Testicular cancer is by far the most common cancer among young men. Our work has identified an unusual ethnic inequality in testicular cancer, whereby Māori men suffer 80% higher rates than European/Other men. This is in stark contrast to other international contexts, where it is the European/White population that suffer the highest rates of this disease. We are engaged in a programme of retrospective and prospective work that aims to explain this unusual disparity, with a view to both improving cancer outcomes for Māori and adding valuable new insights into the currently obscure causes of this cancer.
Ko te mate pukupuku i ngā raho te tino o ngā mate pukupuku ki waenga i ngā tama tāne. Kua tautohu mātau he tino rerekē te ōritenga kore mō te mate pukupuku i ngā raho ki waenga i ngā iwi, arā ka 80% te nui ake o te pānga o tēnei momo mate ki ngā tāne Māori i ngā tāne Pākehā me ētahi atu. He tino rerekē tēnei ki ētahi horopaki ki tāwāhi, arā ko te iwi Pākehā ka tino pāngia e tēnei mate. Kei te whakahaere mātau i tētahi hōtaka ki te titiro whakamuri, ki te titiro whakamua hoki ki te whakamārama i tēnei rerekētanga, me te whakaaro mā tēnei mahi e whakapiki ngā hua mate pukupuku mō Ngāi Māori, e whakaputa i te mātau hou ki ngā take o tēnei momo mate pukupuku e noho huna ana i tēnei wā.
Jason Gurney, James Stanley, Katherine McGlynn, Lorenzo Richiardi, Caroline Shaw, Richard Edwards, Tony R Merriman, Bridget Robson, Jonathan Koea, Melissa McLeod, Martin Kennedy, Diana Sarfati (2018). The Testicular Cancer in New Zealand (TCNZ) study: Protocol for a national case-control study. BMJ Open, 8:e025212. doi:10.1136/bmjopen-2018-025212.
Jason K. Gurney, Andrea Ayers, Ariana Znaor, Jacques Ferlay, Mathieu Laversanne, Diana Sarfati, Freddie Bray, Katherine A. McGlynn. International trends in the incidence of testicular cancer: lessons from the last 35 years. European Urology, Accepted and In-Press. DOI: 10.1111/andr.12584
Signal V, Huang S, Sarfati D, Stanley J, McGlynn K, Gurney J. Diary and risk of testicular cancer: a systematic review. Nutrition and Cancer 2018; DOI: 10.1080/01635581.2018.1470655.
Huang S, Signal V, Sarfati D, Shaw C, Stanley J, McGlynn K, Gurney J. Physical activity and risk of testicular cancer: a systematic review. BMC Cancer 2018; 18:189: https://doi.org/10.1186/s12885-018-4093-3.
Gurney J, Stanley J, York S, Rosenbaum D, Sarfati D. Risk of lower limb amputation in a national prevalent cohort of patients with diabetes. Diabetologia 2018; 61: 626-35.
Gurney, J., Sarfati, D., Morreau, P., Stanley, J., Merriman, T., Signal, V., Shaw, C., Edwards, R., Richiardi, L., Hutson, J., McGlynn, K. (2017). Risk factors for congenital cryptorchidism. Nature Reviews Urology, doi:10.1038/nrurol.2017.90.
Gurney, J., Richiardi, L., McGlynn, K., Signal, V., Sarfati, D. (2016). Analgesia use during pregnancy and risk of cryptorchidism: a systematic review and meta-analysis. Human Reproduction, 32(5), p1118–1129.
Gurney, J., Stanley, J., Shaw, C., Sarfati, D. (2016). Ethnic patterns of hypospadias in New Zealand do not resemble those observed for cryptorchidism and testicular cancer: evidence of differential aetiology? Andrology, 4, p82-86.
Gurney, J., Shaw, C., Stanley, J., Signal, V., Sarfati, D. (2015). Cannabis exposure and risk of testicular cancer: a systematic review and meta-analysis. BMC Cancer, 15, p1-10.
Gurney, J., Sarfati, D., Stanley, J. (2015). Obscure etiology, unusual disparity: the epidemiology of testicular cancer in New Zealand. Cancer Causes and Control, 26, p. 561-569.
Gurney, J.K., Sarfati, D., Stanley, J., Studd, R. (2013) Do ethnic differences in cryptorchidism reflect those found in testicular cancer? The Journal of Urology, 190(5), p. 1852-1857.
Sarfati D, Shaw C, Blakely T, Atkinson J, Stanley J. Ethnic and Socioeconomic trends in testicular cancer incidence in New Zealand. International Journal of Cancer. 2011 128: 1683-91.
Testicular cancer in New Zealand: A mystery to be solved:
Hear Dr Jason Gurney talking about the mysteries of testicular cancer aetiology, and the unique opportunity that we have in New Zealand to answer some fundamental questions about this disease.