Department of Medicine
University of Otago Wellington
PO Box 7343
Tel 64 4 918 6780
Fax 64 385 5489
Research expertise and interest
Currently my main research interest involves the role of probiotics in the prevention of eczema and allergy (Studies of Probiotics and Allergic Disease).
I have expertise in the epidemiology of asthma, eczema and other allergic disease, including study design, preparing funding applications, study management, quality control of protocol adherence, data analysis and manuscript preparation. Over the years, my research interest has evolved from case-control, observational and cohort studies looking at risk factors for asthma to randomized controlled trials of probiotic interventions for the primary and secondary prevention of eczema and allergy in infants and children through to age 6 years.
Wickens, K., Barthow, C., Murphy, R., Abels, P., Maude, R., Stone, P., Mitchell, E., Stanley, T., Purdie, G., Kang, J., Hood, F., Rowden, J., Barnes, P., Fitzharris, P., Crane, J., (2017). Early pregnancy probiotic supplementation with Lactobacillus rhamnosus HN001 may reduce the prevalence of gestational diabetes mellitus: A randomised controlled trial. British Journal of Nutrition, 1-10. doi:10.1017/S0007114517000289
Wickens Kristin, Black Peter, Stanley Thorsten, Mitchell Edwin, Barthow Christine, Fitzharris Penny, Purdie Gordon, Crane Julian A protective effect of Lactobacillus rhamnosus HN001 against eczema in the first 2 years of life persists to 4 years. Clin Exp Allergy 2012 Clin Exp Allergy 2012;42:1071-9.
Crane J, Lampshire P, Wickens K, Epton M, Siebers R, Ingham T, Pattemore P, Town GI; Year Six New Zealand Asthma and Allergy Cohort Study Group. Asthma, atopy and exhaled nitric oxide in a cohort of six year old New Zealand children. Pediatric Allergy and Immunology 2012;23:59-64 doi: 10.1111/j.1399-3038.2011.01227.x.
Wickens K, Beasley R, Town I, Epton M, Pattemore P, Ingham T, Crane J The effects of early and late paracetamol exposure on asthma and atopy: a birth cohort Clin Exp Allergy 2011;41:399-406 doi: 10.1111/j.1365-2222.2010.03610.x
Julie Gillespie-Bennett, Nevil Pierse, Kristin Wickens, Julian Crane, Philippa Howden-Chapman and the Housing, Heating and Health Study Research Team. The respiratory health effects of nitrogen dioxide (NO2) in children with asthma. ERJ doi: 10.1183/09031936.00115409 Eur Respir J 2011;38: 303-9
Camargo CA Jr, Ingham T, Wickens K, Thadhani R, Silvers KM, Epton MJ, Town GI, Pattemore PK, Espinola JA, Crane J, New Zealand Asthma and Allergy Cohort Study Group. Cord blood 25-hydroxyvitamin D levels and risk of respiratory infection, childhood wheezing, and asthma. Pediatrics 2011, 127:e180-7 doi: 10.1542/peds.2010-0442
Dekker JW, Wickens K, Black P, Stanley T, Mitchell E, Fitzharris P, Tannock GW, Purdie G, Crane J Safety aspects of probiotic bacterial strains Lactobacillus rhamnosus HN001 and Bifidobacterium animalis subs. lactis HN019 in human infants aged 0 to 2 years. International Dairy Journal 2009;19:149-154
Silvers K, Frampton C, Wickens K, Epton M, Pattemore P, Ingham T, Fishwick D, Crane J, Town I, and the New Zealand Asthma and Allergy Cohort Study Group. Breast feeding protects against adverse respiratory outcomes at 15 months of age. Mat and Child Nut 2009;5:243-50
Wickens K, Black P, Stanley TV, Mitchell E, Fitzharris P, Tannock G, Purdie G, Crane J A differential effect of 2 probiotics in the prevention of eczema and atopy: A double-blind randomized placebo-controlled trial. J Allergy Clin Immunolog 2008;122:788-94
Wickens K, Ingham T, Epton M, Pattemore P, Fishwick D, Crane J The association of early life exposure to antibiotics and the development of asthma, eczema and atopy in a birth cohort: confounding or causality? Clin Exp Allergy 2008; 38:1318-24.
Susan L. Prescott, Kristin Wickens, Lauren Westcott, Wiebke Jung, Helen Currie Peter N. Black, Thorsten V. Stanley, Edwin A. Mitchell, Penny Fitzharris, Rob Siebers, Lian Wu, Julian Crane and the Probiotic Study Group. Supplementation with Lactobacillus rhamnosus or Bifidobacterium lactis probiotics in pregnancy increases cord blood IFN and breast milk TGF and IgA detection. Clin Exp Allergy 2008;38:1606-14
Wickens, K. L., Barthow, C. A., Murphy, R., Abels, P. R., Maude, R. M., Stone, P. R., … Stanley, T. V., Purdie, G. L., Kang, J. M., Hood, F. E., … Barnes, P. K., … Crane, J. (2017). Early pregnancy probiotic supplementation with Lactobacillus rhamnosus HN001 may reduce the prevalence of gestational diabetes mellitus: A randomised controlled trial. British Journal of Nutrition, 117(6), 804-813. doi: 10.1017/S0007114517000289
Slykerman, R. F., Hood, F., Wickens, K., Thompson, J. M. D., Barthow, C., Murphy, R., Kang, J., … Crane, J., Stanley, T., Abels, P., Purdie, G., … the Probiotic in Pregnancy Study Group. (2017). Effect of Lactobacillus rhamnosus HN001 in pregnancy on postpartum symptoms of depression and anxiety: A randomised double-blind placebo-controlled trial. EBioMedicine, 24, 159-165. doi: 10.1016/j.ebiom.2017.09.013
Wickens, K., Stanley, T. V., Mitchell, E. A., Barthow, C., Fitzharris, P., Purdie, G., Siebers, R., … Crane, J. (2013). Early supplementation with Lactobacillus rhamnosus HN001 reduces eczema prevalence to 6 years: Does it also reduce atopic sensitization? Clinical & Experimental Allergy, 43(9), 1048-1057. doi: 10.1111/cea.12154
Wickens, K., Black, P., Stanley, T. V., Mitchell, E., Barthow, C., Fitzharris, P., Purdie, G., & Crane, J. (2012). A protective effect of Lactobacillus rhamnosus HN001 against eczema in the first 2 years of life persists to age 4 years. Clinical & Experimental Allergy, 42(7), 1071-1079. doi: 10.1111/j.1365-2222.2012.03975.x
Crane, J., Lampshire, P., Wickens, K., Epton, M., Siebers, R., Ingham, T., Pattemore, P., Town, I., and the Year Six New Zealand Asthma and Allergy Cohort Study Group, (NZAACS6) . (2012). Asthma, atopy and exhaled nitric oxide in a cohort of 6-yr-old New Zealand children. Pediatric Allergy & Immunology, 23(1), 59-64. doi: 10.1111/j.1399-3038.2011.01227.x