo, W., Ekambaram, M., Lee, G. H. M., Lo, E. C. M., & Yiu, C. K. Y. (2021). Glass ionomer sealant versus fluoride varnish application to prevent occlusal caries in primary second molars among preschool children: A randomized controlled trial. Caries Research, 55, 322-332. doi: 10.1159/000517390
Journal - Research Article
Lee, Y.-L., Li, K. C., Yiu, C. K. Y., Boyd, D. H., Waddell, J. N., & Ekambaram, M. (2021). Bonding universal dental adhesive to developmentally hypomineralised enamel. Journal of Adhesive Dentistry, 23(6), 513-525. doi: 10.3290/j.jad.b2288247
Journal - Research Article
Bijle, M. N., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2020). Antibacterial and mechanical properties of arginine-containing glass ionomer cements. Dental Materials, 36, 1226-1240. doi: 10.1016/j.dental.2020.05.012
Journal - Research Article
Bijle, M. N., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2020). Synbiotics in caries prevention: A scoping review. PLoS ONE, 15(8), e0237547. doi: 10.1371/journal.pone.0237547
Journal - Research Article
Bijle, M. N., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2020). The enamel remineralization potential of fluoride varnishes containing arginine. Journal of Dentistry, 99, 103411. doi: 10.1016/j.jdent.2020.103411
Journal - Research Article
Bijle, M. N., Ekambaram, M., Lo, E., & Yiu, C. (2020). Physicochemical characteristics of arginine enriched naf varnish: An in vitro study. Polymers, 12, 2998. doi: 10.3390/polym12122998
Journal - Research Article
Bijle, M. N., Neelakantan, P., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2020). Effect of a novel synbiotic on Streptococcus mutans. Scientific Reports, 10, 7951. doi: 10.1038/s41598-020-64956-8
Journal - Research Article
Bijle, M. N., Tsoi, J., Ekambaram, M., Lo, E. C. M., Carey, C. M., & Yiu, C. K. Y. (2020). Enhanced fluoride bioavailability with incorporation of arginine in child dentifrices. Journal of Clinical Pediatric Dentistry, 44(5), 332-341. doi: 10.17796/1053-4625-44.5.7
Journal - Research Article
Bijle, M. N., Tsoi, J., Ekambaram, M., Lo, E. C. M., Carey, C. M., & Yiu, C. K. Y. (2020). Inter-method reliability for determining total and soluble fluorides in child low-fluoride formula dentifrices. Scientific Reports, 10(1), 20880. doi: 10.1038/s41598-020-77920-3
Journal - Research Article
Botelho, M. G., Ekambaram, M., Bhuyan, S. Y., Yeung, A. W. K., Tanaka, R., Bornstein, M. M., & Li, K. Y. (2020). A comparison of visual identification of dental radiographic and nonradiographic images using eye tracking technology. Clinical & Experimental Dental Research, 6, 59-68. doi: 10.1002/cre2.249
Journal - Research Article
Lam, P. P. Y., Sardana, D., Ekambaram, M., Lee, G. H. M., & Yiu, C. K. Y. (2020). Effectiveness of pit and fissure sealants for preventing and arresting occlusal caries in primary molars: A systematic review and meta-analysis. Journal of Evidence-Based Dental Practice, 20(2), 101404. doi: 10.1016/j.jebdp.2020.101404
Journal - Research Article
Bijle, M. N. A., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2019). A meta-epidemiological review of meta-analysis on anti-caries effect of arginine-containing formulations. Journal of Evidence-Based Dental Practice, 19(1), 28-33. doi: 10.1016/j.jebdp.2018.06.008
Journal - Research Article
Bijle, M. N. A., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2019). The combined antimicrobial effect of arginine and fluoride toothpaste. Scientific Reports, 9(1), 8405. doi: 10.1038/s41598-019-44612-6
Journal - Research Article
Bijle, M. N. A., Tung, L. P., Wong, J., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2019). Enhancing the remineralization potential of child formula dentifrices: An in vitro study. Journal of Clinical Pediatric Dentistry, 43(5), 337-344. doi: 10.17796/1053-4625-43.5.6
Journal - Research Article
Sardana, D., Manchanda, S., Ekambaram, M., Yang, Y., McGrath, C. P., & Yiu, C. K. Y. (2019). Effectiveness of self-applied topical fluorides against enamel white spot lesions from multi-bracketed fixed orthodontic treatement: A systematic review. European Journal of Orthodontics, 41(6), 661-668. doi: 10.1093/ejo/cjz015
Journal - Research Article
Sardana, D., Manchanda, S., Ekambaram, M., Yang, Y., McGrath, C. P., & Yiu, C. K. Y. (2019). Prevention of demineralization around orthodontic brackets using sealants: A systematic review and meta-analysis. Pediatric Dentistry, 41(6), 430-531.
Journal - Research Article
Sardana, D., Zhang, J., Ekambaram, M., Yang, Y., McGrath, C. P., & Yiu, C. K. Y. (2019). Effectiveness of professional fluorides against enamel white spot lesions during fixed orthodontic treatment: A systematic review and meta-analysis. Journal of Dentistry, 82, 1-10. doi: 10.1016/j.jdent.2018.12.006
Journal - Research Article
Tan, C., Ekambaram, M., Lee, G. H. M., & Yiu, C. K. Y. (2019). Unerupted permanent incisors and associated dental anomalies. Journal of Investigative & Clinical Dentistry, 10, e12395. doi: 10.1111/jicd.12395
Journal - Research Article
Uy, E., Ekambaram, M., Lee, G. H. M., & Yiu, C. K. Y. (2019). Remineralization potential of calcium and phosphate-based agents and their effects on bonding of orthodontic brackets. Journal of Adhesive Dentistry, 21(3), 219-228. doi: 10.3290/j.jad.a42305
Journal - Research Article
Bijle, M. N. A., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2018). The combined enamel remineralization potential of arginine and fluoride toothpaste. Journal of Dentistry, 76, 75-82. doi: 10.1016/j.jdent.2018.06.009
Journal - Research Article
Bijle, M. N. A., Yiu, C. K. Y., & Ekambaram, M. (2018). Calcium-based caries preventive agents: A meta-evaluation of systematic reviews and meta-analysis. Journal of Evidence-Based Dental Practice, 18(3), 203-217. doi: 10.1016/j.jebdp.2017.09.003
Journal - Research Article
Bijle, M. N. A., Yiu, C. K. Y., & Ekambaram, M. (2018). Can oral ADS activity or arginine levels be a caries risk indicator? A systematic review and meta-analysis. Clinical Oral Investigations, 22(2), 583-596. doi: 10.1007/s00784-017-2322-9
Journal - Research Article
Gamboa, G. C. S., Lee, G. H. M., Ekambaram, M., & Yiu, C. K. Y. (2018). Knowledge, perceptions, and clinical experiences on molar incisor hypomineralization among dental care providers in Hong Kong. BMC Oral Health, 18(1), 217. doi: 10.1186/s12903-018-0678-0
Journal - Research Article
Ekambaram, M., Anthonappa, R. P., Govindool, S. R., & Yiu, C. K. Y. (2017). Comparison of deproteinization agents on bonding to developmentally hypomineralized enamel. Journal of Dentistry, 67, 94-101. doi: 10.1016/j.jdent.2017.10.004
Journal - Research Article
Mohd Said, S. N. B., Ekambaram, M., & Yiu, C. K. Y. (2017). Effect of different fluoride varnishes on remineralization of artificial enamel carious lesions. International Journal of Paediatric Dentistry, 27(3), 163-173. doi: 10.1111/ipd.12243
Journal - Research Article
Wong, S., Anthonappa, R. P., Ekambaram, M., McGrath, C., King, N. M., & Winters, J. C. (2017). Quality of life changes in children following emergency dental extractions under general anaesthesia. International Journal of Paediatric Dentistry, 27(2), 80-86. doi: 10.1111/ipd.12241
Journal - Research Article
Yawary, R., Anthonappa, R. P., Ekambaram, M., McGrath, C., & King, N. M. (2016). Changes in the oral health-related quality of life in children following comprehensive oral rehabilitation under general anaesthesia. International Journal of Paediatric Dentistry, 26(5), 322-329. doi: 10.1111/ipd.12200
Journal - Research Article
Ekambaram, M., Epasinghe, D. J., Yiu, C. K. Y., & Matinlinna, J. P. (2015). Effect of solvents on inhibition of collagen-bound proteases by chlorhexidine. International Journal of Adhesion & Adhesives, 60, 83-87. doi: 10.1016/j.ijadhadh.2015.03.010
Journal - Research Article
Ekambaram, M., Yiu, C. K. Y., & Matinlinna, J. P. (2015). An overview of solvents in resin-dentin bonding. International Journal of Adhesion & Adhesives, 57, 22-33. doi: 10.1016/j.ijadhadh.2014.09.007
Journal - Research Article
Ekambaram, M., Yiu, C. K. Y., & Matinlinna, J. P. (2015). Bonding of adhesive resin to intraradicular dentine: A review of the literature. International Journal of Adhesion & Adhesives, 60, 92-103. doi: 10.1016/j.ijadhadh.2015.04.003
Journal - Research Article
Ekambaram, M., Yiu, C. K. Y., & Matinlinna, J. P. (2015). Bonding of resin adhesives to caries-affected dentin: A systematic review. International Journal of Adhesion & Adhesives, 61, 23-34. doi: 10.1016/j.ijadhadh.2015.04.011
Journal - Research Article
Ekambaram, M., Yiu, C. K. Y., & Matinlinna, J. P. (2015). Effect of solvents on dentin collagen cross-linking potential of carbodiimide. Journal of Adhesive Dentistry, 17(3), 219-226. doi: 10.3290/j.jad.a34137
Journal - Research Article
Ekambaram, M., Yiu, C. K. Y., Matinlinna, J. P., Chang, J. W. W., Tay, F. R., & King, N. M. (2014). Effect of chlorhexidine and ethanol-wet bonding with a hydrophobic adhesive to intraradicular dentine. Journal of Dentistry, 42(7), 872-882. doi: 10.1016/j.jdent.2014.02.006
Journal - Research Article
Ekambaram, M., Yiu, C. K. Y., Matinlinna, J. P., King, N. M., & Tay, F. R. (2014). Adjunctive application of chlorhexidine and ethanol-wet bonding on durability of bonds to sound and caries-affected dentine. Journal of Dentistry, 42(6), 709-719. doi: 10.1016/j.jdent.2014.04.001
Journal - Research Article
Ekambaram, M., Itthagarun, A., & King, N. M. (2011). Comparison of the remineralizing potential of child formula dentifrices. International Journal of Paediatric Dentistry, 21(2), 132-140. doi: 10.1111/j.1365-263X.2010.01101.x
Journal - Research Article
Imran, E., Cooper, P. R., Ratnayake, J., Ekambaram, M., & Mei, M. L. (2023). Potential beneficial effects of hydroxyapatite nanoparticles on caries lesions in vitro: A review of the literature. Dentistry Journal, 11, 40. doi: 10.3390/dj11020040
Journal - Research Other
Sardana, D., Galland, B., Wheeler, B. J., Yiu, C. K. Y., & Ekambaram, M. (2023). Effect of sleep on development of early childhood caries: A systematic review. European Archives of Paediatric Dentistry, 24, 1-14. doi: 10.1007/s40368-022-00753-3
Journal - Research Other
Chua, H., Sardana, D., Turner, R., Ting, G., & Ekambaram, M. (2021). Effectiveness of oral health education methods on oral hygiene in children and adolescents with visual impairment: A systematic review. International Journal of Paediatric Dentistry, 31, 724-741. doi: 10.1111/ipd.12788
Journal - Research Other
Sardana, D., Manchanda, S., Ekambaram, M., Yang, Y., McGrath, C. P., & Yiu, C. K. Y. (2021). Prevention of demineralization during multi-bracketed fixed orthodontic treatment: An overview of systematic reviews. International Journal of Paediatric Dentistry, 32, 473-502. doi: 10.1111/ipd.12927
Journal - Research Other
Bijle, M. N., Ekambaram, M., & Yiu, C. K. Y. (2020). A scoping review on arginine in caries prevention. Journal of Evidence-Based Dental Practice, 20(3), 101470. doi: 10.1016/j.jebdp.2020.101470
Journal - Research Other
Dissanayake, S. S. M., Ekambaram, M., Li, K. C., Harris, P. W. R., & Brimble, M. A. (2020). Identification of key functional motifs of native amelogenin protein for dental enamel remineralisation. Molecules, 25(18), 4214. doi: 10.3390/molecules25184214
Journal - Research Other
Gopalakrishnan, V., Anthonappa, R., Ekambaram, M., & King, N. M. (2019). Qualitative assessment of published studies on pulpotomy medicaments for primary molar teeth. Journal of Investigative & Clinical Dentistry, 10(2), e12389. doi: 10.1111/jicd.12389
Journal - Research Other
Anthonappa, R. P., Ekambaram, M., Neboda, C. N. G., King, N. M., & Rabie, A.-B. M. (2018). Genetic basis of dentigerous cysts associated with supernumerary teeth: A narrative review. Journal of Investigative & Clinical Dentistry, 9(1), e122667. doi: 10.1111/jicd.12267
Journal - Research Other
Ekambaram, M., Mohd Said, S. N. B., & Yiu, C. K. Y. (2017). A review of enamel remineralisation potential of calcium- and phosphate-based remineralisation systems. Oral Health & Preventive Dentistry, 15(5), 415-420. doi: 10.3290/j.ohpd.a38779
Journal - Research Other
Ekambaram, M. (2016). Williams syndrome: Review of clinical features and its medical considerations in dental treatment. HSOA Journal of Dentistry, 1(1), 003. doi: 10.24966/DOHC-6783/100003
Journal - Research Other
Ekambaram, M., & Yiu, C. K. Y. (2016). Bonding to hypomineralized enamel: A systematic review. International Journal of Adhesion & Adhesives, 69, 27-32. doi: 10.1016/j.ijadhadh.2016.03.016
Journal - Research Other
Ekambaram, M., Itthagarun, A., & King, N. M. (2011). Ingestion of fluoride from dentifrices by young children and fluorosis of the teeth-a literature review. Journal of Clinical Pediatric Dentistry, 36(2), 111-122. doi: 10.17796/jcpd.36.2.3106602470287130
Journal - Research Other
Ekambaram, M., Yiu, C. K. Y., & King, N. M. (2008). An unusual case of double teeth with facial and lingual talon cusps. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontology, 105(4), e63-e67. doi: 10.1016/j.tripleo.2007.11.033
Journal - Research Other
