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Dr Dianne Sika Paotonu

Dr Dianne Sika Paotonu thumbnailC.Q.S. Cert AT(AIT) DPH(Otago) BSc BBMedSc PGCertEdPD PGDipHELT MBMEDSC(Hons) PhD(VUW)

TEL +64 4 918 5142
Email dianne.sika-paotonu@otago.ac.nz

Dianne Sika-Paotonu is the Scientific Lead for the Penicillin Research Programme based in New Zealand. She is also the Associate Dean (Pacific) at the University of Otago, Wellington. Selected projects within the VUW Penicillin Research work include: Benzathine Penicillin G (BPG) Reformulation Preferences study, the BPG Pharmacokinetics Study and the BPG Reformulation work. In the past she has worked at the Telethon Kids Institute (TKI) in Perth Western Australia where she remains an Honorary Research Associate and functioned as the Scientific Lead for the Penicillin Research work within the Group A Streptococcal Disease team based at the Wesfarmers Centre for Vaccines and Infectious Diseases.

Dianne is also an Associate Investigator working on projects such as “Towards a new long-acting penicillin formulation for rheumatic fever and rheumatic heart disease“ and the National Science Challenge/Healthier Lives funded work “Circulating tumour DNA for better cancer management”, among others. She is also a member of the New Zealand based research team investigating the Immunogenetics of Rheumatic Fever connected with the Genome Wide-Association Study International Consortium.

Dianne completed her PhD in Biomedical Science at Victoria University of Wellington specializing in Immunology while based at the Malaghan Institute of Medical Research. While there Dianne was a member of the cancer vaccines team and undertook work that explored the modification of these vaccines to generate stronger immune responses against cancer. Her work showed that increased numbers of cancer-killing immune cells could be generated when synthetic compounds that mimic infected tissue were incorporated into the cancer vaccine preparation. Her work also highlighted the role of specific sub-populations of immune cells in generating these cancer killing immune responses. Dianne’s work overall aimed to improve of the potency of these cancer vaccines for the treatment of all cancers.

Dianne has received numerous awards for her PhD and other research work including the MacDiarmid New Zealand Young Scientist of the Year-Advancing Human Health & Wellbeing, Colmar Brunton Research Excellence Award, Australasian Society of Immunology BD Science Communication award, Asia Pacific Science Technology Studies Networks New Contributions to Science Technology & Innovation Award-Indigenous studies and the Australasian Society of Immunology Buck Memorial Award among others.

Dianne’s research interests include Immunology, Rheumatic Fever, Immunogenetics, Cancer and Pharmacology. Dianne is of Tongan descent and also has strong research interests in areas of health research relevant to Pacific populations living in New Zealand and in the Region. Dianne is an Honorary Research Associate with the Wesfarmers Centre for Vaccines & Infectious Diseases, Telethon Kids Institute, Perth, Western Australia and an Affiliate Investigator at the Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland.

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Publications

Sika-Paotonu, D., Beaton, A., & Carapetis, J. (2018). Epidemiology and global burden of rheumatic heart disease. In A. J. Camm, T. F. Lüscher, G. Maurer & P. W. Serruys (Eds.), The ESC textbook of cardiovascular medicine. (3rd ed.) Oxford, UK: Oxford University Press. doi: 10.1093/med/9780198784906.003.0065

Robertson, S. P., Harré Hindmarsh, J., Berry, S., Cameron, V. A., Cox, M. P., Dewes, O., … Matisoo-Smith, E., … Sika-Paotonu, D., … Merriman, T. R., … Wilcox, P. (2018). Genomic medicine must reduce, not compound, health inequities: The case for hauora-enhancing genomic resources for New Zealand. New Zealand Medical Journal, 131(1480), 81-89. Retrieved from https://www.nzma.org.nz/journal

Hand, R. M., Senarathna, G., Page-Sharp, M., Sika-Paotonu, D., Gray, K., Batty, K. T., & Carapetis, J. (2018). Benzathine penicillin G quality and potency: Do we need a new manufacturing standard? Global Heart, 13(4), (pp. 519). doi: 10.1016/j.gheart.2018.09.501

Sika-Paotonu, D., Viali, S., Naseri, L. T. T. K., So'o, F. L. T. I. A., Lameko, T. V., Punivalu, M., … Guilford, P. (2018). The application of ctDNA technology for early Cancer diagnostics in Samoa. Journal of Immunology, 200(1, Suppl.), 120.40. [Abstract]

Sika-Paotonu, D., & Tait, C. (2018). Immunology Education for English Second Language learners within a Postgraduate Nursing Science program in New Zealand. Journal of Immunology, 200(1, Suppl.), 113.18. [Abstract]

Commissioned Report for External Body

Sika-Paotonu, D., Smith, L., Tibby, C., & McDuff, I. (2011). A dynamic evidence-base: Service and clinical quality initiatives addressing Pacific Peoples' health needs. Commissioned by Ministry of Health. Wellington, New Zealand: Litmus. 48p. Retrieved from https://litmus.co.nz

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Working Paper; Discussion Paper; Technical Report

Wyber, R., Johnson, T., Carapetis, J., Davis, K., Gray, K., Marantelli, S., … Sika-Paotonu, D., … Zühlke, L. (2016). Global status of BPG report: The Benzathine Penicillin G report. RHD Action. 52p. Retrieved from http://rhdaction.org

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Other Research Output

Sika-Paotonu, D. (2018, October). IL-25 drives skin inflammation in psoriasis: The potential for clinical utility of IL-25 as a therapeutic target. Science eLetters. Retrieved from http://immunology.sciencemag.org/content/3/23/eaat9662/tab-e-letters

Sika-Paotonu, D. (2018, October). RE: The probacterial effect of type I interferon signaling requires its own negative regulator USP18 . Science eLetters. Retrieved from http://immunology.sciencemag.org/content/3/27/eaau2125/tab-e-letters

Sika-Paotonu, D. (2018, October). RE: PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production. Science eLetters. Retrieved from http://stm.sciencemag.org/content/10/460/eaar8356/tab-e-letters

Sika-Paotonu, D. (2018, October). RE: Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections. Science eLetters. Retrieved from http://stm.sciencemag.org/content/10/460/eaat7520/tab-e-letters

Sika-Paotonu, D. (2018, October). RE: Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumours. Science eLetters. Retrieved from http://science.sciencemag.org/content/359/6371/91/tab-e-letters

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Chapter in Book - Research

Sika-Paotonu, D., Beaton, A., & Carapetis, J. (2018). Epidemiology and global burden of rheumatic heart disease. In A. J. Camm, T. F. Lüscher, G. Maurer & P. W. Serruys (Eds.), The ESC textbook of cardiovascular medicine. (3rd ed.) Oxford, UK: Oxford University Press. doi: 10.1093/med/9780198784906.003.0065

Sika-Paotonu, D., Beaton, A., Raghu, A., Steer, A., & Carapetis, J. (2017). Acute rheumatic fever and rheumatic heart disease. In J. J. Ferretti, D. L. Stevens & V. A. Fischetti (Eds.), Streptococcus pyogenes: Basic biology to clinical manifestations. (pp. 771-826). Oklahoma, OK: University of Oklahoma Health Sciences Center. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK425394/

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Journal - Research Article

Cornwall, J., Robinson, B., & Sika-Paotonu, D. (2016). The availability of clinical anatomy in postgraduate nursing education in New Zealand. Anatomy, 10(2), 138-142. doi: 10.2399/ana.16.022

Delahunt, B., Sika-Paotonu, D., Bethwaite, P. B., Jordan, T. W., Magi-Galluzzi, C., Zhou, M., … Srigley, J. R. (2011). Grading of clear cell renal cell carcinoma should be based on nucleolar prominence. American Journal of Surgical Pathology, 35(8), 1134-1139. doi: 10.1097/PAS.0b013e318220697f

Petersen, T. R., Sika-Paotonu, D., Knight, D. A., Simkins, H. M. A., & Hermans, I. F. (2011). Exploiting the role of endogenous lymphoid-resident dendritic cells in the priming of NKT cells and CD8+ T cells to dendritic cell-based vaccines. PLoS ONE, 6(3), e17657. doi: 10.1371/journal.pone.0017657

Petersen, T. R., Sika-Paotonu, D., Knight, D. A., Dickgreber, N., Farrand, K. J., Ronchese, F., & Hermans, I. F. (2010). Potent anti-tumor responses to immunization with dendritic cells loaded with tumor tissue and an NKT cell ligand. Immunology & Cell Biology, 88(5), 596-604. doi: 10.1038/icb.2010.9

Delahunt, B., Sika-Paotonu, D., Bethwaite, P. B., McCredie, M. R. E., Martignoni, G., Eble, J., & Jordan, T. W. (2007). Fuhrman grading is not appropriate for chromophobe renal cell carcinoma. American Journal of Surgical Pathology, 31(6), 957-960.

Sika-Paotonu, D., Bethwaite, P. B., McCredie, M. R. E., William, J. T., & Delahunt, B. (2006). Nucleolar grade but not Fuhrman grade is applicable to papillary renal cell carcinoma. American Journal of Surgical Pathology, 30(9), 1091-1096. doi: 10.1097/01.pas.0000209833.69972.2b

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Journal - Research Other

Robertson, S. P., Harré Hindmarsh, J., Berry, S., Cameron, V. A., Cox, M. P., Dewes, O., … Matisoo-Smith, E., … Sika-Paotonu, D., … Merriman, T. R., … Wilcox, P. (2018). Genomic medicine must reduce, not compound, health inequities: The case for hauora-enhancing genomic resources for New Zealand. New Zealand Medical Journal, 131(1480), 81-89. Retrieved from https://www.nzma.org.nz/journal

Sika-Paotonu, D., Robinson, B., & Maling, T. (2017). Engaging postgraduate students undertaking clinical pharmacology using GoSoapBox for problem-based learning [Syllabus selections: Innovative learning activities]. Journal of Nursing Education, 56(9), 575-576. doi: 10.3928/01484834-20170817-14

Delahunt, B., Bethwaite, P. B., Miller, R. J., Sika-Paotonu, D., & Srigley, J. R. (2010). Re: Fuhrman grade provides higher prognostic accuracy than nucleolar grade for papillary renal cell carcinoma [Letter to the editor/errata]. Journal of Urology, 185(1), 356-357. doi: 10.1016/j.juro.2010.08.045

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Conference Contribution - Published proceedings: Abstract

Hand, R. M., Senarathna, G., Page-Sharp, M., Sika-Paotonu, D., Gray, K., Batty, K. T., & Carapetis, J. (2018). Benzathine penicillin G quality and potency: Do we need a new manufacturing standard? Global Heart, 13(4), (pp. 519). doi: 10.1016/j.gheart.2018.09.501

Sika-Paotonu, D., & Tait, C. (2018). Immunology Education for English Second Language learners within a Postgraduate Nursing Science program in New Zealand. Journal of Immunology, 200(1, Suppl.), 113.18. [Abstract]

Sika-Paotonu, D., Viali, S., Naseri, L. T. T. K., So'o, F. L. T. I. A., Lameko, T. V., Punivalu, M., … Guilford, P. (2018). The application of ctDNA technology for early Cancer diagnostics in Samoa. Journal of Immunology, 200(1, Suppl.), 120.40. [Abstract]

Sika-Paotonu, D. (2018). The utilization of a clinically relevant Immunological research case example within undergraduate biomedical sciences education. Journal of Immunology, 200(1, Suppl.), 113.12. [Abstract]

Sika-Paotonu, D., & Guilford, P. (2018). Exploring the applicability of ctDNA technology as a diagnostic tool for improved Cancer care and management within the Pacific. Journal of Immunology, 200(1, Suppl.), 120.20. [Abstract]

Hand, R. M., Bowen, A., Manning, L., Salman, S., Joseph, J., Sika-Paotonu, D., … Carapetis, J. (2018). Benzathine penicillin G pharmacokinetics in a predominately Australian Aboriginal adolescent population: A prospective observational study. Global Heart, 13(4), (pp. 519-520). doi: 10.1016/j.gheart.2018.09.503

Sika-Paotonu, D., Tiatia, R., Thornley, C., Betty, B., Wineera-Parai, R., Eddie, B., Baker, M., … Carapetis, J. (2018). Understanding protective plasma levels of penicillin and monitoring antibody responses for the prevention of GAS infection in a paediatric population in New Zealand. Journal of Immunology, 200(1, Suppl.), 45.46. [Abstract]

Sika-Paotonu, D., Vaea, K., 'Ulufonua, L. K., Akau'ola, S., Aho, G., Tuipulotu, A. A., … Guilford, P. (2018). The utilization of ctDNA technology as an early diagnostic tool for Cancer detection in Tonga. Journal of Immunology, 200(1, Suppl.), 120.38. [Abstract]

Sika-Paotonu, D., & Laban, L. W. (2018). Knowledge translation for Cancer Immunotherapy and Immunology that is culturally appropriate and relevant within a Pacific context. Journal of Immunology, 200(1, Suppl.), 113.9. [Abstract]

Sika-Paotonu, D. (2018). Translating knowledge and raising awareness of Immunology related human disease mechanisms via engagement with the general public and lay audience. Journal of Immunology, 200(1, Suppl.), 113.13. [Abstract]

Sika-Paotonu, D. (2018). The successful use of Immunology based Peer Teaching strategies within postgraduate clinical health sciences blended learning education frameworks. Journal of Immunology, 200(1, Suppl.), 113.14. [Abstract]

Sika-Paotonu, D., Viali, S., Naseri, L. T. T. K., So'o, F. L. T. I. A., Lameko, T. V., Punivalu, M., … Tiatia, R., … Norris, P., … Baker, M., & Carapetis, J. (2018). The Benzathine Penicillin G (BPG) Reformulation Preferences Study: Samoa. Journal of Immunology, 200(1, Suppl.), 45.45. [Abstract]

Sika-Paotonu, D., & Tait, C. (2018). The incorporation of Self-Directed Learning for English Second Language learners within postgraduate Clinical Health Sciences Immunology education. Journal of Immunology, 200(1, Suppl.), 113.6. [Abstract]

Sika-Paotonu, D., Tiatia, R., Sung, Y. K., Thornley, C., Betty, B., Wineera-Parai, R., … Baker, M., … Carapetis, J. (2018). The Benzathine Penicillin G (BPG) reformulation preferences study: The importance of cultural awareness and appropriate governance concerning Rheumatic Fever related research in New Zealand. Journal of Immunology, 200(1, Suppl.), 120.39. [Abstract]

Sika-Paotonu, D. (2018). Enhancing student knowledge and understanding of Immunology using integration of a clinically relevant Immunological condition within postgraduate clinical sciences education. Journal of Immunology, 200(1, Suppl.), 113.11. [Abstract]

Sika-Paotonu, D., Aho, G., 'Ulufonua, L. K., 'Ofanoa, M., Vaea, K., Tuipulotu, A. A., … Tiatia, R., … Norris, P., … Baker, M., & Carapetis, J. (2018). The Benzathine Penicillin G (BPG) Reformulation Preferences Study: Tonga. Journal of Immunology, 200(1, Suppl.), 166.68. [Abstract]

Sika-Paotonu, D., & Tait, C. (2018). The utilization of scientific language communication techniques to enhance Immunology Education for Postgraduate Clinical Health Science students. Journal of Immunology, 200(1, Suppl.), 113.10. [Abstract]

Sika-Paotonu, D., Tiatia, R., Sung, Y. K., Thornley, C., Betty, B., Wineera-Parai, R., … Baker, M., … Carapetis, J. (2018). The Benzathine Penicillin G (BPG) reformulation preferences study-edging closer towards a new Penicillin for Rheumatic Fever and Rheumatic Heart Disease. Journal of Immunology, 200(1, Suppl.), 120.35. [Abstract]

Sika-Paotonu, D., & Guilford, P. (2018). The potential application of ctDNA technology as a cancer diagnostic tool within the Socialist Republic of Vietnam. Journal of Immunology, 200(1, Suppl.), 120.21. [Abstract]

Sika-Paotonu, D. (2018). The incorporation of active learner centered strategies to support improved memory recall and classroom engagement within postgraduate education blended learning education frameworks. Journal of Immunology, 200(1, Suppl.), 113.15. [Abstract]

Sika-Paotonu, D. (2017). Self-directed learning within postgraduate immunology education. Journal of Immunology, 198(1, Suppl.), 128.5. [Abstract]

Sika-Paotonu, D., & Laban, L. W. (2017). Cancer immunotherapy: Knowledge translation and outreach education. Journal of Immunology, 198(1, Suppl.), 137.1. [Abstract]

Sika-Paotonu, D., Viali, S. U., Lameko, V., Bunch, S., Best, K., Fiu, F., … Guilford, P. (2017). Exploring the potential application of ctDNA technology within a resource constrained environment. Journal of Immunology, 198(1, Suppl.), 157.18. [Abstract]

Sika-Paotonu, D., Tiatia, R., Sung, Y. K., Lander, L., Haira, T., Thornley, C., … Carapetis, J. (2017). The Benzathine Penicillin G (BPG) reformulation preferences study: Towards a new pencillin for rheumatic fever and rheumatic heart disease. Journal of Immunology, 198(1, Suppl.), 213.2. [Abstract]

Sika-Paotonu, D., & Tait, C. (2017). Scientific language communication within postgraduate Immunology education. Journal of Immunology, 198(1, Suppl.), 137.2. [Abstract]

Sika-Paotonu, D., Azevedo, P., Faatoese, A., Wihongi, H., Nuku, H., Hudson, M., … Merriman, T., & Lennon, D. (2017). Culturally appropriate advisory and governance oversight for the study of rheumatic fever and rheumatic heart disease in New Zealand. Journal of Immunology, 198(1, Suppl.), 125.30. [Abstract]

Sika-Paotonu, D., & Guilford, P. (2017). The potential application of ctDNA for improved cancer management, treatment and diagnosis within the Pacific. Journal of Immunology, 198(1, Suppl.), 157.4. [Abstract]

Sika-Paotonu, D. (2016). Immunology education within a Postgraduate Nursing Science program in New Zealand. Journal of Immunology, 196(1, Suppl.), 130.8. [Abstract]

Sika-Paotonu, D., Marsh, J., Gray, K., Bowen, A., Carapetis, J., Salman, S., … Ramsay, J. (2016). Understanding protective plasma levels of penicillin and monitoring antibody responses for the prevention of GAS infection in a pediatric population. European Journal of Immunology, 46(Suppl. 1), (pp. 619). doi: 10.1002/eji.201670200

Azevedo, P., Merriman, T., Topless, R., Sika-Paotonu, D., Crengle, S., Wilson, N., … Lennon, D. (2016). Association study involving polymorphisms in IL-6, IL1-RA, and CTLA4 genes and rheumatic heart disease in New Zealand population of Māori and Pacific ancestry. European Journal of Immunology, 46(Suppl. 1), (pp. 288). doi: 10.1002/eji.201670200

Cornwall, J., Robinson, B., & Sika-Paotonu, D. (2016). Is clinical anatomy and science-based education readily available in postgraduate nursing education frameworks in New Zealand? Clinical Anatomy, (pp. 221). doi: 10.1002/ca.22682

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Conference Contribution - Verbal presentation and other Conference outputs

Sika-Paotonu, D. (2012, February). Designing vaccines to combat cancer: A pacific journey through the New Zealand science, health and research communities [Invited]. Workshop presentation at the Asia-Pacific Science, Technology and Society Network (APSTSN) Workshop, Wellington, New Zealand.

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