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Associate Professor Esko Wiltshire, Department of Paediatrics and Child Health

photo-of-Esko-Wiltshire
MB ChB MD DipObst DipPaed FRACP
Associate Professor in the Department of Paediatrics


Associate Professor Esko Wiltshire completed his undergraduate training in Medicine at the University of Otago, graduating in 1989 (MBChB with distinction), then worked as a house surgeon/SHO in the greater Wellington region, including the Diploma in Obstetrics and Gynaecology and Diploma in Paediatrics, before completing basic paediatric training and the FRACP examinations. He undertook advanced training in general paediatrics, followed by paediatric endocrinology and metabolic disease, in Adelaide, South Australia. He completed his doctorate during this time, investigating early vascular disease in children with diabetes, before returning to Wellington in 2001 as a senior lecturer in the Department of Paediatrics and Child Health, University of Otago Wellington and Paediatrician/Paediatric Endocrinologist for CCDHB. He has overseen development of services in Paediatric endocrinology and diabetes since 2001, and extended research initiatives in this area. He enjoys teaching medical students, particularly in clinical contexts, but also in integration of foundational sciences (esp biochemistry and physiology) with clinical medicine, something which is a key component of his clinical work. Outside the department he loves spending time with his two children and all their activities and has a passion for the outdoors, especially tramping and cycling (completing the 160 km Taupo cycle classic in 2011). He is currently the covenor for 5th year student teaching.

Research interests

Associate Professor Wiltshire's primary areas of research involve investigation of the acute and chronic complications of diabetes, particularly their pathophysiology and early development, and also treatment. In this work Associate Professor Wiltshire has a major collaboration with Professor J Couper in South Australia. The aims of this research are to identify factors involved in the early pathogenesis of the vascular complications of diabetes, when interventions will have the greatest effect. In addition Associate Professor Wiltshire is a collaborator in the Australasian arm of “TrialNet”, a major international collaboration investigating treatments to prevent type 1 diabetes, and collaborates with Professor K Donaghue in Sydney, addressing aspects of autonomic dysfunction in children with diabetes. In addition, Associate Professor Wiltshire has interests in other aspects of clinical paediatric endocrinology and metabolism, and has published scientific articles concerning clinical aspects of paediatric bone/calcium homeostasis, adrenal function and mitochondrial disease.

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Publications

Peña, A. S., Wiltshire, E., MacKenzie, K., Gent, R., Piotto, L., Hirte, C., & Couper, J. (2006). Vascular endothelial and smooth muscle function relates to body mass index and glucose in obese and nonobese children. Journal of Clinical Endocrinology & Metabolism, 91(11), 4467-4471.

MacKenzie, K. E., Wiltshire, E. J., Gent, R., Hirte, C., Piotto, L., & Couper, J. J. (2006). Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus. Pediatrics, 118, 242-253.

Peña, A. S., Wiltshire, E., Gent, R., Piotto, L., Hirte, C., & Couper, J. (2007). Folic acid does not improve endothelial function in obese children and adolescents. Diabetes Care, 30(8), 2122-2127.

Newton, K. H., Wiltshire, E. J., & Elley, C. R. (2009). Pedometers and text messaging to increase physical activity: Randomized controlled trial of adolescents with type 1 diabetes. Diabetes Care, 32(5), 813-815. doi: 10.2337/dc08-1974

Calvo, S. E., Tucker, E. J., Compton, A. G., Kirby, D. M., Crawford, G., Burtt, N. P., … Wiltshire, E., … Mootha, V. K. (2010). High-throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency. Nature Genetics, 42(10), 851-858. doi: 10.1038/ng.659

Journal - Research Article

McTavish, L., & Wiltshire, E. (2011). Effective treatment of hypoglycemia in children with type 1 diabetes: A randomized controlled clinical trial. Pediatric Diabetes, 12(4pt2), 381-387. doi: 10.1111/j.1399-5448.2010.00725.x

Peña, A. S., Belobrajdic, D. P., Wiltshire, E., Gent, R., Hirte, C., & Couper, J. (2010). Adiponectin relates to smooth muscle function and folate in obese children. International Journal of Pediatric Obesity, 5(2), 185-191. doi: 10.3109/17477160903111748

Calvo, S. E., Tucker, E. J., Compton, A. G., Kirby, D. M., Crawford, G., Burtt, N. P., … Wiltshire, E., … Mootha, V. K. (2010). High-throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency. Nature Genetics, 42(10), 851-858. doi: 10.1038/ng.659

MacKenzie, K. E., Wiltshire, E. J., Peña, A. S., Gent, R., Hirte, C., Piotto, L., & Couper, J. J. (2009). Hs-CRP is associated with weight, BMI, and female sex but not with endothelial function in children with type 1 diabetes. Pediatric Diabetes, 10(1), 44-51. doi: 10.1111/j.1399-5448.2008.00456.x

Newton, K. H., Wiltshire, E. J., & Elley, C. R. (2009). Pedometers and text messaging to increase physical activity: Randomized controlled trial of adolescents with type 1 diabetes. Diabetes Care, 32(5), 813-815. doi: 10.2337/dc08-1974

Wiltshire, E. J., Mohsin, F., Chan, A., & Donaghue, K. C. (2008). Methylenetetrahydrofolate reductase and methionine synthase reductase gene polymorphisms and protection from microvascular complications in adolescents with type 1 diabetes. Pediatric Diabetes, 9(4, Part II), 348-353.

Gleeson, H., Wiltshire, E., Briody, J., Hall, J., Chaitow, J., Sillence, D., … Munns, C. (2008). Childhood chronic recurrent multifocal osteomyelitis: Pamidronate therapy decreases pain and improves vertebral shape. Journal of Rheumatology, 35(4), 707-712.

Wiltshire, E., Davidzon, G., DiMauro, S., Akman, H. O., Sadleir, L., Haas, L., Zuccollo, J., McEwen, A., & Thorburn, D. R. (2008). Juvenile Alpers disease. Archives of Neurology, 65(1), 121-124. doi: 10.1001/archneurol.2007.14

Fox, L., Sadowsky, J., Pringle, K. C., Kidd, A., Murdoch, J., Cole, D. E. C., & Wiltshire, E. (2007). Neonatal hyperparathyroidism and pamidronate therapy in an extremely premature infant. Pediatrics, 120(5), e1350-e1354.

Wilson, C., Kerruish, N. J., Wilcken, B., Wiltshire, E., & Webster, D. (2007). The failure to diagnose inborn errors of metabolism in New Zealand: The case for expanded newborn screening. New Zealand Medical Journal, 120(1262). Retrieved from http://journal.nzma.org.nz/journal/120-1262/2727/content.pdf

Peña, A. S., Wiltshire, E., Gent, R., Piotto, L., Hirte, C., & Couper, J. (2007). Folic acid does not improve endothelial function in obese children and adolescents. Diabetes Care, 30(8), 2122-2127.

Wiltshire, E. J., Newton, K., & McTavish, L. (2006). Unrecognised hypoglycaemia in children and adolescents with type 1 diabetes using the continuous glucose monitoring system: Prevalence and contributors. Journal of Paediatrics & Child Health, 42, 758-763.

Scott, A., Toomath, R., Bouchier, D., Bruce, R., Crook, N., Carroll, D., … Lunt, H., Wiltshire, E., & Wu, D. (2006). First national audit of the outcomes of care in young people with diabetes in New Zealand: High prevalence of nephropathy in Māori and Pacific Islanders. New Zealand Medical Journal, 119(1235). Retrieved from http://journal.nzma.org.nz/journal/119-1235/2015/content.pdf

Peña, A. S., Wiltshire, E., MacKenzie, K., Gent, R., Piotto, L., Hirte, C., & Couper, J. (2006). Vascular endothelial and smooth muscle function relates to body mass index and glucose in obese and nonobese children. Journal of Clinical Endocrinology & Metabolism, 91(11), 4467-4471.

MacKenzie, K. E., Wiltshire, E. J., Gent, R., Hirte, C., Piotto, L., & Couper, J. J. (2006). Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus. Pediatrics, 118, 242-253.

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Journal - Research Other

Gallego, P. H., Wiltshire, E., & Donaghue, K. C. (2007). Identifying children at particular risk of long-term diabetes complications. Pediatric Diabetes, 8(Suppl. 6), 40-48.

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Conference Contribution - Published proceedings: Abstract

Gibbs, S., Sadleir, L., Cole, D. E. C., Hendy, G. N., & Wiltshire, E. (2011). Does the calcium sensing receptor have a role in neuronal function and idiopathic epilepsy? Proceedings of the 8th International Brain Research Organization (IBRO) World Congress. Retrieved from http://www.abstractstosubmit.com/ibro2011/abstracts/

Tucker, E. J., Calvo, S. E., Compton, A. G., Goldberger, O. A., Wiltshire, E., Wilson, C. J., … Thorburn, D. R. (2010). High-throughput, pooled sequencing of a patient cohort identifies novel genes that cause human complex I deficiency. Proceedings of the OzBio Combined Conference: The Molecules of Life: From Discovery to Biotechnology. (pp. 50). Retrieved from http://www.asbmb.org.au/ozbio2010/abstracts.html

Wiltshire, E. J., Pena, A. S., MacKenzie, K., Piotto, L., Gent, R., Bose, T., & Couper, J. J. (2009). Polymorphisms in endothelial nitric oxide synthase influence folate status and predict endothelial response to folate in children and adolescents with type 1 diabetes or obesity. Hormone Research, 72(Suppl. 3), (pp. 58). doi: 10.1159/000239668

McTavish, L., & Wiltshire, E. (2009). Effective treatment of hypoglycaemia in children with type 1 diabetes: A randomised controlled clinical trial. Hormone Research. 71(Suppl. 1), (pp. 148). doi: 10.1159/000178060

Pena, A. S., Wiltshire, E. J., Harrington, J., MacKenzie, K., Gent, R., Piotto, L., … Couper, J. (2009). Deterioration in vascular function during puberty in adolescents with type 1 diabetes. Hormone Research, 72(Suppl. 3), (pp. 57). doi: 10.1159/000239668

McTavish, L., & Wiltshire, E. (2009). Effective treatment of hypoglycaemia in children with type 1 diabetes: A randomised controlled clinical trial. Pediatric Diabetes, 10(Suppl. 11), (pp. 68). [Abstract]

Peña, A., Wiltshire, E., Gent, R., Piotto, L., Hirte, C., & Couper, J. (2007). Folic acid does not improve endothelial function in obese non diabetic children and adolescents. Journal of Paediatrics and Child Health. 43, (pp. A1). [Abstract]

Pena, A., Belobrajdic, D., Wiltshire, E., Gent, R., Piotto, L., Hirte, C., & Couper, J. (2007). Adiponectin relates independently to vascular smooth muscle function to obese and non-obese children. Hormone Research. 68(Suppl. 1), (pp. 129). [Abstract]

Cowell, C. T., Gleeson, H. K., Wiltshire, E., Grimwood, K., Briody, J., Chaitow, J., … Munns, C. F. (2007). Chronic recurrent multifocal osteomyelitis: Effectiveness of cyclic intravenous pamidronate therapy in pain relief and spinal involvement. Bone. 40(6, Suppl. 1), (pp. S34-S35). [Abstract]

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